Identification of lysine succinylation as a new post-translational modification

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  2. Chromatin Succinylation Correlates with Active Gene Expression and Is Perturbed by Defective TCA Cycle Metabolism
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  3. DPF2 reads histone lactylation to drive transcription and tumorigenesis
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  6. Common errors in mass spectrometry‐based analysis of post‐translational modifications
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  7. The Diversity of Histone Versus Nonhistone Sirtuin Substrates
    Paloma Martínez‐Redondo, Alejandro Vaquero · 2013 · Genes & Cancer
  8. CPT 1A‐mediated succinylation of S100A10 increases human gastric cancer invasion
    Chao Wang, Chen Zhang, Xiang Li, Jiajia Shen, Yue Xu, Hui Min Shi, Xianmin Mu, Jinshun Pan, Ting Zhao, Mengjing Li et al. · 2018 · Journal of Cellular and Molecular Medicine
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  10. Succinylome Analysis Reveals the Involvement of Lysine Succinylation in Metabolism in Pathogenic Mycobacterium tuberculosis*
    Mingkun Yang, Yan Wang, Ying Chen, Zhongyi Cheng, Jing Gu, Jiaoyu Deng, Lijun Bi, Chuangbin Chen, Ran Mo, Xude Wang et al. · 2015 · Molecular & Cellular Proteomics
  11. Alpha‐ketoglutarate dehydrogenase complex‐dependent succinylation of proteins in neurons and neuronal cell lines
    Gibson, Gary E., Xu, Hui, Chen, Huan‐Lian, Chen, Wei, Denton, Travis T., Zhang, Sheng · 2015 · Journal of Neurochemistry
  12. Lysine Malonylation Is Elevated in Type 2 Diabetic Mouse Models and Enriched in Metabolic Associated Proteins
    Yipeng Du, Tanxi Cai, Tingting Li, Peng Xue, Bo Zhou, Xiaolong He, Wei Peng, Pingsheng Liu, Fuquan Yang, Taotao Wei · 2014 · Molecular & Cellular Proteomics
  13. Large-scale comparative assessment of computational predictors for lysine post-translational modification sites
    Zhen Chen, Xuhan Liu, Fuyi Li, Chen Li, Tatiana T. Marquez‐Lago, André Leier, Tatsuya Akutsu, Geoffrey I. Webb, Dakang Xu, A. Ian Smith et al. · 2018 · Briefings in Bioinformatics
  14. Enzymatic and metabolic regulation of lysine succinylation
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  15. The roles of histone modifications in tumorigenesis and associated inhibitors in cancer therapy
    Yunkai Yang, Min Zhang, Yan Wang · 2022 · Journal of the National Cancer Center
  16. GABA regulates IL-1β production in macrophages
    Jian Fu, Ziyi Han, Zebiao Wu, Yaoyao Xia, Guan Yang, Yulong Yin, Wenkai Ren · 2022 · Cell Reports
  17. Lysine-222 succinylation reduces lysosomal degradation of lactate dehydrogenase a and is increased in gastric cancer
    Xiang Li, Chen Zhang, Ting Zhao, Zhongping Su, Mengjing Li, Jiancheng Hu, Jianfei Wen, Jiajia Shen, Chao Wang, Jinshun Pan et al. · 2020 · Journal of Experimental & Clinical Cancer Research
  18. Distinct Patterns of Sirtuin Expression During Progression of Alzheimer’s Disease
    Mirjam I. Lutz, Ivan Milenković, Günther Regelsberger, Gábor Géza Kovács · 2014 · NeuroMolecular Medicine
  19. Astrocyte-derived lactate aggravates brain injury of ischemic stroke in mice by promoting the formation of protein lactylation
    Xiao‐Yi Xiong, Xinru Pan, Xia-Xia Luo, Yu-Fei Wang, Xin‐Xiao Zhang, Su-Hao Yang, Zhanqiong Zhong, Chang Liu, Qiong Chen, Peng-Fei Wang et al. · 2024 · Theranostics
  20. Changes in the Acetylome and Succinylome of Bacillus subtilis in Response to Carbon Source
    Saori Kosono, Masaru Tamura, Shota Suzuki, Yumi Kawamura, Ayako Yoshida, Makoto Nishiyama, Minoru Yoshida · 2015 · PLoS ONE
  21. First Succinyl-Proteome Profiling of Extensively Drug-Resistant Mycobacterium tuberculosis Revealed Involvement of Succinylation in Cellular Physiology
    Xie, Longxiang, Liu, Wei, Li, Qiming, Chen, Shudan, Xu, Mengmeng, Huang, Qinqin, Zeng, Jie, Zhou, Mingliang, Xie, Jianping · 2015 · Journal of Proteome Research
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  23. Histone and non-histone lactylation: molecular mechanisms, biological functions, diseases, and therapeutic targets
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  24. Oxidative stress‐triggered interactions between the succinyl‐ and acetyl‐proteomes of rice leaves
    Heng Zhou, Iris Finkemeier, Wenxue Guan, Maria‐Armineh Tossounian, Bo Wei, David Young, Jingjing Huang, Joris Messens, Xibin Yang, Jun Zhu et al. · 2017 · Plant Cell & Environment
  25. Global Proteome Analyses of Lysine Acetylation and Succinylation Reveal the Widespread Involvement of both Modification in Metabolism in the Embryo of Germinating Rice Seed
    He, Dongli, Wang, Qiong, Li, Ming, Damaris, Rebecca Njeri, Yi, Xingling, Cheng, Zhongyi, Yang, Pingfang · 2016 · Journal of Proteome Research
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    Yue Liu, Chao Chen, Xinye Wang, Yihong Sun, Jin Zhang, Juxiang Chen, Yufeng Shi · 2022 · Cells
  27. Profiling of Substrates for Zinc‐dependent Lysine Deacylase Enzymes: HDAC3 Exhibits Decrotonylase Activity In Vitro
    Madsen, Andreas S., Olsen, Christian A. · 2012 · Angewandte Chemie International Edition
  28. The dawn of succinylation: a posttranslational modification
    Matthew D. Alleyn, Mason Breitzig, Richard F. Lockey, Narasaiah Kolliputi · 2017 · American Journal of Physiology-Cell Physiology
  29. Why always lysine? The ongoing tale of one of the most modified amino acids
    Cristina Azevedo, Adolfo Saiardi · 2015 · Advances in Biological Regulation
  30. Genetic alterations in Krebs cycle and its impact on cancer pathogenesis
    Karishma Sajnani, Farhadul Islam, Robert Anthony Smith, Vinod Gopalan, Alfred King-yin Lam · 2017 · Biochimie
  31. Protein acetylation in prokaryotes
    Joshua D. Jones, C. David O’Connor · 2011 · PROTEOMICS
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    Wiggert J. Altenburg, N. Amy Yewdall, Daan F. M. Vervoort, Marleen H. M. E. van Stevendaal, Alexander F. Mason, Jan C. M. van Hest · 2020 · Nature Communications
  33. Interplay Among Metabolism, Epigenetic Modifications, and Gene Expression in Cancer
    Miaomiao Huo, Jingyao Zhang, Wei Huang, Yan Wang · 2021 · Frontiers in Cell and Developmental Biology
  34. SuccinSite: a computational tool for the prediction of protein succinylation sites by exploiting the amino acid patterns and properties
    Md Mehedi Hasan, Shiping Yang, Yuan Zhou, Md. Nurul Haque Mollah · 2015 · Molecular BioSystems
  35. Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH
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  36. Succinate in the cancer–immune cycle
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  37. Lysine lactylation in the regulation of tumor biology
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  38. Alterations in PD-L1 succinylation shape anti-tumor immune responses in melanoma
    Long Liang, Xinwei Kuang, Yi He, Lin Zhu, Poyee Lau, Xin Li, Dingan Luo, Lan Gong, Wenbin Zhou, Fanglin Zhang et al. · 2025 · Nature Genetics
  39. KAT2A succinyltransferase activity-mediated 14-3-3ζ upregulation promotes β-catenin stabilization-dependent glycolysis and proliferation of pancreatic carcinoma cells
    Yingying Tong, Dong Sheng Guo, Yan Dong, Chunmin Ma, Fei Shao, Yugang Wang, Shudi Luo, Liming Lin, Jingjing Tao, Yuhui Jiang et al. · 2019 · Cancer Letters
  40. SIRT5-mediated SDHA desuccinylation promotes clear cell renal cell carcinoma tumorigenesis
    Yuanzhen Ma, Yijun Qi, Lei Wang, Zhaoxu Zheng, Yue Zhang, Junfang Zheng · 2019 · Free Radical Biology and Medicine
  41. Systematic Identification of the Lysine Succinylation in the Protozoan Parasite Toxoplasma gondii
    Xiaolong Li, Xin Hu, Yujing Wan, Guizhen Xie, Xiangzhi Li, Di Chen, Zhongyi Cheng, Xingling Yi, Shaohui Liang, Feng Tan · 2014 · Journal of Proteome Research
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  43. Sending Out an SOS: Mitochondria as a Signaling Hub
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  44. Global Analysis of Protein Lysine Succinylation Profiles and Their Overlap with Lysine Acetylation in the Marine Bacterium Vibrio parahemolyticus
    Jianyi Pan, Ran Chen, Chuchu Li, Weiyan Li, Zhicang Ye · 2015 · Journal of Proteome Research
  45. Comprehensive review of histone lactylation: Structure, function, and therapeutic targets
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  46. Old Enzymes, New Tricks: Sirtuins Are NAD+-Dependent De-acylases
    Matthew D. Hirschey · 2011 · Cell Metabolism
  47. Function and mechanism of histone β-hydroxybutyrylation in health and disease
    Tingting Zhou, Xi Cheng, Yanqiu He, Yumei Xie, Fangyuan Xu, Yong Xu, Wei Gang Huang · 2022 · Frontiers in Immunology
  48. 2-Hydroxyisobutyrylation on histone H4K8 is regulated by glucose homeostasis in Saccharomyces cerevisiae
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  49. Oncometabolites drive tumorigenesis by enhancing protein acylation: from chromosomal remodelling to nonhistone modification
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  50. Lysine succinylation, the metabolic bridge between cancer and immunity
    Rui Dong Shen, Hongyun Ruan, Shuye Lin, Bin Liu, Hang Song, Lu Li, Teng Ma · 2022 · Genes & Diseases
  51. Gcn5 and Esa1 function as histone crotonyltransferases to regulate crotonylation-dependent transcription
    Leonie Kollenstart, Anton J.L. de Groot, George M. C. Janssen, Xue Cheng, Kees Vreeken, Fabrizio Martino, Jacques Côté, Peter A. van Veelen, Haico van Attikum · 2019 · Journal of Biological Chemistry
  52. First comprehensive proteome analysis of lysine crotonylation in seedling leaves of Nicotiana tabacum
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  53. Post-translational modifications and their implications in cancer
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  54. OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB
    Wenhao Ma, Yuchen Sun, Ronghui Yan, Pinggen Zhang, Shengqi Shen, Hui Juan Lu, Zilong Zhou, Zetan Jiang, Ling Ye, Qiankun Mao et al. · 2024 · Molecular Cell
  55. Succinylation of H3K122 destabilizes nucleosomes and enhances transcription
    Zorro Shahidian, Lara, Haas, Mariska, Le Gras, Stephanie, Nitsch, Sandra, Mourão, André, Geerlof, Arie, Margueron, Raphael, Michaelis, Jens, Daujat, Sylvain, Schneider, Robert · 2021 · The EMBO Reports
  56. SUCLG2 Regulates Mitochondrial Dysfunction through Succinylation in Lung Adenocarcinoma
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  57. Biochemistry and regulation of histone lysine l-lactylation
    Xinlei Sheng, Hening Lin, Philip A. Cole, Yingming Zhao · 2025 · Nature Reviews Molecular Cell Biology
  58. iSuc-PseAAC: predicting lysine succinylation in proteins by incorporating peptide position-specific propensity
    Yan Xu, Ya-Xin Ding, Jun Ding, Ya-Hui Lei, Ling‐Yun Wu, Nai-Yang Deng · 2015 · Scientific Reports
  59. HBO1 is a versatile histone acyltransferase critical for promoter histone acylations
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  60. The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5)
    Yeyun Zhou, Hongmin Zhang, Bin He, Jintang Du, Hening Lin, Richard A. Cerione, Quan Hao · 2012 · Journal of Biological Chemistry
  61. Oncometabolites: A New Paradigm for Oncology, Metabolism, and the Clinical Laboratory
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  62. Lysine Succinylation and Acetylation in Pseudomonas aeruginosa
    Charlotte Gaviard, Isabelle Broutin, Pascal Cosette, Emmanuelle Dé, Thierry Jouenne, Julie Hardouin · 2018 · Journal of Proteome Research
  63. Prediction of bio-sequence modifications and the associations with diseases
    Chunyan Ao, Liang Yu, Quan Zou · 2020 · Briefings in Functional Genomics
  64. Recurrent De Novo Mutations Affecting Residue Arg138 of Pyrroline-5-Carboxylate Synthase Cause a Progeroid Form of Autosomal-Dominant Cutis Laxa
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  65. Synthesis of ε-N-propionyl-, ε-N-butyryl-, and ε-N-crotonyl-lysine containing histone H3 using the pyrrolysine system
    Michael J. Gattner, Milan Vrábel, Thomas Carell · 2012 · Chemical Communications
  66. Global Involvement of Lysine Crotonylation in Protein Modification and Transcription Regulation in Rice
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  67. Impact of Post-Translational Modifications of Crop Proteins under Abiotic Stress
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  68. Histone succinylation and its function on the nucleosome
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  69. Global-scale profiling of differential expressed lysine-lactylated proteins in the cerebral endothelium of cerebral ischemia-reperfusion injury rats
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  74. Multiple faces of succinate beyond metabolism in blood
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  75. On Acetyl-CoA as a Gauge of Cellular Metabolic State
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  76. First Comprehensive Proteome Analyses of Lysine Acetylation and Succinylation in Seedling Leaves of Brachypodium distachyon L.
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  77. Expansion of the Lysine Acylation Landscape
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  82. Proteome-Wide Identification of Lysine Succinylation in the Proteins of Tomato (Solanum lycopersicum)
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