The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Darwinian evolution of an alternative genetic system provides support for TNA as an RNA progenitor
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Gilbert, W. (1986) · Nature · doi:10.1038/319618a0 · Cited by 2,721
Selection of single-stranded DNA molecules that bind and inhibit human thrombin
Bock, L. C., Griffin, L. C., Latham, J. A., Vermaas, E. H., & Toole, J. J. (1992) · Nature · doi:10.1038/355564a0 · Cited by 2,469
The origin of the genetic code
Crick, F. H. C. (1968) · Journal of Molecular Biology · doi:10.1016/0022-2836(68)90392-6 · Cited by 2,320
Gilbert, W. (1986) · Nature · Cited by 1,941
In Vitro Selection of Functional Nucleic Acids
Wilson, D. S., & Szostak, J. W. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.611 · Cited by 1,206
RNA-peptide fusions for the in vitro selection of peptides and proteins
Roberts, R. W., & Szostak, J. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12297 · Cited by 1,105
The antiquity of RNA-based evolution.
Joyce, G. F. (2002) · Nature · doi:10.1038/418214a · Cited by 1,070
Evolution of the genetic apparatus
Orgel, L. E. (1968) · Journal of Molecular Biology · doi:10.1016/0022-2836(68)90393-8 · Cited by 996
Chemical etiology of nucleic acid structure
Eschenmoser, A. (1999) · Science · doi:10.1126/science.284.5423.2118 · Cited by 611
Chemical Etiology of Nucleic Acid Structure: The α-Threofuranosyl-(3'→2') Oligonucleotide System
Schöning, K.-U., Scholz, P., Guntha, S., Wu, X., Krishnamurthy, R., & Eschenmoser, A. (2000) · Science · doi:10.1126/science.290.5495.1347 · Cited by 556
Cited by
Prebiotic Systems Chemistry: New Perspectives for the Origins of Life
Ruiz-Mirazo, K., Briones, C., & de la Escosura, A. (2014) · Chemical Reviews · doi:10.1021/cr2004844 · Cited by 930
Analysis of aptamer discovery and technology
Dunn, M. R., Jimenez, R. M., & Chaput, J. C. (2017) · Nature Reviews Chemistry · doi:10.1038/s41570-017-0076 · Cited by 938
Self-citationSynthetic genetic polymers capable of heredity and evolution
Pinheiro, V. B., Taylor, A. I., Cozens, C., Abramov, M., Renders, M., Zhang, S., Chaput, J. C., Wengel, J., Peak-Chew, S.-Y., McLaughlin, S. H., et al. (2012) · Science · doi:10.1126/science.1217622 · Cited by 730
Self-citationThe RNA World: molecular cooperation at the origins of life
Higgs, P. G., & Lehman, N. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3841 · Cited by 604
SELEX: Critical factors and optimization strategies for successful aptamer selection
Kohlberger, M., & Gadermaier, G. (2022) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.2244 · Cited by 341
Metadata
- Authors
- Yu, H., Zhang, S., & Chaput, J. C.
- Venue
- Nature Chemistry
- Published
- 2012-01-10
- Volume
- 4
- Issue
- 3
- Pages
- 183-187
- ISSN
- 1755-4330 (ISSN-L)
- 1755-4349
- OpenAlex
- W1994057976
- Cited by
- 268
- References
- 38
- FWCI
- 10.28
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Darwinian evolution of an alternative genetic system provides support for TNA as an RNA progenitor. https://app.cochat.ai/papers/10.1038/nchem.1241
- The paper
- Yu, H., Zhang, S., & Chaput, J. C. (2012). Darwinian evolution of an alternative genetic system provides support for TNA as an RNA progenitor. Nature Chemistry. https://doi.org/10.1038/nchem.1241
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.