Identification of the ubiquitin–protein ligase that recognizes oxidized IRP2

Yamanaka, Koji, Ishikawa, Haruto, Megumi, Yuzuru, Tokunaga, Fuminori, Kanie, Masato, Rouault, Tracey A., Morishima, Isao, Minato, Nagahiro, Ishimori, Koichiro, Iwai, Kazuhiro·2003·Nature Cell Biology
DOI 10.1038/ncb952

Cited by (181)

Items 101–181 of 181

  1. Metabolic Cardiomyopathies and Cardiac Defects in Inherited Disorders of Carbohydrate Metabolism: A Systematic Review
    Federica Conte, Juda-El S. Jno Baptiste - Sam, Dirk J. Lefeber, R. C. Passier · 2023 · International Journal of Molecular Sciences
  2. Fanconi Anemia and Ubiquitination
    Yingying Zhang, Xiaowei Zhou, Peitang Huang · 2007 · Journal of genetics and genomics/Journal of Genetics and Genomics
  3. Role of the Ubiquitin–Proteasome in Protein Quality Control and Signaling
    Fu Shang, Allen Taylor · 2012 · Progress in molecular biology and translational science
  4. Calcyclin-binding protein-promoted degradation of MdFRUCTOKINASE2 regulates sugar homeostasis in apple
    Jing Su, Tiantian Jiao, Xi Liu, Lingcheng Zhu, Baiquan Ma, Fengwang Ma, Mingjun Li · 2022 · PLANT PHYSIOLOGY
  5. Discovery of linear ubiquitination, a crucial regulator for immune signaling and cell death
    Kazuhiro Iwaï · 2020 · FEBS Journal
  6. Nuclear-Cytoplasmic Shuttling of a RING-IBR Protein RBCK1 and Its Functional Interaction with Nuclear Body Proteins
    Kenji Tatematsu, Nobuo Yoshimoto, Tomoyoshi Koyanagi, Chiharu Tokunaga, Taro Tachibana, Yoshihiro Yoneda, Minoru Yoshida, Toshihide Okajima, Katsuyuki Tanizawa, Shun’ichi Kuroda · 2005 · Journal of Biological Chemistry
  7. Human iron regulatory protein 2 is easily cleaved in its specific domain: consequences for the haem binding properties of the protein
    Camille Dycke, Catherine Bougault, Jacques Gaillard, Jean‐Pierre Andrieu, Kostas Pantopoulos, Jean‐Marc Moulis · 2007 · Biochemical Journal
  8. Self-Association and Ligand-Induced Conformational Changes of Iron Regulatory Proteins 1 and 2
    Emine Yikilmaz, Tracey Ann Rouault, Peter Schuck · 2005 · Biochemistry
  9. The pathway for IRP2 degradation involving 2-oxoglutarate-dependent oxygenase(s) does not require the E3 ubiquitin ligase activity of pVHL
    Jian Wang, Kostas Pantopoulos · 2004 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  10. Mechanisms and Regulation of Iron Homeostasis in the Rhizobia
    Elena Fabiano, Mark R. O’Brian · 2012 · Springer briefs in molecular science
  11. ROS-PIASγ cross talk channelizes ATM signaling from resistance to apoptosis during chemosensitization of resistant tumors
    Suchismita Mohanty, S Saha, Dewan Md Sakib Hossain, Arghya Adhikary, S Mukherjee, Avrajit Manna, Samik Chakraborty, M Mazumdar, Pallab Ray, Kaushik Das et al. · 2014 · Cell Death and Disease
  12. Regulation of protein function and degradation by heme, heme responsive motifs, and CO
    Angela S. Fleischhacker, Anindita Sarkar, Liu Liu, Stephen Wiley Ragsdale · 2021 · Critical Reviews in Biochemistry and Molecular Biology
  13. Role of Linear Ubiquitination in Health and Disease
    Patricia L. Brazee, Laura A. Dada, Jacob Iasha Sznajder · 2016 · American Journal of Respiratory Cell and Molecular Biology
  14. Linear ubiquitination in NF-κB signaling and inflammation: What we do understand and what we do not
    Kelly Verhelst, Lynn Verstrepen, Isabelle Carpentier, Rudi Beyaert · 2011 · Biochemical Pharmacology
  15. RBCK1, a Protein Kinase CβI (PKCβI)-interacting Protein, Regulates PKCβ-dependent Function
    Alice Vallentin, Daria Mochly‐Rosen · 2006 · Journal of Biological Chemistry
  16. Shapes and Patterns of Heme-Binding Motifs in Mammalian Heme-Binding Proteins
    Darshan Rathod, Sonali M. Vaidya, Marie-Thérèse Hopp, Toni Kühl, Diana Imhof · 2023 · Biomolecules
  17. Specific heme binding to heme regulatory motifs in iron regulatory proteins and its functional significance
    Yudai Nishitani, Okutani Hirotaka, Yukiko Takeda, Takeshi Uchida, Kazuhiro Iwaï, Koichiro Ishimori · 2019 · Journal of Inorganic Biochemistry
  18. Mechanistic insights into heme-mediated transcriptional regulation via a bacterial manganese-binding iron regulator, iron response regulator (Irr)
    Dayeon Nam, Yuki Matsumoto, Takeshi Uchida, Mark R. O’Brian, Koichiro Ishimori · 2020 · Journal of Biological Chemistry
  19. How Iron Controls Iron
    Lukas C. Kühn · 2009 · Cell Metabolism
  20. HOIL-1 is not required for iron-mediated IRP2 degradation in HEK293 cells
    Kimberly B. Zumbrennen‐Bullough, Eric S. Hanson, Elizabeth A. Leibold · 2007 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  21. Redox-Dependent Dynamics in Heme-Bound Bacterial Iron Response Regulator (Irr) Protein
    Kazuo Kobayashi, Megumi Nakagaki, Haruto Ishikawa, Kazuhiro Iwaï, Mark R. O’Brian, Koichiro Ishimori · 2016 · Biochemistry
  22. Redox-dependent axial ligand replacement and its functional significance in heme-bound iron regulatory proteins
    Mariko Ogura, Ryosuke Endo, Haruto Ishikawa, Yukiko Takeda, Takeshi Uchida, Kazuhiro Iwaï, Kazuo Kobayashi, Koichiro Ishimori · 2018 · Journal of Inorganic Biochemistry
  23. Ulinastatin prevents acute lung injury led by liver transplantation
    Gangjian Luo, Weifeng Yao, Ye He, Chenfang Luo, Xiaoyun Li, Ziqing Hei · 2014 · Journal of Surgical Research
  24. Cytoplasmic Protein Serine/Threonine Kinases
    Marc Thiriet · 2012 · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems
  25. Rethinking IRPs/IRE system in neurodegenerative disorders: Looking beyond iron metabolism
    Zhengyang Yao, Lin Fu, Fengju Jia, Mingxia Bi, Qian Jiao, Xi Chen, Xixun Du, Hong Fu Jiang · 2021 · Ageing Research Reviews
  26. Biochemical characterization and role of the proteasome in the oxidative stress response of adult Schistosoma mansoni worms
    Renato Graciano de Paula, Alice Maria de Magalhães Ornelas, Enyara Rezende Morais, William de Castro Borges, Massimo Natale, Lizandra Guidi Magalhães, Vanderlei Rodrigues · 2014 · Parasitology Research
  27. Linkage to 20p13 including the ANGPT4 gene in families with mixed Alzheimer's disease and vascular dementia
    Anna Sillén, Jesper Brohede, Lena Lilius, Charlotte Forsell, Jorge Andrade, Jacob Odeberg, Hayao Ebise, Bengt G. Winblad, Caroline Graff · 2010 · Journal of Human Genetics
  28. Dual roles for LUBAC signaling in thymic epithelial cell development and survival
    Reema Jain, Kelin Zhao, Julie M. Sheridan, Melanie Heinlein, Fiona Kupresanin, Waruni Abeysekera, Cathrine M. Hall, James A. Rickard, Philippe Bouillet, Henning Walczak et al. · 2021 · Cell Death and Differentiation
  29. Structures, functions, and inhibitors of LUBAC and its related diseases
    Shuo Ning, Lingling Luo, Beiming Yu, Dina Mai, Feng Wang · 2022 · Journal of Leukocyte Biology
  30. Molecular Mechanism for Heme-Mediated Inhibition of 5-Aminolevulinic Acid Synthase 1
    Chihiro Kitatsuji, Mariko Ogura, Takeshi Uchida, Koichiro Ishimori, Shigetoshi Aono · 2014 · Bulletin of the Chemical Society of Japan
  31. Signaling Lipids
    Marc Thiriet · 2012 · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems
  32. Protein Quality Control by the Ubiquitin Proteolytic Pathway: Roles in Resistance to Oxidative Stress and Disease
    Fu Shang, Edward J. Dudek, Qing Lin Liu, Michael E. Boulton, Allen Taylor · 2006 · Israel Journal of Chemistry
  33. Cytoplasmic Protein Tyrosine Kinases
    Marc Thiriet · 2012 · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems
  34. Mechanisms underlying linear ubiquitination and implications in tumorigenesis and drug discovery
    Jack Li, Sijin Liu, Shitao Li · 2023 · Cell Communication and Signaling
  35. Structural bases of the assembly, recognition and disassembly of linear ubiquitin chain
    Jianping Liu, Lifeng Pan · 2018 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  36. Pathogenic phosphorylation of linear ubiquitin machinery causes inflammasome sensor degradation
    Yu Yang, Shanshan Yu, Zhe Lü, Lihua Qiang, Yanzhao Zhong, Pupu Ge, Zehui Lei, Changgen Qiu, Yingxu Fang, Xinwen Zhang et al. · 2025 · Cell Reports
  37. Guanosine Triphosphatases and Their Regulators
    Marc Thiriet · 2012 · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems
  38. Transferrin receptor 2 is emerging as a major player in the control of iron metabolism
    Alessia Calzolari, Isabella Oliviero, Ugo Testa · 2007 · Open Life Sciences
  39. Identification, Expression, and Assay of an Oxidation‐Specific Ubiquitin Ligase, HOIL‐1
    Kazuhiro Iwaï, Haruto Ishikawa, Takayoshi Kirisako · 2005 · Methods in enzymology on CD-ROM/Methods in enzymology
  40. A Northwestern blotting approach for studying iron regulatory element-binding proteins
    Zvezdana Popović, Douglas M. Templeton · 2005 · Molecular and Cellular Biochemistry
  41. Solution structure of the E3 ligase HOIL‐1 Ubl domain
    Steven Beasley, Susan S. Safadi, Kathryn R. Barber, Gary S. Shaw · 2012 · Protein Science
  42. Mitogen-Activated Protein Kinase Module
    Marc Thiriet · 2012 · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems
  43. Ferrous iron binding to epinephrine promotes the oxidation of iron and impedes activation of adrenergic receptors
    Jelena Korać Jačić, Ljiljana M. Nikolic, Dalibor M. Stanković, Miloš Opačić, Milena Dimitrijević, Danijela Z. Savić, Sanja Grgurić‐Šipka, Ivan Spasojević, Jelena Bogdanović Pristov · 2020 · Free Radical Biology and Medicine
  44. Pathway crosstalk between the central metabolic and heme biosynthetic pathways in Phanerochaete chrysosporium
    Daisuke Miura, Ryoga Tsurigami, Hiroyuki Kato, Hiroyuki Wariishi, Motoyuki Shimizu · 2024 · Applied Microbiology and Biotechnology
  45. Regulation of Iron Metabolism in Mammalian Cells
    Tracey Ann Rouault · 2011 · Humana Press eBooks
  46. RING Fingers and Relatives: Determinators of Protein Fate
    Kevin L. Lorick, Yien Che Tsai, Yili Yang, Allan M. Weissman · 2007 · Wiley eBooks
  47. Deficiency of the E3 Ubiquitin Ligase RBCK1 Causes Diffuse Brain Polyglucosan Accumulation and Neurodegeneration
    Mitchell Anthony Sullivan, Felix Nitschké, Erin E. Chown, Laura F. DiGiovanni, Mackenzie Chown, Ami M. Perri, Sharmistha Mitra, Xiaochu Zhao, Cameron A. Ackerley, Lori Israelian et al. · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  48. Nadolol Attenuates Brain Cell Ferroptosis in Ischemic Stroke Rats by Targeting the HOIL-1/IRP2 Pathway
    Xiaoyan Yang, Wenjun Zhu, Di-Chen, Dan Peng, Jun Peng, Zhijun Zhou, Xiu‐Ju Luo · 2024 · CNS & Neurological Disorders - Drug Targets
  49. Dual-Specificity Protein Kinases
    Marc Thiriet · 2012 · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems
  50. Ubiquitination-Mediated NF-κB Regulation in Inflammatory Response
    Fuminori Tokunaga · 2015 · Springer eBooks
  51. Linear Polyubiquitination: A Crucial Regulator of NF-κB Activation
    Kazuhiro Iwaï · 2015 · Springer eBooks
  52. CHAPTER 1: Literature review
    Clémentine Roth · 2018 · Nomos Verlagsgesellschaft mbH & Co. KG eBooks
  53. Conclusion
    Marc Thiriet · 2012 · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems
  54. Recent advance in the understanding of iron metabolism and its role on host defense
    Kyoko Hishikawa, Kazuhiro Iwaï · 2005 · Japanese Journal of Clinical Immunology
  55. Cellular and Systemic Iron Homeostasis
    Robert R. Crichton · 2016 · Wiley eBooks
  56. in fulfilment of the requirements for the degree of doctor of philosophy
    el Diwany, Fatma Khalil Mostafa · 2005
  57. MetalloregulationBased in part on the article Metalloregulation by Robert P. Hausinger which appeared in theEncyclopedia of Inorganic Chemistry, First Edition.
    Tracey Ann Rouault, Caroline C. Philpott · 2005 · Wiley eBooks
  58. Preamble to Cytoplasmic Protein Kinases
    Marc Thiriet · 2012 · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems
  59. BEHIND THE IRON CURTAIN: DEXRAS1 MEDIATES GLUTAMATEN-MDA INDUCED NEURONAL IRON UPTAKE
    Jaime H. Cheah · 2006
  60. Functional characterization of the basic helix-loop-helix transcription factor LeFER essential for upregulation of iron responses in tomato roots
    Tzvetina Brumbarova · 2006 · Publications of the UdS (Saarland University)
  61. The Proteasome: Source and a Target of Oxidative Stress?
    Barry B. Halliwell · 2007 · Springer eBooks
  62. Transcriptional Regulation by the Nuclear Receptors Steroidogenic Factor-1 and Liver Receptor Homologue-1
    Anna Ehrlund · 2011 · Figshare
  63. Mutations du gène HFE dans le cancer épithélial de l'ovaire
    Sanae Medelci · 2008
  64. Functions of the coregulator protein SNURF (RNF4) in transcription and cell growth
    Marika Häkli · 2005 · Työväentutkimus Vuosikirja
  65. Identification and characterization of a heme responsive element in the hrg-1 promoter
    Jason W. Sinclair · 2008 · University Libraries (University of Maryland)
  66. Cytosolic Protein Phosphatases
    Marc Thiriet · 2012 · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems
  67. Other Major Types of Signaling Mediators
    Marc Thiriet · 2012 · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems
  68. Identification and characterization of Eya1-interacting proteins
    Kathrin Landgraf · 2009 · Common Library Network (Der Gemeinsame Bibliotheksverbund)
  69. Overview of Gas-sensing Systems
    Shigetoshi Aono · 2017 · Royal Society of Chemistry eBooks
  70. Heme is an essential prosthetic group and a key regulator during erythropoiesis
    Jingyuan Tong, Lihong Shi, Jinhua Liu, Jie GAO, YaPu LI · 2017 · Scientia Sinica Vitae
  71. Signaling Pathways
    Marc Thiriet · 2012 · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems
  72. MetalloregulationBased in part on the article Metalloregulation by Robert P. Hausinger which appeared in theEncyclopedia of Inorganic Chemistry, First Edition.
    Tracey Ann Rouault, Caroline C. Philpott · 2005 · Wiley eBooks
  73. Eisen
    T. Ettle, Bernd Elsenhans, Klaus Schümann · 2012 · Wiley eBooks
  74. Additional Pathogenic Pathways in RBCK1 Deficiency
    Ekaterina Demicheva, Khyber Shinwari, Konstantin S. Ushenin, Mikhail A. Bolkov · 2022 · Mathematical Biology and Bioinformatics
  75. Novel functions of LUBAC-mediated M1 poly-ubiquitination in TNFR1-mediated necroptosis
    Nadine Weinelt · 2024 · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt)
  76. Regulatory Systems of Iron Homeostasis in Human Cells with a Focus on IRPs
    Koichiro Ishimori · 2025 · Royal Society of Chemistry eBooks
  77. Triad1 and its role during myelopoiesis.
    Jurgen A. F. Marteijn · 2007 · Radboud Repository (Radboud University)
  78. Role of iron regulatory proteins in the regulation of iron metabolism by nitric oxide
    Agnieska Stys · 2011 · theses.fr (ABES)
  79. Caractérisation du phénotype hépatosplénique d'un nouveau modèle de rats acéruloplasminémiques pour une meilleure compréhension des mécanismes physiopathologiques de l'acéruloplasminémie héréditaire
    Moussa Kenawi · 2019 · theses.fr (ABES)
  80. Heme as a versatile signaling molecule: Coordinating mitochondrial metabolism with global cellular responses
    Iva Chitrakar, Breann L. Brown · 2026 · Journal of Biological Chemistry
  81. La régulation de l’hepcidine à travers les récepteurs Toll-like dans les macrophages
    Antonio Layoun · 2009