Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians

The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools

Thompson, J. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.24.4876 · Cited by 38,685

Natural products as sources of new drugs over the period 1981–2002

Newman, D. J., Cragg, G. M., & Snader, K. M. (2003) · Journal of Natural Products · doi:10.1021/np030096l · Cited by 3,082

BIOLOGY OF BACTERIOCYTE-ASSOCIATED ENDOSYMBIONTS OF PLANT SAP-SUCKING INSECTS

Baumann, P. (2005) · Annual Review of Microbiology · doi:10.1146/annurev.micro.59.030804.121041 · Cited by 1,060

Ubiquitin-mediated proteolysis: biological regulation via destruction

Ciechanover, A. J., Orian, A., & Schwartz, A. L. (2000) · BioEssays · doi:10.1002/(sici)1521-1878(200005)22:5 · Cited by 848

Pathogenic fungus harbours endosymbiotic bacteria for toxin production

Partida‐Martínez, L. P., & Hertweck, C. (2005) · Nature · doi:10.1038/nature03997 · Cited by 702

A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles

Piel, J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222481399 · Cited by 609

Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni , the cyanobacterial symbiont of Lissoclinum patella

Schmidt, E. W., Nelson, J. T., Rasko, D. A., Sudek, S., Eisen, J. A., Haygood, M. G., & Ravel, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501424102 · Cited by 567

Reconstructing immune phylogeny: new perspectives

Litman, G. W., Cannon, J. P., & Dishaw, L. J. (2005) · Nature reviews. Immunology · doi:10.1038/nri1712 · Cited by 352

Molecular genetics of ecological diversification: Duplication and rapid evolution of toxin genes of the venomous gastropod Conus

Duda, T. F., & Palumbi, S. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6820 · Cited by 335

Identification of the antifungal peptide-containing symbiont of the marine sponge Theonella swinhoei as a novel δ-proteobacterium, " Candidatus Entotheonella palauensis"

Schmidt, E. W., Obraztsova, A., Davidson, S. K., Faulkner, D. J., & Haygood, M. G. (2000) · Marine Biology · doi:10.1007/s002270000273 · Cited by 264

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

Arnison, P. G., Bibb, M. J., Bierbaum, G., Bowers, A. A., Bugni, T. S., Bulaj, G. W., Camarero, J. A., Campopiano, D. J., Challis, G. L., Clardy, J., et al. (2012) · Natural Product Reports · doi:10.1039/c2np20085f · Cited by 2,113

Adding New Chemistries to the Genetic Code

Liu, C. C., & Schultz, P. G. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.105824 · Cited by 1,725

Sponge-Associated Microorganisms: Evolution, Ecology, and Biotechnological Potential

Taylor, M. W., Radax, R., Steger, D., & Wagner, M. (2007) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00040-06 · Cited by 1,493

Biosynthesis and Mode of Action of Lantibiotics

Chatterjee, C., Paul, M., Xie, L., & van der Donk, W. A. (2005) · Chemical Reviews · doi:10.1021/cr030105v · Cited by 740

The evolution of genome mining in microbes – a review

Ziemert, N., Alanjary, M. M., & Weber, T. (2016) · Natural Product Reports · doi:10.1039/c6np00025h · Cited by 726

Metabolites from symbiotic bacteria

Piel, J. (2008) · Natural Product Reports · doi:10.1039/b703499g · Cited by 579

Marine Natural Products: A Source of Novel Anticancer Drugs

Khalifa, S. A. M., Elias, N., Farag, M. A., Chen, L., Saeed, A., Hegazy, M.-E. F., Moustafa, M. S., Abd El-Wahed, A., Al-Mousawi, S. M., Musharraf, S. G., et al. (2019) · Marine Drugs · doi:10.3390/md17090491 · Cited by 555

Bioactive natural products from marine cyanobacteria for drug discovery

Tan, L. T. (2007) · Phytochemistry · doi:10.1016/j.phytochem.2007.01.012 · Cited by 534

Marine chemical ecology

Paul, V. J., & Ritson‐Williams, R. (2008) · Natural Product Reports · doi:10.1039/b702742g · Cited by 519

Synthetic biology to access and expand nature's chemical diversity

Smanski, M. J., Zhou, H. L., Claesen, J., Shen, B., Fischbach, M. A., & Voigt, C. A. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2015.24 · Cited by 487

Biosynthesis of polyketides by trans-AT polyketide synthases

Helfrich, E. J. N., & Piel, J. (2015) · Natural Product Reports · doi:10.1039/c5np00125k · Cited by 490

Natural Products Version 2.0: Connecting Genes to Molecules

Walsh, C. T., & Fischbach, M. A. (2010) · Journal of the American Chemical Society · doi:10.1021/ja909118a · Cited by 468

Defensive symbioses of animals with prokaryotic and eukaryotic microorganisms

Flórez, L. V., Biedermann, P. H. W., Engl, T., & Kaltenpoth, M. (2015) · Natural Product Reports · doi:10.1039/c5np00010f · Cited by 422

Follow the leader: the use of leader peptides to guide natural product biosynthesis

Oman, T. J., & van der Donk, W. A. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.286 · Cited by 405

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

Nguyen, T., Ishida, K., Jenke‐Kodama, H., Dittmann, E., Gurgui, C., Hochmuth, T., Taudien, S., Platzer, M., Hertweck, C., & Piel, J. (2008) · Nature Biotechnology · doi:10.1038/nbt1379 · Cited by 389

Natural Product Biosynthetic Diversity and Comparative Genomics of the Cyanobacteria

Dittmann, E., Gugger, M. F., Sivonen, K., & Fewer, D. P. (2015) · Trends in Microbiology · doi:10.1016/j.tim.2015.07.008 · Cited by 326

The evolution of gene collectives: How natural selection drives chemical innovation

Fischbach, M. A., Walsh, C. T., & Clardy, J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709132105 · Cited by 309

A global assembly line for cyanobactins

Donia, M. S., Ravel, J., & Schmidt, E. W. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.84 · Cited by 279

Cyanobactins—ribosomal cyclic peptides produced by cyanobacteria

Sivonen, K., Leikoski, N., Fewer, D. P., & Jokela, J. (2010) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-010-2482-x · Cited by 275

Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria

Ли, Б., Sher, D., Kelly, L., Shi, Y., Huang, K. H., Knerr, P. J., Joewono, I., Rusch, D. B., Chisholm, S. W., & van der Donk, W. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913677107 · Cited by 272

Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds

McIntosh, J. A., Donia, M. S., & Schmidt, E. W. (2009) · Natural Product Reports · doi:10.1039/b714132g · Cited by 273

Natural products as a screening resource

Harvey, A. L. (2007) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2007.08.012 · Cited by 224

YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function

Burkhart, B. J., Schwalen, C. J., Mann, G., Naismith, J. H., & Mitchell, D. A. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00623 · Cited by 207

Venturamides A and B: Antimalarial Constituents of the Panamanian Marine Cyanobacterium Oscillatoria sp.

Linington, R. G., González, J., Ureña, L.-D., Romero, L. I., Ortega‐Barría, E., & Gerwick, W. H. (2007) · Journal of Natural Products · doi:10.1021/np0605790 · Cited by 195

Polyketide assembly lines of uncultivated sponge symbionts from structure-based gene targeting

Fisch, K. M., Gurgui, C., Heycke, N., van der Sar, S. A., Anderson, S. A., Webb, V. L., Taudien, S., Platzer, M., Rubio, B. K., Robinson, S. J., et al. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.176 · Cited by 193

Nature loves nitrogen heterocycles

Walsh, C. T. (2014) · Tetrahedron Letters · doi:10.1016/j.tetlet.2014.11.046 · Cited by 188

Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin

Brown, L. C. W., Acker, M. G., Clardy, J., Walsh, C. T., & Fischbach, M. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900008106 · Cited by 187

Bacterial Biosynthesis and Maturation of the Didemnin Anti-cancer Agents

Xu, Y., Kersten, R. D., Nam, S., Lu, L., Al-Suwailem, A. M., Zheng, H., Fenical, W., Dorrestein, P. C., Moore, B. S., & Qian, P. (2012) · Journal of the American Chemical Society · doi:10.1021/ja301735a · Cited by 185

Structural analysis of leader peptide binding enables leader-free cyanobactin processing

Koehnke, J., Mann, G., Bent, A. F., Ludewig, H., Shirran, S. L., Botting, C. H., Lébl, T., Houssen, W. E., Jaspars, M., & Naismith, J. H. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1841 · Cited by 184

Genome mining for ribosomally synthesized natural products

Velásquez, J. E., & van der Donk, W. A. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2010.10.027 · Cited by 182

Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications

Liao, R., Duan, L., Lei, C., Pan, H., Ding, Y., Zhang, Q., Chen, D., Shen, B., Yu, Y., & Liu, W. (2009) · Chemistry & Biology · doi:10.1016/j.chembiol.2009.01.007 · Cited by 181

Thiazole/oxazole-modified microcins: complex natural products from ribosomal templates

Melby, J. O., Nard, N. J., & Mitchell, D. A. (2011) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2011.02.027 · Cited by 180

Biological targets and mechanisms of action of natural products from marine cyanobacteria

Salvador‐Reyes, L. A., & Luesch, H. (2015) · Natural Product Reports · doi:10.1039/c4np00104d · Cited by 168

Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family

Haft, D. H., Basu, M. K., & Mitchell, D. A. (2010) · BMC Biology · doi:10.1186/1741-7007-8-70 · Cited by 167

New anticancer agents: recent developments in tumor therapy.

Ali, R., Mirza, Z., Ashraf, G. M., Kamal, M. A., Ansari, S. A., Damanhouri, G. A., Abuzenadah, A. M., Chaudhary, A. G., & SHEIKH, I. A. (2012) · PubMed · Cited by 162

Recent Advances in the Discovery and Development of Marine Microbial Natural Products

Xiong, Z., Wang, J.-F., Hao, Y.-Y., & Wang, Y. (2013) · Marine Drugs · doi:10.3390/md11030700 · Cited by 159

Tiny Microbes with a Big Impact: The Role of Cyanobacteria and Their Metabolites in Shaping Our Future

Mazard, S., Penesyan, A., Ostrowski, M. D., Paulsen, I. T., & Egan, S. (2016) · Marine Drugs · doi:10.3390/md14050097 · Cited by 170

Streptolysin S-like virulence factors: the continuing sagA

Molloy, E. M., Cotter, P. D., Hill, C., Mitchell, D. A., & Ross, R. P. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2624 · Cited by 160

Bacterial symbionts and natural products

Crawford, J. M., & Clardy, J. (2011) · Chemical Communications · doi:10.1039/c1cc11574j · Cited by 152

Complex microbiome underlying secondary and primary metabolism in the tunicate- Prochloron symbiosis

Donia, M. S., Fricke, W. F., Partensky, F., Cox, J. E., Elshahawi, S. I., White, J. R., Phillippy, A. M., Schatz, M. C., Piel, J., Haygood, M. G., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111712108 · Cited by 151

Transannular Disulfide Formation in Gliotoxin Biosynthesis and Its Role in Self-Resistance of the Human Pathogen Aspergillus fumigatus

Scharf, D. H., Remme, N., Heinekamp, T., Hortschansky, P., Brakhage, A. A., & Hertweck, C. (2010) · Journal of the American Chemical Society · doi:10.1021/ja103262m · Cited by 149

Metagenomic Approaches for Exploiting Uncultivated Bacteria as a Resource for Novel Biosynthetic Enzymology

Wilson, M. C., & Piel, J. (2013) · Chemistry & Biology · doi:10.1016/j.chembiol.2013.04.011 · Cited by 149

The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain

Koehnke, J., Bent, A., Houssen, W. E., Zollman, D., Morawitz, F., Shirran, S. L., Vendôme, J., Nneoyi-Egbe, A. F., Trembleau, L., Botting, C. H., et al. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2340 · Cited by 147

Diverse backbone-cyclized peptides via codon reprogramming

Kawakami, T., Ohta, A., Ohuchi, M., Ashigai, H., Murakami, H., & Suga, H. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.259 · Cited by 142

Genome streamlining and chemical defense in a coral reef symbiosis

Kwan, J. C., Donia, M. S., Han, A., Hirose, E., Haygood, M. G., & Schmidt, E. W. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213820109 · Cited by 144

Using Marine Natural Products to Discover a Protease that Catalyzes Peptide Macrocyclization of Diverse Substrates

Lee, J., McIntosh, J. A., Hathaway, B. J., & Schmidt, E. W. (2009) · Journal of the American Chemical Society · doi:10.1021/ja8092168 · Cited by 140

Enzymatic Basis of Ribosomal Peptide Prenylation in Cyanobacteria

McIntosh, J. A., Donia, M. S., Nair, S. K., & Schmidt, E. W. (2011) · Journal of the American Chemical Society · doi:10.1021/ja205458h · Cited by 137

Natural products chemistry: The emerging trends and prospective goals

Khan, R. (2018) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2018.02.015 · Cited by 135

Chasing the treasures of the sea — bacterial marine natural products

Gulder, T. A. M., & Moore, B. S. (2009) · Current Opinion in Microbiology · doi:10.1016/j.mib.2009.05.002 · Cited by 137

Aerucyclamides A and B: Isolation and Synthesis of Toxic Ribosomal Heterocyclic Peptides from the Cyanobacterium Microcystis aeruginosa PCC 7806

Portmann, C., Blom, J. F., Gademann, K., & Jüttner, F. (2008) · Journal of Natural Products · doi:10.1021/np800118g · Cited by 134

Isolation of Aerucyclamides C and D and Structure Revision of Microcyclamide 7806A: Heterocyclic Ribosomal Peptides from Microcystis aeruginosa PCC 7806 and Their Antiparasite Evaluation

Portmann, C., Blom, J. F., Kaiser, M., Brun, R., Jüttner, F., & Gademann, K. (2008) · Journal of Natural Products · doi:10.1021/np800409z · Cited by 132

Genome Mining Expands the Chemical Diversity of the Cyanobactin Family to Include Highly Modified Linear Peptides

Leikoski, N., Liu, L., Jokela, J., Wahlsten, M., Gugger, M. F., Calteau, A., Permi, P., Kerfeld, C. A., Sivonen, K., & Fewer, D. P. (2013) · Chemistry & Biology · doi:10.1016/j.chembiol.2013.06.015 · Cited by 129

Recent application of metagenomic approaches toward the discovery of antimicrobials and other bioactive small molecules

Banik, J. J., & Brady, S. F. (2010) · Current Opinion in Microbiology · doi:10.1016/j.mib.2010.08.012 · Cited by 126

Metagenomic approaches to natural products from free-living and symbiotic organisms

Brady, S. F., Simmons, L., Kim, J. H., & Schmidt, E. W. (2009) · Natural Product Reports · doi:10.1039/b817078a · Cited by 125

Natural Products Diversity of Marine Ascidians (Tunicates; Ascidiacea) and Successful Drugs in Clinical Development

Palanisamy, S. K., Rajendran, N. M., & Marino, A. (2017) · Natural Products and Bioprospecting · doi:10.1007/s13659-016-0115-5 · Cited by 131

Ribosomal Route to Small-Molecule Diversity

Tianero, M. D. B., Donia, M. S., Young, T. S., Schultz, P. G., & Schmidt, E. W. (2011) · Journal of the American Chemical Society · doi:10.1021/ja208278k · Cited by 123

Linking Chemistry and Genetics in the Growing Cyanobactin Natural Products Family

Donia, M. S., & Schmidt, E. W. (2011) · Chemistry & Biology · doi:10.1016/j.chembiol.2011.01.019 · Cited by 123

Microcyclamide Biosynthesis in Two Strains ofMicrocystis aeruginosa: from Structure to Genes and Vice Versa

Ziemert, N., Ishida, K., Quillardet, P., Bouchier, C., Hertweck, C., de Marsac, N. T., & Dittmann, E. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.02392-07 · Cited by 121

Chimeric Leader Peptides for the Generation of Non-Natural Hybrid RiPP Products

Burkhart, B. J., Kakkar, N., Hudson, G. A., van der Donk, W. A., & Mitchell, D. A. (2017) · ACS Central Science · doi:10.1021/acscentsci.7b00141 · Cited by 121

The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria

Jones, A. C., Monroe, E. A., Eisman, E. B., Gerwick, L. G., Sherman, D. H., & Gerwick, W. H. (2010) · Natural Product Reports · doi:10.1039/c000535e · Cited by 121

Ribosomally Synthesized and Post‐Translationally Modified Peptide Natural Products: New Insights into the Role of Leader and Core Peptides during Biosynthesis

Yang, X., & van der Donk, W. A. (2013) · Chemistry - A European Journal · doi:10.1002/chem.201300401 · Cited by 125

A sea of biosynthesis: marine natural products meet the molecular age

Lane, A. L., & Moore, B. S. (2010) · Natural Product Reports · doi:10.1039/c0np90032j · Cited by 119

Approaches to Capturing and Designing Biologically Active Small Molecules Produced by Uncultured Microbes

Piel, J. (2010) · Annual Review of Microbiology · doi:10.1146/annurev-micro-090110-102805 · Cited by 120

The Natural Products Chemistry of Cyanobacteria

Tidgewell, K. J., Clark, B. R., & Gerwick, W. H. (2010) · Elsevier eBooks · doi:10.1016/b978-008045382-8.00041-1 · Cited by 117

Peptide Macrocyclization Catalyzed by a Prolyl Oligopeptidase Involved in α-Amanitin Biosynthesis

Luo, H., Hong, S.-Y., Sgambelluri, R. M., Angelos, E. R., Li, X., & Walton, J. D. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2014.10.015 · Cited by 113

Manipulation of Thiocillin Variants by Prepeptide Gene Replacement: Structure, Conformation, and Activity of Heterocycle Substitution Mutants

Bowers, A. A., Acker, M. G., Koglin, A., & Walsh, C. T. (2010) · Journal of the American Chemical Society · doi:10.1021/ja102339q · Cited by 111

One-Pot Synthesis of Azoline-Containing Peptides in a Cell-free Translation System Integrated with a Posttranslational Cyclodehydratase

Goto, Y., Ito, Y., Kato, Y., Tsunoda, S., & Suga, H. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2014.04.008 · Cited by 110

Biosynthetic investigation of phomopsins reveals a widespread pathway for ribosomal natural products in Ascomycetes

Ding, W., Liu, W., Jia, Y., Li, Y., van der Donk, W. A., & Zhang, Q. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522907113 · Cited by 109

Cyanobacteria as photoautotrophic biofactories of high-value chemicals

Noreña-Caro, D., & Benton, M. G. (2018) · Journal of CO2 Utilization · doi:10.1016/j.jcou.2018.10.008 · Cited by 117

A microbial factory for defensive kahalalides in a tripartite marine symbiosis

Zan, J., Li, Z., Tianero, M. D. B., Davis, J., Hill, R. T., & Donia, M. S. (2019) · Science · doi:10.1126/science.aaw6732 · Cited by 107

New tricks from ancient algae: natural products biosynthesis in marine cyanobacteria

Jones, A. C., Gu, L., Sorrels, C. M., Sherman, D. H., & Gerwick, W. H. (2009) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2009.02.019 · Cited by 107

How Nature Morphs Peptide Scaffolds into Antibiotics

Nolan, E. M., & Walsh, C. T. (2008) · ChemBioChem · doi:10.1002/cbic.200800438 · Cited by 106

Marine Invertebrate Metabolites with Anticancer Activities: Solutions to the “Supply Problem”

Gomes, N. G. M., Dasari, R., Chandra, S., Robert Kiss, A., & Kornienko, A. (2016) · Marine Drugs · doi:10.3390/md14050098 · Cited by 109

Trading molecules and tracking targets in symbiotic interactions

Schmidt, E. W. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.101 · Cited by 101

Circular Logic: Nonribosomal Peptide-like Macrocyclization with a Ribosomal Peptide Catalyst

McIntosh, J. A., Robertson, C. R., Agarwal, V., Nair, S. K., Bulaj, G. W., & Schmidt, E. W. (2010) · Journal of the American Chemical Society · doi:10.1021/ja1067806 · Cited by 100

Thiazolyl Peptide Antibiotic Biosynthesis: A Cascade of Post-translational Modifications on Ribosomal Nascent Proteins

Walsh, C. T., Acker, M. G., & Bowers, A. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.135970 · Cited by 97

Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis

Dunbar, K. L., Chekan, J. R., Cox, C. L., Burkhart, B. J., Nair, S. K., & Mitchell, D. A. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1608 · Cited by 93

Mollamides B and C, Cyclic Hexapeptides from the Indonesian Tunicate Didemnum molle

Donia, M. S., Wang, B., Dunbar, D. C., Desai, P. V., Patny, A., Avery, M. A., & Hamann, M. T. (2008) · Journal of Natural Products · doi:10.1021/np700718p · Cited by 93

An Engineered Lantibiotic Synthetase That Does Not Require a Leader Peptide on Its Substrate

Oman, T. J., Knerr, P. J., Bindman, N. A., Velásquez, J. E., & van der Donk, W. A. (2012) · Journal of the American Chemical Society · doi:10.1021/ja3017297 · Cited by 92

Assessing the Combinatorial Potential of the RiPP Cyanobactin tru Pathway

Ruffner, D. E., Schmidt, E. W., & Heemstra, J. R. J. (2014) · ACS Synthetic Biology · doi:10.1021/sb500267d · Cited by 92

Generation of Thiocillin Variants by Prepeptide Gene Replacement and in Vivo Processing by Bacillus cereus

Acker, M. G., Bowers, A. A., & Walsh, C. T. (2009) · Journal of the American Chemical Society · doi:10.1021/ja908777t · Cited by 91

Naturally occurring circular proteins: distribution, biosynthesis and evolution

Cascales, L., & Craik, D. J. (2010) · Organic & Biomolecular Chemistry · doi:10.1039/c0ob00139b · Cited by 93

Species specificity of symbiosis and secondary metabolism in ascidians

Tianero, M. D. B., Kwan, J. C., Wyche, T. P., Presson, A. P., Koch, M., Barrows, L. R., Bugni, T. S., & Schmidt, E. W. (2014) · The ISME Journal · doi:10.1038/ismej.2014.152 · Cited by 89

Emerging evolutionary paradigms in antibiotic discovery

Chevrette, M. G., & Currie, C. R. (2018) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-018-2085-6 · Cited by 94

Symbioses of Cyanobacteria in Marine Environments: Ecological Insights and Biotechnological Perspectives

Mutalipassi, M., Riccio, G., Mazzella, V., Galasso, C., Somma, E., Chiarore, A., de Pascale, D., & Zupo, V. (2021) · Marine Drugs · doi:10.3390/md19040227 · Cited by 97

Cyanobactins from Cyanobacteria: Current Genetic and Chemical State of Knowledge

Martins, J., & Vasconcelos, V. M. (2015) · Marine Drugs · doi:10.3390/md13116910 · Cited by 88

Recognition Sequences and Substrate Evolution in Cyanobactin Biosynthesis

Sardar, D., Pierce, E., McIntosh, J. A., & Schmidt, E. W. (2014) · ACS Synthetic Biology · doi:10.1021/sb500019b · Cited by 86

Highly Diverse Cyanobactins in Strains of the Genus Anabaena

Leikoski, N., Fewer, D. P., Jokela, J., Wahlsten, M., Rouhiainen, L., & Sivonen, K. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01061-09 · Cited by 86

Modularity of RiPP Enzymes Enables Designed Synthesis of Decorated Peptides

Sardar, D., Lin, Z., & Schmidt, E. W. (2015) · Chemistry & Biology · doi:10.1016/j.chembiol.2015.06.014 · Cited by 81

Origin and Variation of Tunicate Secondary Metabolites

Schmidt, E. W., Donia, M. S., McIntosh, J. A., Fricke, W. F., & Ravel, J. (2012) · Journal of Natural Products · doi:10.1021/np200665k · Cited by 81

Life in cellulose houses: symbiotic bacterial biosynthesis of ascidian drugs and drug leads

Schmidt, E. W., & Donia, M. S. (2010) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2010.10.006 · Cited by 80

Insights into Heterocyclization from Two Highly Similar Enzymes

McIntosh, J. A., Donia, M. S., & Schmidt, E. W. (2010) · Journal of the American Chemical Society · doi:10.1021/ja9107116 · Cited by 80

Marine Molecular Machines: Heterocyclization in Cyanobactin Biosynthesis

McIntosh, J. A., & Schmidt, E. W. (2010) · ChemBioChem · doi:10.1002/cbic.201000196 · Cited by 78

Steric complementarity directs sequence promiscuous leader binding in RiPP biosynthesis

Chekan, J. R., Ongpipattanakul, C., & Nair, S. K. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1908364116 · Cited by 75

Parallel lives of symbionts and hosts: chemical mutualism in marine animals

Morita, M., & Schmidt, E. W. (2018) · Natural Product Reports · doi:10.1039/c7np00053g · Cited by 73

Origins and Bioactivities of Natural Compounds Derived from Marine Ascidians and Their Symbionts

Dou, X., & Dong, B. (2019) · Marine Drugs · doi:10.3390/md17120670 · Cited by 72

A Unique Tryptophan C‐Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway

Parajuli, A., Kwak, D. H., Dalponte, L., Leikoski, N., Galica, T., Umeobika, U., Trembleau, L., Bent, A., Sivonen, K., Wahlsten, M., et al. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201509920 · Cited by 72

Total Structure Determination of Grassypeptolide, a New Marine Cyanobacterial Cytotoxin

Kwan, J. C., Rocca, J. R., Abboud, K. A., Paul, V. J., & Luesch, H. (2008) · Organic Letters · doi:10.1021/ol702946d · Cited by 72

Molecular basis for the broad substrate selectivity of a peptide prenyltransferase

Hao, Y., Pierce, E., Roe, D. R., Morita, M., McIntosh, J. A., Agarwal, V., Cheatham, T. E., Schmidt, E. W., & Nair, S. K. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1609869113 · Cited by 71

Evolutionary radiation of lanthipeptides in marine cyanobacteria

Cubillos-Ruiz, A., Berta-Thompson, J. W., Becker, J. W., van der Donk, W. A., & Chisholm, S. W. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1700990114 · Cited by 71

Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni , the cyanobacterial symbiont of Lissoclinum patella

Schmidt, E. W., Nelson, J. T., Rasko, D. A., Sudek, S., Eisen, J. A., Haygood, M. G., & Ravel, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501424102 · Cited by 567

Azole‐Based Cyclic Peptides from the Sea Squirt Lissoclinum Patella: Old Scaffolds, New Avenues

Houssen, W. E., & Jaspars, M. (2010) · ChemBioChem · doi:10.1002/cbic.201000230 · Cited by 49

Genetic Evidence Supports Secondary Metabolic Diversity in Prochloron spp., the Cyanobacterial Symbiont of a Tropical Ascidian

Schmidt, E. W., Sudek, S., & Haygood, M. G. (2004) · Journal of Natural Products · doi:10.1021/np049948n · Cited by 65

Possible Functional Roles of Patellamides in the Ascidian-Prochloron Symbiosis

Baur, P., Kühl, M., Comba, P., & Behrendt, L. (2022) · Marine Drugs · doi:10.3390/md20020119 · Cited by 17

Ascidian-associated photosymbionts from Manado, Indonesia: secondary metabolites, bioactivity simulation, and biosynthetic insight

Rumengan, I. F. M., Roring, V. I. Y., Haedar, J. R., Siby, M. S., Luntungan, A. H., Kolondam, B. J., Uria, A. R., & Wakimoto, T. (2021) · Symbiosis · doi:10.1007/s13199-021-00766-4 · Cited by 9