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Rocuronium Hypersensitivity: Does Off-Target Occupation of the MRGPRX2 Receptor Play a Role?

Gasse, A. L. V., Elst, J., Bridts, C. H., Mertens, C. H., Faber, M. A., Hagendorens, M. M., Clerck, L. S. D., Sabato, V., & Ebo, D. G. (2018) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2018.09.034 · Cited by 45

Thymic Stromal Lymphopoietin Promotes MRGPRX2-Triggered Degranulation of Skin Mast Cells in a STAT5-Dependent Manner with Further Support from JNK

Babina, M., Wang, Z., Franke, K., & Zuberbier, T. (2021) · Cells · doi:10.3390/cells10010102 · Cited by 45

MRGPRX2 Activation by Rocuronium: Insights from Studies with Human Skin Mast Cells and Missense Variants

Ayudhya, C. C. N., Amponnawarat, A., Roy, S., Oskeritzian, C. A., & Ali, H. (2021) · Cells · doi:10.3390/cells10010156 · Cited by 44

A novel MRGPRX2-targeting antagonistic DNA aptamer inhibits histamine release and prevents mast cell-mediated anaphylaxis

Suzuki, Y., Liu, S., Ogasawara, T., Sawasaki, T., Takasaki, Y., Yorozuya, T., & Mogi, M. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173104 · Cited by 43

MRGPRX2, drug pseudoallergies, inflammatory diseases, mechanisms and distinguishing MRGPRX2‐ and IgE/FcεRI‐mediated events

Baldo, B. A. (2023) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.15845 · Cited by 42

Inhibitory function of Shikonin on MRGPRX2-mediated pseudo-allergic reactions induced by the secretagogue

Wang, J., Zhang, Y., Li, C., Ding, Y., Hu, S., & An, H. (2019) · Phytomedicine · doi:10.1016/j.phymed.2019.153149 · Cited by 41

Paeoniflorin inhibits MRGPRX2‐mediated pseudo‐allergic reaction via calcium signaling pathway

Wang, J., Zhang, Y., Wang, J., Liu, R., Zhang, G., Dong, K., & Zhang, T. (2019) · Phytotherapy Research · doi:10.1002/ptr.6531 · Cited by 40

The pseudo-allergic/neurogenic route of mast cell activation via MRGPRX2: discovery, functional programs, regulation, relevance to disease, and relation with allergic stimulation

Babina, M. (2020) · Itch · doi:10.1097/itx.0000000000000032 · Cited by 40

A humanized mouse model to study mast cells mediated cutaneous adverse drug reactions

Mencarelli, A., Gunawan, M., Yong, K. S. M., Bist, P., Tan, W. W. S., Tan, S. Y., Liu, M., Huang, E. K., Fan, Y., Chan, J. K. Y., et al. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ma1219-210rr · Cited by 39

Human Mast Cell Line HMC1 Expresses Functional Mas-Related G-Protein Coupled Receptor 2

Hermans, M. A. W., van Stigt, A. C., van de Meerendonk, S., Schrijver, B., van Daele, P. L. A., van Hagen, P. M., van Splunter, M. E., & Dik, W. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.625284 · Cited by 36

Lactic acid suppresses MRGPRX2 mediated mast cell responses

Syed, M., Kammala, A. K., Callahan, B. N., Oskeritzian, C. A., & Subramanian, H. (2021) · Cellular Immunology · doi:10.1016/j.cellimm.2021.104422 · Cited by 36

Mast cells instruct keratinocytes to produce thymic stromal lymphopoietin: Relevance of the tryptase/protease-activated receptor 2 axis

Redhu, D., Franke, K., Aparicio‐Soto, M., Kumari, V., Pažur, K., Illerhaus, A., Hartmann, K., Worm, M., & Babina, M. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.01.029 · Cited by 36

Mas-related G protein-coupled receptor MRGPRX2 in human basophils: Expression and functional studies

Toscano, A., Elst, J., Gasse, A. L. V., Beyens, M. M. J., van der Poorten, M. M., Bridts, C. H., Mertens, C. H., Houdt, M. V., Hagendorens, M. M., Remoortel, S. V., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1026304 · Cited by 37

Orphan G protein-coupled receptors: the ongoing search for a home

Jobe, A., & Vijayan, R. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1349097 · Cited by 40

Allergenic and Mas-Related G Protein-Coupled Receptor X2-Activating Properties of Drugs: Resolving the Two

Sabato, V., Ebo, D. G., van der Poorten, M. M., Toscano, A., Gasse, A. L. V., Mertens, C. H., Houdt, M. V., Beyens, M. M. J., & Elst, J. (2022) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2022.12.014 · Cited by 35

Screening the anti‐allergic components in Saposhnikoviae Radix using high‐expression Mas‐related G protein‐coupled receptor X2 cell membrane chromatography online coupled with liquid chromatography and mass spectrometry

Jia, Q., Sun, W., Zhang, L., Fu, J., Lv, Y., Lin, Y., & Han, S. (2019) · Journal of Separation Science · doi:10.1002/jssc.201900114 · Cited by 34

Anti-Allergic Effects of Quercetin and Quercetin Liposomes in RBL-2H3 Cells

Zhang, Y., Guan, R., & Huang, H. (2022) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530322666220627151830 · Cited by 33

Non–IgE-Mediated Immediate Drug-Induced Hypersensitivity Reactions

Arango, S. A., Kumar, M., Chow, T. G., & Sabato, V. (2024) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2024.02.019 · Cited by 33

An African-specific haplotype in MRGPRX4 is associated with menthol cigarette smoking

Kozlitina, J., Risso, D. S., Lansu, K., Olsen, R. H. J., Sainz, E., Luiselli, D., Barik, A., Domingues, C. E. F., Pagani, L., Wooding, S., et al. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1007916 · Cited by 33

Proadrenomedullin N‑Terminal 20 Peptides (PAMPs) Are Agonists of the Chemokine Scavenger Receptor ACKR3/CXCR7

Meyrath, M., Palmer, C. B., Reynders, N., Vanderplasschen, A. F. C., Ollert, M. W., Bouvier, M., Szpakowska, M., & Chevigné, A. (2021) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.1c00006 · Cited by 34

Atypical opioid receptors: unconventional biology and therapeutic opportunities

Palmer, C. B., Meyrath, M., Canals, M., Kostenis, E., Chevigné, A., & Szpakowska, M. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108014 · Cited by 34

Itch induced by peripheral mu opioid receptors is dependent on TRPV1-expressing neurons and alleviated by channel activation

Melo, H., Basso, L., Iftinca, M., MacNaughton, W. K., Hollenberg, M. D., McKay, D. M., & Altier, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-33620-7 · Cited by 34

Novel probe for MRGPRX2

Sarah, C. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.77 · Cited by 2

LIGAND DISCOVERY AND FUNCTIONAL CHARACTERIZATION OF MRGPRX FAMILY ORPHAN GPCRS

Lansu, K. (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/p9r4-re19

Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands

Iio, K., Kutsumura, N., Nagumo, Y., Saitoh, T., Tokuda, A., Hashimoto, K., Yamamoto, N., Kise, R., Inoue, A., Mizoguchi, H., et al. (2021) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2021.128485 · Cited by 7

Computational Studies of Mitragynine Analogue Binding at the Human Mu-Opioid Receptor

Fanning, J. (2020) · The Knowledge Bank (The Ohio State University)

MAS-related G protein-coupled receptors X (MRGPRX): Orphan GPCRs with potential as targets for future drugs

Hamwi, G. A., Riedel, Y. K., Clemens, S., Namasivayam, V., Thimm, D., & Müller, C. E. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108259 · Cited by 66