Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians

The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools

Thompson, J. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.24.4876 · Cited by 38,685

Natural products as sources of new drugs over the period 1981–2002

Newman, D. J., Cragg, G. M., & Snader, K. M. (2003) · Journal of Natural Products · doi:10.1021/np030096l · Cited by 3,082

BIOLOGY OF BACTERIOCYTE-ASSOCIATED ENDOSYMBIONTS OF PLANT SAP-SUCKING INSECTS

Baumann, P. (2005) · Annual Review of Microbiology · doi:10.1146/annurev.micro.59.030804.121041 · Cited by 1,060

Ubiquitin-mediated proteolysis: biological regulation via destruction

Ciechanover, A. J., Orian, A., & Schwartz, A. L. (2000) · BioEssays · doi:10.1002/(sici)1521-1878(200005)22:5 · Cited by 848

Pathogenic fungus harbours endosymbiotic bacteria for toxin production

Partida‐Martínez, L. P., & Hertweck, C. (2005) · Nature · doi:10.1038/nature03997 · Cited by 702

A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles

Piel, J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222481399 · Cited by 609

Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni , the cyanobacterial symbiont of Lissoclinum patella

Schmidt, E. W., Nelson, J. T., Rasko, D. A., Sudek, S., Eisen, J. A., Haygood, M. G., & Ravel, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501424102 · Cited by 567

Reconstructing immune phylogeny: new perspectives

Litman, G. W., Cannon, J. P., & Dishaw, L. J. (2005) · Nature reviews. Immunology · doi:10.1038/nri1712 · Cited by 352

Molecular genetics of ecological diversification: Duplication and rapid evolution of toxin genes of the venomous gastropod Conus

Duda, T. F., & Palumbi, S. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6820 · Cited by 335

Identification of the antifungal peptide-containing symbiont of the marine sponge Theonella swinhoei as a novel δ-proteobacterium, " Candidatus Entotheonella palauensis"

Schmidt, E. W., Obraztsova, A., Davidson, S. K., Faulkner, D. J., & Haygood, M. G. (2000) · Marine Biology · doi:10.1007/s002270000273 · Cited by 264

An Aldol Switch Discovered in Stilbene Synthases Mediates Cyclization Specificity of Type III Polyketide Synthases

Austin, M. B., Bowman, M. E., Ferrer, J.-L., Schröder, J., & Noel, J. P. (2004) · Chemistry & Biology · doi:10.1016/j.chembiol.2004.05.024 · Cited by 253

Lacticin 481: In Vitro Reconstitution of Lantibiotic Synthetase Activity

Xie, L., Miller, L. M., Chatterjee, C., Averin, O., Kelleher, N. L., & van der Donk, W. A. (2004) · Science · doi:10.1126/science.1092600 · Cited by 244

Chlorophyll b and phycobilins in the common ancestor of cyanobacteria and chloroplasts

Tomitani, A., Okada, K., Miyashita, H., Matthijs, H. C. P., Ohno, T., & Tanaka, A. (1999) · Nature · doi:10.1038/22101 · Cited by 220

Microbial diversity of extant stromatolites in the hypersaline marine environment of Shark Bay, Australia

Burns, B. P., Goh, F. Q. Y., Allen, M. A., & Neilan, B. A. (2004) · Environmental Microbiology · doi:10.1111/j.1462-2920.2004.00651.x · Cited by 218

Prochlorophyta as a proposed new division of algae

Lewin, R. A. (1976) · Nature · doi:10.1038/261697b0 · Cited by 199

Antineoplastic cyclic peptides from the marine tunicate Lissoclinum patella

Ireland, C. M., Durso, A. R., Newman, R. A., & Hacker, M. P. (1982) · The Journal of Organic Chemistry · doi:10.1021/jo00349a002 · Cited by 177

Shotgun Cloning and Heterologous Expression of the Patellamide Gene Cluster as a Strategy to Achieving Sustained Metabolite Production

Long, P. F., Dunlap, W. C., Battershill, C. N., & Jaspars, M. (2005) · ChemBioChem · doi:10.1002/cbic.200500210 · Cited by 176

Evolution of Nitrate Reductase: Molecular and Structural Variations on a Common Function

Stolz, J. F., & Basu, P. (2002) · ChemBioChem · doi:10.1002/1439-7633(20020301)3:2/3 · Cited by 171

Venomous cone snails: molecular phylogeny and the generation of toxin diversity

Espiritu, D. J. D., Watkins, M., Monje, V. D., Cartier, G. E., Cruz, L. J., & Olivera, B. M. (2001) · Toxicon · doi:10.1016/s0041-0101(01)00175-1 · Cited by 156

New cyclic peptides with cytotoxic activity from the ascidian Lissoclinum patella

Degnan, B. M., Hawkins, C. J., Lavin, M. F., McCaffrey, E. J., Parry, D. L., van den Brenk, A. L., & Watters, D. J. (1989) · Journal of Medicinal Chemistry · doi:10.1021/jm00126a034 · Cited by 150

Combinatorial biosynthesis—Potential and problems

Floss, H. G. (2006) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2005.12.001 · Cited by 148

Molecular cloning and functional expression of triterpene synthases from pea (Pisum sativum)

Morita, M., Shibuya, M., Kushiro, T., Masuda, K., & Ebizuka, Y. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01357.x · Cited by 143

Development of eptifibatide

Scarborough, R. M. (1999) · American Heart Journal · doi:10.1016/s0002-8703(99)70075-x · Cited by 143

Extraordinary pigment composition of a prokaryotic alga

Lewin, R. A., & Withers, N. W. (1975) · Nature · doi:10.1038/256735a0 · Cited by 138

The frequency and rate of pilin antigenic variation in Neisseria gonorrhoeae

Criss, A. K., Kline, K. A., & Seifert, H. S. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04838.x · Cited by 129

Structure of Trichamide, a Cyclic Peptide from the Bloom-Forming Cyanobacterium Trichodesmium erythraeum , Predicted from the Genome Sequence

Sudek, S., Haygood, M. G., Youssef, D. T. A., & Schmidt, E. W. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.00380-06 · Cited by 128

Relationship between DNA cycle and growth rate in Synechococcus sp. strain PCC 6301

Binder, B. J., & Chisholm, S. W. (1990) · Journal of Bacteriology · doi:10.1128/jb.172.5.2313-2319.1990 · Cited by 108

A marine natural product, patellamide D, reverses multidrug resistance in a human leukemic cell line

Williams, A. B., & Jacobs, R. S. (1993) · Cancer Letters · doi:10.1016/0304-3835(93)90103-g · Cited by 98

Prochloron: A Microbial Enigma

(1989) · Springer eBooks · doi:10.1007/978-1-4613-0853-9 · Cited by 98

New Cyclic Peptides from the AscidianLissoclinumpatella

Fu, X., Do, T., Schmitz, F. J., Andrusevich, V. E., & Engel, M. H. (1998) · Journal of Natural Products · doi:10.1021/np9802872 · Cited by 89

Genetic Evidence Supports Secondary Metabolic Diversity in Prochloron spp., the Cyanobacterial Symbiont of a Tropical Ascidian

Schmidt, E. W., Sudek, S., & Haygood, M. G. (2004) · Journal of Natural Products · doi:10.1021/np049948n · Cited by 65

Multiple origins of the ascidian-Prochloron symbiosis: Molecular phylogeny of photosymbiotic and non-symbiotic colonial ascidians inferred from 18S rDNA sequences

Yokobori, S., Kurabayashi, A., Neilan, B. A., Maruyama, T., & Hirose, E. (2006) · Molecular Phylogenetics and Evolution · doi:10.1016/j.ympev.2005.11.025 · Cited by 62

Compounds produced from potential tunicate-blue-green algal symbiosis: A review

Sings, H. L., & RINEHART, K. L. J. (1996) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/bf01574769 · Cited by 62

Localization Studies of Bioactive Cyclic Peptides in the Ascidian Lissoclinum patella

Salomon, C. E., & Faulkner, D. J. (2002) · Journal of Natural Products · doi:10.1021/np010556f · Cited by 58

The Chemistry of Lissoclinum Patella

Sesin, D. F., Gaskell, S. J., & Ireland, C. M. (1986) · Bulletin des Sociétés Chimiques Belges · doi:10.1002/bscb.19860950911 · Cited by 41

Pigment composition, photosynthesis and fine structure of a non-blue-green prokaryotic algal symbiont (Prochloron sp.) in a didemnid ascidian from Hawaiian waters

Withers, N. W., Vidaver, W. E., & Lewin, R. A. (1978) · Phycologia · doi:10.2216/i0031-8884-17-2-167.1 · Cited by 35

Polyazamacrolides from ladybird beetles: Ring-size selective oligomerization

Schroeder, F. C., Smedley, S. R., Gibbons, L. K., Farmer, J. J., Attygalle, A. B., Eisner, T., & Meinwald, J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13387 · Cited by 20

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

Arnison, P. G., Bibb, M. J., Bierbaum, G., Bowers, A. A., Bugni, T. S., Bulaj, G. W., Camarero, J. A., Campopiano, D. J., Challis, G. L., Clardy, J., et al. (2012) · Natural Product Reports · doi:10.1039/c2np20085f · Cited by 2,113

Adding New Chemistries to the Genetic Code

Liu, C. C., & Schultz, P. G. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.105824 · Cited by 1,725

Sponge-Associated Microorganisms: Evolution, Ecology, and Biotechnological Potential

Taylor, M. W., Radax, R., Steger, D., & Wagner, M. (2007) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00040-06 · Cited by 1,493

Biosynthesis and Mode of Action of Lantibiotics

Chatterjee, C., Paul, M., Xie, L., & van der Donk, W. A. (2005) · Chemical Reviews · doi:10.1021/cr030105v · Cited by 740

The evolution of genome mining in microbes – a review

Ziemert, N., Alanjary, M. M., & Weber, T. (2016) · Natural Product Reports · doi:10.1039/c6np00025h · Cited by 726

Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni , the cyanobacterial symbiont of Lissoclinum patella

Schmidt, E. W., Nelson, J. T., Rasko, D. A., Sudek, S., Eisen, J. A., Haygood, M. G., & Ravel, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501424102 · Cited by 567

Azole‐Based Cyclic Peptides from the Sea Squirt Lissoclinum Patella: Old Scaffolds, New Avenues

Houssen, W. E., & Jaspars, M. (2010) · ChemBioChem · doi:10.1002/cbic.201000230 · Cited by 49

Genetic Evidence Supports Secondary Metabolic Diversity in Prochloron spp., the Cyanobacterial Symbiont of a Tropical Ascidian

Schmidt, E. W., Sudek, S., & Haygood, M. G. (2004) · Journal of Natural Products · doi:10.1021/np049948n · Cited by 65

Possible Functional Roles of Patellamides in the Ascidian-Prochloron Symbiosis

Baur, P., Kühl, M., Comba, P., & Behrendt, L. (2022) · Marine Drugs · doi:10.3390/md20020119 · Cited by 17

Ascidian-associated photosymbionts from Manado, Indonesia: secondary metabolites, bioactivity simulation, and biosynthetic insight

Rumengan, I. F. M., Roring, V. I. Y., Haedar, J. R., Siby, M. S., Luntungan, A. H., Kolondam, B. J., Uria, A. R., & Wakimoto, T. (2021) · Symbiosis · doi:10.1007/s13199-021-00766-4 · Cited by 9