Cited by 285Computational Drug Discovery MethodsBioinformatics and Genomic NetworksBiomedical Text Mining and Ontologies

The Druggable Genome: Evaluation of Drug Targets in Clinical Trials Suggests Major Shifts in Molecular Class and Indication

Rask-Andersen, Mathias, Masuram, Surendar, Schiöth, Helgi B.·2014·Annual Review of Pharmacology and Toxicology

Abstract

The largest innovations within pharmaceutical development come through new compounds that have unique and novel modes of action. These innovations commonly involve expanding the protein space targeted by pharmaceutical agents. At present, information about drugs and drug targets is available online via public databases such as DrugBank and the Therapeutic Targets Database. However, this information is biased, understandably so, toward established drugs and drug-target interactions. To gain a better overview of the drug-targeted portion of the human proteome and the directions of current drug development, we developed a data set of clinical trial drug-target interactions based on CenterWatch's Drugs in Clinical Trials Database, one of the largest databases of its kind. Our curation identified 475 potentially novel clinical trial drug targets. This review aims to identify trends in drug development based on the potentially novel targets currently being explored in clinical trials.

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Crossref · 10.1146/annurev-pharmtox-011613-135943

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35 of 35 references verified0 citation errors · 0 not checkable

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  • Small molecule drugs target only 2-5% of the human genome, so alternative therapies are necessary.

    “Although the research of small molecule drug delivery has established a solid foundation, the target of small molecule drugs accounts for only 2–5% of the human genome, so the development of other alternative therapies is necessary.293”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [293]

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Authors
Rask-Andersen, M., Masuram, S., & Schiöth, H. B.
Affiliations
  • Department of Neuroscience and Uppsala Biomedical Center, Uppsala University, 75124 Uppsala, Sweden;
  • Uppsala Monitoring Centre (SE)
  • Uppsala University (SE)
Venue
Annual Review of Pharmacology and Toxicology
Published
2014-01-06
Volume
54
Issue
1
Pages
9-26
ISSN
  • 0362-1642 (ISSN-L)
  • 1545-4304
OpenAlex
W2147241078
Cited by
282
References
35
Citations by year
2026: 6 · 2025: 14 · 2024: 12 · 2023: 23 · 2022: 23 · 2021: 25 · 2020: 25 · 2019: 22 · 2018: 22 · 2017: 34 · 2016: 34 · 2015: 27 · 2014: 13 · 2013: 2
FWCI
2.37
Type
journal article
Language
en
Open access
closed
Locations
  • The Annual Review of Pharmacology and Toxicology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Vetenskapsrådet
Topics
  • Physical Sciences › Computer Science › Computational Theory and Mathematics › Computational Drug Discovery Methods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biomedical Text Mining and Ontologies
Keywords
druggable genome, therapeutic target, new drug development, human proteome, treatment indications, drug development trends, DrugBank
MeSH terms
Alzheimer Disease, Anti-Inflammatory Agents, Antineoplastic Agents, Appetite Regulation, Clinical Trials as Topic, Evaluation Studies as Topic, Humans, Hypoglycemic Agents, Genome, Human, Databases, Factual, Proteome, G-Protein-Coupled Receptor Kinases, Molecular Targeted Therapy

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