The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Genetic and environmental influences interact with age and sex in shaping the human methylome
Open accessAbstract
The methylome is subject to genetic and environmental effects. Their impact may depend on sex and age, resulting in sex- and age-related physiological variation and disease susceptibility. Here we estimate the total heritability of DNA methylation levels in whole blood and estimate the variance explained by common single nucleotide polymorphisms at 411,169 sites in 2,603 individuals from twin families, to establish a catalogue of between-individual variation in DNA methylation. Heritability estimates vary across the genome (mean=19%) and interaction analyses reveal thousands of sites with sex-specific heritability as well as sites where the environmental variance increases with age. Integration with previously published data illustrates the impact of genome and environment across the lifespan at methylation sites associated with metabolic traits, smoking and ageing. These findings demonstrate that our catalogue holds valuable information on locations in the genome where methylation variation between people may reflect disease-relevant environmental exposures or genetic variation.
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Citations
Cites
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Cited by
Facing up to the global challenges of ageing
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Self-citationDNA methylation aging clocks: challenges and recommendations
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Self-citationGenomic and phenotypic insights from an atlas of genetic effects on DNA methylation
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Self-citationSingle-cell chromatin modification profiling reveals increased epigenetic variations with aging
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“Our findings are highly similar to results from twin analyses on DNA methylation, where environmental influences explain approximately 80% of the variance in DNA methylation (McRae et al., 2014; van Dongen et al., 2016).”
The role of sex in the genomics of human complex traits
Khramtsova, E. A., Davis, L. K., & Stranger, B. E. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-018-0083-1 · Cited by 303
Metadata
- Authors
- van Dongen, J., Nivard, M. G., Willemsen, G., Hottenga, J.-J., Helmer, Q., Dolan, C. V., Ehli, E. A., Davies, G. E., van Iterson, M., Breeze, C. E., Beck, S., BIOS Consortium, Hoen, P. A. C. ’., Pool, R., van Greevenbroek, M. M. J., Stehouwer, C. D. A., Kallen, C. J. H. V. D., Schalkwijk, C. G., Wijmenga, C., Zhernakova, S., Tigchelaar, E. F., Beekman, M., Deelen, J., van Heemst, D., Veldink, J. H., van den Berg, L. H., van Duijn, C. M., Hofman, B. A., Uitterlinden, A. G., Jhamai, P. M., Verbiest, M., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Mei, H., Bot, J., Zhernakova, D. V., van’t Hof, P., Deelen, P., Nooren, I., Moed, M., Vermaat, M., Luijk, R., Bonder, M. J., van Dijk, F., van Galen, M., Arindrarto, W., Kielbasa, S. M., Swertz, M. A., van Zwet, E. W., Isaacs, A., Franke, L., Suchiman, H. E., Jansen, R., van Meurs, J. B., Heijmans, B. T., Slagboom, P. E., & Boomsma, D. I.
- Venue
- Nature Communications
- Published
- 2016-04-07
- Volume
- 7
- Issue
- 1
- Pages
- 11115-11115
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2334107927
- Cited by
- 402
- References
- 18
- FWCI
- 17.30
- Type
- journal article
- Language
- en
- Open access
- gold
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- The paper
- van Dongen, J., Nivard, M. G., Willemsen, G., Hottenga, J.-J., Helmer, Q., Dolan, C. V., Ehli, E. A., Davies, G. E., van Iterson, M., Breeze, C. E., Beck, S., BIOS Consortium, Hoen, P. A. C. ’., Pool, R., van Greevenbroek, M. M. J., Stehouwer, C. D. A., Kallen, C. J. H. V. D., Schalkwijk, C. G., Wijmenga, C., . . . Boomsma, D. I. (2016). Genetic and environmental influences interact with age and sex in shaping the human methylome. Nature Communications. https://doi.org/10.1038/ncomms11115
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
