The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Using personal glucose meters and functional DNA sensors to quantify a variety of analytical targets
Open accessAbstract
Portable, low-cost and quantitative detection of a broad range of targets at home and in the field has the potential to revolutionize medical diagnostics and environmental monitoring. Despite many years of research, very few such devices are commercially available. Taking advantage of the wide availability and low cost of the pocket-sized personal glucose meter—used worldwide by diabetes sufferers—we demonstrate a method to use such meters to quantify non-glucose targets, ranging from a recreational drug (cocaine, 3.4 μM detection limit) to an important biological cofactor (adenosine, 18 μM detection limit), to a disease marker (interferon-gamma of tuberculosis, 2.6 nM detection limit) and a toxic metal ion (uranium, 9.1 nM detection limit). The method is based on the target-induced release of invertase from a functional-DNA–invertase conjugate. The released invertase converts sucrose into glucose, which is detectable using the meter. The approach should be easily applicable to the detection of many other targets through the use of suitable functional-DNA partners (aptamers DNAzymes or aptazymes).
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Cites
CELLULAR RESPONSES TO INTERFERON-γ
Boehm, U., Klamp, T., Groot, M., & Howard, J. C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.749 · Cited by 2,890
Overview on self-monitoring of blood glucose
Montagnana, M., Caputo, M., Giavarina, D., & Lippi, G. (2009) · Clinica Chimica Acta · doi:10.1016/j.cca.2009.01.002 · Cited by 116
Cited by
Swan, M. (2012) · Journal of Sensor and Actuator Networks · doi:10.3390/jsan1030217 · Cited by 934
Device integration of electrochemical biosensors
Wu, J., Liu, H., Chen, W., Ma, B., & Ju, H. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00032-w · Cited by 895
Xiong, Y., Zhang, J., Yang, Z., Mou, Q., Ma, Y., Xiong, Y., & Lu, Y. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.9b09211 · Cited by 689
Self-citationLiu, C., Zhao, J., Tian, F., Cai, L., Zhang, W., Feng, Q., Chang, J., Wan, F., Yang, Y., Dai, B., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0343-6 · Cited by 482
Nucleic Acid Biosensors: Recent Advances and Perspectives
Du, Y., & Dong, S. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.6b04190 · Cited by 429
Metadata
- Authors
- Xiang, Y., & Lu, Y.
- Venue
- Nature Chemistry
- Published
- 2011-07-24
- Volume
- 3
- Issue
- 9
- Pages
- 697-703
- ISSN
- 1755-4330 (ISSN-L)
- 1755-4349
- OpenAlex
- W2120172812
- Cited by
- 677
- References
- 2
- FWCI
- 16.22
- Type
- journal article
- Language
- en
- Open access
- green
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