Animal models of human pregnancy and placentation: alternatives to the mouse
Open accessAbstract
The mouse is often criticized as a model for pregnancy research as gestation is short, with much of organ development completed postnatally. There are also differences in the structure and physiology of the placenta between mouse and human. This review considers eight alternative models that recently have been proposed and two established ones that seem underutilized. A promising newcomer among rodents is the spiny mouse, which has a longer gestation than the mouse with organogenesis complete at birth. The guinea pig is also recommended both because it has well-developed neonates and because there is a wealth of information on pregnancy and placentation in the literature. Several smaller primates are considered. The mouse lemur has its advocates yet is less suited as a model for human pregnancy as its young are altricial, placentation very different from that of humans, and husbandry requirements not fully assessed. In contrast, the common marmoset, a New World monkey, has well-developed neonates and is kept at many primate centres. Marmoset placenta has some features that closely resemble human placentation, such as the interhaemal barrier, although it is uncertain if invasion of the uterine arteries occurs in this species. In conclusion, pregnancy research would benefit greatly from increased use of alternative models such as the spiny mouse and common marmoset.
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In rats, the initial 12 postnatal days parallel the third human trimester, marked by extensive neurogenesis, synaptogenesis, and circuit maturation.
“In rats, the initial 12 postnatal days parallel the third human trimester, marked by extensive neurogenesis, synaptogenesis, and circuit maturation [63–67].”
From Nicotine on the developing brain. (2023) · cites this paper as [67]
The Reproductive strategies section says rats have altricial young and that much organ development in such animals occurs after birth; the Discussion (p. R138) also describes rat newborns as altricial. The paper does not establish that the first 12 postnatal days correspond to the human third trimester or describe neurogenesis, synaptogenesis, and circuit maturation during that period. (LLM, conf=0.76)
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- Authors
- Carter, A. M.
- Affiliations
- University of Southern Denmark (DK)
- Corresponding author
- Carter, Anthony M
- ORCID
- Carter, Anthony M
- Venue
- Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-12-01
- Volume
- 160
- Issue
- 6
- Pages
- R129-R143
- ISSN
- 1470-1626 (ISSN-L)
- 1741-7899
- OpenAlex
- W3083518835
- Cited by
- 130
- References
- 153
- Citations by year
- 2026: 17 · 2025: 17 · 2024: 32 · 2023: 21 · 2022: 25 · 2021: 18
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Reproduction (publishedVersion)
- PubMed (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- animal models of pregnancy, placentation, spiny mouse, guinea pig, marmoset, mouse lemurs, primates, gestation length, placental development
- MeSH terms
- Animals, Female, Humans, Placenta, Placentation, Pregnancy, Models, Animal
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