Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence

NIH Image to ImageJ: 25 years of image analysis

Schneider, C. A., Rasband, W. S., & Eliceiri, K. W. (2012) · Nature Methods · doi:10.1038/nmeth.2089 · Cited by 64,638

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays.

Zhang, J.-H., Chung, T. D. Y., & Oldenburg, K. R. (1999) · SLAS Discovery · doi:10.1177/108705719900400206 · Cited by 6,847

Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling

Betts, J. C., Lukey, P. T., Robb, L. C., McAdam, R. A., & Duncan, K. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02779.x · Cited by 1,395

Anti-virulence strategies to combat bacteria-mediated disease

Rasko, D. A., & Sperandio, V. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3013 · Cited by 1,383

Inhibition of Respiration by Nitric Oxide Induces a Mycobacterium tuberculosis Dormancy Program

Voskuil, M. I., Schnappinger, D., Visconti, K. C., Harrell, M. I., Dolganov, G., Sherman, D. R., & Schoolnik, G. K. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030205 · Cited by 975

Nonreplicating Persistence of Mycobacterium Tuberculosis

Wayne, L. G., & Sohaskey, C. D. (2001) · Annual Review of Microbiology · doi:10.1146/annurev.micro.55.1.139 · Cited by 807

Mycobacterium tuberculosis: success through dormancy

Gengenbacher, M., & Kaufmann, S. H. E. (2012) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2012.00331.x · Cited by 722

Rv3133c/ dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis

Park, H., Guinn, K. M., Harrell, M. I., Liao, R., Voskuil, M. I., Tompa, M., Schoolnik, G. K., & Sherman, D. R. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03474.x · Cited by 712

The Transcriptional Responses of Mycobacterium tuberculosis to Inhibitors of Metabolism

Boshoff, H. I., Myers, T. G., Copp, B. R., McNeil, M., Wilson, M. A., & Barry, C. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406796200 · Cited by 603

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

Pethe, K., Bifani, P. J., Jang, J., Kang, S., Park, S., Ahn, S., Jiřiček, J., Jung, J., Jeon, H. K., Cechetto, J. D., et al. (2013) · Nature Medicine · doi:10.1038/nm.3262 · Cited by 601

Targeting QseC Signaling and Virulence for Antibiotic Development

Rasko, D. A., Moreira, C. G., Li, D. R., Reading, N. C., Ritchie, J. M., Waldor, M. K., Williams, N. S., Taussig, R., Wei, S., Roth, M. G., et al. (2008) · Science · doi:10.1126/science.1160354 · Cited by 520

A Novel In Vitro Multiple-Stress Dormancy Model for Mycobacterium tuberculosis Generates a Lipid-Loaded, Drug-Tolerant, Dormant Pathogen

Deb, C., Lee, C., Dubey, V. S., Daniel, J., Abomoelak, B., Sirakova, T. D., Pawar, S., Rogers, L. M., & Kolattukudy, P. E. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006077 · Cited by 447

The Mycobacterium tuberculosis regulatory network and hypoxia

Galagan, J. E., Minch, K., Peterson, M., Lyubetskaya, A., Azizi, E., Sweet, L., Gomes, A., Rustad, T., Dolganov, G., Glotova, I., et al. (2013) · Nature · doi:10.1038/nature12337 · Cited by 431

Artemisinins: their growing importance in medicine

Krishna, S., Bustamante, L. Y., Haynes, R. K., & Staines, H. M. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.07.004 · Cited by 396

Mycobacterium tuberculosis Invasion of Macrophages: Linking Bacterial Gene Expression to Environmental Cues

Rohde, K. H., Abramovitch, R. B., & Russell, D. G. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.09.006 · Cited by 395

Diarylquinolines Are Bactericidal for Dormant Mycobacteria as a Result of Disturbed ATP Homeostasis

Koul, A., Vranckx, L., Dendouga, N., Balemans, W., Van den Wyngaert, I., Vergauwen, K., Göhlmann, H. W. H., Willebrords, R., Poncelet, A., Guillemont, J., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803899200 · Cited by 364

Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensor

Kumar, A., Toledo, J. C., Patel, R. P., Lancaster, J. R., & Steyn, A. J. C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705054104 · Cited by 325

Metabolic Regulation of Mycobacterial Growth and Antibiotic Sensitivity

Baek, S.-H., Li, A. H., & Sassetti, C. M. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001065 · Cited by 324

From Mechanistic Studies on Artemisinin Derivatives to New Modular Antimalarial Drugs

Robert, A., Dechy‐Cabaret, O., Cazelles, J., & Meunier, B. (2002) · Accounts of Chemical Research · doi:10.1021/ar990164o · Cited by 288

The Mycobacterium tuberculosis DosR Regulon Assists in Metabolic Homeostasis and Enables Rapid Recovery from Nonrespiring Dormancy

Leistikow, R. L., Morton, R. A., Bartek, I. L., Frimpong, I., Wagner, K., & Voskuil, M. I. (2009) · Journal of Bacteriology · doi:10.1128/jb.00926-09 · Cited by 279

Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium’s Metabolism Is Constrained by the Intracellular Environment

VanderVen, B. C., Fahey, R. J., Lee, W., Liu, Y., Abramovitch, R. B., Memmott, C., Crowe, A. M., Eltis, L. D., Perola, E., Deininger, D. D., et al. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004679 · Cited by 271

Two Sensor Kinases Contribute to the Hypoxic Response of Mycobacterium tuberculosis

Roberts, D. M., Liao, R., Wisedchaisri, G., Hol, W. G. J., & Sherman, D. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401230200 · Cited by 259

Mycobacterium bovis BCG Response Regulator Essential for Hypoxic Dormancy

Boon, C., & Dick, T. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.24.6760-6767.2002 · Cited by 254

aprABC : a Mycobacterium tuberculosis complex‐specific locus that modulates pH‐driven adaptation to the macrophage phagosome

Abramovitch, R. B., Rohde, K. H., Hsu, F., & Russell, D. G. (2011) · Molecular Microbiology · doi:10.1111/j.1365-2958.2011.07601.x · Cited by 211

Novel Insights into the Mechanism of Inhibition of MmpL3, a Target of Multiple Pharmacophores in Mycobacterium tuberculosis

Li, W., Upadhyay, A., Fontes, F. L., North, E. J., Wang, Y., Crans, D. C., Grzegorzewicz, A. E., Jones, V., Franzblau, S. G., Lee, R. E., et al. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.03229-14 · Cited by 202

Slow growth of M ycobacterium tuberculosis at acidic pH is regulated by phoPR and host‐associated carbon sources

Baker, J. J., Johnson, B. K., & Abramovitch, R. B. (2014) · Molecular Microbiology · doi:10.1111/mmi.12688 · Cited by 181

The DosR Regulon Modulates Adaptive Immunity and is Essential for Mycobacterium tuberculosis Persistence

Mehra, S., Foreman, T. W., Didier, P. J., Ahsan, M. H., Hudock, T. A., Kissee, R. S., Golden, N., Gautam, U. S., Johnson, A.-M., Alvarez, X. A., et al. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201408-1502oc · Cited by 173

Design, Synthesis, and Study of a Mycobactin−Artemisinin Conjugate That Has Selective and Potent Activity against Tuberculosis and Malaria

Miller, M. J., Walz, A. J., Zhu, H. H., Wu, C., Moraski, G. C., Möllmann, U., Tristani, E. M., Crumbliss, A. L., Ferdig, M. T., Checkley, L. A., et al. (2011) · Journal of the American Chemical Society · doi:10.1021/ja109665t · Cited by 171

Mycobacterium tuberculosis Responds to Chloride and pH as Synergistic Cues to the Immune Status of its Host Cell

Tan, S., Sukumar, N., Abramovitch, R. B., Parish, T., & Russell, D. G. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003282 · Cited by 164

Role of the dosR - dosS Two-Component Regulatory System in Mycobacterium tuberculosis Virulence in Three Animal Models

Converse, P. J., Karakousis, P. C., Klinkenberg, L. G., Kesavan, A. K., Ly, L. H., Allen, S. S., Grosset, J. H. E., Jain, S. K., Lamichhane, G., Manabe, Y. C., et al. (2008) · Infection and Immunity · doi:10.1128/iai.01117-08 · Cited by 152

DosT and DevS are oxygen‐switched kinases in Mycobacterium tuberculosis

Sousa, E. H. S., Tuckerman, J. R., Gonzalez, G., & Gilles‐Gonzalez, M. (2007) · Protein Science · doi:10.1110/ps.072897707 · Cited by 145

Unique Roles of DosT and DosS in DosR Regulon Induction and Mycobacterium tuberculosis Dormancy

Honaker, R. W., Leistikow, R. L., Bartek, I. L., & Voskuil, M. I. (2009) · Infection and Immunity · doi:10.1128/iai.01449-08 · Cited by 139

Mycobacterium tuberculosis Transcriptional Adaptation, Growth Arrest and Dormancy Phenotype Development Is Triggered by Vitamin C

Taneja, N. K., Dhingra, S., Mittal, A., Naresh, M., & Tyagi, J. S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010860 · Cited by 129

The Carbonic Anhydrase Inhibitor Ethoxzolamide Inhibits the Mycobacterium tuberculosis PhoPR Regulon and Esx-1 Secretion and Attenuates Virulence

Johnson, B. K., Colvin, C. J., Needle, D. B., Medie, F. M., Champion, P. A. D., & Abramovitch, R. B. (2015) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00719-15 · Cited by 124

Alkylation of heme by the antimalarial drug artemisinin

Robert, A., Coppel, Y., & Meunier, B. (2002) · Chemical Communications · doi:10.1039/b110817b · Cited by 122

A High-Throughput Screen To Identify Inhibitors of ATP Homeostasis in Non-replicating Mycobacterium tuberculosis

Mak, P. A., Rao, S. P. S., Tan, M. P., Lin, X., Chyba, J., Tay, J. A., Ng, S. H., Tan, B. H., Cherian, J., Duraiswamy, J., et al. (2012) · ACS Chemical Biology · doi:10.1021/cb2004884 · Cited by 121

Structural Insight into the Heme-based Redox Sensing by DosS from Mycobacterium tuberculosis

Cho, H. Y., Cho, H. J., Kim, Y., Oh, J. I., & Kang, B. S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808905200 · Cited by 106

Anticytolytic Screen Identifies Inhibitors of Mycobacterial Virulence Protein Secretion

Rybniker, J., Chen, J. M., Sala, C., Hartkoorn, R. C., Vocat, A., Benjak, A., Boy‐Röttger, S., Zhang, M., Székely, R., Greff, Z., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.09.008 · Cited by 98

Heme activates artemisinin more efficiently than hemin, inorganic iron, or hemoglobin

Zhang, S., & Gerhard, G. S. (2008) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2008.02.034 · Cited by 92

Broad Spectrum Pro-Quorum-Sensing Molecules as Inhibitors of Virulence in Vibrios

Ng, W., Perez, L. J., Cong, J.-P., Semmelhack, M. F., & Bassler, B. L. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002767 · Cited by 82

2.3 Å X-ray Structure of the Heme-Bound GAF Domain of Sensory Histidine Kinase DosT of Mycobacterium tuberculosis

Podust, L. M., Ioanoviciu, A., & de Montellano, P. R. O. (2008) · Biochemistry · doi:10.1021/bi8012356 · Cited by 80

Structure-Based Design of DevR Inhibitor Active against NonreplicatingMycobacterium tuberculosis

Gupta, R. K., Thakur, T. S., Desiraju, G. R., & Tyagi, J. S. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm900358q · Cited by 79

DevS, a Heme-Containing Two-Component Oxygen Sensor of Mycobacterium tuberculosis

Ioanoviciu, A., Yukl, E. T., Moënne‐Loccoz, P., & de Montellano, P. R. O. (2007) · Biochemistry · doi:10.1021/bi602422p · Cited by 79

The DosS-DosT/DosR Mycobacterial Sensor System

Sivaramakrishnan, S., & de Montellano, P. R. O. (2013) · Biosensors · doi:10.3390/bios3030259 · Cited by 68

The reaction of artemisinins with hemoglobin: A unified picture

Luigi Messori, A., Gabbiani, C., Casini, A., Siragusa, M., Vincieri, F. F., & Bilia, A. R. (2006) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2005.12.038 · Cited by 66

Different Roles of DosS and DosT in the Hypoxic Adaptation of Mycobacteria

Kim, M., Park, K.-J., Ko, I.-J., Kim, Y. M., & Oh, J. (2010) · Journal of Bacteriology · doi:10.1128/jb.00550-10 · Cited by 63

DosS Is Required for the Complete Virulence of Mycobacterium tuberculosis in Mice with Classical Granulomatous Lesions

Gautam, U. S., McGillivray, A., Mehra, S., Didier, P. J., Midkiff, C. C., Kissee, R. S., Golden, N., Alvarez, X. A., Niu, T., Rengarajan, J., et al. (2014) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2014-0230oc · Cited by 53

Small-Molecule Inhibitors of toxT Expression in Vibrio cholerae

Anthouard, R., & DiRita, V. J. (2013) · mBio · doi:10.1128/mbio.00403-13 · Cited by 47

DevS Oxy Complex Stability Identifies This Heme Protein as a Gas Sensor inMycobacterium tuberculosisDormancy

Ioanoviciu, A., Meharenna, Y. T., Poulos, T. L., & de Montellano, P. R. O. (2009) · Biochemistry · doi:10.1021/bi802309y · Cited by 43

Alkylation of human hemoglobin A 0 by the antimalarial drug artemisinin

Selmeczi, K., Robert, A., Claparols, C., & Meunier, B. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)01448-0 · Cited by 43

SPARTA: Simple Program for Automated reference-based bacterial RNA-seq Transcriptome Analysis

Johnson, B. K., Scholz, M. B., Teal, T. K., & Abramovitch, R. B. (2016) · BMC Bioinformatics · doi:10.1186/s12859-016-0923-y · Cited by 42

Macrophage Infection Models for Mycobacterium tuberculosis

Johnson, B. K., & Abramovitch, R. B. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2450-9_20 · Cited by 27

Ultrafast Ligand Dynamics in the Heme-Based GAF Sensor Domains of the Histidine Kinases DosS and DosT from Mycobacterium tuberculosis

Vos, M. H., Bouzhir-Sima, L., Lambry, J., Luo, H., Eaton‐Rye, J. J., Ioanoviciu, A., de Montellano, P. R. O., & Liebl, U. (2011) · Biochemistry · doi:10.1021/bi201467c · Cited by 25

Gene Replacement in Mycobacterium tuberculosis and Mycobacterium bovis BCG Using rpsL+ as a Dominant Negative Selectable Marker

Sander, P., Springer, B., & Böttger, E. C. (2003) · Humana Press eBooks · doi:10.1385/1-59259-147-7:093 · Cited by 20

Blockage of the channel to heme by the E87 side chain in the GAF domain ofMycobacterium tuberculosisDosS confers the unique sensitivity of DosS to oxygen

Cho, H. Y., Cho, H. J., Kim, M. H., & Kang, B. S. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.04.050 · Cited by 18

Anti-tuberculosis treatment strategies and drug development: challenges and priorities

Dartois, V. A., & Rubin, E. J. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00731-y · Cited by 490

The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis

Shen, Q., Zhang, L., Liao, Z., Wang, S., Yan, T., Shi, P., Liu, M., Fu, X., Pan, Q., Wang, Y., et al. (2018) · Molecular Plant · doi:10.1016/j.molp.2018.03.015 · Cited by 315

Bacterial Heterogeneity and Antibiotic Survival: Understanding and Combatting Persistence and Heteroresistance

Dewachter, L., Fauvart, M., & Michiels, J. J. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.09.028 · Cited by 236

Targeting Antibiotic Tolerance, Pathogen by Pathogen

Meylan, S., Andrews, I. W., & Collins, J. J. (2018) · Cell · doi:10.1016/j.cell.2018.01.037 · Cited by 194

Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival

Mok, S., Stokes, B. H., Gnädig, N. F., Ross, L. S., Yeo, T., Amaratunga, C., Allman, E. L., Solyakov, L. S., Bottrill, A. R., Tripathi, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20805-w · Cited by 151

Inhibiting Mycobacterium tuberculosis DosRST Signaling by Targeting Response Regulator DNA Binding and Sensor Kinase Heme

Zheng, H., Williams, J. T., Aleiwi, B., Ellsworth, E. L., & Abramovitch, R. B. (2019) · ACS Chemical Biology · doi:10.1021/acschembio.8b00849 · Cited by 62

Inhibiting DosRST As a New Approach to Tuberculosis Therapy

Zheng, H., & Abramovitch, R. B. (2020) · Future Medicinal Chemistry · doi:10.4155/fmc-2019-0263 · Cited by 33

The Mycobacterium DosR regulon structure and diversity revealed by comparative genomic analysis

Chen, T., He, L., Deng, W., & Xie, J. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24302 · Cited by 48

Design, synthesis and in vitro evaluation of a series of endoperoxide hybrids designed to tackle latent tuberculosis

Amado, P. S. M. (2023) · Universidade do Algarve

The DosRST two-component system of Mycobacterium tuberculosis: Characterizing the activation mechanism of DosR response regulator as a potential target for novel antimycobacterial drugs

Marszalek, M. (2014) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)