Histone deacetylase 6 structure and molecular basis of catalysis and inhibition

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Items 101–200 of 490

1. Design of Dual Inhibitors of Histone Deacetylase 6 and Heat Shock Protein 90
   Luca Pinzi, Rosaria Benedetti, Lucia Altucci, Giulio Rastelli · 2020 · ACS Omega
2. A Multitargeted Approach: Organorhodium Anticancer Agent Based on Vorinostat as a Potent Histone Deacetylase Inhibitor
   Muhammad Hanif, Jahan Zaib Arshad, Jonathan W. Astin, Zohaib Rana, Ayesha Zafar, Sanam Movassaghi, Euphemia Yee Leung, Kamal D. Patel, Tilo Söhnel, Jóhannes Reynisson et al. · 2020 · Angewandte Chemie International Edition
3. Cellular defence or viral assist: the dilemma of HDAC6
   Kai Zheng, Yingchun Jiang, Zhendan He, Kaio Kitazato, Yifei Wang · 2016 · Journal of General Virology
4. Histone Deacetylase and Enhancer of Zeste Homologue 2 Dual Inhibitors Presenting a Synergistic Effect for the Treatment of Hematological Malignancies
   Dehua Lu, Cheng Wang, Lailiang Qu, Fucheng Yin, Shang Li, Heng Luo, Yonglei Zhang, Xingchen Liu, Xinye Chen, Zhongwen Luo et al. · 2022 · Journal of Medicinal Chemistry
5. Bromo-protopine, a novel protopine derivative, alleviates tau pathology by activating chaperone-mediated autophagy for Alzheimer’s disease therapy
   Sravan Gopalkrishnashetty Sreenivasmurthy, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Rambabu N. Reddi, Ananth Kumar Kammala, Karthick Vasudevan, Sanjib Senapati, Zhou Zhu, Cheng-Fu Su, Jia Liu et al. · 2022 · Frontiers in Molecular Biosciences
6. Largazole Analogues as Histone Deacetylase Inhibitors and Anticancer Agents: An Overview of Structure–Activity Relationships
   Giulio Poli, Romano Di Fabio, Luca Ferrante, Vincenzo Summa, Maurizio Botta · 2017 · ChemMedChem
7. The unraveling of substrate specificity of histone deacetylase 6 domains using acetylome peptide microarrays and peptide libraries
   Zsófia Kutil, L. Skultetyova, David Rauh, Marat Meleshin, Ivan Šnajdr, Zora Nováková, Jana Mikesova, Jiřı́ Pavlı́ček, Martin Hadzima, Petra Baranová et al. · 2018 · The FASEB Journal
8. Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors
   Michael Morgen, Raphael R. Steimbach, Magalie N. E. Géraldy, Lars Hellweg, Peter A. Sehr, Johannes Ridinger, Olaf Witt, Ina Oehme, Corey J. Herbst‐Gervasoni, J.D. Osko et al. · 2020 · ChemMedChem
9. Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor
   Anna Skwarska, Ewen D. D. Calder, Deborah Sneddon, Hannah R. Bolland, Maria L. Odyniec, Ishna N. Mistry, Jennifer Martin, Lisa K. Folkes, Stuart J. Conway, Ester M. Hammond · 2021 · Cell chemical biology
10. Structural aspects of HDAC8 mechanism and dysfunction in Cornelia de Lange syndrome spectrum disorders
    Matthew A. Deardorff, Nicholas J. Porter, David W. Christianson · 2016 · Protein Science
11. Chemical editing of macrocyclic natural products and kinetic profiling reveal slow, tight-binding histone deacetylase inhibitors with picomolar affinities
    Kitir, Betül, Maolanon, Alex R., Ohm, Ragnhild G., Colaço, Ana R., Fristrup, Peter, Madsen, Andreas S., Olsen, Christian A. · 2017 · Biochemistry
12. Structural and chemical biology of deacetylases for carbohydrates, proteins, small molecules and histones
    Marco Bürger, Joanne Chory · 2018 · Communications Biology
13. Discovery of in Vivo Chemical Probes for Treating Alzheimer’s Disease: Dual Phosphodiesterase 5 (PDE5) and Class I Histone Deacetylase Selective Inhibitors
    Obdulia Rabal, Juan Antonio Sánchez-Arias, Mar Cuadrado‐Tejedor, Irene de Miguel, Marta Pérez-González, Carolina García, Ana Ugarte, Ander Estella‐Hermoso de Mendoza, Elena Sáez, María Espelosin et al. · 2018 · ACS Chemical Neuroscience
14. Discovery of 1,2,4-oxadiazole-Containing hydroxamic acid derivatives as histone deacetylase inhibitors potential application in cancer therapy
    Zhuang Yang, Mingsheng Shen, Minghai Tang, Wanhua Zhang, Xue Jun Cui, Zihao Zhang, Heying Pei, Yong Li, Mengshi Hu, Peng Bai et al. · 2019 · European Journal of Medicinal Chemistry
15. Structural Basis for the Selective Inhibition of HDAC10, the Cytosolic Polyamine Deacetylase
    Corey J. Herbst‐Gervasoni, Raphael R. Steimbach, Michael Morgen, Aubry K. Miller, David W. Christianson · 2020 · ACS Chemical Biology
16. Hierarchical virtual screening of the dual MMP-2/HDAC-6 inhibitors from natural products based on pharmacophore models and molecular docking
    Yijun Wang, Li-Mei C. Yang, Jiaying Hou, Qing Song Zou, Qi Gao, Wenhui Yao, Qizheng Yao, Ji Zhang · 2018 · Journal of Biomolecular Structure and Dynamics
17. HDAC6 Inhibition Alleviates Ischemia- and Cisplatin-Induced Acute Kidney Injury by Promoting Autophagy
    Lang Shi, Zhixia Song, Chenglong Li, Fangjing Deng, Yao Xia, Jing Huang, Xiongfei Wu, Jiefu Zhu · 2022 · Cells
18. Chemical Versatility in Catalysis and Inhibition of the Class IIb Histone Deacetylases
    David W. Christianson · 2024 · Accounts of Chemical Research
19. HDAC6 as a potential therapeutic target for peripheral nerve disorders
    Robert Ciarán Prior, Lawrence Van Helleputte, Yvonne Eileen Klingl, Ludo Van Den Bosch · 2018 · Expert Opinion on Therapeutic Targets
20. Exploration of certain 1,3-oxazole- and 1,3-thiazole-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents
    Duong Tien Anh, Hai Pham‐The, Huong Le‐Thi‐Thu, Eun Jae Park, Hye Won Jun, Jong Soon Kang, Joo‐Hee Kwon, Do Thi Mai Dung, Vu Tran Anh, Văn Thị Mỹ Huệ et al. · 2020 · Bioorganic Chemistry
21. Targeting the Epigenome in Malignant Melanoma: Facts, Challenges and Therapeutic Promises
    Ioannis Anestopoulos, Sotiris Kyriakou, Venetia Tragkola, Ioannis Paraskevaidis, Eleni Tzika, Melina Mitsiogianni, Maria V. Deligiorgi, George Petrakis, Dimitrios T. Trafalis, Sotirios Botaitis et al. · 2022 · Pharmacology & Therapeutics
22. Rational Drug Design of Antineoplastic Agents Using 3D-QSAR, Cheminformatic, and Virtual Screening Approaches
    Jelica Vučićević, Katarina M. Nikolic, John B. O. Mitchell · 2019 · Current Medicinal Chemistry
23. Oxazole-Bridged Combretastatin A-4 Derivatives with Tethered Hydroxamic Acids: Structure–Activity Relations of New Inhibitors of HDAC and/or Tubulin Function
    Florian Schmitt, Lisa Chiara Gosch, Alexandra Dittmer, Matthias Rothemund, Thomas Mueller, Rainer Schobert, Bernhard Biersack, Andrea Volkamer, Michael Höpfner · 2019 · International Journal of Molecular Sciences
24. HDAC6—An Emerging Target Against Chronic Myeloid Leukemia?
    Hélène Losson, Michaël Schnekenburger, Mario A. Dicato, Marc F. Diederich · 2020 · Cancers
25. Discovery of HDAC6-Selective Inhibitor NN-390 with in Vitro Efficacy in Group 3 Medulloblastoma
    Nabanita Nawar, Shazreh Bukhari, Ashley Adile, Yujin Suk, Pimyupa Manaswiyoungkul, Krimo Toutah, Olasunkanmi O. Olaoye, Yasir S. Raouf, Abootaleb Sedighi, Harsimran Kaur Garcha et al. · 2022 · Journal of Medicinal Chemistry
26. Multitarget Anticancer Agents Based on Histone Deacetylase and Protein Kinase CK2 Inhibitors
    Regina Martínez, Bruno Di Geronimo, Miryam Pastor, José María Zapico, Claire Coderch, Rostyslav R. Panchuk, Nadia R. Skorokhyd, Maciej Masłyk, Ana Ramos, Beatriz de Pascual‐Teresa · 2020 · Molecules
27. Design, synthesis and biological evaluation of brain penetrant benzazepine-based histone deacetylase 6 inhibitors for alleviating stroke-induced brain infarction
    Zheng Guo, Zixue Zhang, Yi Zhang, Guan Wang, Ziyi Huang, Qinwei Zhang, Jianqi Li · 2021 · European Journal of Medicinal Chemistry
28. Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot–Marie–Tooth Type 2A Mouse Model
    Sida Shen, Cristina Picci, Kseniya Ustinova, Veronick Benoy, Zsófia Kutil, Guiping Zhang, Maurício T. Tavares, Jiřı́ Pavlı́ček, Chad Zimprich, Matthew B. Robers et al. · 2021 · Journal of Medicinal Chemistry
29. Dual Targeting Strategies on Histone Deacetylase 6 (HDAC6) and Heat Shock Protein 90 (Hsp90)
    Davide Bonanni, Andrea Citarella, Davide Moi, Luca Pinzi, Elisa Bergamini, Giulio Rastelli · 2021 · Current Medicinal Chemistry
30. Impact of the Protein Data Bank on antineoplastic approvals
    John Westbrook, Rose Soskind, Brian P. Hudson, Stephen Kevin Burley · 2020 · Drug Discovery Today
31. Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with In Vivo Efficacy in Multiple Myeloma
    Obdulia Rabal, Edurne San José‐Eneriz, Xabier Agirre, Juan Antonio Sánchez-Arias, Irene de Miguel, Raquel Ordóñez, Leire Gárate, Estíbaliz Miranda, Elena Sáez, Amaia Vilas‐Zornoza et al. · 2021 · Journal of Medicinal Chemistry
32. Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function
    Julien Bricambert, Dimitri Favre, Saška Brajkovic, Amélie Bonnefond, Raphaël Boutry, Roberto Salvi, Valérie Plaisance, Mohamed Chikri, Giulia Chinetti, Bart Staels et al. · 2016 · Molecular Metabolism
33. Structural and Functional Influence of the Glycine-Rich Loop G ³⁰² GGGY on the Catalytic Tyrosine of Histone Deacetylase 8
    Porter, Nicholas J., Christianson, Nicolas H., Decroos, Christophe, Christianson, David W. · 2016 · Biochemistry
34. Synthesis and biological evaluation of novel quinolone derivatives dual targeting histone deacetylase and tubulin polymerization as antiproliferative agents
    Xuan Wang, Xiaoye Jiang, Shiyou Sun, Yongqiong Liu · 2018 · RSC Advances
35. In silico design of novel benzohydroxamate-based compounds as inhibitors of histone deacetylase 6 based on 3D-QSAR, molecular docking, and molecular dynamics simulations
    Han Chu, Qingxiu He, Juan Wang, Yong Qiang Hu, Yuanqiang Wang, Zhihua Lin · 2020 · New Journal of Chemistry
36. Identification of novel 1,3-diaryl-1,2,4-triazole-capped histone deacetylase 6 inhibitors with potential anti-gastric cancer activity
    Xinhui Zhang, Huiqin Kang, Yuanyuan Tao, Yihan Li, Junru Zhao, Ya-Gao, Liying Ma, Hong‐Min Liu · 2021 · European Journal of Medicinal Chemistry
37. Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability
    Stefano Federico, Tuhina Khan, Anna Fontana, Simone Brogi, Rosaria Benedetti, Federica Sarno, Gabriele Carullo, Alex Pezzotta, Akella Prasanth Saraswati, Eugenia Passaro et al. · 2022 · European Journal of Medicinal Chemistry
38. Selective and Bioavailable HDAC6 2-(Difluoromethyl)-1,3,4-oxadiazole Substrate Inhibitors and Modeling of Their Bioactivation Mechanism
    Lena Ripa, Jenny Sandmark, Glyn A. Hughes, Igor L. Shamovsky, Anders Gunnarsson, Julia Johansson, Antonio Llinàs, Mia Collins, Bomi Jung, Anna Novén et al. · 2023 · Journal of Medicinal Chemistry
39. Photochromic histone deacetylase inhibitors based on dithienylethenes and fulgimides
    D. Wutz, D. Gluhacevic, Alokta Chakrabarti, K. Schmidtkunz, Dina Robaa, Frank Erdmann, Christophe Romier, Wolfgang Sippl, Manfred Jung, Burkhard König · 2017 · Organic & Biomolecular Chemistry
40. Molecular Basis for the Selective Inhibition of Histone Deacetylase 6 by a Mercaptoacetamide Inhibitor
    Nicholas J. Porter, Sida Shen, Cyril Bařinka, Alan P. Kozikowski, David W. Christianson · 2018 · ACS Medicinal Chemistry Letters
41. Synthesis and Pharmacological Evaluation of Selective Histone Deacetylase 6 Inhibitors in Melanoma Models
    Maurício T. Tavares, Sida Shen, Tessa J. Knox, Melissa M. Hadley, Zsófia Kutil, Cyril Bařinka, Alejandro Villagra, Alan P. Kozikowski · 2017 · ACS Medicinal Chemistry Letters
42. Binding of N8-Acetylspermidine Analogues to Histone Deacetylase 10 Reveals Molecular Strategies for Blocking Polyamine Deacetylation
    Corey J. Herbst‐Gervasoni, David W. Christianson · 2019 · Biochemistry
43. Histone Deacetylase 6 and the Disease Mechanisms of α-Synucleinopathies
    Miguel Lemos, Nadia Stefanova · 2020 · Frontiers in Synaptic Neuroscience
44. Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype
    Olasunkanmi O. Olaoye, Paris R. Watson, Nabanita Nawar, Mulu Geletu, Abootaleb Sedighi, Shazreh Bukhari, Yasir S. Raouf, Pimyupa Manaswiyoungkul, Fettah Erdogan, Ayah Abdeldayem et al. · 2021 · Journal of Medicinal Chemistry
45. Novel 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Pyrimidin-4-ether Histone Deacetylase Inhibitors for Controlling Rust Disease: Design, Synthesis, Activity, and Structure–Activity Relationship
    Xing‐Hai Liu, Chang-Kuan Fu, Jian Wang, You-Chang Wei, Cheng‐Xia Tan, Jian‐Quan Weng, Li‐Jing Min, Tianming Xu, Ningjie Wu · 2025 · Journal of Agricultural and Food Chemistry
46. Structure-Based Drug Designing Recommends HDAC6 Inhibitors To Attenuate Microtubule-Associated Tau-Pathogenesis
    Amir Zeb, Chanin Park, Shailima DV Rampogu, Minky Son, Gihwan Lee, Keun Woo Lee · 2018 · ACS Chemical Neuroscience
47. Divergent Access to Histone Deacetylase Inhibitory Cyclopeptides via a Late-Stage Cyclopropane Ring Cleavage Strategy. Short Synthesis of Chlamydocin
    Gábor Zoltán Elek, Kaur Koppel, Dzmitry M. Zubrytski, Nele Konrad, Ivar Järving, Margus Lopp, Dzmitry G. Kananovich · 2019 · Organic Letters
48. Targeting Metalloenzymes by Boron-Containing Metal-Binding Pharmacophores
    You‐Cai Xiao, Junlin Yu, Qing-Qing Dai, Gen Li, Guo‐Bo Li · 2021 · Journal of Medicinal Chemistry
49. Design, synthesis, and biological evalution of bifunctional inhibitors against Hsp90-HDAC6 interplay
    Hye Yun Chae, Sun You Park, Sonam Jha, Sunil Gupta, Mi Kyung Kim, Eunyoung Ha, Young Ho Seo · 2022 · European Journal of Medicinal Chemistry
50. Development of Fluorinated Peptoid-Based Histone Deacetylase (HDAC) Inhibitors for Therapy-Resistant Acute Leukemia
    Nina Reßing, Julian Schliehe‐Diecks, Paris R. Watson, Melf Sönnichsen, Abigail D. Cragin, Andrea Schöler, Jing Chun Yang, Linda Schäker‐Hübner, Arndt Borkhardt, David W. Christianson et al. · 2022 · Journal of Medicinal Chemistry
51. Discovery of HDAC6, HDAC8, and 6/8 Inhibitors and Development of Cell-Based Drug Screening Models for the Treatment of TGF-β-Induced Idiopathic Pulmonary Fibrosis
    Wei-Chieh Yu, T.Y. Yeh, Chih-Hung Ye, Patrick Chun Theng Chong, Yi-Hsun Ho, Dorothy Kazuno So, Kah Yi Yap, Guan-Ru Peng, Chi-Hsuan Shao, Ajit Dhananjay Jagtap et al. · 2023 · Journal of Medicinal Chemistry
52. Targeting Histone Deacetylases 6 in Dual-Target Therapy of Cancer
    Milan Beljkaš, Aleksandra Ilić, Alen Čebzan, B. Radović, Nemanja Djoković, Dušan Ružić, Katarina M. Nikolic, Slavica Oljačić · 2023 · Pharmaceutics
53. Hydroxyl Ketone-Based Histone Deacetylase Inhibitors To Gain Insight into Class I HDAC Selectivity versus That of HDAC6
    Mohamed Dit Mady Traore, Vincent Zwick, Claudia Avello Simões‐Pires, Alessandra Nurisso, Mark E. Issa, Muriel Cuendet, Marjorie Maynadier, Sharon Wein, Henri Joseph Vial, Hélène Jamet et al. · 2017 · ACS Omega
54. Design, Synthesis, and Biological Evaluation of 2,4-Imidazolinedione Derivatives as HDAC6 Isoform-Selective Inhibitors
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55. HDAC6 interacts with PTPN1 to enhance melanoma cells progression
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56. Role of Fluorination in the Histone Deacetylase 6 (HDAC6) Selectivity of Benzohydroxamate-Based Inhibitors
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57. Evolutionary relationships among protein lysine deacetylases of parasites causing neglected diseases
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58. Synthesis and Biological Evaluation of HDAC Inhibitors With a Novel Zinc Binding Group
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59. Cyclic Tetrapeptide HDAC Inhibitors with Improved Plasmodium falciparum Selectivity and Killing Profile
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60. SKLB-23bb, A HDAC6-Selective Inhibitor, Exhibits Superior and Broad-Spectrum Antitumor Activity via Additionally Targeting Microtubules
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61. X-ray Crystallographic Snapshots of Substrate Binding in the Active Site of Histone Deacetylase 10
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62. Density functional theory (DFT) studies in HDAC-based chemotherapeutics: Current findings, case studies and future perspectives
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63. Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression
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64. HDAC6 Inhibition Extinguishes Autophagy in Cancer: Recent Insights
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65. Histone deacetylase 6’s function in viral infection, innate immunity, and disease: latest advances
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66. Highly fluorescent and HDAC6 selective scriptaid analogues
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67. Structural and energetic basis for the inhibitory selectivity of both catalytic domains of dimeric HDAC6
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68. N-(2′-Hydroxyphenyl)-2-Propylpentanamide (HO-AAVPA) Inhibits HDAC1 and Increases the Translocation of HMGB1 Levels in Human Cervical Cancer Cells
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69. Harmine-based dual inhibitors targeting histone deacetylase (HDAC) and DNA as a promising strategy for cancer therapy
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70. Synthesis and bioactivity evaluation of ferrocene-based hydroxamic acids as selective histone deacetylase 6 inhibitors
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71. Role of Histone Deacetylase 6 and Histone Deacetylase 6 Inhibition in Colorectal Cancer
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72. Discovery of a potent histone deacetylase (HDAC) 3/6 selective dual inhibitor
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73. Design and Synthesis of Topoisomerases-Histone Deacetylase Dual Targeted Quinoline-Bridged Hydroxamates as Anticancer Agents
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74. Critical review of non‐histone human substrates of metal‐dependent lysine deacetylases
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75. Structure of Arabidopsis HISTONE DEACETYLASE15
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76. HDAC6 Degrades nsp8 of Porcine Deltacoronavirus through Deacetylation and Ubiquitination to Inhibit Viral Replication
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77. Discovery of potent pyrrolo-pyrimidine and purine HDAC inhibitors for the treatment of advanced prostate cancer
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78. Design and synthesis of benzodiazepine analogs as isoform-selective human lysine deacetylase inhibitors
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79. Carboxylic acid derivatives display potential selectivity for human histone deacetylase 6: Structure-based virtual screening, molecular docking and dynamics simulation studies
    Abdullahi İbrahim Uba, Kemal Yelekçi · 2018 · Computational Biology and Chemistry
80. Targeting prostate cancer cells with enzalutamide‐HDAC inhibitor hybrid drug 2‐75
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81. Novel alkoxyamide-based histone deacetylase inhibitors reverse cisplatin resistance in chemoresistant cancer cells
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82. TFEB agonist clomiphene citrate activates the autophagy-lysosomal pathway and ameliorates Alzheimer's disease symptoms in mice
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83. A selenium-containing selective histone deacetylase 6 inhibitor for targeted in vivo breast tumor imaging and therapy
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84. Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction
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85. A minimally-masked inactive prodrug of panobinostat that is bioorthogonally activated by gold chemistry
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86. New Druggable Targets for Rheumatoid Arthritis Based on Insights From Synovial Biology
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87. First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement**
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88. Emerging therapeutic strategies in cancer therapy by HDAC inhibition as the chemotherapeutic potent and epigenetic regulator
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89. Combined Ligand and Fragment‐based Drug Design of Selective Histone Deacetylase – 6 Inhibitors
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90. Methods for the expression, purification, and crystallization of histone deacetylase 6–inhibitor complexes
    J.D. Osko, David W. Christianson · 2019 · Methods in enzymology on CD-ROM/Methods in enzymology
91. Structure-activity relationship study of thiazolyl-hydroxamate derivatives as selective histone deacetylase 6 inhibitors
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92. Exploration of Hydrazide-Based HDAC8 PROTACs for the Treatment of Hematological Malignancies and Solid Tumors
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93. RETRACTED ARTICLE: Discovery of novel benzohydroxamate-based histone deacetylase 6 (HDAC6) inhibitors with the ability to potentiate anti-PD-L1 immunotherapy in melanoma
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94. Discovery of the First Irreversible HDAC6 Isoform Selective Inhibitor with Potent Anti-Multiple Myeloma Activity
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95. Advances in dual-targeting inhibitors of HDAC6 for cancer treatment
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