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Cited by 440

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

RNA SHAPE analysis in living cells

Open access
Spitale, Robert C, Crisalli, Pete, Flynn, Ryan A, Torre, Eduardo A, Kool, Eric T, Chang, Howard Y·2013·Nature Chemical Biology

Abstract

RNA structure plays important roles in practically every facet of gene regulation, but the paucity of structural probes that function in vivo has limited current understanding. Here we design, synthesize, and demonstrate two novel chemical probes that enable selective 2’-hydroxyl acylation for accurate RNA structural analysis in living cells. RNA structure in embryonic stem cells and several other species is read out at single nucleotide resolution, revealing tertiary contacts and RNA-protein interactions.

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Crossref · 10.1038/nchembio.1131

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Metadata

Authors
Spitale, R. C., Crisalli, P., Flynn, R. A., Torre, E. A., Kool, E. T., & Chang, H. Y.
Venue
Nature Chemical Biology
Published
2012-11-25
Volume
9
Issue
1
Pages
18-20
ISSN
  • 1552-4450 (ISSN-L)
  • 1552-4469
OpenAlex
W2007205568
Cited by
440
References
4
FWCI
8.71
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: RNA SHAPE analysis in living cells. https://app.cochat.ai/papers/10.1038/nchembio.1131
The paper
Spitale, R. C., Crisalli, P., Flynn, R. A., Torre, E. A., Kool, E. T., & Chang, H. Y. (2013). RNA SHAPE analysis in living cells. Nature Chemical Biology. https://doi.org/10.1038/nchembio.1131

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.