Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults

Young, Andrew L., Challen, Grant A., Birmann, Brenda M., Druley, Todd E.·2016·Nature Communications

DOI 10.1038/ncomms12484

Cited by (692)

Items 101–200 of 692

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Detection of clonal hematopoiesis of indeterminate potential in clinical sequencing of solid tumor specimens
Eric Allan Severson, Gregory Riedlinger, Caitlin F. Connelly, Jo‐Anne Vergilio, Mendel Goldfinger, Shakti H Ramkissoon, Garrett Michael Frampton, Jeffrey S. Ross, Anthony Fratella-Calabrese, Laurie M. Gay et al. · 2018 · Blood
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Bernhard Haring, Alex P. Reiner, Jingmin Liu, Deirdre Kay Tobias, Eric A. Whitsel, Jeffrey S. Berger, Pinkal M. Desai, Sylvia W Wassertheil-Smoller, Michael J. LaMonte, Kathleen M. Hayden et al. · 2021 · Journal of the American Heart Association
Donor-engrafted CHIP is common among stem cell transplant recipients with unexplained cytopenias
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High-sensitivity C-reactive protein is associated with clonal hematopoiesis of indeterminate potential
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The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene <i>Ppm1d</i> Promotes Inflammation and Non-Ischemic Heart Failure in Mice
Yura, Yoshimitsu, Miura-Yura, Emiri, Katanasaka, Yasufumi, Min, Kyung-Duk, Chavkin, Nicholas, Polizio, Ariel H., Ogawa, Hayato, Horitani, Keita, Doviak, Heather, Evans, Megan A. et al. · 2021 · Circulation Research
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Evolutionary landscape of clonal hematopoiesis in 3,359 individuals from the general population
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Underlying Causes and Therapeutic Targeting of the Inflammatory Tumor Microenvironment
Elizabeth Anne Comen, Robert L. Bowman, Maria Kleppe · 2018 · Frontiers in Cell and Developmental Biology
Clonal Hematopoiesis of Indeterminate Potential Reshapes Age-Related CVD
Sumeet A. Khetarpal, Arman Qamar, Alexander G. Bick, José J. Fuster, Sekar Kathiresan, Siddhartha Jaiswal, Pradeep Natarajan · 2019 · Journal of the American College of Cardiology
Prevalence, predictors, and outcomes of clonal hematopoiesis in individuals aged ≥80 years
Isabelle A. van Zeventer, Jonas B. Salzbrunn, Aniek O. de Graaf, Bert A. van der Reijden, H. Marike Boezen, Judith M. Vonk, Pim van der Harst, Jan Jacob Schuringa, Joop H. Jansen, Gerwin A Huls · 2021 · Blood Advances
Germline risk of clonal haematopoiesis
Alexander J. Silver, Alexander G. Bick, Michael Robert Savona · 2021 · Nature Reviews Genetics
Digital PCR: A Sensitive and Precise Method for KIT D816V Quantification in Mastocytosis
Greiner, Georg, Gurbisz, Michael, Ratzinger, Franz, Witzeneder, Nadine, Simonitsch-Klupp, Ingrid, Mitterbauer-Hohendanner, Gerlinde, Mayerhofer, Matthias, Müllauer, Leonhard, Sperr, Wolfgang R, Valent, Peter et al. · 2018 · Clinical Chemistry
High-throughput sequencing for noninvasive disease detection in hematologic malignancies
Florian Scherer, David Matthew Kurtz, Maximilian Diehn, Ash A. Alizadeh · 2017 · Blood
Clonal hematopoiesis in donors and long-term survivors of related allogeneic hematopoietic stem cell transplantation
Steffen Boettcher, Christian Matthias Wilk, Jochen Singer, Fabian Beier, Elodie Burcklen, Christian Beisel, Mónica S. Ventura Ferreira, Elise Gourri, Christoph Gassner, Beat M. Frey et al. · 2020 · Blood
Circulating tumor DNA (ctDNA) as a biomarker for lung cancer: Early detection, monitoring and therapy prediction
Michael Joe Duffy · 2023 · Tumor Biology
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Clonal hematopoiesis and inflammation – the perpetual cycle
Avagyan, Serine, Zon, Leonard I. · 2023 · Trends in Cell Biology
Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor
Yung‐Hsin Huang, Chun-Wei Chen, Venkatasubramaniam Sundaramurthy, Mikolaj Michal Slabicki, Dapeng Hao, Caroline J. Watson, Ayala Tovy, Jaime M. Reyes, Olga Dakhova, Brielle R. Crovetti et al. · 2021 · Cancer Discovery
Concise Review: Age-Related Clonal Hematopoiesis: Stem Cells Tempting the Devil
Lambert Busque, Manuel Buscarlet, Luigina R. Mollica, Ross L. Levine · 2018 · Stem Cells
Normal Hematopoiesis Is a Balancing Act of Self-Renewal and Regeneration
Oakley C. Olson, Yoon-A Kang, Emmanuelle A. Passegue · 2020 · Cold Spring Harbor Perspectives in Medicine
Prognostic and therapeutic implications of measurable residual disease in acute myeloid leukemia
Marisa J.L. Aitken, Farhad Ravandi, Keyur Pravinchandra Patel, Nicholas James Short · 2021 · Journal of Hematology & Oncology
Clonal dynamics of haematopoiesis across the human lifespan
Emily Mitchell, Michael Spencer Chapman, Nicholas Williams, Kevin J. Dawson, Nicole Mende, Emily F. Calderbank, Hyunchul Jung, Thomas J. Mitchell, Tim H. H. Coorens, David H. Spencer et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
Connections Between Clonal Hematopoiesis, Cardiovascular Disease, and Cancer
Oscar Calvillo Arguelles, Siddhartha Jaiswal, Liran I. Shlush, Javid J. Moslehi, Aaron David Schimmer, Ana Barac, Paaladinesh Thavendiranathan · 2019 · JAMA Cardiology
Mutational spectrum and dynamics of clonal hematopoiesis in anemia of older individuals
Isabelle A. van Zeventer, Aniek O. de Graaf, Hanneke J. C. M. Wouters, Bert A. van der Reijden, Melanie M. van der Klauw, Theo M. de Witte, Marianne A. Jonker, Luca Malcovati, Joop H. Jansen, Geert A. Huls · 2020 · Blood
Integrative analysis of multi-omics data for liquid biopsy
Geng Chen, Jing Zhang, Qiaoting Fu, Valérie Taly, Fei Tan · 2022 · British Journal of Cancer
Environmental influences on clonal hematopoiesis
Katherine Y. King, Yun Huang, Daisuke Nakada, Margaret A. Goodell · 2019 · Experimental Hematology
Genome Sequencing during a Patient’s Journey through Cancer
Nangalia, Jyoti, Campbell, Peter J. · 2019 · New England Journal of Medicine
Clonal Hematopoiesis in Clinical and Experimental Heart Failure With Preserved Ejection Fraction
Jesse D. Cochran, Yoshimitsu Yura, Mark Charles Thel, Heather Doviak, Ariel Héctor Polizio, Yuka Arai, Yohei Arai, Keita Horitani, Eunbee Park, Nicholas W. Chavkin et al. · 2023 · Circulation
Genomic profiling of a randomized trial of interferon-α vs hydroxyurea in MPN reveals mutation-specific responses
Trine Alma Knudsen, Vibe Skov, Kristen E. Stevenson, Lillian L. Werner, William Duke, Charles Laurore, Christopher James Gibson, Anwesha Nag, Aaron R. Thorner, Bruce M. Wollison et al. · 2021 · Blood Advances
Synonymous mutations reveal genome-wide levels of positive selection in healthy tissues
Gladys Y. P. Poon, Caroline J. Watson, Daniel S. Fisher, Jamie R. Blundell · 2021 · Nature Genetics
Stool and blood biomarkers for colorectal cancer management: an update on screening and disease monitoring
Alessandro Mannucci, Ajay Goel · 2024 · Molecular Cancer
The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly
Pinese, Mark, Lacaze, Paul, Rath, Emma M., Stone, Andrew, Brion, Marie-Jo, Ameur, Adam, Nagpal, Sini, Puttick, Clare, Husson, Shane, Degrave, Dmitry et al. · 2020 · Nature Communications
Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics
Md Mesbah Uddin, Ying Zhou, Alexander G. Bick, Bala Bharathi Burugula, Siddhartha Jaiswal, Pinkal M. Desai, Michael C. Honigberg, Shelly-Ann M. Love, Ana Barac, Kathleen M. Hayden et al. · 2022 · Immunity & Ageing
Screening for Coronary Artery Disease in Cancer Survivors
Ragani Velusamy, Mark T. Nolan, Andrew James Murphy, Paaladinesh Thavendiranathan, Thomas Hugh Marwick · 2023 · JACC CardioOncology
41BB-based and CD28-based CD123-redirected T-cells ablate human normal hematopoiesis in vivo
Matteo Libero Baroni, Diego Sánchez‐Martínez, Francisco Gutiérrez‐Agüera, Heleia Roca-Ho, María Castellà, Samanta Romina Zanetti, Talía Velasco-Hernández, Rafael Díaz de la Guardia, Julio Castaño, Eduardo Anguita et al. · 2020 · Journal for ImmunoTherapy of Cancer
Clonal hematopoiesis and non-hematologic disorders
Jaiswal, Siddhartha · 2020 · Blood
Clonal Hematopoiesis: A New Step Linking Inflammation to Heart Failure
Yoshimitsu Yura, Soichi Sano, Kenneth X. Walsh · 2020 · JACC Basic to Translational Science
Increased prevalence of clonal hematopoiesis of indeterminate potential amongst people living with HIV
Alexander G. Bick, Konstantin Popadin, Christian W. Thorball, Md Mesbah Uddin, Markella V. Zanni, Bing Yu, Matthias Cavassini, Andri Rauch, Philip Tarr, Patrick Schmid et al. · 2022 · Scientific Reports
Clonal hematopoiesis as a model for premalignant changes during aging
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Recent advances in understanding clonal haematopoiesis in aplastic anaemia
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Combined genetic mutations and DNA-methylated genes as biomarkers for endometrial cancer detection from cervical scrapings
Phui‐Ly Liew, Rui Huang, Tzu-I Wu, Chi-Chun Liao, Chien-Wen Chen, Po‐Hsuan Su, Hui-Chen Wang, Yu‐Chun Weng, Hung‐Cheng Lai · 2019 · Clinical Epigenetics
Clonal hematopoiesis in cancer
Soo Jean Park, Rafael L. Bejar · 2020 · Experimental Hematology
Prevalence and dynamics of clonal hematopoiesis caused by leukemia-associated mutations in elderly individuals without hematologic disorders
Danica Midic, Jenny Rinke, Florian Perner, Violetta Müller, Anna Hinze, Frank Pester, Jürgen Landschulze, Jana Ernst, Bernd Gruhn, Georg Matziolis et al. · 2020 · Leukemia
Assessing clonal haematopoiesis: clinical burdens and benefits of diagnosing myelodysplastic syndrome precursor states
Lukasz P. Gondek, Amy Elizabeth Dezern · 2019 · The Lancet Haematology
Clonal Hematopoiesis: Somatic Mutations in Blood Cells and Atherosclerosis
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Preleukemia: one name, many meanings
Harold Phillip Koeffler, Genevieve Xin Yin Leong · 2016 · Leukemia
High prevalence of clonal hematopoiesis in the blood and bone marrow of healthy volunteers
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Shared genetic and epigenetic changes link aging and cancer
Daniel J. Zabransky, Elizabeth M. Jaffee, Ashani T. Weeraratna · 2022 · Trends in Cell Biology
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Francesco Marchetti, Renato Cardoso, Connie L. Chen, George R. Douglas, Joanne M. Elloway, Patricia A. Escobar, Tod A. Harper, Robert H. Heflich, Darren Kidd, Anthony M. Lynch et al. · 2023 · Mutation Research/Reviews in Mutation Research
ASXL1 mutation in clonal hematopoiesis
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Preleukemic Hematopoietic Stem Cells in Human Acute Myeloid Leukemia
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