The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Target identification and mechanism of action in chemical biology and drug discovery
Open accessAbstract
Target-identification and mechanism-of-action studies have important roles in small-molecule probe and drug discovery. Biological and technological advances have resulted in the increasing use of cell-based assays to discover new biologically active small molecules. Such studies allow small-molecule action to be tested in a more disease-relevant setting at the outset, but they require follow-up studies to determine the precise protein target or targets responsible for the observed phenotype. Target identification can be approached by direct biochemical methods, genetic interactions or computational inference. In many cases, however, combinations of approaches may be required to fully characterize on-target and off-target effects and to understand mechanisms of small-molecule action.
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Dixon, S. J., Winter, G. E., Musavi, L. S., Lee, E. D., Snijder, B., Rebsamen, M., Superti-Furga, G., & Stockwell, B. R. (2015) · ACS Chemical Biology · doi:10.1021/acschembio.5b00245 · Cited by 1,043
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Metadata
- Authors
- Schenone, M., Dančík, V., Wagner, B. K., & Clemons, P. A.
- Venue
- Nature Chemical Biology
- Published
- 2013-03-18
- Volume
- 9
- Issue
- 4
- Pages
- 232-240
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- OpenAlex
- W2038252445
- Cited by
- 1,096
- References
- 19
- FWCI
- 65.86
- Type
- journal article
- Language
- en
- Open access
- green
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- Schenone, M., Dančík, V., Wagner, B. K., & Clemons, P. A. (2013). Target identification and mechanism of action in chemical biology and drug discovery. Nature Chemical Biology. https://doi.org/10.1038/nchembio.1199
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
