An Expressed Fgf4 Retrogene Is Associated with Breed-Defining Chondrodysplasia in Domestic Dogs
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Going Retro: In a year celebrating Darwin, the question of how new functional genes arise during evolution is of particular interest. Through a multibreed genetic analysis of the domestic dog, Parker et al. (p. 995 , published online 16 July; see the Perspective by Kaessmann ) find that the short-legged phenotype that characterizes at least 19 common dog breeds, including the corgi, dachshund, and basset hound, is specifically associated with the expression in developing bone of a gene encoding fibroblast growth factor 4 ( fgf4 ), a member of a gene family previously implicated in dwarfism in humans. Interestingly, the culprit fgf4 gene in dogs has the hallmarks of a “retrogene,” a gene that arises when a parental gene is duplicated through an RNA-based copying mechanism.
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Short legs in dog breeds such as dachshunds and basset hounds are due to a retrogene encoding FGF4, inserted and evidently controlled by cis-regulatory elements carried in non-LTR transposons.
“short legs in dog breeds such as dachshunds and basset hounds is due to a retrogene encoding FGF4, inserted and evidently controlled by cis-regulatory elements carried in non-LTR transposons (Parker et al., 2009).”
From Evolution of Gene Regulatory Networks Controlling Body Plan Development (2011) · cites this paper as Parker et al., 2009
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Velvet: Algorithms for de novo short read assembly using de Bruijn graphsPreprint
Zerbino, D. R., & Birney, E. (2008) · Genome Research · doi:10.1101/gr.074492.107 · Cited by 9,387 · see citing works
On the Origin of Species by Means of Natural Selection
Livezey, R. L., & Darwin, C. R. (1953) · The American Midland Naturalist · doi:10.2307/2485224 · Cited by 5,430 · see citing works
Bankier, J. C. (1993) · Elsevier eBooks · doi:10.1016/c2009-0-03338-8 · Cited by 2,155 · see citing works
Transposable elements and the evolution of regulatory networks
Feschotte, C. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2337 · Cited by 1,324 · see citing works
Properties of statistical tests of neutrality for DNA polymorphism data
Simonsen, K. L., Churchill, G. A., & Aquadro, C. F. (1995) · Genetics · doi:10.1093/genetics/141.1.413 · Cited by 681 · see citing works
A Single IGF1 Allele Is a Major Determinant of Small Size in Dogs
Sutter, N. B., Bustamante, C. D., Chase, K., GRAY, M. M., Zhao, K., Zhu, L., Padhukasahasram, B., Karlins, E., Davis, S. R., Jones, P. G., et al. (2007) · Science · doi:10.1126/science.1137045 · Cited by 673 · see citing works
Self-citationMolecular origins of rapid and continuous morphological evolution
Fondon, J. W., & Garner, H. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408118101 · Cited by 614 · see citing works
The Dog Genome: Survey Sequencing and Comparative Analysis
Kirkness, E. F., Bafna, V., Halpern, A. L., Levy, S., Remington, K., Rusch, D. B., Delcher, A. L., Pop, M., Wang, W., Fraser, C. M., et al. (2003) · Science · doi:10.1126/science.1086432 · Cited by 548 · see citing works
Minowada, G., Jarvis, L. A., Chi, C. L., Neubüser, A., Sun, X., Hacohen, N., Krasnow, M. A., & Martin, G. R. (1999) · Development · doi:10.1242/dev.126.20.4465 · Cited by 506 · see citing works
RNA-based gene duplication: Mechanistic and evolutionary insights
Kaessmann, H., Vinckenbosch, N., & Long, M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2487 · Cited by 449 · see citing works
Evolutionary fate of retroposed gene copies in the human genome
Vinckenbosch, N., Dupanloup, I., & Kaessmann, H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511307103 · Cited by 405 · see citing works
Genetic Structure of the Purebred Domestic Dog
Parker, H., Kim, L., Sutter, N., Carlson, S., Lorentzen, T. D., Malek, T. B., Johnson, G. S., DeFrance, H. B., Ostrander, E., & Kruglyak, L. (2004) · Science · doi:10.1126/science.1097406 · Cited by 405 · see citing works
Self-citationGermonpré, M., Sablin, M., Stevens, R. E., Hedges, R. E. M., Hofreiter, M., Stiller, M., & Després, V. R. (2008) · Journal of Archaeological Science · doi:10.1016/j.jas.2008.09.033 · Cited by 393 · see citing works
Gene duplication and the uniqueness of vertebrate genomes circa 1970–1999
Ohno, S. (1999) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.1999.0332 · Cited by 336 · see citing works
Emergence of Young Human Genes after a Burst of Retroposition in Primates
Marques, A. C., Dupanloup, I., Vinckenbosch, N., Reymond, A., & Kaessmann, H. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030357 · Cited by 311 · see citing works
Hillbertz, N. S., Isaksson, M., Karlsson, E. K., Hellmén, E., Pielberg, G., Savolainen, P., Wade, C. M., von Euler, H., Gustafson, U., Hedhammar, Å. A., et al. (2007) · Nature Genetics · doi:10.1038/ng.2007.4 · Cited by 220 · see citing works
The Earliest Ice Age Dogs: Evidence from Eliseevichi 1
Sablin, M., & Khlopachev, G. (2002) · Current Anthropology · doi:10.1086/344372 · Cited by 209 · see citing works
Lessons learned from the dog genome
Wayne, R. K., & Ostrander, E. A. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.08.013 · Cited by 206 · see citing works
Self-citationGenomes were forged by massive bombardments with retroelements and retrosequences
Brosius, J. (2000) · Springer eBooks · doi:10.1007/978-94-011-4156-7_23 · Cited by 171 · see citing works
The legacy of domestication: accumulation of deleterious mutations in the dog genome
Cruz, F., Vila, C., & Webster, M. T. (2008) · Molecular Biology and Evolution · doi:10.1093/molbev/msn177 · Cited by 154 · see citing works
Parker, H. G., Kukekova, A. V., Akey, D. T., Goldstein, O., Kirkness, E. F., Baysac, K. C., Mosher, D. S., Aguirre, G. K., Acland, G. M., & Ostrander, E. A. (2007) · Genome Research · doi:10.1101/gr.6772807 · Cited by 152 · see citing works
Self-citationA Mutation in Hairless Dogs Implicates FOXI3 in Ectodermal Development
Drögemüller, C., Karlsson, E. K., Hytönen, M. K., Perloski, M., Dolf, G., Sainio, K., Lohi, H., Lindblad‐Toh, K., & Leeb, T. (2008) · Science · doi:10.1126/science.1162525 · Cited by 151 · see citing works
Genomes were forged by massive bombardments with retroelements and retrosequences
Brosius, J. (1999) · Genetica · doi:10.1023/a:1004018519722 · Cited by 131 · see citing works
Selective sweep mapping of genes with large phenotypic effectsPreprint
Pollinger, J. P., Bustamante, C. D., Fledel-Alon, A., Schmutz, S. M., GRAY, M. M., & Wayne, R. K. (2005) · Genome Research · doi:10.1101/gr.4374505 · Cited by 121 · see citing works
Self-citationThe Genetic and Endocrinic Basis for Differences in Form and Behavior
Hunt, H. F., Stockard, C. R., Anderson, O. D., & James, W. (1943) · The American Journal of Psychology · doi:10.2307/1417368 · Cited by 99 · see citing works
Heuertz, S., Merrer, M. F. L., Zabel, B., Wright, M., Legeai‐Mallet, L., Cormier‐Daire, V., Gibbs, L., & Bonaventure, J. (2006) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201700 · Cited by 87 · see citing works
Rohozinski, J., & Bishop, C. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401130101 · Cited by 76 · see citing works
Stockard, C. R., Anderson, O. D., & James, W. (1941) · doi:10.5962/bhl.title.6460 · Cited by 60 · see citing works
Palmer, N. (1993) · Elsevier eBooks · doi:10.1016/b978-0-08-057133-1.50009-6 · Cited by 54 · see citing works
Fraidenraich, D., Lang, R. A., & Basilico, C. (1998) · Developmental Biology · doi:10.1006/dbio.1998.9053 · Cited by 44 · see citing works
Nowling, T. K., Bernadt, C. T., Johnson, L. R., Desler, M. M., & Rizzino, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207567200 · Cited by 42 · see citing works
Fibroblast Growth Factor Receptor 3 Mutations in Achondroplasia and Related Forms of Dwarfism
Horton, W. A., & Lunstrum, G. P. (2002) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/a:1020914026829 · Cited by 41 · see citing works
Guo, C., Degnin, C., Laederich, M. B., Lunstrum, G. P., Holden, P. K., Bihlmaier, J., Krakow, D., Cho, Y., & Horton, W. A. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.04.001 · Cited by 32 · see citing works
Betrán, E. (2006) · Molecular Biology and Evolution · doi:10.1093/molbev/msl090 · Cited by 24 · see citing works
Unexpected similarities in cellular responses to bacterial and viral invasion
Pitha, P. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307303101 · Cited by 20 · see citing works
The effect of adaptive mutagenesis on genetic variation at a linked, neutral locus.
Colby, C., & Williams, S. M. (1995) · Genetics · doi:10.1093/genetics/140.3.1129 · Cited by 4 · see citing works
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Research works printed but not linked: 2
- [10]American Kennel Club Official Publication of the American Kennel Club The Complete Dog Book 1998 ed. 19th Edition Revised New York, NY Howell Book House 790
- [25]Germonpre M Journal of Archaeological Science 2009 Feb 36 473
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Ornitz, D. M., & Itoh, N. (2015) · WIREs Developmental Biology · doi:10.1002/wdev.176 · Cited by 2,050 · see citing works
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Kaessmann, H. (2010) · Genome Research · doi:10.1101/gr.101386.109 · Cited by 818 · see citing works
Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication
vonHoldt, B. M., Pollinger, J. P., Lohmueller, K. E., Han, E., Parker, H. G., Quignon, P., Degenhardt, J. D., Boyko, A. R., Earl, D. A., Auton, A., et al. (2010) · Nature · doi:10.1038/nature08837 · Cited by 804 · see citing works
Self-citationLINE-1 elements in structural variation and disease
Beck, C. R., Garcia-Perez, J. L., Badge, R. M., & Moran, J. V. (2011) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-082509-141802 · Cited by 615 · see citing works
Active human retrotransposons: variation and disease
Hancks, D. C., & Kazazian, H. H. (2012) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2012.02.006 · Cited by 592 · see citing works
Rethinking Dog Domestication by Integrating Genetics, Archeology, and Biogeography
Larson, G., Karlsson, E. K., Perri, A., Webster, M. T., Ho, S. Y. W., Peters, J., Stahl, P. W., Piper, P. J., Lingaas, F., Fredholm, M., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203005109 · Cited by 540 · see citing works
Facioscapulohumeral Dystrophy: Incomplete Suppression of a Retrotransposed Gene
Snider, L. D., Geng, L. N., Lemmers, R. J. L. F., Kyba, M., Ware, C. B., Nelson, A. M., Tawil, R., Filippova, G. N., van der Maarel, S. M., Tapscott, S. J., et al. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001181 · Cited by 503 · see citing works
A Simple Genetic Architecture Underlies Morphological Variation in Dogs
Boyko, A., Quignon, P., Li, L., Schoenebeck, J., Degenhardt, J. D., Lohmueller, K., Zhao, K., Brisbin, A., Parker, H., Vonholdt, B., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000451 · Cited by 469 · see citing works
Self-citationMutational effects and the evolution of new protein functions
Soskine, M., & Tawfik, D. S. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2808 · Cited by 455 · see citing works
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Chen, S., Krinsky, B. H., & Long, M. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3521 · Cited by 428 · see citing works
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Frantz, L., Mullin, V. E., Pionnier-Capitan, M., Lebrasseur, O., Ollivier, M., Perri, A. R., Linderholm, A. E., Mattiangeli, V., Teasdale, M. D., Dimopoulos, E. A., et al. (2016) · Science · doi:10.1126/science.aaf3161 · Cited by 449 · see citing works
Evolution of Gene Regulatory Networks Controlling Body Plan Development
Peter, I. S., & Davidson, E. H. (2011) · Cell · doi:10.1016/j.cell.2011.02.017 · Cited by 417 · see citing works
Parker, H. G., Dreger, D. L., Rimbault, M., Davis, B. W., Mullen, A. B., Carpintero-Ramirez, G., & Ostrander, E. A. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.079 · Cited by 438 · see citing works
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Vaysse, A., Ratnakumar, A., Derrien, T., Axelsson, E., Pielberg, G., Sigurðsson, S., Fall, T., Seppälä, E. H., Hansen, M. S., Lawley, C., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002316 · Cited by 390 · see citing works
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Schrader, L., & Schmitz, J. (2018) · Molecular Ecology · doi:10.1111/mec.14794 · Cited by 337 · see citing works
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Richardson, S. R., Doucet, A. J., Kopera, H. C., Moldovan, J. B., Garcia-Perez, J. L., & Moran, J. V. (2015) · Microbiology Spectrum · doi:10.1128/microbiolspec.mdna3-0061-2014 · Cited by 313 · see citing works
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Hayward, J. J., Castelhano, M. G., Oliveira, K. C., Corey, E. E., Balkman, C. E., Baxter, T. L., Casal, M. L., Fang, M., Garrison, S. J., Kalla, S. E., et al. (2016) · Nature Communications · doi:10.1038/ncomms10460 · Cited by 272 · see citing works
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Jagannathan, V., Drögemüller, C., & Leeb, T. (2019) · Animal Genetics · doi:10.1111/age.12834 · Cited by 191 · see citing works
vonHoldt, B. M., Shuldiner, E., Koch, I. J., Kartzinel, R. Y., Hogan, A., Brubaker, L., Wanser, S., Stahler, D., Wynne, C. D. L., Ostrander, E. A., et al. (2017) · Science Advances · doi:10.1126/sciadv.1700398 · Cited by 186 · see citing works
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Bergknut, N., Egenvall, A., Hagman, R., Gustås, P., Hazewinkel, H. A. W., Meij, B. P., & Lagerstedt, A. (2012) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.240.11.1300 · Cited by 170 · see citing works
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Self-citationLorenz, A. J., Hamblin, M. T., & Jannink, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014079 · Cited by 153 · see citing works
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Donner, J., Anderson, H., Davison, S., Hughes, A. M., Bouirmane, J., Lindqvist, J., Lytle, K. M., Ganesan, B., Ottka, C., Ruotanen, P., et al. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007361 · Cited by 111 · see citing works
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Marchant, T. W., Johnson, E. J., McTeir, L., Johnson, C. I., Gow, A. G., Liuti, T., Kuehn, D., Svenson, K. L., Bermingham, M. L., Drögemüller, M., et al. (2017) · Current Biology · doi:10.1016/j.cub.2017.04.057 · Cited by 106 · see citing works
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Amin, S. B., Anderson, K. J., Boudreau, C. E., Martínez-Ledesma, E., Kocakavuk, E., Johnson, K. C., Barthel, F. P., Varn, F. S., Kassab, C., Ling, X., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.01.004 · Cited by 104 · see citing works
Bergknut, N., Auriemma, E., Wijsman, S., Voorhout, G., Hagman, R., Lagerstedt, A., Hazewinkel, H. A. W., & Meij, B. P. (2011) · American Journal of Veterinary Research · doi:10.2460/ajvr.72.7.893 · Cited by 104 · see citing works
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Parker, H. G., & Kilroy-Glynn, P. (2012) · Journal of Veterinary Cardiology · doi:10.1016/j.jvc.2012.01.006 · Cited by 103 · see citing works
Self-citationThe Domestication Makeup: Evolution, Survival, and Challenges
Ahmad, H. I., Ahmad, M. J., Jabbir, F., Ahmar, S., Ahmad, N., Elokil, A. A., & Chen, J. (2020) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2020.00103 · Cited by 98 · see citing works
Miyadera, K., Acland, G. M., & Aguirre, G. D. (2011) · Mammalian Genome · doi:10.1007/s00335-011-9361-3 · Cited by 97 · see citing works
Self-citationArticle Commentary: The Genetic Architecture of Domestication in Animals
Wright, D. (2015) · Bioinformatics and Biology Insights · doi:10.4137/bbi.s28902 · Cited by 92 · see citing works
The insulin-like growth factor 1 receptor (IGF1R) contributes to reduced size in dogs
Hoopes, B. C., Rimbault, M., Liebers, D. T., Ostrander, E. A., & Sutter, N. B. (2012) · Mammalian Genome · doi:10.1007/s00335-012-9417-z · Cited by 91 · see citing works
Self-citationMartins, T. R., Berg, J. J., Blinka, S. M., Rausher, M. D., & Baum, D. (2012) · New Phytologist · doi:10.1111/nph.12062 · Cited by 91 · see citing works
Smith, B. F., Yue, Y., Woods, P. R., Kornegay, J. N., Shin, J., Williams, R. R., & Duan, D. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.146 · Cited by 89 · see citing works
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Schoenebeck, J. J., & Ostrander, E. A. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-012927 · Cited by 89 · see citing works
Self-citationComparative and Veterinary Pharmacology
Cunningham, F. M., Elliott, J., & Lees, P. (2010) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-10324-7 · Cited by 88 · see citing works
Kranenburg, H. C., Grinwis, G. C. M., Bergknut, N., Gahrmann, N., Voorhout, G., Hazewinkel, H. A. W., & Meij, B. P. (2012) · The Veterinary Journal · doi:10.1016/j.tvjl.2012.06.001 · Cited by 85 · see citing works
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Vonholdt, B., Kays, R., Pollinger, J., & Wayne, R. (2016) · Molecular Ecology · doi:10.1111/mec.13667 · Cited by 86 · see citing works
Self-citationMolecular genetic variation of animals and plants under domestication
Andersson, L., & Purugganan, M. D. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2122150119 · Cited by 78 · see citing works
Novel origins of copy number variation in the dog genome
Berglund, J., Nevalainen, E., Molin, A.-M., Perloski, M., André, C., Zody, M. C., Sharpe, T., Hitte, C., Lindblad‐Toh, K., Lohi, H., et al. (2012) · Genome biology · doi:10.1186/gb-2012-13-8-r73 · Cited by 78 · see citing works
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Kim, J., Williams, F. J., Dreger, D. L., Plassais, J., Davis, B. W., Parker, H. G., & Ostrander, E. A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1800455115 · Cited by 77 · see citing works
Self-citationPopulation structure and genetic heterogeneity in popular dog breeds in the UK
Mellanby, R. J., Ogden, R., Clements, D. N., French, A. T., Gow, A. G., Powell, R. M., CORCORAN, B. M., Schoeman, J. P., & SUMMERS, K. M. (2012) · The Veterinary Journal · doi:10.1016/j.tvjl.2012.08.009 · Cited by 77 · see citing works
The dynamic proliferation of CanSINEs mirrors the complex evolution of Feliforms
Walters-Conte, K., Johnson, D. L., Johnson, W. E., O’Brien, S. J., & Pecon‐Slattery, J. (2014) · BMC Evolutionary Biology · doi:10.1186/1471-2148-14-137 · Cited by 75 · see citing works
Canine Morphology: Hunting for Genes and Tracking Mutations
Shearin, A. L., & Ostrander, E. A. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000310 · Cited by 76 · see citing works
Self-citationGenetic architecture of body size in mammals
Kemper, K. E., Visscher, P. M., & Goddard, M. E. (2012) · Genome biology · doi:10.1186/gb4016 · Cited by 105 · see citing works
How selective sweeps in domestic animals provide new insight into biological mechanisms
Andersson, L. (2011) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2011.02450.x · Cited by 74 · see citing works
The effect of inbreeding, body size and morphology on health in dog breeds
Bannasch, D. L., Famula, T. R., Donner, J., Anderson, H., Honkanen, L., Batcher, K., Safra, N., Thomasy, S. M., & Rebhun, R. B. (2021) · Canine Medicine and Genetics · doi:10.1186/s40575-021-00111-4 · Cited by 73 · see citing works
Gudernová, I., Veselá, I., Bálek, L., Buchtová, M., Dosedělová, H., Bosakova, M. K., Pivnička, J., Jelínková, I., Roubalová, L., Kozubı́k, A., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv441 · Cited by 70 · see citing works
Collins, L., Asher, L., Summers, J. F., & McGreevy, P. D. (2011) · The Veterinary Journal · doi:10.1016/j.tvjl.2011.06.012 · Cited by 69 · see citing works
Protein-Coding Genes’ Retrocopies and Their Functions
Kubiak, M. R., & Makałowska, I. (2017) · Viruses · doi:10.3390/v9040080 · Cited by 65 · see citing works
Marden, J. H. (2013) · Molecular Ecology · doi:10.1111/mec.12534 · Cited by 65 · see citing works
Genetic Pathways of Aging and Their Relevance in the Dog as a Natural Model of Human Aging
Sándor, S., & Kubinyi, E. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00948 · Cited by 66 · see citing works
Uhl, E. W. (2018) · International Journal of Paleopathology · doi:10.1016/j.ijpp.2018.03.001 · Cited by 63 · see citing works
Differential Genetic Regulation of Canine Hip Dysplasia and Osteoarthritis
Zhou, Z., Sheng, X., Zhang, Z., Zhao, K., Zhu, L., Guo, G., Friedenberg, S. G., Hunter, L. S., Berg-Foels, W. S. V., Hornbuckle, W. E., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013219 · Cited by 62 · see citing works
Self-citationCOL9A2 and COL9A3 mutations in canine autosomal recessive oculoskeletal dysplasia
Goldstein, O., Guyon, R., Kukekova, A. V., Kuznetsova, T. N., Pearce-Kelling, S. E., Johnson, J. L., Aguirre, G. D., & Acland, G. M. (2010) · Mammalian Genome · doi:10.1007/s00335-010-9276-4 · Cited by 61 · see citing works
Self-citationPhenotypic Effects of FGF4 Retrogenes on Intervertebral Disc Disease in Dogs
Batcher, K., Dickinson, P. J., Giuffrida, M. A., Sturges, B. K., Vernau, K. M., Knipe, M. F., Rasouliha, S. H., Drögemüller, C., Leeb, T., Maciejczyk, K., et al. (2019) · Genes · doi:10.3390/genes10060435 · Cited by 60 · see citing works
Packer, R. M. A., Hendricks, A., Volk, H. A., Shihab, N. K., & Burn, C. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069650 · Cited by 60 · see citing works
Goldfish: an old and new model system to study vertebrate development, evolution and human disease
Omori, Y., & Kon, T. (2018) · The Journal of Biochemistry · doi:10.1093/jb/mvy076 · Cited by 60 · see citing works
Dreger, D. L., Rimbault, M., Davis, B. W., Bhatnagar, A., Parker, H. G., & Ostrander, E. A. (2016) · Disease Models & Mechanisms · doi:10.1242/dmm.027037 · Cited by 59 · see citing works
Self-citationGene duplications and the time thereafter - examples from plant secondary metabolism
Ober, D. (2010) · Plant Biology · doi:10.1111/j.1438-8677.2009.00317.x · Cited by 58 · see citing works
Current Understanding of the Genetics of Intervertebral Disc Degeneration
Dickinson, P. J., & Bannasch, D. L. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.00431 · Cited by 58 · see citing works
The canine era: the rise of a biomedical model
van Steenbeek, F. G., Hytönen, M. K., Leegwater, P. A. J., & Lohi, H. (2016) · Animal Genetics · doi:10.1111/age.12460 · Cited by 57 · see citing works
Halo, J. V., Pendleton, A. L., Shen, F., Doucet, A. J., Derrien, T., Hitte, C., Kirby, L. E., Myers, B., Śliwerska, E., Emery, S. B., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2016274118 · Cited by 56 · see citing works
LTR-mediated retroposition as a mechanism of RNA-based duplication in metazoansPreprint
Tan, S., Cardoso-Moreira, M., Shi, W., Zhang, D., Huang, J., Mao, Y., Jia, H., Zhang, Y., Chen, C., Shao, Y., et al. (2016) · Genome Research · doi:10.1101/gr.204925.116 · Cited by 53 · see citing works
Donner, J., Freyer, J., Davison, S., Anderson, H., Blades, M., Honkanen, L., Inman, L., Brookhart-Knox, C. A., Louviere, A., Forman, O. P., et al. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010651 · Cited by 55 · see citing works
Nothing in Evolution Makes Sense Except in the Light of DNA
Kalinowski, S. T., Leonard, M. J., & Andrews, T. M. (2010) · CBE—Life Sciences Education · doi:10.1187/cbe.09-12-0088 · Cited by 54 · see citing works
Molecular consequences of animal breeding
Andersson, L. (2013) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.02.014 · Cited by 54 · see citing works
Guo, Y., Gu, X., Sheng, Z., Wang, Y., Luo, C., Liu, R., Qu, H., Shu, D., Wen, J., Crooijmans, R. P. M. A., et al. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006071 · Cited by 57 · see citing works
- Authors
- Parker, H. G., VonHoldt, B. M., Quignon, P., Margulies, E. H., Shao, S., Mosher, D. S., Spady, T. C., Elkahloun, A., Cargill, M., Jones, P. G., Maslen, C. L., Acland, G. M., Sutter, N. B., Kuroki, K., Bustamante, C. D., Wayne, R. K., & Ostrander, E. A.
- Affiliations
- National Institutes of Health (US)
- University of California, Los Angeles (US)
- Affymetrix (United States) (US)
- Waltham Centre for Pet Nutrition (GB)
- Oregon Health & Science University (US)
- Cornell University (US)
- University of Missouri (US)
- Corresponding author
- Cargill, Michele
- Ostrander, Elaine A.
- ORCID
- Venue
- Science
- Published
- 2009-08-21
- Volume
- 325
- Issue
- 5943
- Pages
- 995-998
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2748762
- OpenAlex
- W1981244256
- Cited by
- 342
- References
- 36
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 28 · 2023: 17 · 2022: 18 · 2021: 20 · 2020: 22 · 2019: 20 · 2018: 19 · 2017: 13 · 2016: 25 · 2015: 15 · 2014: 14 · 2013: 22 · 2012: 28
- FWCI
- 16.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 HG999999)
- National Human Genome Research Institute (T32HG002536)
- National Eye Institute (R01EY006855)
- National Institute of General Medical Sciences (R01GM083606, 1R01GM83606, R24GM082910)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Human-Animal Interaction Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Keywords
- FGF4, retrogenes, retrotransposition, chondrodysplasia, gene expression, phenotypic diversity, dog evolution
- MeSH terms
- Animals, Breeding, Dogs, Extremities, Gene Expression Regulation, Gene Frequency, Haplotypes, Humerus, Pedigree, Phenotype, Regulatory Sequences, Nucleic Acid, Selection, Genetic, Retroelements, Evolution, Molecular, Chondrocytes, Long Interspersed Nucleotide Elements, Genes, Duplicate, Oligonucleotide Array Sequence Analysis, Gene Duplication, Polymorphism, Single Nucleotide, Fibroblast Growth Factor 4, Genome-Wide Association Study
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