The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration
Open accessAbstract
An emerging aspect of redox signaling is the pathway mediated by electrophilic byproducts, such as nitrated cyclic nucleotide (for example, 8-nitroguanosine 3′,5′-cyclic monophosphate (8-nitro-cGMP)) and nitro or keto derivatives of unsaturated fatty acids, generated via reactions of inflammation-related enzymes, reactive oxygen species, nitric oxide and secondary products. Here we report that enzymatically generated hydrogen sulfide anion (HS−) regulates the metabolism and signaling actions of various electrophiles. HS− reacts with electrophiles, best represented by 8-nitro-cGMP, via direct sulfhydration and modulates cellular redox signaling. The relevance of this reaction is reinforced by the significant 8-nitro-cGMP formation in mouse cardiac tissue after myocardial infarction that is modulated by alterations in HS− biosynthesis. Cardiac HS−, in turn, suppresses electrophile-mediated H-Ras activation and cardiac cell senescence, contributing to the beneficial effects of HS− on myocardial infarction–associated heart failure. Thus, this study reveals HS−-induced electrophile sulfhydration as a unique mechanism for regulating electrophile-mediated redox signaling.
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Metadata
- Authors
- Nishida, M., Sawa, T., Kitajima, N., Ono, K., Inoue, H., Ihara, H., Motohashi, H., Yamamoto, M., Suematsu, M., Kurose, H., van der Vliet, A., Freeman, B. A., Shibata, T., Uchida, K., Kumagai, Y., & Akaike, T.
- Venue
- Nature Chemical Biology
- Published
- 2012-07-01
- Volume
- 8
- Issue
- 8
- Pages
- 714-724
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- OpenAlex
- W2003014947
- Cited by
- 293
- References
- 7
- FWCI
- 10.33
- Type
- journal article
- Language
- en
- Open access
- green
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- Nishida, M., Sawa, T., Kitajima, N., Ono, K., Inoue, H., Ihara, H., Motohashi, H., Yamamoto, M., Suematsu, M., Kurose, H., van der Vliet, A., Freeman, B. A., Shibata, T., Uchida, K., Kumagai, Y., & Akaike, T. (2012). Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration. Nature Chemical Biology. https://doi.org/10.1038/nchembio.1018
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