The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Complex disease and phenotype mapping in the domestic dog
Open accessAbstract
The domestic dog is becoming an increasingly valuable model species in medical genetics, showing particular promise to advance our understanding of cancer and orthopaedic disease. Here we undertake the largest canine genome-wide association study to date, with a panel of over 4,200 dogs genotyped at 180,000 markers, to accelerate mapping efforts. For complex diseases, we identify loci significantly associated with hip dysplasia, elbow dysplasia, idiopathic epilepsy, lymphoma, mast cell tumour and granulomatous colitis; for morphological traits, we report three novel quantitative trait loci that influence body size and one that influences fur length and shedding. Using simulation studies, we show that modestly larger sample sizes and denser marker sets will be sufficient to identify most moderate- to large-effect complex disease loci. This proposed design will enable efficient mapping of canine complex diseases, most of which have human homologues, using far fewer samples than required in human studies.
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Matplotlib: a 2D graphics environment
Hunter, J. D. (2007) · Computing in Science & Engineering · doi:10.1109/mcse.2007.55 · Cited by 39,249
PLINK: a tool set for whole-genome association and population-based linkage analyses.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089
A method and server for predicting damaging missense mutations.
Adzhubei, I. A., Schmidt, S., Peshkin, L., Ramensky, V. E., Gerasimova, A., Bork, P., Kondrashov, A. S., & Sunyaev, S. R. (2010) · Nature Methods · doi:10.1038/nmeth0410-248 · Cited by 13,194
Principal components analysis corrects for stratification in genome-wide association studies
Price, A. L., Patterson, N. J., Plenge, R. M., Weinblatt, M. E., Shadick, N. A., & Reich, D. (2006) · Nature Genetics · doi:10.1038/ng1847 · Cited by 10,248
Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
The International IBD Genetics Consortium (IIBDGC), Jostins, L., Ripke, S., Weersma, R. K., Duerr, R. H., McGovern, D. P., Hui, K. Y., Lee, J. C., Philip Schumm, L., Sharma, Y., et al. (2012) · Nature · doi:10.1038/nature11582 · Cited by 4,722
Howie, B. N., Donnelly, P., & Marchini, J. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000529 · Cited by 3,928
Genome-wide efficient mixed-model analysis for association studies
Zhou, X., & Stephens, M. (2012) · Nature Genetics · doi:10.1038/ng.2310 · Cited by 3,627
Genome partitioning of genetic variation for complex traits using common SNPs
Yang, J., Manolio, T. A., Pasquale, L. R., Boerwinkle, E., Caporaso, N., Cunningham, J. M., de Andrade, M., Feenstra, B., Feingold, E., Hayes, M. G., et al. (2011) · Nature Genetics · doi:10.1038/ng.823 · Cited by 890
An Expressed Fgf4 Retrogene Is Associated with Breed-Defining Chondrodysplasia in Domestic Dogs
Parker, H. G., VonHoldt, B. M., Quignon, P., Margulies, E. H., Shao, S., Mosher, D. S., Spady, T. C., Elkahloun, A., Cargill, M., Jones, P. G., et al. (2009) · Science · doi:10.1126/science.1173275 · Cited by 342
Self-citationThe Melanocortin 5 Receptor is Expressed in Human Sebaceous Glands and Rat Preputial Cells
Thiboutot, D., Sivarajah, A., Gilliland, K., Cong, Z., & Clawson, G. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00094.x · Cited by 90
Cited by
Parker, H. G., Dreger, D. L., Rimbault, M., Davis, B. W., Mullen, A. B., Carpintero-Ramirez, G., & Ostrander, E. A. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.079 · Cited by 435
Highly heritable and functionally relevant breed differences in dog behaviour
MacLean, E. L., Snyder-Mackler, N., vonHoldt, B. M., & Serpell, J. A. (2019) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2019.0716 · Cited by 144
Body size, inbreeding, and lifespan in domestic dogs
Yordy, J., Kraus, C., Hayward, J. J., White, M. E., Shannon, L. M., Creevy, K. E., Promislow, D. E. L., & Boyko, A. R. (2020) · Conservation Genetics · doi:10.1007/s10592-019-01240-x · Cited by 92
Self-citationAbsolute brain size predicts dog breed differences in executive function
Horschler, D. J., Hare, B., Call, J., Kaminski, J., Miklósi, Á., & MacLean, E. L. (2019) · Animal Cognition · doi:10.1007/s10071-018-01234-1 · Cited by 87
Current Understanding of the Genetics of Intervertebral Disc Degeneration
Dickinson, P. J., & Bannasch, D. L. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.00431 · Cited by 58
Metadata
- Authors
- Hayward, J. J., Castelhano, M. G., Oliveira, K. C., Corey, E., Balkman, C., Baxter, T. L., Casal, M. L., Center, S. A., Fang, M., Garrison, S. J., Kalla, S. E., Korniliev, P., Kotlikoff, M. I., Moise, N. S., Shannon, L. M., Simpson, K. W., Sutter, N. B., Todhunter, R. J., & Boyko, A. R.
- Venue
- Nature Communications
- Published
- 2016-01-22
- Volume
- 7
- Issue
- 1
- Pages
- 10460-10460
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2268306343
- Cited by
- 271
- References
- 10
- FWCI
- 21.04
- Type
- journal article
- Language
- en
- Open access
- gold
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- Hayward, J. J., Castelhano, M. G., Oliveira, K. C., Corey, E., Balkman, C., Baxter, T. L., Casal, M. L., Center, S. A., Fang, M., Garrison, S. J., Kalla, S. E., Korniliev, P., Kotlikoff, M. I., Moise, N. S., Shannon, L. M., Simpson, K. W., Sutter, N. B., Todhunter, R. J., & Boyko, A. R. (2016). Complex disease and phenotype mapping in the domestic dog. Nature Communications. https://doi.org/10.1038/ncomms10460
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