The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

Planas-Paz, Lara, Orsini, Vanessa, Boulter, Luke, Calabrese, Diego, Pikiolek, Monika, Nigsch, Florian, Xie, Yang, Roma, Guglielmo +25 more·2016·Nature Cell Biology
DOI 10.1038/ncb3337

Cited by (362)

Items 201–300 of 362

  1. Human Liver Organoid Models for Assessment of Drug Toxicity at the Preclinical Stage
    Mustafa Karabicici, Soheil Akbari, Özge Ertem, Mukaddes Gümüştekin, Esra Erdal · 2023 · Endocrine Metabolic & Immune Disorders - Drug Targets
  2. GVHD targets organoid-forming bile duct stem cells in a TGF-β–dependent manner
    Yuta Hasegawa, Daigo Hashimoto, Zixuan Zhang, Toru Miyajima, Yumika Saito, Wenyu Li, Ryo Kikuchi, Hajime Senjo, Tomoko Sekiguchi, Takahiro Tateno et al. · 2024 · Blood
  3. Regenerating the liver: not so simple after all?
    Malcolm Ronald Alison, Wey‐Ran Lin · 2016 · F1000Research
  4. Lgr4 Regulates Oviductal Epithelial Secretion Through the WNT Signaling Pathway
    Xue Tan, Lingling Zhang, Tianqi Li, Jianmin Zhan, Kun Qiao, Haili Wu, Shenfei Sun, Meina Huang, Fangxi Zhang, Meixing Zhang et al. · 2021 · Frontiers in Cell and Developmental Biology
  5. Synergy of 5-aminolevulinate supplement and CX3CR1 suppression promotes liver regeneration via elevated IGF-1 signaling
    Liang Chen, Lele Zhang, Guanghui Jin, Yasong Liu, Na Guo, Haobin Sun, Yong Jiang, Xiaomei Zhang, Guobin He, Guo Lv et al. · 2023 · Cell Reports
  6. Evaluating the regenerative potential and functionality of human liver cells in mice
    Antson Kiat Yee Tan, Kyle M. Loh, Lay Teng Ang · 2017 · Differentiation
  7. Wnt/β‐catenin signalling controls bile duct regeneration by regulating differentiation of ductular reaction cells
    Nan Wang, Rui Kong, Wei Han, Jie Lu · 2020 · Journal of Cellular and Molecular Medicine
  8. Investigation of amodiaquine localization in liver lobules using matrix‐assisted laser desorption/ionization imaging mass spectrometry
    Kerri J. Grove, Shaila Hoque, Patrick J. Rudewicz · 2018 · Rapid Communications in Mass Spectrometry
  9. Wnt ligand and receptor patterning in the liver
    Eider Valle-Encinas, Trevor C. Dale · 2019 · Current Opinion in Cell Biology
  10. Ring finger protein 152 inhibits colorectal cancer cell growth and is a novel prognostic biomarker.
    Ximao Cui, Wenbin Shen, Guanghui Wang, Zhenyu Huang, Dongpeng Wen, Yili Yang, Yun Liu, Long Cui · 2018 · Europe PMC (PubMed Central)
  11. Maladaptive regeneration and metabolic dysfunction associated steatotic liver disease: Common mechanisms and potential therapeutic targets
    Dandan Wu, Stan F.J. van de Graaf · 2024 · Biochemical Pharmacology
  12. Self-maintenance of zonal hepatocytes during adult homeostasis and their complex plasticity upon distinct liver injuries
    Chow Hiang Ang, Philip Arandjelovic, Jinming Cheng, Jicheng Yang, Fusheng Guo, Yuanquan Yu, Sarmilla Nelameham, Lachlan W. Whitehead, Jiangtao Li, David L. Silver et al. · 2024 · Cell Reports
  13. Hepatic zonation determines tumorigenic potential of mutant β-catenin
    Alexander Raven, Kathryn L. Gilroy, Hu Jin, Joseph A. Waldron, Holly Leslie, June Munro, Holly Hall, Rachel A. Ridgway, Catriona A. Ford, D. Gulhan et al. · 2025 · Nature
  14. Non-Genomic Control of Dynamic MYCN Gene Expression in Liver Cancer
    Xian‐Yang Qin, Luc Gailhouste · 2021 · Frontiers in Oncology
  15. Magnetic resonance imaging and ultrasound elastography in the context of preclinical pharmacological research: significance for the 3R principles
    Michael Obrecht, Stefan Zurbruegg, Nathalie Accart, Christian Lambert, Arno Doelemeyer, Birgit Ledermann, Nicolau Beckmann · 2023 · Frontiers in Pharmacology
  16. Upstream regulators of hepatic Wnt/β‐catenin activity control liver metabolic zonation, development, and regeneration
    Laure‐Alix Clerbaux, Rita Manco, Isabelle Anne Leclercq · 2016 · Hepatology
  17. Xenobiotic CAR Activators Induce Dlk1-Dio3 Locus Noncoding RNA Expression in Mouse Liver
    Lucie Pouché, Antonio Vitobello, Michael Römer, Milica Glogovac, A. Kenneth MacLeod, Heidrun C. Ellinger-Ziegelbauer, Magdalena Westphal, Valérie Dubost, Daniel P. Stiehl, Berengere M Dumotier et al. · 2017 · Toxicological Sciences
  18. Focusing on beta‐catenin activating mutations to refine liver tumor profiling
    Sabine Colnot · 2016 · Hepatology
  19. The biological functions of LGR5 in promoting non-small cell lung cancer progression
    Fei Gao, Junchi Xu, Xinran You, Xin Gao, Jia-Ling Wei, Shuxiang Li, Chenlu Zhu, Chen Guang Yang · 2019 · Translational Cancer Research
  20. The many ways to mend your liver: A critical appraisal
    Malcolm Ronald Alison · 2018 · International Journal of Experimental Pathology
  21. Imbalanced Activation of Wnt-/β-Catenin-Signaling in Liver Endothelium Alters Normal Sinusoidal Differentiation
    Philipp-Sebastian Reiners-Koch, Kajetan Sandorski, Joschka Heil, Christian David Schmid, Sina W. Kürschner, Johannes N. Hoffmann, Manuel Winkler, Theresa Staniczek, Carolina De La Torre, Carsten Sticht et al. · 2021 · Frontiers in Physiology
  22. A Spatial Atlas of Wnt Receptors in Adult Mouse Liver
    Jenesis D. Gayden, Shikai Hu, Paul Joseph, Evan R. Delgado, Silvia Liu, Aaron W. Bell, Stéphanie Puig, Satdarshan P. Monga, Zachary Freyberg · 2023 · American Journal Of Pathology
  23. Liver zonation—a journey through space and time
    Stefano Annunziato, Jan S. Tchorz · 2021 · Nature Metabolism
  24. Hepatic Zonation Now on Hormones!
    Sungjin Ko, Satdarshan P. Monga · 2018 · Hepatology
  25. Genetic and Cellular Contributions to Liver Regeneration
    Roger J. Liang, Yu-Hsuan Lin, Hao Zhu · 2021 · Cold Spring Harbor Perspectives in Biology
  26. Advancing liver metabolic zonation with single-cell and spatial omics
    Masanori Fujimoto, Tomoaki Tanaka · 2025 · Endocrine Journal
  27. A Model Mechanism-Based Explanation of an In Vitro-In Vivo Disconnect for Improving Extrapolation and Translation
    Andrew Allen Smith, Yanli Xu, Glen E. P. Ropella, C. Anthony Hunt · 2018 · Journal of Pharmacology and Experimental Therapeutics
  28. “Small Hepatocytes” in the Liver
    Toshihiro Mitaka, Norihisa Ichinohe, Naoki Tanimizu · 2023 · Cells
  29. Erratum: Corrigendum: The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size
    Lara Planas‐Paz, Vanessa Orsini, Luke Boulter, Diego Calabrese, Monika Pikiolek, Florian Nigsch, Yang Xie, Guglielmo Roma, Adriana Donovan, Patricia Marti et al. · 2016 · Nature Cell Biology
  30. Diploid hepatocytes drive physiological liver renewal in adult humans
    Paula Heinke, Fabian Rost, Julian Rode, Thilo Welsch, Kanar Alkass, Joshua Feddema, Mehran Salehpour, Göran Possnert, Henrik Druid, Lutz Brusch et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  31. Prometheus revisited: liver homeostasis and repair
    Sun, Tianliang, Annunziato, Stefano, Tchorz, Jan S. · 2020 · Aging
  32. Gallbladder cholangiocyte organoids
    Ankita Dutta, Nandita Chowdhury, Shinjini Chandra, Payel Guha, Vaskar Saha, Dwijit GuhaSarkar · 2025 · Biology of the Cell
  33. R-spondins secreted by human pancreas-derived mesenchymal stromal cells support pancreatic organoid proliferation
    Alessandro Cherubini, Clelia Pistoni, Maria Chiara Iachini, Cecilia Mei, Francesco Rusconi, Valeria Peli, Mario Barilani, Dorian Tace, Noemi Elia, Fabio Lepore et al. · 2025 · Cellular and Molecular Life Sciences
  34. Developing and regenerating a sense of taste
    Christina M. Piarowski, Trevor J. Isner, Linda A. Barlow · 2025 · Current topics in developmental biology/Current Topics in Developmental Biology
  35. Rspo2-LGR4 exacerbates hepatocellular carcinoma progression via activation of Wnt/β-catenin signaling pathway
    Yanghui Bi, Liping Zhang, Yan Song, Lijun Sun, Michael W. Mulholland, Yue Yin, Weizhen Zhang · 2023 · Gastroenterología y Hepatología
  36. Rspo3-mediated metabolic liver zonation regulates systemic glucose metabolism and body mass in mice
    Kenji Uno, Takuya Uchino, Takashi A. SUZUKI, 佐山 遥平, Naoki Edo, kiyoko uno, Koji Morita, Toshio Ishikawa, Miho Koizumi, Hiroaki Honda et al. · 2025 · PLoS Biology
  37. Home Away From Home: Bioengineering Advancements to Mimic the Developmental and Adult Stem Cell Niche
    Patrick S. Barhouse, Melisa J. Andrade, Quinton Smith · 2022 · Frontiers in Chemical Engineering
  38. Blood flow‐induced angiocrine signals promote organ growth and regeneration
    Paula Follert, Linda Große‐Segerath, Eckhard Lammert · 2024 · BioEssays
  39. Founder cells for hepatocytes during liver regeneration: from identification to application
    Saisai Wei, Jiacheng Tang, Xiujun Cai · 2020 · Cellular and Molecular Life Sciences
  40. The Conundrum of the Pericentral Hepatic Niche: WNT/-Catenin Signaling, Metabolic Zonation, and Many Open Questions
    Tchorz, Jan S. · 2020 · Gene Expression
  41. Loss of RNF43/ZNRF3 predisposes to Hepatocellular carcinoma by impairing liver regeneration and altering liver fat metabolism
    Gianmarco Mastrogiovanni, Clare Pacini, Sofia Kakava, Robert Arnes‐Benito, Charles Richard Bradshaw, Susan E. Davies, Kourosh Saeb‐Parsy, Bon‐Kyoung Koo, Meritxell Huch · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  42. Zonated mechanosensing by PIEZO1 controls liver regeneration
    Zhang, Ying, Sun, Yuzhuo, Xu, Guangkui, Wu, Yue, Shi, Zhijun, Chang, Zhuo, Liu, Junjun, Pang, Kaidan, Liu, Siyu, Wang, Han et al. · 2026 · Science
  43. Midlobular zone 2 hepatocytes: A gatekeeper of liver homeostasis
    Naoto Kubota, Tetsuya Kubota, Takashi Kadowaki · 2021 · Cell Metabolism
  44. c-Maf: The magic wand that turns on LSEC fate
    Anna R. Smith, Valerie Gouon–Evans · 2022 · Cell stem cell
  45. MRI as Primary End Point for Pharmacologic Experiments of Liver Regeneration in a Murine Model of Partial Hepatectomy
    Vanessa Orsini, Stefan Zurbruegg, Monika Pikiolek, Jan S. Tchorz, Nicolau Beckmann · 2016 · Academic Radiology
  46. LGRs receptors as peculiar GPCRs involved in cancer
    Marie‐Isabelle Garcia · 2017 · Journal of Stem Cell Research and Medicine
  47. Array-based Western-blotting reveals spatial differences in hepatic signaling and metabolism following CAR activation
    Fridolin Treindl, Elke Zabinsky, Simon Kling, Michael Schwarz, Albert Braeuning, Markus F. Templin · 2020 · Archives of Toxicology
  48. Gustatory-neuron-supplied R-spondin-2 is required for taste bud replenishment
    Xu Jiang, Alan de Araujo, Ranhui Xi, Kaihua Luo, Mingyue Han, Xiaoli Lin, Chanyi Lu, Minliang Zhou, Kurt David Hankenson, Robert F. Margolskee et al. · 2025 · Stem Cell Reports
  49. Towards a reference cell atlas of liver diversity over the human lifespan
    Sarah A. Taylor, Gary D. Bader, Sonya A. MacParland, Alan C. Mullen, Tallulah S. Andrews, Alex G. Cuenca, Ramanuj DasGupta, Adam J. Gehring, Dominic Grün, Martin Guilliams et al. · 2025 · Nature Reviews Gastroenterology & Hepatology
  50. Recapitulating the liver niche in vitro
    Kiryu K. Yap, Geraldine M. Mitchell · 2022 · Advances in stem cells and their niches
  51. A gene edited pig model for studying LGR5+ stem cells: implications for future applications in tissue regeneration and biomedical research
    Amanda B. T. Hill, Yanet Murphy, Kathryn M. Polkoff, Laura Edwards, Derek M. Walker, Adele Moatti, Alon Greenbaum, Jorge A. Piedrahita · 2024 · Frontiers in Genome Editing
  52. Large‐Scale Formation and Long‐Term Culture of Hepatocyte Organoids From Streamlined In Vivo Genome‐Edited GGTA1−/− Pigs for Bioartificial Liver Applications
    Yuting He, Mengyu Gao, Xinglong Zhu, Wanliu Peng, Yanyan Zhou, Jingqiu Cheng, Lang Bai, Ji Bao · 2024 · Xenotransplantation
  53. Telomerase Activity Links to Regenerative Capacity of Hepatocytes
    Wei‐Yu Lu, Stuart John Forbes · 2018 · Transplantation
  54. Self‐Renewal Capability of Hepatocytic Parental Progenitor Cells Derived From Adult Rat Liver Is Maintained Long Term When Cultured on Laminin 111 in Serum‐Free Medium
    Junichi Kino, Norihisa Ichinohe, Masayuki Ishii, Hiromu Suzuki, Toru Mizuguchi, Naoki Tanimizu, Toshihiro Mitaka · 2019 · Hepatology Communications
  55. Seeds in the liver
    Hongjie Ji, Yanrong Lu, Yujun Shi · 2017 · Acta Histochemica
  56. Gastrointestinal Tract Development
    Reed A. Dimmitt, Zachary M. Sellers, Eric Sibley · 2018 · Avery's Diseases of the Newborn
  57. The spatio-temporal program of liver zonal regeneration
    Shani Ben‐Moshe, Tamar Veg, Rita Manco, Stav Dan, Aleksandra A. Kolodziejczyk, Keren Bahar Halpern, Eran Elinav, Shalev Itzkovitz · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  58. Oncogenic function and transcriptional dynamics of MYCN in liver tumorigenesis
    Xian‐Yang Qin, Yali Xu, Hricha Mishra, Yohei Shirakami, Shiou‐Hwei Yeh, Chiao‐Ling Li, K. Numata, Yusuke Suenaga, Feifei Wei, Reiko Ando et al. · 2026 · Proceedings of the National Academy of Sciences
  59. Strategies for targeted protein degradation through lysosomal pathways
    W. P. Wang, Yuxin Fang, Chunquan Sheng · 2026 · Advanced Drug Delivery Reviews
  60. WNT signaling contributes to the extrahepatic bile duct proliferative response to obstruction in mice
    Ashley N. Calder, Mirabelle Q. Peter, John W. Tobias, Nureen H. Mohamad Zaki, Theresa M. Keeley, Timothy L. Frankel, Linda C. Samuelson, Nataliya Razumilava · 2024 · JCI Insight
  61. Induction of MASH-like pathogenesis in the Nwd1−/− mouse liver
    Seiya Yamada, Hayato Ogawa, Miona Funato, Misaki Kato, Kazuhiko Nakadate, Tomoya Mizukoshi, Kiyoharu Kawakami, Ryosuke Kobayashi, Takuro Horii, Izuho Hatada et al. · 2025 · Communications Biology
  62. Structure, Function and Responses to Injury
    James M. Crawford, Paulette Bioulac‐Sage, Prodromos Hytiroglou · 2023 · Elsevier eBooks
  63. Loss of ZNRF3/RNF43 unleashes EGFR in cancer
    Fei Yue, Amy Tsu Ku, Payton D. Stevens, Megan N. Michalski, Weiyu Jiang, Jianghua Tu, Zhongcheng Shi, Yongchao Dou, Yi Wang, Xin‐Hua Feng et al. · 2026 · eLife
  64. Discovery of Transcription Factors Involved in the Maintenance of Resident Vascular Endothelial Stem Cell Properties
    Hirotaka Konishi, Fitriana Nur Rahmawati, Naoki Okamoto, Keigo Akuta, Koichi Inukai, Weizhen Jia, Fumitaka Muramatsu, Nobuyuki Takakura · 2024 · Molecular and Cellular Biology
  65. Synchronization by Daytime Restricted Food Access Modulates the Presence and Subcellular Distribution of β-Catenin and Its Phosphorylated Forms in the Rat Liver
    Dalia De Ita‐Pérez, Mauricio Díaz‐Muñoz · 2017 · Frontiers in Endocrinology
  66. Establishment of a tagged variant of Lgr4 receptor suitable for functional and expression studies in the mouse
    Vı́tězslav Křı́ž, Michaela Krausová, Petra Burešová, Jan Dobeš, Dušan Hrčkulák, Oľga Babošová, Jiří Švec, Vladimír Kořínek · 2017 · Transgenic Research
  67. Integrative network analysis of circular RNAs reveals regulatory mechanisms for hepatic specification of human iPSC-derived endoderm
    Fang Bai, Jinliang Duan, Daopeng Yang, Xingqiang Lai, Xiaofeng Zhu, Xiaoshun He, Anbin Hu · 2022 · Stem Cell Research & Therapy
  68. Non-canonical Wnt signalling initiates scarring in biliary disease
    David H. Wilson, RP Mellin, Nicholas T. Younger, Edward J. Jarman, Alexander Raven, P Chen, Charlotte H. Dean, Deborah J. Henderson, Timothy James Kendall, Luke Boulter · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  69. Loss of ZNRF3/RNF43 unleashes EGFR in cancer
    Fei Yue, Amy Tsu Ku, Payton D. Stevens, Megan N. Michalski, Weiyu Jiang, Jianghua Tu, Zhongcheng Shi, Yongchao Dou, Yi Wang, Xin‐Hua Feng et al. · 2024 · eLife
  70. Triggering Mechanisms of Hepatocyte Repopulation during Liver Regeneration
    Eui Jin Lee, Na Young Lee, Myeung Gi Choi, Ho Jae Ryu, Ja Hyun Koo · 2025 · Biomolecules & Therapeutics
  71. Olfactory epithelium regeneration and homeostasis: cellular and molecular mechanisms and novel methodological advances
    Jiaming Qi, Yiqun Yu · 2026 · Cell Regeneration
  72. Prometheus 2.0: drug-induced liver regeneration arising
    Jan S. Tchorz · 2024 · Cell Research
  73. Prognostic prediction and diagnostic role of Rspondin 1 expression in esophageal squamous cell carcinoma
    Xiaoxia Cheng, Jiao Liu, Danye Niu, Changsong Zhang, Yuansheng Lin, Shengjun Li, Jiao Yang, Wen Jiangtao · 2024 · Indian Journal of Pathology and Microbiology
  74. Case report: exome sequencing identified mutations in the LRP5 and LGR4 genes in a case of osteoporosis with recurrent fractures and extraskeletal manifestations
    Poonam Mehta, Aakriti Sharma, Anupam Goswami, Sushil Kumar Gupta, Vaibhav Singhal, Kinshuk Raj Srivastava, Naibedya Chattopadhyay, Singh Rajender · 2024 · Frontiers in Endocrinology
  75. The E3 ubiquitin ligase ZNRF3 restricts WNT receptor complex activity by stimulating the selective degradation of WNT-engaged FZD
    Bo Lu, Feng Cong · 2025 · Science Signaling
  76. Molecular basis of liver disease
    Satdarshan P. Monga, Jaideep Behari · 2020 · Elsevier eBooks
  77. The role of roof plate-specific spondins in liver homeostasis and disease
    Le Yang, Wenhui Yue, Hang Zhang, Yue Gao, Lin Yang, Liying Li · 2022 · Liver Research
  78. The Hepatic Central Vein: Anatomical and Molecular Links to Perivenous Liver Biology
    Ki Mark Mak · 2019 · Journal of Gastroenterology and Hepatology Research
  79. Liver stem cells
    Dagmara Szkolnicka, David C. Hay · 2020 · Elsevier eBooks
  80. Absent expansion of pericentral hepatocytes and altered physiology in Axin2CreERT2 mice
    Stephanie May, Miryam Müller, Callum R. Livingstone, George Skalka, Colin Nixon, Ann Hedley, Robin Shaw, William Andrew Clark, Thomas M. Drake, Christos Kiourtis et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  81. How the liver keeps itself in shape
    Stephanie May, Thomas Graham Bird · 2023 · eLife
  82. Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling
    Vincent Quoc‐Huy Trinh, Ting‐Fang Lee, Sara Lemoinne, Kevin C. Ray, Maria D. Ybanez, Takuma Tsuchida, James K. Carter, Judith Agudo, Brian D. Brown, Kemal Marc Akat et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  83. Binucleated human hepatocytes arise through loss of membrane anchorage to the midbody during endomitosis
    Gabriella S Darmasaputra, Susana M. Chuva de Sousa Lopes, H. Clevers, M. Galli · 2023 · bioRxiv
  84. Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer
    Fei Yue, Amy Tsu Ku, Payton D. Stevens, Megan N. Michalski, Weiyu Jiang, Jianghua Tu, Zhongcheng Shi, Yongchao Dou, Yi Wang, Xin‐Hua Feng et al. · 2024 · eLife
  85. Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer
    Fei Yue, Amy Tsu Ku, Payton D. Stevens, Megan N. Michalski, Weiyu Jiang, Jianghua Tu, Zhongcheng Shi, Yongchao Dou, Yi Wang, Xin‐Hua Feng et al. · 2025 · eLife
  86. Chromatin remodeling in pericentral hepatocytes modulates MASH through CYP450 activity
    Zhisen Zhang, Shuangshuang Lu, Yinyin Shu, Shuhui Zhang, Yuhan Guo, Yiping Lin, Wei Qing Xu, Xiaoni Jin, Yukun Hu, Mintao Ji et al. · 2026 · Journal of Hepatology
  87. Bioartificial Livers Developed From Gene‐Edited Pig Hepatocyte Organoids Improve Amino Acid and Lipid Profiles in the Plasma of Patients With Liver Failure
    Yuting He, Yang Deng, Xinglong Zhu, Mengyu Gao, Q F Liu, Wanliu Peng, Yanyan Zhou, Lang Bai, Ji Bao · 2026 · MedComm
  88. Haemodynamic control of zonated liver function via instructive vascular Wnt signalling
    Ki Hong Lee, Moritz Jakab, Alexey Uvarovskii, Dimitris N. Papageorgiou, Donato Inverso, Jingjing Shi, Maria Riedel, Stephanie Gehrs, Shubhada Kulkarni, Stefanie Bobe et al. · 2026 · Nature Communications
  89. Dynamic Tissue Remodeling in Chronic Liver Diseases: Abnormal Proliferation and Differentiation of Hepatocytes and Bile Ducts/Ductules
    Yuji Nishikawa · 2018 · Elsevier eBooks
  90. Endogenous beta‐galactosidase activity marks a TREM2‐expressing Kupffer cell population in injured livers of Lgr5‐LacZ and wild‐type mice
    Mariliis Klaas, Kristina Mäemets‐Allas, Kadi Lõhmussaar, Mikk Tooming, Janeli Viil, Viljar Jaks · 2019 · FEBS Letters
  91. New Advances in Classical Wnt/β-Catenin Signaling in Cancer
    Akhlaq Ahmad, Akhlaq Ahmad, Ailin Tao, Mushtaq Ahmed, Nadia Mushtaq, Ayesha Ali Khan, Qingxin Li, Muhammad Wasim Khan · 2020 · Clinical Oncology and Research
  92. Liver Development
    Matthew C. Gillen, Stacey S. Huppert · 2021 · Cambridge University Press eBooks
  93. β‐Catenin Signaling
    Satdarshan P. Monga · 2020 · Liver
  94. Technical advances in the development of zonation liver in vitro systems that incorporate localized Wnt activating signals
    Eider Valle-Encinas, Michael Dawes, Carmen Velasco Martinez, Kate McSweeney, Miryam Müller, Tom Bird, Trevor C. Dale · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  95. Clonal dynamics of normal hepatocyte expansions in homeostatic human livers and their association with the biliary epithelium
    Adam M. Passman, Magnus J. Haughey, Emanuela Carlotti, Marc J. Williams, Biancastella Cereser, Meng‐Lay Lin, Shruthi Devkumar, Jonathon p Gabriel, Francesco Paolo Russo, Matthew Hoare et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  96. Induction of NASH in the Nwd1 −/− mouse liver via SERCA2-dependent endoplasmic reticulum stress
    Seiya Yamada, Kazuhiko Nakadate, Tomoya Mizukoshi, Kiyoharu Kawakami, Ryosuke Kobayashi, Takuro Horii, Izuho Hatada, Shin‐ichi Sakakibara · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  97. Targeting ZNRF3 and RNF43 to Restore Regeneration and Reverse Metabolic Dysfunction-Associated Steatotic Liver Disease
    Federico Di Tullio, Sue Bin Yang, Lida Yang, Bruno Cogliati, Shamsa Roshan, Kaiyuan Guo, Abigail Glezer, Joseph Conrad, Siddarth Vinod Kumar, Joana Almeida et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  98. Plasticity of Liver Epithelial Cells in Healthy and Injured Livers
    Naoki Tanimizu, Toshihiro Mitaka · 2018 · Elsevier eBooks
  99. Generation of Zone-specific Hepatocyte-like Cells from Human Induced Pluripotent Stem Cells for Accurate Prediction of Drug-induced Hepatotoxicity
    Seiji Mitani · 2019 · YAKUGAKU ZASSHI
  100. Rspos and malignant tumors of digestive system.
    Qian Wang, Meng Wang, Lin Tan, Weiming Qu, Hongbing Zhou, Wei-Shun Chen · 2020 · PubMed