The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Peptidomic discovery of short open reading frame–encoded peptides in human cells
Open accessAbstract
The amount of the transcriptome that is translated into polypeptides is of fundamental importance. We developed a peptidomic strategy to detect short ORF (sORF)-encoded polypeptides (SEPs) in human cells. We identified 90 SEPs, 86 of which are novel, the largest number of human SEPs ever reported. SEP abundances range from 10-1000 molecules per cell, identical to known proteins. SEPs arise from sORFs in non-coding RNAs as well as multi-cistronic mRNAs, and many SEPs initiate with non-AUG start codons, indicating that non-canonical translation may be more widespread in mammals than previously thought. In addition, coding sORFs are present in a small fraction (8/1866) of long intergenic non-coding RNAs (lincRNAs). Together, these results provide the strongest evidence to date that the human proteome is more complex than previously appreciated.
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TopHat: discovering splice junctions with RNA-Seq
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Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
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Cited by
lincRNAs: Genomics, Evolution, and Mechanisms
Ulitsky, I., & Bartel, D. P. (2013) · Cell · doi:10.1016/j.cell.2013.06.020 · Cited by 2,608
Liu, B., Sun, L., Liu, Q., Gong, C., Yao, Y., Lv, X., Lin, L., Yao, H., Su, F., Li, D., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.02.004 · Cited by 908
A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle
Nelson, B. R., Makarewich, C. A., Anderson, D. M., Winders, B. R., Troupes, C. D., Wu, F., Reese, A. L., McAnally, J. R., Chen, X., Kavalali, E. T., et al. (2016) · Science · doi:10.1126/science.aad4076 · Cited by 788
Proteogenomics: concepts, applications and computational strategies
Nesvizhskii, A. I. (2014) · Nature Methods · doi:10.1038/nmeth.3144 · Cited by 770
Ribosome Profiling Provides Evidence that Large Noncoding RNAs Do Not Encode Proteins
Guttman, M., Russell, P., Ingolia, N. T., Weissman, J. S., & Lander, E. S. (2013) · Cell · doi:10.1016/j.cell.2013.06.009 · Cited by 745
Metadata
- Authors
- Slavoff, S. A., Mitchell, A. J., Schwaid, A. G., Cabili, M. N., Ma, J., Levin, J. Z., Karger, A. D., Budnik, B. A., Rinn, J. L., & Saghatelian, A.
- Venue
- Nature Chemical Biology
- Published
- 2012-11-18
- Volume
- 9
- Issue
- 1
- Pages
- 59-64
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- OpenAlex
- W2100424218
- Cited by
- 686
- References
- 49
- FWCI
- 14.63
- Type
- journal article
- Language
- en
- Open access
- green
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