Insights into the activation mechanism of class I HDAC complexes by inositol phosphates

Watson, Peter J., Millard, Christopher J., Riley, Andrew M., Robertson, Naomi S., Wright, Lyndsey C., Godage, Himali Y., Cowley, Shaun M., Jamieson, Andrew G., Potter, Barry V. L., Schwabe, John W. R.·2016·Nature Communications
DOI 10.1038/ncomms11262

Cited by (264)

Items 201–264 of 264

  1. Inhibition of histone deacetylase (HDAC) isoforms by hibiscus cannabinus phytochemicals
    Valens Munyembaraga, Sunday Amos Onikanni, Adewale Oluwaseun Fadaka, Tran Nhat Phong Dao, Nicole Remaliah Samantha Sibuyi, Omolola Esther Amos, Morenike Grace Ajayi, Oluwafemi Shittu Bakare, Hen‐Hong Chang, Leandro Miranda‐Alves · 2025 · Next research.
  2. Novel 5‐(Trifluoromethyl)‐1,2,4‐Oxadiazole Substituted Benzamide Derivatives Containing 5‐(Trifluoromethyl)‐1,2,4‐Oxadiazole Moiety: Design, Synthesis, Anti‐Rust and In Silico Study
    Chang-Kuan Fu, Jian Wang, You‐Chang Wei, Cheng‐Xia Tan, Tianming Xu, Li‐Jing Min, Ningjie Wu, Xing‐Hai Liu · 2025 · Journal of Heterocyclic Chemistry
  3. Investigation of the histone deacetylase inhibitor potential of phorbazole analogues
    Ida Amalie Nystad Reierth, Yngve Guttormsen, Jeanette Hammer Andersen, Espen Holst Hansen, Ahmed Mossad Abdelhady, Manuel K. Langer, Bengt Erik Haug, Annette Bayer, Guillaume A. Petit · 2025 · Bioorganic & Medicinal Chemistry
  4. Cellular Target Engagement and Dissociation Kinetics of Class I-Selective Histone Deacetylase (HDAC) Inhibitors
    Irina Honin, Zora Nováková, Felix Feller, Simon Schneider, Linda Schäker‐Hübner, Cyril Bařinka, Finn K. Hansen · 2026 · International Journal of Molecular Sciences
  5. Synthesis and evaluation of novel N-arylamide-quinoline derivatives as HDAC isoform-selective inhibitors: in vitro and in vivo anticancer efficacy and pharmacokinetic studies
    Bingyan Yu, Ning Wang, Gaojie Lou, Lingjie Wu, Yule Wang, Sijia Yin, Yi Lu, Jun Xu, Ze Wang, Xinyuan Chen et al. · 2026 · Bioorganic Chemistry
  6. Class I histone deacetylase inhibition by aryl butenoic acid derivatives: In silico and in vitro studies
    Gamze Bora, Suat Sarı, Gülce Taşkor Önel, Sevim Dalkara, Hayat Erdem‐Yurter · 2019 · Journal of Research in Pharmacy
  7. Exploring the potential of Andrographis paniculata for developing novel HDAC inhibitors: an in silico approach
    Debalina Das, Ritesh Banerjee, Maumita Bandyopadhyay, Anish Nag · 2023 · Journal of Biomolecular Structure and Dynamics
  8. Oxidation/Alkylation of Amino Acids with α-Bromo Carbonyls Catalyzed by Copper and Quick Access to HDAC Inhibitor
    Yuqiong Tan, Huan Xiang, Jiayan Jin, Xingrui He, Shijun Li, Yang Ye · 2023 · The Journal of Organic Chemistry
  9. Futuristic Approaches Towards Designing of Isozyme-Selective Histone Deacetylase Inhibitors Against Zinc-Dependent Histone Deacetylases
    Shabir Ahmad Ganai · 2020 · Springer eBooks
  10. Structural Biology of Epigenetic Targets: Exploiting Complexity
    Martin Marek, Tajith Baba Shaik, Christophe Romier · 2019 · Methods and principles in medicinal chemistry
  11. βA3/A1-crystallin is an epigenetic regulator of histone deacetylase 3 (HDAC3) in the retinal pigmented epithelial (RPE) cells
    Sujan Chatterjee, Sayan Ghosh, Zachary Sin, Emily Davis, Loretta Viera Preval, Nguyen Tran, Sridhar Bammidi, Pooja Gautam, Stacey Hose, Yuri V. Sergeev et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  12. Studies Towards Broadening The Substrate Profile And Regulation Of Histone Deacetylase 1
    Dhanusha A. Nalawansha · 2016 · Human Biology
  13. Analysis of the physiological role of histone deacetylase 3 (HDAC3) and its regulation by inositol phosphates
    Lyndsey C. Wright · 2017 · Figshare
  14. Hydroxamic Acid-Containing Peptides in the Study of Histone Deacetylases
    Carlos Moreno–Yruela, Christian Adam Olsen · 2019 · Topics in medicinal chemistry
  15. Understanding the Architecture, Assembly, and Interactome of the Nucleosome Remodelling and Deacetylase (NuRD) Complex
    Mehdi Sharifi Tabar · 2019 · The Sydney eScholarship Repository (The University of Sydney)
  16. Molecular basis of UHRF1 allosteric activation for synergistic histone modification binding by PI5P
    Papita Mandal, Zhadyra Yerkesh, Vladlena Kharchenko, Levani Zandarashvili, Dalila Bensaddek, Łukasz Jaremko, Ben E. Black, Wolfgang Fischle · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  17. [Investigation of operative process in treating lumbar intervertebral disc protrusion in aged patients].
    Long-Jun Zhang, Xiao-Dong Zheng, Jianliang Chen, Ying-Gang Shao, Jing Chen · 2013 · PubMed
  18. First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Inhibitors of Neuroblastoma Cell Colony Growth That Increase Lysosome Accumulation
    Daniel Herp, Johannes Ridinger, Dina Robaa, Stephen A. Shinsky, Karin Schmidtkunz, Talha Z. Yesiloglu, Theresa Bayer, Peter A. Sehr, Nikolas Gunkel, Aubry K. Miller et al. · 2020 · ChemRxiv
  19. Function and mechanism of PA200 proteasome-mediated protein degradation
    Tian-Xia Jiang, Xiao‐Bo Qiu · 2022 · Scientia Sinica Vitae
  20. Discovery of Structurally Novel HDAC Inhibitors from In-House Trans-Β-Arylacryl Tetrahydroisoquinoline Derivatives as Potential Anti-Tumor Therapeutics
    Xin Gao, Weiwei Han, Shiyi Tian, Fang Fang, Xiaodong Ma, Huayi Chai, Jingjing Han · 2022 · SSRN Electronic Journal
  21. Targeting reader domains of the epigenetic code
    Nicolas Bauer · 2024
  22. Additional file 3 of Increased genital mucosal cytokines in Canadian women associate with higher antigen-presenting cells, inflammatory metabolites, epithelial barrier disruption, and the depletion of L. crispatus
    Christina Farr Zuend, Alana Lamont, Laura Noël‐Romas, Samantha Knodel, Kenzie Birse, Kateryna Kratzer, Peter McQueen, Michelle Perner, Hossaena Ayele, Sarah A. Mutch et al. · 2023 · Figshare
  23. Additional file 5 of Increased genital mucosal cytokines in Canadian women associate with higher antigen-presenting cells, inflammatory metabolites, epithelial barrier disruption, and the depletion of L. crispatus
    Christina Farr Zuend, Alana Lamont, Laura Noël‐Romas, Samantha Knodel, Kenzie Birse, Kateryna Kratzer, Peter McQueen, Michelle Perner, Hossaena Ayele, Sarah A. Mutch et al. · 2023 · Figshare
  24. Additional file 4 of Increased genital mucosal cytokines in Canadian women associate with higher antigen-presenting cells, inflammatory metabolites, epithelial barrier disruption, and the depletion of L. crispatus
    Christina Farr Zuend, Alana Lamont, Laura Noël‐Romas, Samantha Knodel, Kenzie Birse, Kateryna Kratzer, Peter McQueen, Michelle Perner, Hossaena Ayele, Sarah A. Mutch et al. · 2023 · Figshare
  25. Additional file 6 of Increased genital mucosal cytokines in Canadian women associate with higher antigen-presenting cells, inflammatory metabolites, epithelial barrier disruption, and the depletion of L. crispatus
    Christina Farr Zuend, Alana Lamont, Laura Noël‐Romas, Samantha Knodel, Kenzie Birse, Kateryna Kratzer, Peter McQueen, Michelle Perner, Hossaena Ayele, Sarah A. Mutch et al. · 2023 · Figshare
  26. Multiple inositol phosphate species enhance stability of active mTOR
    Lucia E. Rameh, John D. York, Raymond D. Blind · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  27. Design, Synthesis, and Biological Evaluation of Β-Carboline Derivatives as Selective Hdac1/2 Inhibitors with Potential Antitumor Effects
    Qingchun Zhao, Zhiya Wang, Limeng Wu, Kaisi Yang, Yiming Qi, Zhenshu Li, Wenjie Liu, Xiangbo Xu, Fangyuan Zheng, Wenbo Zeng et al. · 2025 · SSRN Electronic Journal
  28. Hispidulin: a potential alternative to vorinostat against HDAC1 for acute myeloid leukemia
    Sathyanarayan Balaji, Suvitha Anbarasu, Sudha Ramaiah, Anand Anbarasu · 2025 · Discover Oncology
  29. Design, synthesis, and biological evaluation of phenylisoxazole-based histone deacetylase inhibitors
    Xiuguang Qin, Meng Han, Peng Hu, Huadong Que, Zhen-lei Shao, Dong Yan · 2025 · PLoS ONE
  30. Additional file 1 of Increased genital mucosal cytokines in Canadian women associate with higher antigen-presenting cells, inflammatory metabolites, epithelial barrier disruption, and the depletion of L. crispatus
    Christina Farr Zuend, Alana Lamont, Laura Noël‐Romas, Samantha Knodel, Kenzie Birse, Kateryna Kratzer, Peter McQueen, Michelle Perner, Hossaena Ayele, Sarah A. Mutch et al. · 2023 · Figshare
  31. Additional file 2 of Increased genital mucosal cytokines in Canadian women associate with higher antigen-presenting cells, inflammatory metabolites, epithelial barrier disruption, and the depletion of L. crispatus
    Christina Farr Zuend, Alana Lamont, Laura Noël‐Romas, Samantha Knodel, Kenzie Birse, Kateryna Kratzer, Peter McQueen, Michelle Perner, Hossaena Ayele, Sarah A. Mutch et al. · 2023 · Figshare
  32. Etude structurale du complexe de remodelage de la chromatine NuRD et sa sous-unité MBD3 liée à l'ADN
    Rachel Tabaroni · 2018 · theses.fr (ABES)
  33. Impact du microbiote sur les fonctions immuno-régulatrices des cellules épithéliales intestinales humaines
    Camille Martin‐Gallausiaux · 2018 · theses.fr (ABES)
  34. Biochemical, biophysical and structural study of proteins associated to human diseases : tcDAC2 and ADAT complex
    Elizabeth Ramos‐Morales · 2021 · theses.fr (ABES)
  35. Phosphoinositides and inositol phosphates as molecular glues
    Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind · 2026 · FEBS Letters
  36. Multivalent interactions mediate SNAIL transcription factor stimulation of the nucleosome deacetylase activity of the CoREST complex
    Eunju Nam, Manuel Osorio‐Valeriano, Zhipeng A. Wang, Samuel D. Whedon, Hanjie Jiang, Maggie Xinran Zhang, Sarah E. DuBois-Coyne, Ishraq A. Haque, Jennifer Jiang, Jennifer Ferreira et al. · 2026 · Nucleic Acids Research
  37. Design, Synthesis, and Antitumor Activities of Novel Coumarin-Based Histone Deacetylase Inhibitors
    Sichang Yan, Jie Chang, Dongyu Lei, Xiangyang Lv, YJ Li, Yue Zhuo, Lu Jin, Le Pan · 2026 · Biomolecules
  38. Design, synthesis, and evaluation of anti-solid-tumor activity of niclosamide-based STAT3/HDAC dual-target inhibitors
    Yuchen Shi, 张齐好, C F Wang, Zipeng Lu, Fangfang Chen, H F Liu, Zhouyang Xu, Yuan Zhang, Shumei Ma, Faqing Ye et al. · 2026 · Bioorganic Chemistry
  39. Structure-Based Discovery of Trifluoromethyl Oxadiazole Oxime Ethers as Potent Histone Deacetylase Inhibitors
    Shuyu Dong, Fang Qin, Zongwei Lu, Kai Zhang, Yixuan Fu, Meiyun Peng, Hong‐Yan Lin, Meng Cai, Ge Wei, Xiao‐Lei Zhu et al. · 2026 · Journal of Agricultural and Food Chemistry
  40. Microbiota-driven epigenetic programming of local immunity
    Su Jin Lim, Young Min Son · 2026 · Frontiers in Immunology
  41. Novel 1,2,4-oxadiazole-pyrimidine hybrids: Design, synthesis, and mechanistic insights into potent anti-rust agents via integrated in vivo and in silico approaches
    Zhen-yu Lian, Jian Wang, Tianming Xu, Li‐Jing Min, Ningjie Wu, Xing‐Hai Liu · 2026 · Journal of the Indian Chemical Society
  42. Schaftoside from galgeuntang as a multi-target class I histone deacetylase inhibitor: Integrated molecular docking, dynamics, and systems pharmacology analysis
    Fahad Hassan Shah, Jung Sig Cho, Seung Hyeun Lee, Young Rae Jo, Seok Jae Huh, Hyung-Joo Chung, Junyang Jung, Na Young Jeong · 2026 · Computational Biology and Chemistry
  43. BindingDB Entry 50008290: Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors.
    BindingDB · 2021 · UC San Diego
  44. BindingDB Entry 50020288: 2-Substituted 1,5-benzothiazepine-based HDAC inhibitors exert anticancer activities on human solid and acute myeloid leukemia cell lines.
    BindingDB · 2024 · UC San Diego
  45. BindingDB Entry 50001930: Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
    BindingDB · 2020 · UC San Diego
  46. BindingDB Entry 50010450: Novel alkoxyamide-based histone deacetylase inhibitors reverse cisplatin resistance in chemoresistant cancer cells.
    BindingDB · 2021 · UC San Diego
  47. BindingDB Entry 50013991: Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model.
    BindingDB · 2022 · UC San Diego
  48. BindingDB Entry 50020467: Discovery of Novel Fedratinib-Based HDAC/JAK/BRD4 Triple Inhibitors with Remarkable Antitumor Activity against Triple Negative Breast Cancer.
    BindingDB · 2024 · UC San Diego
  49. BindingDB Entry 50001796: Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity.
    BindingDB · 2020 · UC San Diego
  50. BindingDB Entry 50008152: Discovery of 1,2,4-oxadiazole-Containing hydroxamic acid derivatives as histone deacetylase inhibitors potential application in cancer therapy.
    BindingDB · 2021 · UC San Diego
  51. BindingDB Entry 50000278: Class I HDAC Inhibitors Display Different Antitumor Mechanism in Leukemia and Prostatic Cancer Cells Depending on Their p53 Status.
    BindingDB · 2019 · UC San Diego
  52. BindingDB Entry 50023024: Multicomponent syntheses enable the discovery of novel quisinostat-derived chemotypes as histone deacetylase inhibitors.
    BindingDB · 2026 · UC San Diego
  53. BindingDB Entry 50019892: Discovery of HDAC6, HDAC8, and 6/8 Inhibitors and Development of Cell-Based Drug Screening Models for the Treatment of TGF-β-Induced Idiopathic Pulmonary Fibrosis.
    BindingDB · 2024 · UC San Diego
  54. BindingDB Entry 50012424: Structure-activity relationship and mechanistic studies for a series of cinnamyl hydroxamate histone deacetylase inhibitors.
    BindingDB · 2022 · UC San Diego
  55. BindingDB Entry 50000483: Design, synthesis and biological evaluation of quinoline derivatives as HDAC class I inhibitors.
    BindingDB · 2019 · UC San Diego
  56. BindingDB Entry 50017531: Antitumor activity of novel POLA1-HDAC11 dual inhibitors.
    BindingDB · 2023 · UC San Diego
  57. BindingDB Entry 50023724: Bifunctionality and Antitumor Efficacy of ZG-126, a Vitamin D Receptor Agonist/Histone Deacetylase Inhibitor Hybrid Molecule.
    BindingDB · 2026 · UC San Diego
  58. BindingDB Entry 50015516: Cysteine derivatives as acetyl lysine mimics to inhibit zinc-dependent histone deacetylases for treating cancer.
    BindingDB · 2023 · UC San Diego
  59. BindingDB Entry 50011127: Design, synthesis and anticancer activities of novel dual poly(ADP-ribose) polymerase-1/histone deacetylase-1 inhibitors.
    BindingDB · 2021 · UC San Diego
  60. BindingDB Entry 50020539: The evolution of small molecule enzyme activators.
    BindingDB · 2024 · UC San Diego
  61. BindingDB Entry 50010412: Achiral Derivatives of Hydroxamate AR-42 Potently Inhibit Class I HDAC Enzymes and Cancer Cell Proliferation.
    BindingDB · 2021 · UC San Diego
  62. BindingDB Entry 50009567: Discovery of Novel Dual Histone Deacetylase and Mammalian Target of Rapamycin Target Inhibitors as a Promising Strategy for Cancer Therapy.
    BindingDB · 2021 · UC San Diego
  63. BindingDB Entry 50018327: Novel 2, 5-diketopiperazine derivatives as potent selective histone deacetylase 6 inhibitors: Rational design, synthesis and antiproliferative activity.
    BindingDB · 2024 · UC San Diego
  64. BindingDB Entry 50011652: Studying Histone Deacetylase Inhibition and Apoptosis Induction of Psammaplin A Monomers with Modified Thiol Group.
    BindingDB · 2022 · UC San Diego