Histone deacetylase 6 structure and molecular basis of catalysis and inhibition

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Items 401–491 of 491

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7. Discovery of Novel Selenocyanate Derivatives as Histone Deacetylase 6 Inhibitors for the Treatment of Hepatocellular Carcinoma
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8. Structure-Based Design and Free Energy Perturbation-Guided Synthesis of Novel VEGFR2 and HDAC Dual Inhibitors with Potent Antitumor Efficacy
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9. Recommended Tool Compounds: Isoform- and Class-Specific Histone Deacetylase Inhibitors
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10. Bridging protein quality control and epigenetic dysregulation: The HDAC6 paradox in neurological disorders and therapeutic targeting
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14. A Selective Histone Deacetylase 6 Inhibitor Showed Antiviral Activity Against Dengue and Zika Viruses
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15. 2-Substituted 1,5-benzothiazepine-based HDAC inhibitors exert anticancer activities on human solid and acute myeloid leukemia cell lines
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16. HDAC6 inhibitor promotes reactive oxygen species ‐meditated clearance of Staphylococcus aureus in macrophage
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17. Repurposing of known drugs from multiple libraries to identify novel and potential selective inhibitors of HDAC6 via in silico approach and molecular modeling
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18. Discovery of a Promising Hydroxyamino-Piperidine HDAC6 Inhibitor via Integrated Virtual Screening and Experimental Validation in Multiple Myeloma
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19. Immunoprecipitation of HDAC6 and Interacting Proteins
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20. Preparation of a new construct of human histone deacetylase 8 for the crystallization of enzyme-inhibitor complexes
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23. Expression and Crystallization of HDAC6 Tandem Catalytic Domains
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28. Integrated virtual screening, ADMET profiling, and molecular dynamics simulations of novel natural HDAC6 inhibitors with the potential to ameliorate skeletal muscle degeneration
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29. Design, Synthesis, and Biological Evaluation of Novel Triazine‐Based Dual Histone Deacetylase/phosphatidylinositol 3‐kinase Inhibitors for Breast Cancer Therapy
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30. Multifunctional SAHA-derived 8-hydroxyquinoline metallopharmacophores: HDAC inhibition and antiproliferative activity
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31. An integrated machine learning and chemical space network approach for the design of potent epigenetic HDAC6 inhibitors for targeting neurological disorders
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32. Histone Deacetylase Inhibitors (HDACis) as Latency-Reversing Agents in HIV Cure Strategies: Chemistry, Selectivity, and Clinical Perspective
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33. Functional divergence and structural changes of Class IV histone deacetylases (HDACs) across the tree of life
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34. From design to clinic: Medicinal chemistry and pharmacology of approved epigenetic drugs
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35. Exploration of novel hydroxamic acid-based candidates integrating chalcone scaffold cap as multitarget HDAC inhibitors: design, anti-prostatic cancer assessment, in silico docking and molecular dynamic simulation
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36. In silico screening of a designed focused chemical space identifies novel alkyl hydrazides as potent HDAC11 inhibitors
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37. In silico study of the synergistic anti-tumor effect of hybrid topoisomerase-HDAC inhibitors
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38. Fluorescence Polarization-Based Competition Assays to Evaluate Histone Deacetylase 6 Inhibitors
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39. Novel (E)‐3‐(3‐Oxo‐4‐substituted‐3,4‐dihydro‐2H‐benzo[b][1,4]oxazin‐6‐yl)‐N‐hydroxypropenamides as Histone Deacetylase Inhibitors: Design, Synthesis and Bioevaluation
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40. Structural Biology of Epigenetic Targets: Exploiting Complexity
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41. Studies Towards Broadening The Substrate Profile And Regulation Of Histone Deacetylase 1
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42. Computer‐based Lead Identification for Epigenetic Targets
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43. Research Progress on HDAC6 Structure and Its Crystal Complexes
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44. Structure-Based Design of Epigenetic Inhibitors
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45. First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Inhibitors of Neuroblastoma Cell Colony Growth That Increase Lysosome Accumulation
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46. Histone Deacetylase 6 at Crossroads of Invection and Innate Immunity
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47. Histone Deacetylase 6 as A Putative Target in Alzheimer’s Disease Therapeutics
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48. Histone deacetylase inhibition mitigates cognitive deficits and astrocyte dysfunction induced by Aβ oligomers
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49. 2D-Qsar and molecular docking studies of hydroxamic acid derivatives bearing benzimidazole scaffold as histone deacetylase 6 inhibitors
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50. Design, Synthesis, and Biological Evaluation of Novel Aak1/Hdacs Dual Inhibitors Against Sars-Cov-2 Entry
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51. Structure similarity based screening coupled to integrated structural biochemistry approach for exploring the high affinity inhibitors against histone deacetylase (HDAC)-6
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52. Mechanism-Based Inhibition of Histone Deacetylase 6 by a Selenocyanate is Subject to Redox Modulation
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53. Target engagement studies and kinetic live-cell degradation assays enable the systematic characterization of HDAC6 PROTACs
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54. Investigation of the Histone Deacetylase Inhibitor Potential of Phorbazole Analogues
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55. Ar-A014418-Based Dual Glycogen Synthase Kinase 3β / Histone Deacetylases Inhibitors as Potential Therapeutics for Alzheimer's Disease
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56. Harnessing Deep Belief Networks for Selective HDAC6 Inhibitors Identification
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57. Intepirdine Derivatives Possessing Dual 5HT6 Antagonism / HDAC6 Inhibitory Activity
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68. In vitro characterization of the catalytic domain of human histone deacetylase 5
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70. Combinaisons de nouveaux inhibiteurs de désacétylase d’histones 6 avec des inhibiteurs de tyrosine kinase pour le traitement de la leucémie myéloïde chronique
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75. HDAC6 and SSAT2 orchestrate acetyllysine metabolism and protein homeostasis
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