In silico design of novel probes for the atypical opioid receptor MRGPRX2

ZINC − A Free Database of Commercially Available Compounds for Virtual Screening

Irwin, J. J., & Shoichet, B. K. (2005) · Journal of Chemical Information and Modeling · doi:10.1021/ci049714+ · Cited by 4,058 · see citing works

How many drug targets are there?

Overington, J. P., Al-Lazikani, B., & Hopkins, A. L. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2199 · Cited by 3,505 · see citing works

[19] Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors

Ballesteros, J. A., & Weinstein, H. (1995) · Methods in neurosciences · doi:10.1016/s1043-9471(05)80049-7 · Cited by 3,001 · see citing works

Comparative Protein Structure Modeling Using MODELLER

Eswar, N., Webb, B., Martı́-Renom, M. A., Madhusudhan, M. S., Eramian, D., Shen, M., Pieper, U., & Šali, A. (2007) · Current Protocols in Protein Science · doi:10.1002/0471140864.ps0209s50 · Cited by 2,862 · see citing works

On the Role of the Crystal Environment in Determining Protein Side-chain Conformations

Jacobson, M. P., Friesner, R. A., Xiang, Z., & Honig, B. H. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00470-9 · Cited by 1,289 · see citing works

PROMALS3D: a tool for multiple protein sequence and structure alignments

Pei, J., Kim, B., & Grishin, N. V. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn072 · Cited by 1,267 · see citing works

Identification of a mast cell specific receptor crucial for pseudo-allergic drug reactions

McNeil, B. D., Pundir, P., Meeker, S., Han, L., Undem, B., Kulka, M., & Dong, X.-Z. (2014) · Nature · doi:10.1038/nature14022 · Cited by 1,164 · see citing works

GPCRdb: an information system for G protein-coupled receptors

Ísberg, V., Mordalski, S., Munk, C., Rataj, K., Harpsøe, K., Hauser, A. S., Vroling, B., Bojarski, A. J., Vriend, G., & Gloriam, D. E. I. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1178 · Cited by 1,067 · see citing works

Automated docking with grid‐based energy evaluation

Meng, E. C., Shoichet, B. K., & Kuntz, I. D. (1992) · Journal of Computational Chemistry · doi:10.1002/jcc.540130412 · Cited by 956 · see citing works

Transfecting Mammalian Cells: Optimization of Critical Parameters Affecting Calcium-Phosphate Precipitate Formation

Jordan, M., Schallhorn, A., & Wurm, F. M. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.4.596 · Cited by 862 · see citing works

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

Kroeze, W. K., Sassano, M. F., Huang, X.-P., Lansu, K., McCorvy, J. D., Giguère, P. M., Sciaky, N., & Roth, B. L. (2015) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3014 · Cited by 755 · see citing works

A Diverse Family of GPCRs Expressed in Specific Subsets of Nociceptive Sensory Neurons

Dong, X., Han, S.-K., Zylka, M. J., Simon, M. I., & Anderson, D. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00483-4 · Cited by 742 · see citing works

The Repertoire of G-Protein–Coupled Receptors in Fully Sequenced Genomes

Fredriksson, R., & Schiöth, H. B. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.009001 · Cited by 613 · see citing works

Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcεRI or FcγRI

Kirshenbaum, A. S., Akin, C., Wu, Y., Rottem, M., Goff, J. P., Beaven, M. A., Rao, V. K., & Metcalfe, D. D. (2003) · Leukemia Research · doi:10.1016/s0145-2126(02)00343-0 · Cited by 513 · see citing works

Exploring the Neuroimmunopharmacology of Opioids: An Integrative Review of Mechanisms of Central Immune Signaling and Their Implications for Opioid Analgesia

Hutchinson, M. R., Shavit, Y., Grace, P. M., Rice, K. C., Maier, S. F., & Watkins, L. R. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.004135 · Cited by 397 · see citing works

Proenkephalin A gene products activate a new family of sensory neuron–specific GPCRs

Lembo, P. M. C., Grazzini, E., Groblewski, T., O’Donnell, D., Roy, M., Zhang, J., Hoffert, C., Cao, J., Schmidt, R., Pelletier, M., et al. (2002) · Nature Neuroscience · doi:10.1038/nn815 · Cited by 385 · see citing works

Immunoglobulin E-independent activation of mast cell is mediated by Mrg receptors.

Tatemoto, K., Nozaki, Y., Tsuda, R., Konno, S., Tomura, K., Furuno, M., Ogasawara, H., Edamura, K., Takagi, H., Iwamura, H., et al. (2006) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2006.08.177 · Cited by 364 · see citing works

Model for Aqueous Solvation Based on Class IV Atomic Charges and First Solvation Shell Effects

Chambers, C. C., Hawkins, G. D., Cramer, C. J., & Truhlar, D. G. (1996) · The Journal of Physical Chemistry · doi:10.1021/jp9610776 · Cited by 360 · see citing works

GPCRDB: an information system for G protein-coupled receptors

Horn, F. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.1.275 · Cited by 338 · see citing works

Rapid Context-Dependent Ligand Desolvation in Molecular Docking

Mysinger, M. M., & Shoichet, B. K. (2010) · Journal of Chemical Information and Modeling · doi:10.1021/ci100214a · Cited by 319 · see citing works

Histamine Release during Morphine and Fentanyl Anesthesia

Rosow, C. E., Moss, J., Philbin, D. M., & Savarese, J. J. (1982) · Anesthesiology · doi:10.1097/00000542-198202000-00003 · Cited by 314 · see citing works

Ligand discovery from a dopamine D3 receptor homology model and crystal structure

Carlsson, J., Coleman, R. G., Setola, V., Irwin, J. J., Fan, H., Schlessinger, A., Šali, A., Roth, B. L., & Shoichet, B. K. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.662 · Cited by 305 · see citing works

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65

Huang, X.-P., Karpiak, J., Kroeze, W. K., Zhu, H., Chen, X., Moy, S. S., Saddoris, K. A., Nikolova, V. D., Farrell, M. S., Wang, S., et al. (2015) · Nature · doi:10.1038/nature15699 · Cited by 284 · see citing works

The Druggable Genome: Evaluation of Drug Targets in Clinical Trials Suggests Major Shifts in Molecular Class and Indication

Rask-Andersen, M., Masuram, S., & Schiöth, H. B. (2014) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-135943 · Cited by 282 · see citing works

Docking Screens for Novel Ligands Conferring New Biology

Irwin, J. J., & Shoichet, B. K. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b02008 · Cited by 281 · see citing works

Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family

Zylka, M. J., Dong, X., Southwell, A. L., & Anderson, D. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1732949100 · Cited by 266 · see citing works

New Class IV Charge Model for Extracting Accurate Partial Charges from Wave Functions

Li, J., Zhu, T., Cramer, C. J., & Truhlar, D. G. (1998) · The Journal of Physical Chemistry A · doi:10.1021/jp972682r · Cited by 260 · see citing works

MrgX2 Is a High Potency Cortistatin Receptor Expressed in Dorsal Root Ganglion

Robas, N. M., Mead, E. J., & Fidock, M. D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302456200 · Cited by 250 · see citing works

Strategies to Discover Unexpected Targets for Drugs Active at G Protein–Coupled Receptors

Allen, J. A., & Roth, B. L. (2011) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010510-100553 · Cited by 216 · see citing works

Discovery of Dinaciclib (SCH 727965): A Potent and Selective Inhibitor of Cyclin-Dependent Kinases

Paruch, K., Dwyer, M. P., Alvarez, C., Brown, C., Chan, T., Doll, R. J., Keertikar, K. M., Knutson, C. E., McKittrick, B. A., Rivera, J., et al. (2010) · ACS Medicinal Chemistry Letters · doi:10.1021/ml100051d · Cited by 184 · see citing works

Screening β-Arrestin Recruitment for the Identification of Natural Ligands for Orphan G-Protein–Coupled Receptors

Southern, C., Cook, J. M., Neetoo‐Isseljee, Z., Taylor, D. L., Kettleborough, C. A., Merritt, A. T., Bassoni, D. L., Raab, W. J., Quinn, E. R., Wehrman, T. S., et al. (2013) · SLAS DISCOVERY · doi:10.1177/1087057113475480 · Cited by 181 · see citing works

Neuraxial opioid-induced pruritus: An update

Kumar, K., & Singh, S. (2013) · Journal of Anaesthesiology Clinical Pharmacology · doi:10.4103/0970-9185.117045 · Cited by 177 · see citing works

New insights from structural biology into the druggability of G protein-coupled receptors

Mason, J. S., Bortolato, A., Congreve, M., & Marshall, F. H. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.02.005 · Cited by 171 · see citing works

Histamine-Releasing and Allergenic Properties of Opioid Analgesic Drugs: Resolving the Two

Baldo, B. A., & Pham, N. H. (2012) · Anaesthesia and Intensive Care · doi:10.1177/0310057x1204000204 · Cited by 170 · see citing works

Stereospecific and Nonstereospecific Effects of (+)- and (—)-Morphine: Evidence for a New Class of Receptors?

Jacquet, Y. F., Klee, W. A., Rice, K. C., Iijima, I., & Minamikawa, J. (1977) · Science · doi:10.1126/science.199942 · Cited by 165 · see citing works

β-Defensins Activate Human Mast Cells via Mas-Related Gene X2

Subramanian, H., Gupta, K., Lee, D., Bayir, A., Ahn, H., & Ali, H. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300023 · Cited by 146 · see citing works

Determining the Neurotransmitter Concentration Profile at Active Synapses

Scimemi, A., & Beato, M. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8087-7 · Cited by 145 · see citing works

Identification of Novel Functionally Selective κ-Opioid Receptor Scaffolds

White, K. L., Scopton, A. P., Rives, M., Bikbulatov, R. V., Polepally, P. R., Brown, P. J., Kenakin, T., Javitch, J. A., Zjawiony, J. K., & Roth, B. L. (2013) · Molecular Pharmacology · doi:10.1124/mol.113.089649 · Cited by 142 · see citing works

Mast Cell/Nerve Interactions In Vitro and In Vivo

Bienenstock, J., MacQUEEN, G. M., Sestini, P., Marshall, J. S., Stead, R. H., & Perdue, M. H. (1991) · American Review of Respiratory Disease · doi:10.1164/ajrccm/143.3_pt_2.s55 · Cited by 138 · see citing works

Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum.

Yamasaki, H. (1976) · PubMed · Cited by 136 · see citing works

Structure-based ligand discovery for the protein–protein interface of chemokine receptor CXCR4

Mysinger, M. M., Weiss, D. R., Ziarek, J. J., Gravel, S., Doak, A. K., Karpiak, J. D., Heveker, N., Shoichet, B. K., & Volkman, B. F. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120431109 · Cited by 129 · see citing works

Polyelectrolyte electrostatics: Salt dependence, entropic, and enthalpic contributions to free energy in the nonlinear Poisson–Boltzmann model

Sharp, K. A. (1995) · Biopolymers · doi:10.1002/bip.360360210 · Cited by 117 · see citing works

Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides

Kamohara, M., Matsuo, A., Takasaki, J., Kohda, M., Matsumoto, M., Matsumoto, S., Soga, T., Hiyama, H., Kobori, M., & Katou, M. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.088 · Cited by 110 · see citing works

A pharmacological organization of G protein–coupled receptors

Lin, H., Sassano, M. F., Roth, B. L., & Shoichet, B. K. (2013) · Nature Methods · doi:10.1038/nmeth.2324 · Cited by 103 · see citing works

NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor

O’Connor, C., White, K. L., Doncescu, N., Didenko, T., Roth, B. L., Czaplicki, G., Stevens, R. C., Kurt Wüthrich, A., & Milon, A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1510117112 · Cited by 96 · see citing works

Identifying ligands at orphan GPCRs: current status using structure‐based approaches

Ngo, T., Kufareva, I., Coleman, J. L. J., Graham, R. M., Abagyan, R. A., & Smith, N. J. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13452 · Cited by 87 · see citing works

The Recognition of Identical Ligands by Unrelated Proteins

Barelier, S., Sterling, T., O’Meara, M. J., & Shoichet, B. K. (2015) · ACS Chemical Biology · doi:10.1021/acschembio.5b00683 · Cited by 74 · see citing works

The Emerging Role of Spinal Dynorphin in Chronic Pain: A Therapeutic Perspective

Podvin, S., Yaksh, T. L., & HOOK, V. Y. H. (2016) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010715-103042 · Cited by 56 · see citing works

Computer-Aided Discovery of Aromatic l -α-Amino Acids as Agonists of the Orphan G Protein-Coupled Receptor GPR139

Ísberg, V., Andersen, K. B., Bisig, C., Dietz, G. P. H., Bräuner‐Osborne, H., & Gloriam, D. E. I. (2014) · Journal of Chemical Information and Modeling · doi:10.1021/ci500197a · Cited by 56 · see citing works

Minocycline prevents dynorphin-induced neurotoxicity during neuropathic pain in rats

Rojewska, E., Makuch, W., Przewłocka, B., & Mika, J. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.08.001 · Cited by 52 · see citing works

The pharmacological profile of δ opioid receptor ligands, (+) and (−) TAN-67 on pain modulation

Nagase, H., Yajima, Y., Fujii, H., Kawamura, K., Narita, M., Kamei, J., & Suzuki, T. (2001) · Life Sciences · doi:10.1016/s0024-3205(01)01010-4 · Cited by 49 · see citing works

Localization of immunoreactive dynorphin in neurons cultured from spinal cord and dorsal root ganglia.

Sweetnam, P. M., Neale, J. H., Barker, J. L., & D, A. G. M. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.21.6742 · Cited by 45 · see citing works

Activation of opioid μ-receptor by sinomenine in cell and mice

Wang, M. H., Chang, C.-K., Cheng, J.-H., Wu, H., Li, Y.-X., & Cheng, J. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.07.088 · Cited by 36 · see citing works

Discovery of non-peptidergic MrgX1 and MrgX2 receptor agonists and exploration of an initial SAR using solid-phase synthesis

Malik, L., Kelly, N. M., Ma, J., Currier, E. A., Burstein, E. S., & Olsson, R. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.01.085 · Cited by 29 · see citing works

A mast cell degranulation screening assay for the identification of novel mast cell activating agents

Staats, H. F., Kirwan, S. M., Choi, H. W., Shelburne, C. P., Abraham, S. N., Leung, G. Y. C., & Chen, D. Y. ‐. (2012) · MedChemComm · doi:10.1039/c2md20073b · Cited by 24 · see citing works

Building alternate protein structures using the elastic network model

Yang, Q., & Sharp, K. A. (2008) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.22184 · Cited by 23 · see citing works

Preliminary Pharmacological Evaluation of Enantiomeric Morphinans

Sromek, A. W., Provencher, B. A., Russell, S. E., Chartoff, E. H., Knapp, B. I., Bidlack, J. M., & Neumeyer, J. L. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn400205z · Cited by 21 · see citing works

Complanadine A, a selective agonist for the Mas-related G protein-coupled receptor X2

Johnson, T., & Siegel, D. R. (2014) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2014.05.060 · Cited by 20 · see citing works

dextro-Morphine attenuates the morphine-produced conditioned place preference via the sigma1 receptor activation in the rat

Wu, H.-E., Schwasinger, E. T., Terashvili, M., & Tseng, L. F. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.01.083 · Cited by 17 · see citing works

Morphine is an exogenous ligand for MrgX2, a G protein-coupled receptor for cortistatin

Akuzawa, N., Obinata, H., Izumi, T., & Takeda, S. (2009) · Journal of Cell and Animal Biology · doi:10.5897/jcab.9000110 · Cited by 13 · see citing works

Epilepsy in aging populations

Jacobson, M. P. (2002) · Current Treatment Options in Neurology · doi:10.1007/s11940-002-0002-8 · Cited by 5 · see citing works

[Recreational usage of dextromethorphan--analysis based on internet users experiences].

Zając, M., Andrzejczyk, A. P., Kuich, A., Tyrańska-Fobke, A., Waldman, W., & Anand, J. S. (2013) · PubMed · Cited by 4 · see citing works

How Ligands Illuminate GPCR Molecular Pharmacology

Wacker, D., Stevens, R. C., & Roth, B. L. (2017) · Cell · doi:10.1016/j.cell.2017.07.009 · Cited by 560 · see citing works

A practical guide to large-scale docking

Bender, B. J., Gahbauer, S., Luttens, A., Lyu, J., Webb, C. M., Stein, R. M., Fink, E. A., Balius, T. E., Carlsson, J., Irwin, J. J., et al. (2021) · Nature Protocols · doi:10.1038/s41596-021-00597-z · Cited by 546 · see citing works

The Art and Science of Molecular Docking

Paggi, J. M., Pandit, A., & Dror, R. O. (2024) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-030222-120000 · Cited by 511 · see citing works

Unexplored therapeutic opportunities in the human genome

Oprea, T. I., Bologa, C. G., Brunak, S., Campbell, A., Gan, G. N., Gaulton, A., Gomez, S. M., Guha, R., Hersey, A., Holmes, J., et al. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.14 · Cited by 378 · see citing works

House dust mites activate nociceptor–mast cell clusters to drive type 2 skin inflammation

Serhan, N., Basso, L., Sibilano, R., Petitfils, C., Meixiong, J., Bonnart, C., Reber, L. L., Marichal, T., Starkl, P. M., Cénac, N., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0493-z · Cited by 347 · see citing works

Erratum: Unexplored therapeutic opportunities in the human genome

Oprea, T. I., Bologa, C., Brunak, S., Campbell, A., Gan, G. N., Gaulton, A., Gomez, S. M., Guha, R., Hersey, A., Holmes, J., et al. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.52 · Cited by 304 · see citing works

Virtual discovery of melatonin receptor ligands to modulate circadian rhythms

Stein, R. M., Kang, H. J., McCorvy, J. D., Glatfelter, G. C., Jones, A., Che, T., Slocum, S. T., Huang, X., Savych, O., Moroz, Y. S., et al. (2020) · Nature · doi:10.1038/s41586-020-2027-0 · Cited by 306 · see citing works

Physiology and Pathophysiology of Itch

Cevikbas, F., & Lerner, E. A. (2019) · Physiological Reviews · doi:10.1152/physrev.00017.2019 · Cited by 284 · see citing works

D4dopamine receptor high-resolution structures enable the discovery of selective agonists

Wang, S., Wacker, D., Levit, A., Che, T., Betz, R. M., McCorvy, J. D., Venkatakrishnan, A., Huang, X., Dror, R. O., Shoichet, B. K., et al. (2017) · Science · doi:10.1126/science.aan5468 · Cited by 263 · see citing works

Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity

Kaplan, A. L., Confair, D. N., Kim, K., Barros-Álvarez, X., Rodriguiz, R. M., Ying, Y., Kweon, O. S., Che, T., McCorvy, J. D., Kamber, D. N., et al. (2022) · Nature · doi:10.1038/s41586-022-05258-z · Cited by 249 · see citing works

Structure, function and pharmacology of human itch GPCRs

Cao, C., Kang, H. J., Singh, I., Chen, H., Zhang, C., Ye, W., Hayes, B. W., Liu, J., Gumpper, R. H., Bender, B. J., et al. (2021) · Nature · doi:10.1038/s41586-021-04126-6 · Cited by 236 · see citing works

Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions

Porębski, G., Kwiecień, K., Pawica, M., & Kwitniewski, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03027 · Cited by 191 · see citing works

Multifaceted MRGPRX2: New insight into the role of mast cells in health and disease

Roy, S., Ayudhya, C. C. N., Thapaliya, M., Deepak, V., & Ali, H. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.03.049 · Cited by 178 · see citing works

Structure, function and pharmacology of human itch receptor complexes

Yang, F., Guo, L., Li, Y., Wang, G., Wang, J., Zhang, C., Fang, G.-X., Chen, X., Liu, L., Yan, X., et al. (2021) · Nature · doi:10.1038/s41586-021-04077-y · Cited by 144 · see citing works

MRGPRX4 is a G protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus

Meixiong, J., Vasavda, C., Snyder, S. H., & Dong, X. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1903316116 · Cited by 162 · see citing works

Structure-Based Virtual Screening for Ligands of G Protein–Coupled Receptors: What Can Molecular Docking Do for You?

Ballante, F., Kooistra, A. J., Kampen, S., de Graaf, C., & Carlsson, J. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000246 · Cited by 160 · see citing works

MRGPRX2-mediated mast cell response to drugs used in perioperative procedures and anaesthesia

Navinés‐Ferrer, A., Serrano‐Candelas, E., Lafuente, A., Muñoz‐Cano, R., Martı́n, M., & Gastaminza, G. (2018) · Scientific Reports · doi:10.1038/s41598-018-29965-8 · Cited by 160 · see citing works

Comparative epidemiology of suspected perioperative hypersensitivity reactions

Mertès, P., Ebo, D. G., Garcez, T. P., Rose, M. A., Sabato, V., Takazawa, T., Cooke, P., Clarke, R. C., Dewachter, P., Garvey, L. H., et al. (2019) · British Journal of Anaesthesia · doi:10.1016/j.bja.2019.01.027 · Cited by 153 · see citing works

Human mast cells and basophils—How are they similar how are they different?

Varricchi, G., Raap, U., Rivellese, F., Marone, G., & Gibbs, B. F. (2018) · Immunological Reviews · doi:10.1111/imr.12627 · Cited by 151 · see citing works

Mas-related G protein–coupled receptor X2 and its activators in dermatologic allergies

Kühn, H., Kolkhir, P., Babina, M., Düll, M. M., Frischbutter, S., Fok, J. S., Jiao, Q., Metz, M., Scheffel, J., Wolf, K., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.08.027 · Cited by 138 · see citing works

Property-Unmatched Decoys in Docking Benchmarks

Stein, R. M., Ying, Y., Balius, T. E., O’Meara, M. J., Lyu, J., Young, J., Tang, K. G., Shoichet, B. K., & Irwin, J. J. (2021) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.0c00598 · Cited by 136 · see citing works

The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides

Meyrath, M., Szpakowska, M., Zeiner, J., Massotte, L., Merz, M. P., Benkel, T., Simon, K., Ohnmacht, J., Turner, J. D., Krüger, R., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16664-0 · Cited by 130 · see citing works

Biased ligands at opioid receptors: Current status and future directions

Che, T., Dwivedi‐Agnihotri, H., Shukla, A. K., & Roth, B. L. (2021) · Science Signaling · doi:10.1126/scisignal.aav0320 · Cited by 125 · see citing works

Molecular basis of opioid receptor signaling

Che, T., & Roth, B. L. (2023) · Cell · doi:10.1016/j.cell.2023.10.029 · Cited by 123 · see citing works

MRGPRX2 and Adverse Drug Reactions

McNeil, B. D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.676354 · Cited by 117 · see citing works

Unlocking the Non-IgE-Mediated Pseudo-Allergic Reaction Puzzle with Mas-Related G-Protein Coupled Receptor Member X2 (MRGPRX2)

Kumar, M., Duraisamy, K., & Chow, B. (2021) · Cells · doi:10.3390/cells10051033 · Cited by 113 · see citing works

Heterogeneity of Human Mast Cells With Respect to MRGPRX2 Receptor Expression and Function

Varricchi, G., Pecoraro, A., Loffredo, S., Poto, R., Rivellese, F., Genovese, A., Marone, G., & Spadaro, G. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00299 · Cited by 111 · see citing works

Molecular mechanisms and pathophysiology of perioperative hypersensitivity and anaphylaxis: a narrative review

Ebo, D. G., Clarke, R. C., Mertès, P., Platt, P. R., Sabato, V., & Sadleir, P. H. M. (2019) · British Journal of Anaesthesia · doi:10.1016/j.bja.2019.01.031 · Cited by 110 · see citing works

Discovery of new GPCR ligands to illuminate new biology

Roth, B. L., Irwin, J. J., & Shoichet, B. K. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2490 · Cited by 94 · see citing works

VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells

English, J. G., Olsen, R. H. J., Lansu, K., Patel, M., White, K., Cockrell, A. S., Singh, D., Strachan, R. T., Wacker, D., & Roth, B. L. (2019) · Cell · doi:10.1016/j.cell.2019.05.051 · Cited by 98 · see citing works

Inflamed Ulcerative Colitis Regions Associated With MRGPRX2-Mediated Mast Cell Degranulation and Cell Activation Modules, Defining a New Therapeutic Target

Chen, E., Chuang, L.-S. F., Giri, M., Villaverde, N., Hsu, N.-Y., Sabic, K., Joshowitz, S., Gettler, K., Nayar, S., Chai, Z., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.12.076 · Cited by 100 · see citing works

Mast Cell-Specific MRGPRX2: a Key Modulator of Neuro-Immune Interaction in Allergic Diseases

Thapaliya, M., Ayudhya, C. C. N., Amponnawarat, A., Roy, S., & Ali, H. (2021) · Current Allergy and Asthma Reports · doi:10.1007/s11882-020-00979-5 · Cited by 95 · see citing works

The transcriptional program, functional heterogeneity, and clinical targeting of mast cells

Cildir, G., Pant, H., Lopez, A. F., & Tergaonkar, V. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20170910 · Cited by 94 · see citing works

Nonantimicrobial Actions of Macrolides: Overview and Perspectives for Future Development

Kricker, J. A., Page, C. P., Gardarsson, F. R., Baldursson, Ó., Guðjónsson, Þ., & Parnham, M. J. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000300 · Cited by 92 · see citing works

Therapeutic Potential of MRGPRX2 Inhibitors on Mast Cells

Ogasawara, H., & Noguchi, M. (2021) · Cells · doi:10.3390/cells10112906 · Cited by 87 · see citing works

Neurotransmitter and neuropeptide regulation of mast cell function: a systematic review

Xu, H., Shi, X., Li, X., Zou, J.-X., Zhou, C., Liu, W., Shao, H., Chen, H., & Shi, L. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-02029-3 · Cited by 87 · see citing works

Naturally occurring Missense MRGPRX2 variants display Loss of Function Phenotype for Mast Cell Degranulation in response to Substance P, Hemokinin-1, Human β-defensin 3 and Icatibant

Alkanfari, I., Gupta, K., Jahan, T., & Ali, H. (2018) · Journal of Immunology · doi:10.4049/jimmunol.1701793 · Cited by 80 · see citing works

In Vitro Diagnosis of Immediate Drug Hypersensitivity During Anesthesia: A Review of the Literature

Ebo, D. G., Faber, M. A., Elst, J., Gasse, A. L. V., Bridts, C. H., Mertens, C. H., Clerck, L. S. D., Hagendorens, M. M., & Sabato, V. (2018) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2018.01.004 · Cited by 80 · see citing works

Osthole, a Natural Plant Derivative Inhibits MRGPRX2 Induced Mast Cell Responses

Callahan, B. N., Kammala, A. K., Syed, M., Yang, C., Occhiuto, C. J., Nellutla, R., Chumanevich, A. P., Oskeritzian, C. A., Das, R., & Subramanian, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00703 · Cited by 78 · see citing works

New roles and controls of mast cells

Espinosa, É., & Valitutti, S. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.10.012 · Cited by 78 · see citing works

Role of mast cells and basophils in pruritus

Steinhoff, M. S., Buddenkotte, J., & Lerner, E. A. (2018) · Immunological Reviews · doi:10.1111/imr.12635 · Cited by 78 · see citing works

Quercetin inhibits Mrgprx2-induced pseudo-allergic reaction via PLCγ-IP3R related Ca2+ fluctuations

Ding, Y., Che, D., Li, C., Cao, J., Wang, J., Ma, P., Zhao, T., An, H., & Zhang, T. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.11.025 · Cited by 76 · see citing works

Mechanisms of human drug-induced anaphylaxis

Bruhns, P., & Chollet‐Martin, S. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.02.013 · Cited by 76 · see citing works

Identification of Gain and Loss of Function Missense Variants in MRGPRX2’s Transmembrane and Intracellular Domains for Mast Cell Activation by Substance P

Ayudhya, C. C. N., Roy, S., Alkanfari, I., Ganguly, A., & Ali, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215247 · Cited by 74 · see citing works

In vitro diagnostic tests for perioperative hypersensitivity, a narrative review: potential, limitations, and perspectives

Takazawa, T., Sabato, V., & Ebo, D. G. (2019) · British Journal of Anaesthesia · doi:10.1016/j.bja.2019.01.002 · Cited by 73 · see citing works

MRGPRX2 is essential for sinomenine hydrochloride induced anaphylactoid reactions

Liu, R., Che, D., Zhao, T., Pundir, P., Cao, J., Lv, Y., Wang, J., Ma, P., Fu, J., Wang, N., et al. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.09.017 · Cited by 71 · see citing works

Structure-based discovery of selective positive allosteric modulators of antagonists for the M 2 muscarinic acetylcholine receptor

Korczynska, M., Clark, M. J., Valant, C., Xu, J. Z., Moo, E. V., Albold, S., Weiss, D. R., Torosyan, H., Huang, W., Kruse, A. C., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718037115 · Cited by 71 · see citing works

Intrathecal Drug Delivery: Advances and Applications in the Management of Chronic Pain Patient

Andrés, J. A. D., Hayek, S. M., Perruchoud, C., Lawrence, M. M., Reina, M. Á., Andrés-Serrano, C. D., Rubio-Haro, R., Hunt, M. A., & Yaksh, T. L. (2022) · Frontiers in Pain Research · doi:10.3389/fpain.2022.900566 · Cited by 72 · see citing works

Saikosaponin A inhibits compound 48/80-induced pseudo-allergy via the Mrgprx2 pathway in vitro and in vivo

Wang, N., Che, D., Zhang, T., Liu, R., Cao, J., Wang, J., Zhao, T., Ma, P., Dong, X., & He, L. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.12.017 · Cited by 70 · see citing works

Emerging Roles for MAS-Related G Protein-Coupled Receptor-X2 in Host Defense Peptide, Opioid, and Neuropeptide-Mediated Inflammatory Reactions

Ali, H. (2017) · Advances in immunology · doi:10.1016/bs.ai.2017.06.002 · Cited by 69 · see citing works

Molecular pharmacology of metabotropic receptors targeted by neuropsychiatric drugs

Roth, B. L. (2019) · Nature Structural & Molecular Biology · doi:10.1038/s41594-019-0252-8 · Cited by 68 · see citing works

Mast cell disorders: From infancy to maturity

Wilcock, A., Bahri, R., Bulfone‐Paus, S., & Arkwright, P. D. (2018) · Allergy · doi:10.1111/all.13657 · Cited by 68 · see citing works

MAS-related G protein-coupled receptors X (MRGPRX): Orphan GPCRs with potential as targets for future drugs

Hamwi, G. A., Riedel, Y. K., Clemens, S., Namasivayam, V., Thimm, D., & Müller, C. E. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108259 · Cited by 66 · see citing works

Novel MRGPRX2 antagonists inhibit IgE-independent activation of human umbilical cord blood-derived mast cells

Ogasawara, H., Furuno, M., Edamura, K., & Noguchi, M. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.2ab1018-405r · Cited by 66 · see citing works

The Interplay between Chronic Pain, Opioids, and the Immune System

Malafoglia, V., Ilari, S., Vitiello, L., Tenti, M., Balzani, E., Muscoli, C., Raffaeli, W., & Bonci, A. (2021) · The Neuroscientist · doi:10.1177/10738584211030493 · Cited by 63 · see citing works

Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91

Trauelsen, M., Ulven, E. R., Hjorth, S. A., Brvar, M., Monaco, C. G., Frimurer, T. M., & Schwartz, T. W. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.09.005 · Cited by 63 · see citing works

Mast cells, cortistatin, and its receptor, MRGPRX2, are linked to the pathogenesis of chronic prurigo

Kolkhir, P., Pyatilova, P., Ashry, T., Jiao, Q., Abad‐Perez, A. T., Altrichter, S., Vera, C., Church, M. K., He, J., Lohse, K., et al. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.02.021 · Cited by 63 · see citing works

MRGPRX2 signals its importance in cutaneous mast cell biology: Does MRGPRX2 connect mast cells and atopic dermatitis?

Wang, Z., & Babina, M. (2020) · Experimental Dermatology · doi:10.1111/exd.14182 · Cited by 63 · see citing works

MrgX2 is a promiscuous receptor for basic peptides causing mast cell pseudo‐allergic and anaphylactoid reactions

Grimes, J., Desai, S. D., Charter, N. W., Lodge, J., Santos, R. M., Isidro‐Llobet, A., Mason, A. M., Wu, Z., Wolfe, L. A., Anantharaman, L., et al. (2019) · Pharmacology Research & Perspectives · doi:10.1002/prp2.547 · Cited by 59 · see citing works

MRGPRX2 Is the Codeine Receptor of Human Skin Mast Cells: Desensitization through β-Arrestin and Lack of Correlation with the FcεRI Pathway

Babina, M., Wang, Z., Roy, S., Guhl, S., Franke, K., Artuc, M., Ali, H., & Zuberbier, T. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.09.017 · Cited by 55 · see citing works

The MRGPR family of receptors in immunity

Gour, N., & Dong, X. (2024) · Immunity · doi:10.1016/j.immuni.2023.12.012 · Cited by 58 · see citing works

Computational chemical biology and drug design: Facilitating protein structure, function, and modulation studies

Zheng, M., Zhao, J., Cui, C., Fu, Z., Li, X., Liu, X., Ding, X., Tan, X., Li, F., Luo, X., et al. (2018) · Medicinal Research Reviews · doi:10.1002/med.21483 · Cited by 53 · see citing works

A group of cationic amphiphilic drugs activates MRGPRX2 and induces scratching behavior in mice

Wolf, K., Kühn, H., Boehm, F., Gebhardt, L., Glaudo, M., Agelopoulos, K., Ständer, S., Ectors, P., Zahn, D., Riedel, Y. K., et al. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.12.655 · Cited by 53 · see citing works

The structure, function, and pharmacology of MRGPRs

Cao, C., & Roth, B. L. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.02.002 · Cited by 57 · see citing works

Mast cell-mediated hypersensitivity to fluoroquinolone is MRGPRX2 dependent

Liu, R., Hu, S., Zhang, Y., Che, D., Cao, J., Wang, J., Zhao, T., Jia, Q., Wang, N., & Zhang, T. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.02.001 · Cited by 53 · see citing works

Morphine acts on spinal dynorphin neurons to cause itch through disinhibition

Nguyen, E. K., Lim, G., Ding, H., Hachisuka, J., Ko, M., & Ross, S. E. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abc3774 · Cited by 53 · see citing works

Mast cell activation tests by flow cytometry: A new diagnostic asset?

Elst, J., van der Poorten, M. M., Gasse, A. L. V., Puysseleyr, L. P. D., Hagendorens, M. M., Faber, M. A., Houdt, M. V., Passante, E., Bahri, R., Walschot, M., et al. (2021) · Clinical & Experimental Allergy · doi:10.1111/cea.13984 · Cited by 52 · see citing works

A single amino acid in MRGPRX2 necessary for binding and activation by pruritogens

Reddy, V. B., Graham, T. A., Azimi, E., & Lerner, E. A. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.05.046 · Cited by 51 · see citing works

Structural Insights Accelerate the Discovery of Opioid Alternatives

Che, T., & Roth, B. L. (2021) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061620-044044 · Cited by 51 · see citing works

Drug Hypersensitivity Reactions

Dykewicz, M. S., & Lam, J. K. (2019) · Medical Clinics of North America · doi:10.1016/j.mcna.2019.09.003 · Cited by 50 · see citing works

Inhibition of MRGPRX2 but not FcεRI or MrgprB2-mediated mast cell degranulation by a small molecule inverse receptor agonist

Bawazir, M., Amponnawarat, A., Hui, Y. Y., Oskeritzian, C. A., & Ali, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1033794 · Cited by 49 · see citing works

Cisatracurium induces mast cell activation and pseudo-allergic reactions via MRGPRX2

Che, D., Liu, R., Cao, J., Wang, J., Zhang, Y., Ding, Y., Zhao, T., Ma, P., An, H., Gao, Z., et al. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.07.020 · Cited by 49 · see citing works

Angiogenic Host Defense Peptide AG-30/5C and Bradykinin B2 Receptor Antagonist Icatibant Are G Protein Biased Agonists for MRGPRX2 in Mast Cells

Roy, S., Ganguly, A., Haque, M., & Ali, H. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801227 · Cited by 49 · see citing works

MRGPRX2 and Immediate Drug Hypersensitivity: Insights From Cultured Human Mast Cells

Elst, J., Sabato, V., Faber, M. A., Bridts, C. H., Mertens, C. H., Houdt, M. V., Gasse, A. L. V., Hagendorens, M. M., Tendeloo, V. F. V., Maurer, M., et al. (2020) · Journal of Investigational Allergology and Clinical Immunology · doi:10.18176/jiaci.0557 · Cited by 48 · see citing works

Store-Operated Calcium Entry via STIM1 Contributes to MRGPRX2 Induced Mast Cell Functions

Occhiuto, C. J., Kammala, A. K., Yang, C., Nellutla, R., Garcia, M., Gomez, G., & Subramanian, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03143 · Cited by 48 · see citing works

Substance P Serves as a Balanced Agonist for MRGPRX2 and a Single Tyrosine Residue Is Required for β-Arrestin Recruitment and Receptor Internalization

Ayudhya, C. C. N., Amponnawarat, A., & Ali, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105318 · Cited by 47 · see citing works

Novel small molecule MRGPRX2 antagonists inhibit a murine model of allergic reaction

Kumar, M., Duraisamy, K., Annapureddy, R. R., Chan, C. B., & Chow, B. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.12.805 · Cited by 47 · see citing works

Selectivity Challenges in Docking Screens for GPCR Targets and Antitargets

Weiss, D. R., Karpiak, J. D., Huang, X., Sassano, M. F., Lyu, J., Roth, B. L., & Shoichet, B. K. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b00718 · Cited by 45 · see citing works

Rocuronium Hypersensitivity: Does Off-Target Occupation of the MRGPRX2 Receptor Play a Role?

Gasse, A. L. V., Elst, J., Bridts, C. H., Mertens, C. H., Faber, M. A., Hagendorens, M. M., Clerck, L. S. D., Sabato, V., & Ebo, D. G. (2018) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2018.09.034 · Cited by 45 · see citing works

Thymic Stromal Lymphopoietin Promotes MRGPRX2-Triggered Degranulation of Skin Mast Cells in a STAT5-Dependent Manner with Further Support from JNK

Babina, M., Wang, Z., Franke, K., & Zuberbier, T. (2021) · Cells · doi:10.3390/cells10010102 · Cited by 45 · see citing works

MRGPRX2 Activation by Rocuronium: Insights from Studies with Human Skin Mast Cells and Missense Variants

Ayudhya, C. C. N., Amponnawarat, A., Roy, S., Oskeritzian, C. A., & Ali, H. (2021) · Cells · doi:10.3390/cells10010156 · Cited by 44 · see citing works

A novel MRGPRX2-targeting antagonistic DNA aptamer inhibits histamine release and prevents mast cell-mediated anaphylaxis

Suzuki, Y., Liu, S., Ogasawara, T., Sawasaki, T., Takasaki, Y., Yorozuya, T., & Mogi, M. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173104 · Cited by 43 · see citing works

MRGPRX2, drug pseudoallergies, inflammatory diseases, mechanisms and distinguishing MRGPRX2‐ and IgE/FcεRI‐mediated events

Baldo, B. A. (2023) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.15845 · Cited by 42 · see citing works

Inhibitory function of Shikonin on MRGPRX2-mediated pseudo-allergic reactions induced by the secretagogue

Wang, J., Zhang, Y., Li, C., Ding, Y., Hu, S., & An, H. (2019) · Phytomedicine · doi:10.1016/j.phymed.2019.153149 · Cited by 41 · see citing works

Paeoniflorin inhibits MRGPRX2‐mediated pseudo‐allergic reaction via calcium signaling pathway

Wang, J., Zhang, Y., Wang, J., Liu, R., Zhang, G., Dong, K., & Zhang, T. (2019) · Phytotherapy Research · doi:10.1002/ptr.6531 · Cited by 40 · see citing works

The pseudo-allergic/neurogenic route of mast cell activation via MRGPRX2: discovery, functional programs, regulation, relevance to disease, and relation with allergic stimulation

Babina, M. (2020) · Itch · doi:10.1097/itx.0000000000000032 · Cited by 40 · see citing works

A humanized mouse model to study mast cells mediated cutaneous adverse drug reactions

Mencarelli, A., Gunawan, M., Yong, K. S. M., Bist, P., Tan, W. W. S., Tan, S. Y., Liu, M., Huang, E. K., Fan, Y., Chan, J. K. Y., et al. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ma1219-210rr · Cited by 39 · see citing works

Human Mast Cell Line HMC1 Expresses Functional Mas-Related G-Protein Coupled Receptor 2

Hermans, M. A. W., van Stigt, A. C., van de Meerendonk, S., Schrijver, B., van Daele, P. L. A., van Hagen, P. M., van Splunter, M. E., & Dik, W. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.625284 · Cited by 36 · see citing works

Lactic acid suppresses MRGPRX2 mediated mast cell responses

Syed, M., Kammala, A. K., Callahan, B. N., Oskeritzian, C. A., & Subramanian, H. (2021) · Cellular Immunology · doi:10.1016/j.cellimm.2021.104422 · Cited by 36 · see citing works

Mast cells instruct keratinocytes to produce thymic stromal lymphopoietin: Relevance of the tryptase/protease-activated receptor 2 axis

Redhu, D., Franke, K., Aparicio‐Soto, M., Kumari, V., Pažur, K., Illerhaus, A., Hartmann, K., Worm, M., & Babina, M. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.01.029 · Cited by 36 · see citing works

Mas-related G protein-coupled receptor MRGPRX2 in human basophils: Expression and functional studies

Toscano, A., Elst, J., Gasse, A. L. V., Beyens, M. M. J., van der Poorten, M. M., Bridts, C. H., Mertens, C. H., Houdt, M. V., Hagendorens, M. M., Remoortel, S. V., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1026304 · Cited by 35 · see citing works

Orphan G protein-coupled receptors: the ongoing search for a home

Jobe, A., & Vijayan, R. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1349097 · Cited by 35 · see citing works

Allergenic and Mas-Related G Protein-Coupled Receptor X2-Activating Properties of Drugs: Resolving the Two

Sabato, V., Ebo, D. G., van der Poorten, M. M., Toscano, A., Gasse, A. L. V., Mertens, C. H., Houdt, M. V., Beyens, M. M. J., & Elst, J. (2022) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2022.12.014 · Cited by 35 · see citing works

Screening the anti‐allergic components in Saposhnikoviae Radix using high‐expression Mas‐related G protein‐coupled receptor X2 cell membrane chromatography online coupled with liquid chromatography and mass spectrometry

Jia, Q., Sun, W., Zhang, L., Fu, J., Lv, Y., Lin, Y., & Han, S. (2019) · Journal of Separation Science · doi:10.1002/jssc.201900114 · Cited by 34 · see citing works

Anti-Allergic Effects of Quercetin and Quercetin Liposomes in RBL-2H3 Cells

Zhang, Y., Guan, R., & Huang, H. (2022) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530322666220627151830 · Cited by 33 · see citing works

Non–IgE-Mediated Immediate Drug-Induced Hypersensitivity Reactions

Arango, S. A., Kumar, M., Chow, T. G., & Sabato, V. (2024) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2024.02.019 · Cited by 33 · see citing works

An African-specific haplotype in MRGPRX4 is associated with menthol cigarette smoking

Kozlitina, J., Risso, D. S., Lansu, K., Olsen, R. H. J., Sainz, E., Luiselli, D., Barik, A., Domingues, C. E. F., Pagani, L., Wooding, S., et al. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1007916 · Cited by 33 · see citing works

Proadrenomedullin N‑Terminal 20 Peptides (PAMPs) Are Agonists of the Chemokine Scavenger Receptor ACKR3/CXCR7

Meyrath, M., Palmer, C. B., Reynders, N., Vanderplasschen, A. F. C., Ollert, M. W., Bouvier, M., Szpakowska, M., & Chevigné, A. (2021) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.1c00006 · Cited by 34 · see citing works

Atypical opioid receptors: unconventional biology and therapeutic opportunities

Palmer, C. B., Meyrath, M., Canals, M., Kostenis, E., Chevigné, A., & Szpakowska, M. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108014 · Cited by 33 · see citing works

Itch induced by peripheral mu opioid receptors is dependent on TRPV1-expressing neurons and alleviated by channel activation

Melo, H., Basso, L., Iftinca, M., MacNaughton, W. K., Hollenberg, M. D., McKay, D. M., & Altier, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-33620-7 · Cited by 32 · see citing works

Novel probe for MRGPRX2

Sarah, C. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.77 · Cited by 2 · see citing works

LIGAND DISCOVERY AND FUNCTIONAL CHARACTERIZATION OF MRGPRX FAMILY ORPHAN GPCRS

Lansu, K. (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/p9r4-re19

Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands

Iio, K., Kutsumura, N., Nagumo, Y., Saitoh, T., Tokuda, A., Hashimoto, K., Yamamoto, N., Kise, R., Inoue, A., Mizoguchi, H., et al. (2021) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2021.128485 · Cited by 7 · see citing works

Computational Studies of Mitragynine Analogue Binding at the Human Mu-Opioid Receptor

Fanning, J. (2020) · The Knowledge Bank (The Ohio State University)

MAS-related G protein-coupled receptors X (MRGPRX): Orphan GPCRs with potential as targets for future drugs

Hamwi, G. A., Riedel, Y. K., Clemens, S., Namasivayam, V., Thimm, D., & Müller, C. E. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108259 · Cited by 66 · see citing works