The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Glycolytic regulation of cell rearrangement in angiogenesis
Open accessAbstract
During vessel sprouting, endothelial cells (ECs) dynamically rearrange positions in the sprout to compete for the tip position. We recently identified a key role for the glycolytic activator PFKFB3 in vessel sprouting by regulating cytoskeleton remodelling, migration and tip cell competitiveness. It is, however, unknown how glycolysis regulates EC rearrangement during vessel sprouting. Here we report that computational simulations, validated by experimentation, predict that glycolytic production of ATP drives EC rearrangement by promoting filopodia formation and reducing intercellular adhesion. Notably, the simulations correctly predicted that blocking PFKFB3 normalizes the disturbed EC rearrangement in high VEGF conditions, as occurs during pathological angiogenesis. This interdisciplinary study integrates EC metabolism in vessel sprouting, yielding mechanistic insight in the control of vessel sprouting by glycolysis, and suggesting anti-glycolytic therapy for vessel normalization in cancer and non-malignant diseases.
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Cites
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302047 · Cited by 2,894
Self-citationSimulation of biological cell sorting using a two-dimensional extended Potts model
Graner, F., & Glazier, J. A. (1992) · Physical Review Letters · doi:10.1103/physrevlett.69.2013 · Cited by 1,377
VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread
Li, X., Padhan, N., Sjöström, E. O., Roche, F. P., Testini, C., Honkura, N., Sáinz-Jaspeado, M., Gordon, E., Bentley, K., Philippides, A., et al. (2016) · Nature Communications · doi:10.1038/ncomms11017 · Cited by 149
Self-citation
Cited by
Eelen, G., de Zeeuw, P., Treps, L., Harjes, U., Wong, B. W., & Carmeliet, P. (2018) · Physiological Reviews · doi:10.1152/physrev.00001.2017 · Cited by 572
Self-citationYang, E., Wang, X., Gong, Z., Yu, M., Wu, H., & Zhang, D. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00359-5 · Cited by 494
Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors
Andrejeva, G., & Rathmell, J. C. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.004 · Cited by 373
Endothelial cell metabolism in cardiovascular physiology and disease
Pasut, A., Lama, E., Van Craenenbroeck, A. H., Kroon, J., & Carmeliet, P. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01162-x · Cited by 74
Self-citationMatrix stiffness modulates tip cell formation through the p-PXN-Rac1-YAP signaling axis
Guo, Y., Mei, F., Huang, Y., Ma, S., Wei, Y., Zhang, X., Xu, M., He, Y., Heng, B. C., Chen, L., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.05.033 · Cited by 74
Metadata
- Authors
- Cruys, B., Wong, B. W., Kuchnio, A., Verdegem, D., Cantelmo, A. R., Conradi, L.-C., Vandekeere, S., Bouché, A., Cornelissen, I., Vinckier, S., Merks, R. M. H., Dejana, E., Gerhardt, H., Dewerchin, M., Bentley, K., & Carmeliet, P.
- Venue
- Nature Communications
- Published
- 2016-07-20
- Volume
- 7
- Issue
- 1
- Pages
- 12240-12240
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2482374135
- Cited by
- 167
- References
- 3
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- gold
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- Cruys, B., Wong, B. W., Kuchnio, A., Verdegem, D., Cantelmo, A. R., Conradi, L.-C., Vandekeere, S., Bouché, A., Cornelissen, I., Vinckier, S., Merks, R. M. H., Dejana, E., Gerhardt, H., Dewerchin, M., Bentley, K., & Carmeliet, P. (2016). Glycolytic regulation of cell rearrangement in angiogenesis. Nature Communications. https://doi.org/10.1038/ncomms12240
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
