Genome Sequencing during a Patient’s Journey through Cancer

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works

Signatures of mutational processes in human cancer

Initiative, A. P. C. G., Alexandrov, L. B., ICGC Breast Cancer Consortium, ICGC MMML-Seq Consortium, PedBrain, I., Nik-Zainal, S., Wedge, D. C., Aparicio, S. A. J. R., Behjati, S., Biankin, A. V., et al. (2013) · Nature · doi:10.1038/nature12477 · Cited by 9,660 · see citing works

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

Le, D. T., Uram, J. N., Wang, H., Bartlett, B. R., Kemberling, H., Eyring, A. D., Skora, A. D., Luber, B. S., Azad, N. S., Laheru, D., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1500596 · Cited by 9,377 · see citing works

Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer

Rizvi, N. A., Hellmann, M. D., Snyder, A., Kvistborg, P., Makarov, V., Havel, J. J., Lee, W., Yuan, J., Wong, P., Ho, T. S., et al. (2015) · Science · doi:10.1126/science.aaa1348 · Cited by 7,802 · see citing works

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

Gerlinger, M., Rowan, A. J., Horswell, S., Larkin, J., Endesfelder, D., Gronroos, E., Martinez, P., Matthews, N., Stewart, A., Tarpey, P., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1113205 · Cited by 7,774 · see citing works

Improved survival with vemurafenib in melanoma with BRAF V600E mutation

Chapman, P. B., Hauschild, A., Robert, C., Haanen, J. B., Ascierto, P., Larkin, J., Dummer, R., Garbe, C., Testori, A., Maio, M., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1103782 · Cited by 7,720 · see citing works

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Farmer, H., McCabe, N., Lord, C. J., Tutt, A. N. J., Johnson, D. A., Richardson, T. B., Santarosa, M., Dillon, K. J., Hickson, I., Knights, C., et al. (2005) · Nature · doi:10.1038/nature03445 · Cited by 6,683 · see citing works

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

METABRIC Group, Curtis, C., Shah, S. P., Chin, S.-F., Turashvili, G., Rueda, O. M., Dunning, M. J., Speed, D., Lynch, A. G., Samarajiwa, S., et al. (2012) · Nature · doi:10.1038/nature10983 · Cited by 6,097 · see citing works

Erlotinib in Previously Treated Non–Small-Cell Lung Cancer

Shepherd, F. A., Rodrigues Pereira, J., Ciuleanu, T., Tan, E. H., Hirsh, V., Thongprasert, S., Campos, D., Maoleekoonpiroj, S., Smylie, M., Martins, R., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050753 · Cited by 5,419 · see citing works

Age-related clonal hematopoiesis associated with adverse outcomes

Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841 · see citing works

<i>MET</i> Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling

Engelman, J. A., Zejnullahu, K., Mitsudomi, T., Song, Y., Hyland, C., Park, J. O., Lindeman, N., Gale, C.-M., Zhao, X., Christensen, J., et al. (2007) · Science · doi:10.1126/science.1141478 · Cited by 4,496 · see citing works

Genomic classification and prognosis in acute myeloid leukemia

Papaemmanuil, E., Gerstung, M., Bullinger, L., Gaidzik, V. I., Paschka, P., Roberts, N. D., Potter, N. E., Heuser, M., Thol, F., Bolli, N., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1516192 · Cited by 4,350 · see citing works

<i>K-ras</i> Mutations and Benefit from Cetuximab in Advanced Colorectal Cancer

Karapetis, C. S., Khambata-Ford, S., Jonker, D. J., O'Callaghan, C. J., Tu, D., Tebbutt, N. C., Simes, R. J., Chalchal, H., Shapiro, J. D., Robitaille, S., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0804385 · Cited by 3,622 · see citing works

Imatinib Compared with Interferon and Low-Dose Cytarabine for Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia

O’Brien, S. G., Guilhot, F., Larson, R. A., Gathmann, I., Baccarani, M., Cervantes, F., Cornelissen, J. J., Fischer, T. H., Hochhaus, A., Hughes, T. P., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022457 · Cited by 3,550 · see citing works

Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence

Genovese, G., Kähler, A. K., Handsaker, R. E., Lindberg, J., Rose, S. A., Bakhoum, S. F., Chambert, K., Mick, E., Neale, B. M., Fromer, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1409405 · Cited by 3,531 · see citing works

Comprehensive molecular characterization of clear cell renal cell carcinoma

The Cancer Genome Atlas Research Network (2013) · Nature · doi:10.1038/nature12222 · Cited by 3,485 · see citing works

Crizotinib versus Chemotherapy in Advanced <i>ALK</i> -Positive Lung Cancer

Shaw, A. T., Kim, D.-W., Nakagawa, K., Seto, T., Crinó, L., Ahn, M.-J., De Pas, T., Besse, B., Solomon, B. J., Blackhall, F., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1214886 · Cited by 3,381 · see citing works

Olaparib for Metastatic Breast Cancer in Patients with a Germline <i>BRCA</i> Mutation

Robson, M., Im, S.-A., Senkus, E., Xu, B., Domchek, S. M., Masuda, N., Delaloge, S., Li, W., Tung, N., Armstrong, A., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1706450 · Cited by 3,294 · see citing works

Discovery and saturation analysis of cancer genes across 21 tumour types

Lawrence, M. S., Stojanov, P., Mermel, C. H., Robinson, J. T., Garraway, L. A., Golub, T. R., Meyerson, M., Gabriel, S. B., Lander, E. S., & Getz, G. (2014) · Nature · doi:10.1038/nature12912 · Cited by 3,096 · see citing works

Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

McGranahan, N., Furness, A. J. S., Rosenthal, R., Ramskov, S., Lyngaa, R., Saini, S. K., Jamal-Hanjani, M., Wilson, G. A., Birkbak, N. J., Hiley, C. T., et al. (2016) · Science · doi:10.1126/science.aaf1490 · Cited by 3,065 · see citing works

Maintenance Olaparib in Patients with Newly Diagnosed Advanced Ovarian Cancer

Moore, K., Colombo, N., Scambia, G., Kim, B.-G., Oaknin, A., Friedlander, M., Lisyanskaya, A., Floquet, A., Leary, A., Sonke, G. S., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1810858 · Cited by 2,870 · see citing works

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

Sharma, S. V., Lee, D. Y., Li, B., Quinlan, M. P., Takahashi, F., Maheswaran, S., McDermott, U., Azizian, N., Zou, L., Fischbach, M. A., et al. (2010) · Cell · doi:10.1016/j.cell.2010.02.027 · Cited by 2,770 · see citing works

Circulating mutant DNA to assess tumor dynamics

Diehl, F., Schmidt, K., Choti, M. A., Romans, K. E., Goodman, S. N., Li, M., Thornton, K. A., Agrawal, N., Sokoll, L. J., Szabo, S., et al. (2008) · Nature Medicine · doi:10.1038/nm.1789 · Cited by 2,747 · see citing works

Whole genomes redefine the mutational landscape of pancreatic cancer

Initiative, A. P. C. G., Waddell, N., Pajic, M., Patch, A.-M., Chang, D. K., Kassahn, K. S., Bailey, P., Johns, A. L., Miller, D., Nones, K., et al. (2015) · Nature · doi:10.1038/nature14169 · Cited by 2,642 · see citing works

Massive genomic rearrangement acquired in a single catastrophic event during cancer development

Stephens, P. J., Greenman, C. D., Fu, B., Yang, F., Bignell, G. R., Mudie, L. J., Pleasance, E. D., Lau, K. W., Beare, D., Stebbings, L. A., et al. (2011) · Cell · doi:10.1016/j.cell.2010.11.055 · Cited by 2,414 · see citing works

Tracking the Evolution of Non–Small-Cell Lung Cancer

Jamal-Hanjani, M., Wilson, G. A., McGranahan, N., Birkbak, N. J., Watkins, T. B. K., Veeriah, S., Shafi, S., Johnson, D. H., Mitter, R., Rosenthal, R., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1616288 · Cited by 2,349 · see citing works

Maintenance Olaparib for Germline <i>BRCA</i> -Mutated Metastatic Pancreatic Cancer

Golan, T., Hammel, P., Reni, M., Van Cutsem, E., Macarulla, T., Hall, M. J., Park, J.-O., Hochhauser, D., Arnold, D., Oh, D.-Y., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1903387 · Cited by 2,302 · see citing works

Comprehensive Characterization of Cancer Driver Genes and Mutations

Bailey, M. H., Tokheim, C., Porta-Pardo, E., Sengupta, S., Bertrand, D., Weerasinghe, A., Colaprico, A., Wendl, M. C., Kim, J., Reardon, B., et al. (2018) · Cell · doi:10.1016/j.cell.2018.02.060 · Cited by 2,256 · see citing works

Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer

Dawson, S.-J., Tsui, D. W. Y., Murtaza, M., Biggs, H., Rueda, O. M., Chin, S.-F., Dunning, M. J., Gale, D., Forshew, T., Mahler-Araujo, B., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1213261 · Cited by 2,207 · see citing works

A Landscape of Pharmacogenomic Interactions in Cancer

Iorio, F., Knijnenburg, T. A., Vis, D. J., Bignell, G. R., Menden, M. P., Schubert, M., Aben, N., Gonçalves, E., Barthorpe, S., Lightfoot, H., et al. (2016) · Cell · doi:10.1016/j.cell.2016.06.017 · Cited by 2,090 · see citing works

Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)

Thatcher, N., Chang, A., Parikh, P., Rodrigues Pereira, J., Ciuleanu, T., von Pawel, J., Thongprasert, S., Tan, E. H., Pemberton, K., Archer, V., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67625-8 · Cited by 2,079 · see citing works

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

Ding, L., Ley, T. J., Larson, D. E., Miller, C. A., Koboldt, D. C., Welch, J. S., Ritchey, J. K., Young, M. A., Lamprecht, T., McLellan, M. D., et al. (2012) · Nature · doi:10.1038/nature10738 · Cited by 1,993 · see citing works

Combined BRAF and MEK Inhibition versus BRAF Inhibition Alone in Melanoma

Long, G. V., Stroyakovskiy, D., Gogas, H. J., Levchenko, E., de Braud, F., Larkin, J., Garbe, C., Jouary, T., Hauschild, A., Grob, J., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1406037 · Cited by 1,916 · see citing works

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

Abbosh, C., Birkbak, N. J., Wilson, G. A., Jamal‐Hanjani, M., Constantin, T. P., Salari, R., Quesne, J. P. C. L., Moore, D. A., Veeriah, S., Rosenthal, R., et al. (2017) · Nature · doi:10.1038/nature22364 · Cited by 1,880 · see citing works

Age-related mutations associated with clonal hematopoietic expansion and malignancies

Xie, M., Lu, C., Wang, J., McLellan, M. D., Johnson, K. J., Wendl, M. C., McMichael, J. F., Schmidt, H. K., Yellapantula, V., Miller, C. A., et al. (2014) · Nature Medicine · doi:10.1038/nm.3733 · Cited by 1,874 · see citing works

Pan-cancer patterns of somatic copy number alteration

Zack, T. I., Schumacher, S. E., Carter, S. L., Cherniack, A. D., Saksena, G., Tabak, B., Lawrence, M. S., Zhang, C., Wala, J. A., Mermel, C. H., et al. (2013) · Nature Genetics · doi:10.1038/ng.2760 · Cited by 1,843 · see citing works

Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy

Brown, C. E., Alizadeh, D., Starr, R., Weng, L., Wagner, J. R., Naranjo, A., Ostberg, J. R., Blanchard, M. S., Kilpatrick, J., Simpson, J., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1610497 · Cited by 1,842 · see citing works

Highly Recurrent <i>TERT</i> Promoter Mutations in Human Melanoma

Huang, F. W., Hodis, E., Xu, M. J., Kryukov, G. V., Chin, L., & Garraway, L. A. (2013) · Science · doi:10.1126/science.1229259 · Cited by 1,816 · see citing works

<i>TERT</i> Promoter Mutations in Familial and Sporadic Melanoma

Horn, S., Figl, A., Rachakonda, P. S., Fischer, C., Sucker, A., Gast, A., Kadel, S., Moll, I., Nagore, E., Hemminki, K., et al. (2013) · Science · doi:10.1126/science.1230062 · Cited by 1,799 · see citing works

Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing

Imielinski, M., Berger, A. H., Hammerman, P. S., Hernandez, B., Pugh, T. J., Hodis, E., Cho, J., Suh, J., Capelletti, M., Sivachenko, A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.029 · Cited by 1,789 · see citing works

The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers

Diaz Jr, L. A., Williams, R. T., Wu, J., Kinde, I., Hecht, J. R., Berlin, J., Allen, B., Bozic, I., Reiter, J. G., Nowak, M. A., et al. (2012) · Nature · doi:10.1038/nature11219 · Cited by 1,713 · see citing works

A comprehensive catalogue of somatic mutations from a human cancer genome

Pleasance, E. D., Cheetham, R. K., Stephens, P. J., McBride, D. J., Humphray, S. J., Greenman, C. D., Varela, I., Lin, M.-L., Ordóñez, G. R., Bignell, G. R., et al. (2010) · Nature · doi:10.1038/nature08658 · Cited by 1,696 · see citing works

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

Murtaza, M., Dawson, S.-J., Tsui, D. W. Y., Gale, D., Forshew, T., Piskorz, A. M., Parkinson, C., Chin, S.-F., Kingsbury, Z., Wong, A. S. C., et al. (2013) · Nature · doi:10.1038/nature12065 · Cited by 1,624 · see citing works

Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia

Lo-Coco, F., Avvisati, G., Vignetti, M., Thiede, C., Orlando, S. M., Iacobelli, S., Ferrara, F., Fazi, P., Cicconi, L., Di Bona, E., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1300874 · Cited by 1,611 · see citing works

The origin and evolution of mutations in acute myeloid leukemia

Welch, J. S., Ley, T. J., Link, D. C., Miller, C. A., Larson, D. E., Koboldt, D. C., Wartman, L. D., Lamprecht, T. L., Liu, F., Xia, J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.023 · Cited by 1,575 · see citing works

Universal Patterns of Selection in Cancer and Somatic Tissues

Martincorena, I., Raine, K. M., Gerstung, M., Dawson, K. J., Haase, K., Van Loo, P., Davies, H., Stratton, M. R., & Campbell, P. J. (2017) · Cell · doi:10.1016/j.cell.2017.09.042 · Cited by 1,523 · see citing works

Prophylactic Oophorectomy in Carriers of BRCA1 or BRCA2 Mutations

Rebbeck, T. R., Lynch, H. T., Neuhausen, S. L., Narod, S. A., Veer, L. V., Garber, J. E., Evans, D. G., Isaacs, C. J., Daly, M. B., Matloff, E. T., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012158 · Cited by 1,462 · see citing works

The Life History of 21 Breast Cancers

Nik-Zainal, S., Van Loo, P., Wedge, D. C., Alexandrov, L. B., Greenman, C. D., Lau, K. W., Raine, K., Jones, D., Marshall, J., Ramakrishna, M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.023 · Cited by 1,443 · see citing works

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

Keskin, D. B., Anandappa, A. J., Sun, J., Tirosh, I., Mathewson, N. D., Li, S., Oliveira, G., Giobbie-Hurder, A., Felt, K., Gjini, E., et al. (2019) · Nature · doi:10.1038/s41586-018-0792-9 · Cited by 1,432 · see citing works

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

Ley, T. J., Mardis, E. R., Ding, L., Fulton, B., McLellan, M. D., Chen, K., Dooling, D. J., Dunford-Shore, B. H., McGrath, S. D., Hickenbotham, M. T., et al. (2008) · Nature · doi:10.1038/nature07485 · Cited by 1,415 · see citing works

Adjuvant Docetaxel or Vinorelbine with or without Trastuzumab for Breast Cancer

Joensuu, H., Kellokumpu‐Lehtinen, P., Bono, P., Alanko, T., Kataja, V. V., Asola, R., Utriainen, T., Kokko, R., Hemminki, A., Tarkkanen, M., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa053028 · Cited by 1,401 · see citing works

Association analysis identifies 65 new breast cancer risk loci

Michailidou, K., Lindström, S., Dennis, J., Beesley, J., Hui, S., Kar, S., Lemaçon, A., Soucy, P., Glubb, D. M., Rostamianfar, A., et al. (2017) · Nature · doi:10.1038/nature24284 · Cited by 1,380 · see citing works

Evolution and impact of subclonal mutations in chronic lymphocytic leukemia

Landau, D. A., Carter, S. L., Stojanov, P., McKenna, A., Stevenson, K., Lawrence, M. S., Sougnez, C., Stewart, C., Sivachenko, A., Wang, L., et al. (2013) · Cell · doi:10.1016/j.cell.2013.01.019 · Cited by 1,379 · see citing works

Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens

Behan, F. M., Iorio, F., Picco, G., Gonçalves, E., Beaver, C. M., Migliardi, G., Santos, R., Rao, Y., Sassi, F., Pinnelli, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1103-9 · Cited by 1,338 · see citing works

Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy

Davoli, T., Uno, H., Wooten, E. C., & Elledge, S. J. (2017) · Science · doi:10.1126/science.aaf8399 · Cited by 1,325 · see citing works

The patterns and dynamics of genomic instability in metastatic pancreatic cancer

Campbell, P. J., Yachida, S., Mudie, L. J., Stephens, P. J., Pleasance, E. D., Stebbings, L. A., Morsberger, L. A., Latimer, C., McLaren, S., Lin, M.-L., et al. (2010) · Nature · doi:10.1038/nature09460 · Cited by 1,317 · see citing works

Punctuated Evolution of Prostate Cancer Genomes

Baca, S. C., Prandi, D., Lawrence, M. S., Mosquera, J. M., Romanel, A., Drier, Y., Park, K., Kitabayashi, N., MacDonald, T. Y., Ghandi, M., et al. (2013) · Cell · doi:10.1016/j.cell.2013.03.021 · Cited by 1,300 · see citing works

Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution

McGranahan, N., Rosenthal, R., Hiley, C. T., Rowan, A. J., Watkins, T. B. K., Wilson, G. A., Birkbak, N. J., Veeriah, S., Van Loo, P., Herrero, J., et al. (2017) · Cell · doi:10.1016/j.cell.2017.10.001 · Cited by 1,298 · see citing works

Somatic<i>SF3B1</i>Mutation in Myelodysplasia with Ring Sideroblasts

Papaemmanuil, E., Cazzola, M., Boultwood, J., Malcovati, L., Vyas, P., Bowen, D., Pellagatti, A., Wainscoat, J. S., Hellstrom-Lindberg, E., Gambacorti-Passerini, C., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1103283 · Cited by 1,222 · see citing works

Genome remodelling in a basal-like breast cancer metastasis and xenograft

Ding, L., Ellis, M. J., Li, S., Larson, D. E., Chen, K., Wallis, J. W., Harris, C. C., McLellan, M. D., Fulton, R. S., Fulton, L., et al. (2010) · Nature · doi:10.1038/nature08989 · Cited by 1,134 · see citing works

Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

de Bruin, E. C., McGranahan, N., Mitter, R., Salm, M., Wedge, D. C., Yates, L., Jamal-Hanjani, M., Shafi, S., Murugaesu, N., Rowan, A. J., et al. (2014) · Science · doi:10.1126/science.1253462 · Cited by 1,117 · see citing works

Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers

Pfeifer, G. P., Denissenko, M. F., Olivier, M., Tretyakova, N. Y., Hecht, S. S., & Hainaut, P. L. (2002) · Oncogene · doi:10.1038/sj.onc.1205803 · Cited by 1,114 · see citing works

The whole-genome landscape of medulloblastoma subtypes

Northcott, P. A., Buchhalter, I., Morrissy, A. S., Hovestadt, V., Weischenfeldt, J., Ehrenberger, T., Gröbner, S., Segura-Wang, M., Zichner, T., Rudneva, V. A., et al. (2017) · Nature · doi:10.1038/nature22973 · Cited by 1,112 · see citing works

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

Davies, H., Glodzik, D., Morganella, S., Yates, L. R., Staaf, J., Zou, X., Ramakrishna, M., Martin, S., Boyault, S., Sieuwerts, A. M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4292 · Cited by 1,086 · see citing works

Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets

Brastianos, P. K., Carter, S. L., Santagata, S., Cahill, D. P., Taylor-Weiner, A. N., Jones, R. T., Allen, E. M. V., Lawrence, M. S., Horowitz, P. M., Cibulskis, K., et al. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0369 · Cited by 1,084 · see citing works

A small-cell lung cancer genome with complex signatures of tobacco exposure

Pleasance, E., Stephens, P. J., O’Meara, S., McBride, D. J., Meynert, A. M., Jones, D., Lin, M., Beare, D. M., Lau, K. W., Greenman, C., et al. (2009) · Nature · doi:10.1038/nature08629 · Cited by 1,067 · see citing works

Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

Shah, S. P., Morin, R. D., Khattra, J. S., Prentice, L., Pugh, T. J., Burleigh, A., Delaney, A. D., Gelmon, K. A., Guliany, R., Senz, J., et al. (2009) · Nature · doi:10.1038/nature08489 · Cited by 1,063 · see citing works

A Big Bang model of human colorectal tumor growth

Sottoriva, A., Kang, H., Ma, Z., Graham, T. A., Salomon, M. P., Zhao, J., Marjoram, P., Siegmund, K. D., Press, M. F., Shibata, D. K., et al. (2015) · Nature Genetics · doi:10.1038/ng.3214 · Cited by 1,010 · see citing works

The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma

Allen, E. M. V., Wagle, N., Sucker, A., Treacy, D. J., Johannessen, C. M., Goetz, E. M., Place, C. S., Taylor-Weiner, A. N., Whittaker, S. R., Kryukov, G. V., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0617 · Cited by 904 · see citing works

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

Study, T. P., Schumacher, F. R., (APCB), A. P. C. B., Study, T. I., Canary PASS Investigators, Breast and Prostate Cancer Cohort Consortium (BPC3), The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, (CAPS), C. O. T. P. I. S., Prostate Cancer Genome-wide Association Study of Uncommon Susceptibility Loci (PEGASUS), The Genetic Associations and Mechanisms in Oncology (GAME-ON)/Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) Consortium, et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0142-8 · Cited by 902 · see citing works

Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia

Wong, T. N., Ramsingh, G., Young, A. L., Miller, C. A., Touma, W., Welch, J. S., Lamprecht, T. L., Shen, D., Hundal, J., Fulton, R. S., et al. (2015) · Nature · doi:10.1038/nature13968 · Cited by 892 · see citing works

Prediction of acute myeloid leukaemia risk in healthy individuals

Abelson, S., Collord, G., Ng, S. W. K., Weissbrod, O., Mendelson Cohen, N., Niemeyer, E., Barda, N., Zuzarte, P. C., Heisler, L., Sundaravadanam, Y., et al. (2018) · Nature · doi:10.1038/s41586-018-0317-6 · Cited by 850 · see citing works

Pathogenic Germline Variants in 10,389 Adult Cancers

Huang, K., Mashl, R. J., Wu, Y., Ritter, D., Wang, J., Oh, C., Paczkowska, M., Reynolds, S. M., Wyczalkowski, M. A., Oak, N., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.039 · Cited by 838 · see citing works

Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal

Turajlic, S., Xu, H., Litchfield, K., Rowan, A., Chambers, T., Lopez, J. I., Nicol, D. L., O’Brien, T., Larkin, J., Horswell, S. D., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.057 · Cited by 831 · see citing works

Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome

Davoli, T., Xu, A. W., Mengwasser, K. E., Sack, L. M., Yoon, J. C., Park, P. J., & Elledge, S. J. (2013) · Cell · doi:10.1016/j.cell.2013.10.011 · Cited by 815 · see citing works

Non-coding recurrent mutations in chronic lymphocytic leukaemia

Puente, X. S., Beà, S., Valdés‐Mas, R., Villamor, N., Gutiérrez‐Abril, J., Martín-Subero, J. I., Munar, M., Rubio-Pérez, C., Jares, P., Aymerich, M., et al. (2015) · Nature · doi:10.1038/nature14666 · Cited by 813 · see citing works

Subclonal diversification of primary breast cancer revealed by multiregion sequencing

Yates, L. R., Gerstung, M., Knappskog, S., Desmedt, C., Gundem, G., Loo, P. V., Aas, T., Alexandrov, L. B., Larsimont, D., Davies, H., et al. (2015) · Nature Medicine · doi:10.1038/nm.3886 · Cited by 812 · see citing works

Trans-ancestry mutational landscape of hepatocellular carcinoma genomes

Totoki, Y., Tatsuno, K., Covington, K. R., Ueda, H., Creighton, C. J., Kato, M., Tsuji, S., Donehower, L. A., Slagle, B. L., Nakamura, H., et al. (2014) · Nature Genetics · doi:10.1038/ng.3126 · Cited by 781 · see citing works

Landscape of Somatic Retrotransposition in Human Cancers

Lee, E., Iskow, R., Yang, L., Gokcumen, O., Haseley, P., Luquette, L. J., Lohr, J. G., Harris, C. C., Ding, L., Wilson, R. K., et al. (2012) · Science · doi:10.1126/science.1222077 · Cited by 762 · see citing works

Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults

Young, A. L., Challen, G. A., Birmann, B. M., & Druley, T. E. (2016) · Nature Communications · doi:10.1038/ncomms12484 · Cited by 692 · see citing works

Genomic Evolution of Breast Cancer Metastasis and Relapse

Yates, L. R., Knappskog, S., Wedge, D. C., Farmery, J. H. R., González, S., Martincorena, I., Alexandrov, L. B., Loo, P. V., Haugland, H. K., Lilleng, P. K., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.07.005 · Cited by 666 · see citing works

Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal

Turajlic, S., Xu, H., Litchfield, K., Rowan, A., Horswell, S. D., Chambers, T., O’Brien, T., Lopez, J. I., Watkins, T. B. K., Nicol, D. L., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.043 · Cited by 663 · see citing works

A Compendium of Mutational Signatures of Environmental Agents

Kucab, J. E., Zou, X., Morganella, S., Joel, M., Nanda, A. S., Nagy, E., Gomez, C., Degasperi, A., Harris, R., Jackson, S. P., et al. (2019) · Cell · doi:10.1016/j.cell.2019.03.001 · Cited by 660 · see citing works

Microsatellite alterations in serum DNA of head and neck cancer patients

Nawroz, H., Koch, W. M., Anker, P., Stroun, M., & Sidransky, D. (1996) · Nature Medicine · doi:10.1038/nm0996-1035 · Cited by 656 · see citing works

Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia

O’Hare, T., Eide, C. A., & Deininger, M. W. (2007) · Blood · doi:10.1182/blood-2007-03-066936 · Cited by 634 · see citing works

Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms

Lundberg, P., Karow, A., Nienhold, R., Looser, R., Hao-Shen, H., Nissen, I., Girsberger, S., Lehmann, T., Passweg, J. R., Stern, M., et al. (2014) · Blood · doi:10.1182/blood-2013-11-537167 · Cited by 632 · see citing works

Classification and Personalized Prognosis in Myeloproliferative Neoplasms

Grinfeld, J., Nangalia, J., Baxter, E. J., Wedge, D. C., Angelopoulos, N., Cantrill, R., Godfrey, A. L., Papaemmanuil, E., Gundem, G., MacLean, C., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1716614 · Cited by 630 · see citing works

Integrative Molecular Characterization of Malignant Pleural Mesothelioma

Hmeljak, J., Sanchez-Vega, F., Hoadley, K. A., Shih, J., Stewart, C., Heiman, D., Tarpey, P., Danilova, L., Drill, E., Gibb, E. A., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0804 · Cited by 618 · see citing works

Realizing the promise of cancer predisposition genes

Rahman, N. (2014) · Nature · doi:10.1038/nature12981 · Cited by 616 · see citing works

Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: 11 year follow-up of a prospective observational study

Villani, A., Shore, A., Wasserman, J. D., Stephens, D., Kim, R. H., Druker, H., Gallinger, B., Naumer, A., Kohlmann, W., Novokmet, A., et al. (2016) · The Lancet Oncology · doi:10.1016/s1470-2045(16)30249-2 · Cited by 546 · see citing works

A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer

Polak, P., Kim, J., Braunstein, L. Z., Karlic, R., Haradhavala, N. J., Tiao, G., Rosebrock, D., Livitz, D., Kübler, K., Mouw, K. W., et al. (2017) · Nature Genetics · doi:10.1038/ng.3934 · Cited by 531 · see citing works

Development of Personalized Tumor Biomarkers Using Massively Parallel Sequencing

Leary, R. J., Kinde, I., Diehl, F., Schmidt, K., Clouser, C., Duncan, C., Antipova, A. A., Lee, C. C., McKernan, K. J., Vega, F. M. D. L., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3000702 · Cited by 517 · see citing works

Punctuated copy number evolution and clonal stasis in triple-negative breast cancer

Gao, R., Davis, A., McDonald, T. O., Sei, E., Shi, X., Wang, Y., Tsai, P. C., Casasent, T. D., Waters, J., Zhang, H., et al. (2016) · Nature Genetics · doi:10.1038/ng.3641 · Cited by 516 · see citing works

Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal

Mitchell, T. J., Turajlic, S., Rowan, A., Nicol, D. L., Farmery, J. H. R., O’Brien, T., Martincorena, I., Tarpey, P. S., Angelopoulos, N., Yates, L. R., et al. (2018) · Cell · doi:10.1016/j.cell.2018.02.020 · Cited by 502 · see citing works

Performance of a Multigene Genomic Classifier in Thyroid Nodules With Indeterminate Cytology

Steward, D. L., Carty, S. E., Sippel, R. S., Yang, S. P., Sosa, J. A., Sipos, J. A., Figge, J. J., Mandel, S. J., Haugen, B. R., Burman, K. D., et al. (2018) · JAMA Oncology · doi:10.1001/jamaoncol.2018.4616 · Cited by 493 · see citing works

Spatial genomic heterogeneity within localized, multifocal prostate cancer

Boutros, P. C., Fraser, M. E., Harding, N. J., de Borja, R., Trudel, D., Lalonde, E., Meng, A. X., Hennings-Yeomans, P. H., McPherson, A., Sabelnykova, V. Y., et al. (2015) · Nature Genetics · doi:10.1038/ng.3315 · Cited by 472 · see citing works

WRN helicase is a synthetic lethal target in microsatellite unstable cancers

Chan, E. M., Shibue, T., McFarland, J. M., Gaeta, B., Ghandi, M., Dumont, N., Gonzalez, A., McPartlan, J. S., Li, T., Zhang, Y., et al. (2019) · Nature · doi:10.1038/s41586-019-1102-x · Cited by 458 · see citing works

Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

Tubio, J. M. C., Li, Y., Ju, Y. S., Martincorena, I., Cooke, S. L., Tojo, M., Gundem, G., Pipinikas, C. P., Zamora, J., Raine, K., et al. (2014) · Science · doi:10.1126/science.1251343 · Cited by 412 · see citing works

Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups

Rueda, O. M., Sammut, S., Seoane, J. A., Chin, S., Caswell-Jin, J. L., Callari, M., Batra, R. N., Pereira, B., Bruna, A., Ali, H. R., et al. (2019) · Nature · doi:10.1038/s41586-019-1007-8 · Cited by 412 · see citing works

RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia

Papaemmanuil, E., Rapado, I., Li, Y., Potter, N. E., Wedge, D. C., Tubío, J. M. C., Alexandrov, L. B., Loo, P. V., Cooke, S. L., Marshall, J., et al. (2014) · Nature Genetics · doi:10.1038/ng.2874 · Cited by 400 · see citing works

Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics

Ding, L., Bailey, M. H., Porta-Pardo, E., Thorsson, V., Colaprico, A., Bertrand, D., Gibbs, D. L., Weerasinghe, A., Huang, K.-L., Tokheim, C., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.033 · Cited by 399 · see citing works

Only three driver gene mutations are required for the development of lung and colorectal cancers

Tomasetti, C., Marchionni, L., Nowak, M. A., Parmigiani, G., & Vogelstein, B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421839112 · Cited by 395 · see citing works

Adjuvant trastuzumab in the treatment of her-2-positive early breast cancer: a meta-analysis of published randomized trials

Viani, G. A., Afonso, S., Stefano, E. J., Fendi, L. I. D., & Soares, F. V. (2007) · BMC Cancer · doi:10.1186/1471-2407-7-153 · Cited by 381 · see citing works

Single-Molecule Detection of Epidermal Growth Factor Receptor Mutations in Plasma by Microfluidics Digital PCR in Non–Small Cell Lung Cancer Patients

Yung, T., Chan, K. C. A., Mok, T. S. K., TONG, J. H. M., To, K., & Lo, Y. M. D. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2622 · Cited by 381 · see citing works

Copy number alteration burden predicts prostate cancer relapse

Hieronymus, H., Schultz, N. D., Gopalan, A., Carver, B. S., Chang, M. T., Xiao, Y., Heguy, A., Huberman, K. H., Bernstein, M. L., Assel, M. J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411446111 · Cited by 364 · see citing works

Minimal residual disease-directed risk stratification using real-time quantitative PCR analysis of immunoglobulin and T-cell receptor gene rearrangements in the international multicenter trial AIEOP-BFM ALL 2000 for childhood acute lymphoblastic leukemia

Flohr, T., Schrauder, A., Cazzaniga, G., Panzer‐Grümayer, R., van der Velden, V., Fischer, S. H., Stanulla, M., Basso, G., Niggli, F. K., Schäfer, B. W., et al. (2008) · Leukemia · doi:10.1038/leu.2008.5 · Cited by 361 · see citing works

A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing

Alioto, T., Buchhalter, I., Derdak, S. V., Hutter, B., Eldridge, M., Hovig, E. J., Heisler, L. E., Beck, T. A., Simpson, J. T., Tonon, L., et al. (2015) · Nature Communications · doi:10.1038/ncomms10001 · Cited by 308 · see citing works

Whole-genome sequencing provides new insights into the clonal architecture of Barrett's esophagus and esophageal adenocarcinoma

Ross-Innes, C. S., Becq, J., Warren, A., Cheetham, R. K., Northen, H., O’Donovan, M., Malhotra, S., di Pietro, M., Ivakhno, S., He, M., et al. (2015) · Nature Genetics · doi:10.1038/ng.3357 · Cited by 299 · see citing works

Recurrent and functional regulatory mutations in breast cancer

Rheinbay, E., Parasuraman, P., Grimsby, J., Tiao, G., Engreitz, J., Kim, J., Lawrence, M. S., Taylor-Weiner, A. N., Rodriguez-Cuevas, S. A., Rosenberg, M. W., et al. (2017) · Nature · doi:10.1038/nature22992 · Cited by 299 · see citing works

In silico prescription of anticancer drugs to cohorts of 28 tumor types reveals targeting opportunities

Rubio-Perez, C., Tamborero, D., Schroeder, M. P., Antolín, A. A., Deu-Pons, J., Perez-Llamas, C., Mestres, J., Gonzalez-Perez, A., & Lopez-Bigas, N. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.02.007 · Cited by 296 · see citing works

Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis

Letouzé, É., Shinde, J., Renault, V., Couchy, G., Blanc, J., Tubacher, E., Bayard, Q., Bacq, D., Meyer, V., Semhoun, J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01358-x · Cited by 290 · see citing works

Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool

Poon, S. L., Pang, S., McPherson, J. R., Yu, W., Huang, K. K., Guan, P., Weng, W., Siew, E. Y., Liu, Y., Heng, H. L., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006086 · Cited by 287 · see citing works

Mutational Signature of Aristolochic Acid Exposure as Revealed by Whole-Exome Sequencing

Hoang, M. L., Chen, C., Sidorenko, V. S., He, J., Dickman, K. G., Yun, B. H., Moriya, M., Niknafs, N., Douville, C. B., Karchin, R., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006200 · Cited by 285 · see citing works

Systematic analysis of noncoding somatic mutations and gene expression alterations across 14 tumor types

Fredriksson, N. J., Ny, L., Nilsson, J. A., & Larsson, E. (2014) · Nature Genetics · doi:10.1038/ng.3141 · Cited by 282 · see citing works

Precision oncology for acute myeloid leukemia using a knowledge bank approach

Gerstung, M., Papaemmanuil, E., Martin, S., Bullinger, L., Gaidzik, V. I., Paschka, P., Heuser, M., Thol, F. R., Bolli, N., Ganly, P. S., et al. (2017) · Nature Genetics · doi:10.1038/ng.3756 · Cited by 275 · see citing works

Genotype-phenotype correlations in von Hippel-Lindau disease

Ong, K. R., Woodward, E. R., Killick, P., Lim, C., MacDonald, F., & Maher, E. R. (2006) · Human Mutation · doi:10.1002/humu.20385 · Cited by 250 · see citing works

Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions

TEIXEIRA, V. H., Pipinikas, C., Pennycuick, A., Lee-Six, H., Chandrasekharan, D. P., Beane, J., Morris, T. J., Karpathakis, A., Feber, A., Breeze, C. E., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0323-0 · Cited by 250 · see citing works

Comprehensive Genomic Profiling of Carcinoma of Unknown Primary Site

Ross, J. S., Wang, K., Gay, L. M., Otto, G. A., White, E. T., Iwanik, K., Palmer, G. A., Yelensky, R., Lipson, D., Chmielecki, J., et al. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2014.216 · Cited by 248 · see citing works

Use of cancer‐specific genomic rearrangements to quantify disease burden in plasma from patients with solid tumors

McBride, D. J., Orpana, A., Sotiriou, C. P., Joensuu, H., Stephens, P. J., Mudie, L. J., Hämäläinen, E., Stebbings, L. A., Andersson, L. C., Flanagan, A. M., et al. (2010) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20815 · Cited by 194 · see citing works

Variation in genomic landscape of clear cell renal cell carcinoma across Europe

Scélo, G., Riazalhosseini, Y., Greger, L., Létourneau, L., Gonzàlez-Porta, M., Wozniak, M. B., Bourgey, M., Harnden, P., Egevad, L., Jackson, S., et al. (2014) · Nature Communications · doi:10.1038/ncomms6135 · Cited by 190 · see citing works

Mutation Status of RAS, TP53 , and SMAD4 is Superior to Mutation Status of RAS Alone for Predicting Prognosis after Resection of Colorectal Liver Metastases

Kawaguchi, Y., Kopetz, S., Newhook, T. E., Bellis, M. D., Chun, Y. S., Tzeng, C.-W. D., Aloia, T. A., & Vauthey, J. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-0863 · Cited by 173 · see citing works

The Tandem Duplicator Phenotype Is a Prevalent Genome-Wide Cancer Configuration Driven by Distinct Gene Mutations

Menghi, F., Barthel, F. P., Yadav, V. K., Tang, M., Ji, B., Tang, Z., Carter, G. W., Ruan, Y., Scully, R., Verhaak, R. G. W., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.06.008 · Cited by 169 · see citing works

Molecular monitoring of BCR–ABL as a guide to clinical management in chronic myeloid leukaemia

Hughes, T. P., & Branford, S. (2005) · Blood Reviews · doi:10.1016/j.blre.2005.01.008 · Cited by 159 · see citing works

The evolutionary landscape of colorectal tumorigenesis

Cross, W. C. H., Kovac, M. B., Mustonen, V., Temko, D., Belnoue-Davis, H. L., Baker, A., Biswas, S., Arnold, R. R., Chegwidden, L., Gatenbee, C., et al. (2018) · Nature Ecology & Evolution · doi:10.1038/s41559-018-0642-z · Cited by 149 · see citing works

Philadelphia chromosome-negative chronic myeloproliferative neoplasms: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Vannucchi, A. M., Barbui, T., Cervantes, F., Harrison, C. N., Kiladjian, J., Kröger, N. M., Thiele, J., & Buske, C. (2015) · Annals of Oncology · doi:10.1093/annonc/mdv203 · Cited by 147 · see citing works

Conditional Selection of Genomic Alterations Dictates Cancer Evolution and Oncogenic Dependencies

Mina, M., Raynaud, F., Tavernari, D., Battistello, E., Sungalee, S., Saghafinia, S., Laessle, T., Sanchez-Vega, F., Schultz, N., Oricchio, E., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.06.010 · Cited by 129 · see citing works

SWOG S1400D (NCT02965378), a Phase II Study of the Fibroblast Growth Factor Receptor Inhibitor AZD4547 in Previously Treated Patients With Fibroblast Growth Factor Pathway–Activated Stage IV Squamous Cell Lung Cancer (Lung-MAP Substudy)

Aggarwal, C., Redman, M. W., Lara, P. N., Borghaei, H., Hoffman, P. C., Bradley, J. D., Newman, A. J., Feldman, M. J., Minichiello, K., Miao, J., et al. (2019) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2019.05.041 · Cited by 89 · see citing works

SWOG S1400B (NCT02785913), a Phase II Study of GDC-0032 (Taselisib) for Previously Treated PI3K-Positive Patients with Stage IV Squamous Cell Lung Cancer (Lung-MAP Sub-Study)

Langer, C. J., Redman, M. W., Wade, J. L., Aggarwal, C., Bradley, J. D., Crawford, J., Stella, P. J., Knapp, M. H., Miao, J., Minichiello, K., et al. (2019) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2019.05.029 · Cited by 85 · see citing works

G-to-T Transversions and Small Tandem Base Deletions Are the Hallmark of Mutations Induced by Ultraviolet A Radiation in Mammalian Cells

Nia, A. B., Synold, T. W., Xi, B., & Pfeifer, G. P. (2004) · Biochemistry · doi:10.1021/bi049761v · Cited by 83 · see citing works

SWOG S1400C (NCT02154490)—A Phase II Study of Palbociclib for Previously Treated Cell Cycle Gene Alteration–Positive Patients with Stage IV Squamous Cell Lung Cancer (Lung-MAP Substudy)

Edelman, M. J., Redman, M. W., Albain, K. S., McGary, E. C., Rafique, N. M., Petro, D. P., Waqar, S. N., Minichiello, K., Miao, J., Papadimitrakopoulou, V. A., et al. (2019) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2019.06.027 · Cited by 76 · see citing works

Mutational signature of aristolochic acid: Clue to the recognition of a global disease.

Rosenquist, T., & Grollman, A. (2016) · DNA Repair · doi:10.1016/j.dnarep.2016.05.027 · Cited by 64 · see citing works

National Cancer Institute Basket/Umbrella Clinical Trials

Chen, A. P., Eljanne, M., Harris, L. N., Malik, S. M., & Seibel, N. L. (2019) · The Cancer Journal · doi:10.1097/ppo.0000000000000389 · Cited by 25 · see citing works

Analyzing the clinical actionability of germline pharmacogenomic findings in oncology

Wellmann, R. M., Borden, B. A., Danahey, K., Nanda, R., Polite, B. N., Stadler, W. M., Ratain, M. J., & O’Donnell, P. H. (2018) · Cancer · doi:10.1002/cncr.31382 · Cited by 18 · see citing works

Sequencing of Tumor DNA to Guide Cancer Risk Assessment and Therapy

Spencer, D. H., & Ley, T. J. (2018) · JAMA · doi:10.1001/jama.2018.2281 · Cited by 11 · see citing works

Pan-cancer landscape of homologous recombination deficiency.

Nguyen, L., W. M. Martens, J., Van Hoeck, A., & Cuppen, E. (2020) · Nature communications · doi:10.1038/s41467-020-19406-4 · Cited by 532 · see citing works

A Highly Sensitive CRISPR‐Empowered Surface Plasmon Resonance Sensor for Diagnosis of Inherited Diseases with Femtomolar‐Level Real‐Time Quantification

Zheng, F. Y., Chen, Z., Li, J., Wu, R., Zhang, B., Nie, G., Xie, Z., & Zhang, H. (2022) · Advanced Science · doi:10.1002/advs.202105231 · Cited by 294 · see citing works

Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers

Duncavage, E. J., Schroeder, M. C., O’Laughlin, M., Wilson, R., MacMillan, S., Bohannon, A. S., Kruchowski, S. S., Garza, J. E., Du, F., Hughes, A. E. O., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2024534 · Cited by 293 · see citing works

Breast Cancer: A Molecularly Heterogenous Disease Needing Subtype-Specific Treatments

Testa, U., Castelli, G., & Pelosi, E. (2020) · Medical Sciences · doi:10.3390/medsci8010018 · Cited by 226 · see citing works

Guiding the global evolution of cytogenetic testing for hematologic malignancies

Akkari, Y. M. N., Baughn, L. B., Dubuc, A. M., Smith, A. C., Mallo, M., Cin, P. D., Díez‐Campelo, M., Gallego, M. S., Granada, I., Haase, D. T., et al. (2022) · Blood · doi:10.1182/blood.2021014309 · Cited by 90 · see citing works

Liquid Biopsy Based on Cell-Free DNA and RNA

Loy, C., Ahmann, L. S., Vlaminck, I. D., & Gu, W. (2024) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-110222-111259 · Cited by 86 · see citing works

Machine learning-based tissue of origin classification for cancer of unknown primary diagnostics using genome-wide mutation features

Nguyen, L., van Hoeck, A., & Cuppen, E. P. J. G. (2022) · Nature Communications · doi:10.1038/s41467-022-31666-w · Cited by 81 · see citing works

Cellular barcoding to decipher clonal dynamics in disease

Sankaran, V. G., Weissman, J. S., & Zon, L. I. (2022) · Science · doi:10.1126/science.abm5874 · Cited by 81 · see citing works

Feasibility of whole genome and transcriptome profiling in pediatric and young adult cancers

Shukla, N. N., Levine, M. F., Gundem, G., Domenico, D., Spitzer, B. G., Bouvier, N., Ossa, J. A., Głodzik, D., Medina-Martinez, J. S., Bhanot, U. K., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30233-7 · Cited by 70 · see citing works

In vivo functional screening for systems-level integrative cancer genomics

Weber, J., Braun, C. J., Saur, D., & Rad, R. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0275-9 · Cited by 57 · see citing works

Feasibility of whole‐genome sequencing‐based tumor diagnostics in routine pathology practice

Samsom, K. G., Schipper, L. J., Roepman, P., Bosch, L. J. W., Lalezari, F., Klompenhouwer, E. G., de Langen, A. J., Buffart, T. E., Riethorst, I., Schoenmaker, L., et al. (2022) · The Journal of Pathology · doi:10.1002/path.5988 · Cited by 44 · see citing works

Chromosome structural variation in tumorigenesis: mechanisms of formation and carcinogenesis

Wang, W., Li, L., & Cui, J. (2020) · Epigenetics & Chromatin · doi:10.1186/s13072-020-00371-7 · Cited by 44 · see citing works

Comparison of three commercial decision support platforms for matching of next-generation sequencing results with therapies in patients with cancer

Perakis, S. O., Weber, S., Zhou, Q. X., Graf, R., Hojas, S., Riedl, J. M., Gerger, A., Dandachi, N., Balić, M., Höefler, G., et al. (2020) · ESMO Open · doi:10.1136/esmoopen-2020-000872 · Cited by 40 · see citing works

Developing a classification of hematologic neoplasms in the era of precision medicine

Cazzola, M., & Sehn, L. H. (2022) · Blood · doi:10.1182/blood.2022015849 · Cited by 42 · see citing works

Discovery through clinical sequencing in oncology

Donoghue, M. T. A., Schram, A. M., Hyman, D. M., & Taylor, B. S. (2020) · Nature Cancer · doi:10.1038/s43018-020-0100-0 · Cited by 38 · see citing works

Challenges of diagnostic genomics in Latin America

Álvarez-Gómez, R. M., la Fuente-Hernández, M. A. D., Herrera, L. A., & Hidalgo‐Miranda, A. (2021) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2020.12.010 · Cited by 36 · see citing works

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Jacobo-Tovar, E., Medel-Sánchez, A., Durán-Castillo, C., & Guardado‐Mendoza, R. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.06.006 · Cited by 29 · see citing works

Implementing FAIR data management within the German Network for Bioinformatics Infrastructure (de.NBI) exemplified by selected use cases

Mayer, G., Müller, W., Schork, K., Uszkoreit, J., Weidemann, A., Wittig, U., Rey, M., Quast, C., Felden, J., Glöckner, F. O., et al. (2021) · Briefings in Bioinformatics · doi:10.1093/bib/bbab010 · Cited by 28 · see citing works

Molecular Tests and Target Therapies in Oncology: Recommendations from the Italian Workshop

Pinto, C., Biffoni, M., Popoli, P., Marchetti, A., Marchetti, P., Martini, N., & Normanno, N. (2021) · Future Oncology · doi:10.2217/fon-2021-0286 · Cited by 27 · see citing works

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Schwartzberg, L. S., Li, G., Tolba, K. A., Bourla, A. B., Schulze, K., Gadgil, R. Y., Fine, A. D., Lofgren, K. T., Graf, R. P., Oxnard, G. R., et al. (2022) · JTO Clinical and Research Reports · doi:10.1016/j.jtocrr.2022.100386 · Cited by 27 · see citing works

Contribution of Genomics to the Surgical Management and Study of Oral Cancer

Saidak, Z., Lailler, C., Testelin, S., Chauffert, B., Clatot, F., & Galmiche, A. (2021) · Annals of Surgical Oncology · doi:10.1245/s10434-021-09904-0 · Cited by 27 · see citing works

Ultra-sensitive monitoring of leukemia patients using superRCA mutation detection assays

Chen, L., Eriksson, A., Weström, S., Pandzic, T., Lehmann, S., Cavelier, L. B., & Landegren, U. D. (2022) · Nature Communications · doi:10.1038/s41467-022-31397-y · Cited by 26 · see citing works

Precision Medicine in Soft Tissue Sarcoma Treatment

Nakano, K., & Takahashi, S. (2020) · Cancers · doi:10.3390/cancers12010221 · Cited by 25 · see citing works

RNA-biology ruling cancer progression? Focus on 3′UTRs and splicing

Erson-Bensan, A. E. (2020) · Cancer and Metastasis Reviews · doi:10.1007/s10555-020-09884-9 · Cited by 23 · see citing works

Genomic heterogeneity in myeloproliferative neoplasms and applications to clinical practice

Lee, J., Godfrey, A. L., & Nangalia, J. (2020) · Blood Reviews · doi:10.1016/j.blre.2020.100708 · Cited by 21 · see citing works

Barriers to Prescribing Targeted Therapies for Patients With NSCLC With Highly Actionable Gene Variants in the Veterans Affairs National Precision Oncology Program

Vashistha, V., Armstrong, J. L., Winski, D., Poonnen, P. J., Hintze, B. J., Price, M. J., Snowdon, J. L., Weeraratne, D., Brotman, D., Jackson, G. P., et al. (2021) · JCO Oncology Practice · doi:10.1200/op.20.00703 · Cited by 20 · see citing works

Clinical whole‐genome sequencing in cancer diagnosis

Hou, Y. C., Neidich, J., Duncavage, E. J., Spencer, D. H., & Schroeder, M. C. (2022) · Human Mutation · doi:10.1002/humu.24381 · Cited by 20 · see citing works

Radiogenomics of gastroenterological cancer: The dawn of personalized medicine with artificial intelligence‐based image analysis

Hoshino, I., & Yokota, H. (2021) · Annals of Gastroenterological Surgery · doi:10.1002/ags3.12437 · Cited by 19 · see citing works

Estimating the predictive power of silent mutations on cancer classification and prognosis

Gutman, T., Goren, G., Efroni, O., & Tuller, T. (2021) · npj Genomic Medicine · doi:10.1038/s41525-021-00229-1 · Cited by 20 · see citing works

The Community Oncology and Academic Medical Center Alliance in the Age of Precision Medicine: Cancer Genetics and Genomics Considerations

Melas, M., Subbiah, S. P., Saadat, S., Rajurkar, S. P., & McDonnell, K. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072125 · Cited by 19 · see citing works

Genomics and precision surgery for head and neck squamous cell carcinoma

Galmiche, A., Saidak, Z., Bouaoud, J., Mirghani, H., Page, C., Dakpé, S., & Clatot, F. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.04.004 · Cited by 18 · see citing works

Clonal dynamics and copy number variants by single‐cell analysis in leukemic evolution of myeloproliferative neoplasms

Calabresi, L., Carretta, C., Romagnoli, S., Rotunno, G., Parenti, S., Bertesi, M., Bartalucci, N., Rontauroli, S., Chiereghin, C., Castellano, S., et al. (2023) · American Journal of Hematology · doi:10.1002/ajh.27013 · Cited by 17 · see citing works

AI (Artificial Intelligence) and Hypertension Research

Mueller, F. B. (2020) · Current Hypertension Reports · doi:10.1007/s11906-020-01068-8 · Cited by 16 · see citing works

Evaluation of false positive and false negative errors in targeted next generation sequencing

Moon, Y., Kim, Y.-H., Kim, J.-K., Hong, C. H., Kang, E., Choi, H., Lee, D. E., Kim, T., Heo, S. G., Han, N., et al. (2025) · Genome biology · doi:10.1186/s13059-025-03882-2 · Cited by 12 · see citing works

Distinct Genomic Profiles Are Associated with Treatment Response and Survival in Ovarian Cancer

de Witte, C. J., Kutzera, J., van Hoeck, A., Nguyen, L., Boere, I. A., Jalving, M., Ottevanger, P. B., de Mheen, C. V. S.-V., Stevense, M., Kloosterman, W. P., et al. (2022) · Cancers · doi:10.3390/cancers14061511 · Cited by 12 · see citing works

Risk stratifying MDS in the time of precision medicine

Cazzola, M. (2022) · Hematology · doi:10.1182/hematology.2022000349 · Cited by 12 · see citing works

Anti-cancer treatment schedule optimization based on tumor dynamics modelling incorporating evolving resistance

Yin, A., van Hasselt, J. G. C., Guchelaar, H., Friberg, L. E., & Moes, D. J. A. R. (2022) · Scientific Reports · doi:10.1038/s41598-022-08012-7 · Cited by 10 · see citing works

Innovative Tumor Tissue Dissection Tool for Molecular Oncology Diagnostics

Javey, M., Reinsch, C., Feldkamp, M., Siemann, S., Blüher, A., Woestmann, C., Cai, L., Tran, I., May, T., Havnar, C. A., et al. (2021) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2021.01.006 · Cited by 7 · see citing works

HER2 transmembrane domain mutation: comprehensive characteristics and real-world evidence of treatment response in Chinese lung adenocarcinoma

Jia, Z., Xing, J., Li, J., Wang, W., Wang, Y., Song, Y., Yang, X., Xue, J., Ye, J., Li, B., et al. (2021) · Translational Lung Cancer Research · doi:10.21037/tlcr-21-107 · Cited by 7 · see citing works

Evaluation of Breast Implant–Associated Anaplastic Large Cell Lymphoma With Whole Exome and Genome Sequencing

Akkad, N., Kodgule, R., Duncavage, E. J., Mehta–Shah, N., Spencer, D. H., Watkins, M. P., Shirai, C. L., & Myckatyn, T. M. (2022) · Aesthetic Surgery Journal · doi:10.1093/asj/sjac282 · Cited by 7 · see citing works

Applied genomics in MPN presentation

Moliterno, A. R., & Kaizer, H. (2020) · Hematology · doi:10.1182/hematology.2020000128 · Cited by 7 · see citing works

Reovirus and the Host Integrated Stress Response: On the Frontlines of the Battle to Survive

Bussiere, L. D., & Miller, C. L. (2021) · Viruses · doi:10.3390/v13020200 · Cited by 7 · see citing works

Artificial Intelligence in Clinical Oncology: From Productivity Enhancement to Creative Discovery

Kuno, M., Osumi, H., Udagawa, S., Yoshikawa, K., Ooki, A., Shinozaki, E., Ishikawa, T., Oba, J., Yamaguchi, K., & Sakurada, K. (2025) · Current Oncology · doi:10.3390/curroncol32110588 · Cited by 7 · see citing works

Identifying Safeguards Disabled by Epstein-Barr Virus Infections in Genomes From Patients With Breast Cancer: Chromosomal Bioinformatics Analysis

Friedenson, B. (2024) · JMIRx Med · doi:10.2196/50712 · Cited by 6 · see citing works

Genetic meta-analysis of cancer diagnosis following statin use identifies new associations and implicates human leukocyte antigen (HLA) in women

Sun, M., Lemaçon, A., Legault, M., Asselin, G., Provost, S., Aschard, H., Barhdadi, A., Zada, Y. F., Valois, D., Mongrain, I., et al. (2021) · The Pharmacogenomics Journal · doi:10.1038/s41397-021-00221-z · Cited by 6 · see citing works

Insights into RAS-driven melanoma and its therapeutic implications

Chatziioannou, E., Lallas, K., Sinnberg, T. W., Niessner, H., Stratigos, A., Flatz, L., & Amaral, T. (2026) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2026.103090 · Cited by 5 · see citing works

Whole-genome sequencing of myeloproliferative neoplasms revealed dynamic clonal changes in the fibrotic or leukemic transformation and novel FOXP1 mutations in the fibrotic transformation

Takamori, H., Huang, Y., Fukushima, H., Yokoyama, K., Huang, T., Kuo, M., Ogawa, S., Nannya, Y., & Shih, L. (2025) · Leukemia · doi:10.1038/s41375-025-02576-9 · Cited by 5 · see citing works

Combined Longitudinal Clinical and Autopsy Phenomic Assessment in Lethal Metastatic Prostate Cancer: Recommendations for Advancing Precision Medicine

Jasu, J., Tolonen, T. T., Antonarakis, E. S., Beltran, H., Halabi, S., Eisenberger, M. A., Carducci, M. A., Loriot, Y., der Eecken, K. V., Lolkema, M. P., et al. (2021) · European Urology Open Science · doi:10.1016/j.euros.2021.05.011 · Cited by 4 · see citing works

Mutational profiling using liquid biopsy to guide targeted therapy in patients with metastatic cancer

Mazouji, O., Ouhajjou, A., Anouar, N., Nejjari, C., Incitti, R., & Mansour, H. (2025) · Scientific Reports · doi:10.1038/s41598-025-88094-1 · Cited by 3 · see citing works

Greater expectations: meeting clinical needs through broad and rapid genomic testing

Poveda-Rogers, C., & Morrissette, J. J. D. (2022) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2022-1016 · Cited by 3 · see citing works

Scientific techniques in adolescent and young adult classic Hodgkin lymphoma

Maura, F., Adams, R., & Aoki, T. (2023) · eJHaem · doi:10.1002/jha2.786 · Cited by 2 · see citing works

Molecular diagnostics in oncology: new trends

Имянитов, Е. Н. (2020) · Medical academic journal · doi:10.17816/maj19281 · Cited by 3 · see citing works

Mucin-producing urothelial-type adenocarcinoma of the prostate with a gene mutation characteristic of intestinal adenocarcinoma: case report and literature review

Yu, A., Su, H., Yu, P., Cai, S., Mu, S., Yu, J., Lu, Q., Miao, Y., & Li, A. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2024.1494952 · Cited by 2 · see citing works

Uncontrolled Intracellular Osmotic Pressure Leads to CancerPreprint

Zhang, F., Jiang, R., & Zhang, C. (2020) · Preprints.org · doi:10.20944/preprints202006.0270.v1 · Cited by 2 · see citing works

Toward mutational epidemiology: using mutational signatures of environmental exposures to assess cancer risk

Sherman, F., Rozowsky, J. S., Okafor, A. E., & Petljak, M. (2026) · Trends in cancer · doi:10.1016/j.trecan.2025.12.010 · Cited by 1 · see citing works

Germline genetic risk and prostate cancer–specific mortality in a population-based incident cohort

Lu, L., Xu, J., Shi, Z., Engelmann, V., Tran, H., Wei, J., Ashworth, A., Cornell, B., Pieczonka, C., Isaacs, W. B., et al. (2025) · Prostate Cancer and Prostatic Diseases · doi:10.1038/s41391-026-01140-5 · Cited by 1 · see citing works

Leveraging technological opportunities in cancer genomics

Valle-Inclán, J. E. (2021) · doi:10.33540/480

Application of Second-Generation Sequencing in the Diagnosis and Treatment of Gynecological Tumors

寻, 方. (2021) · Advances in Clinical Medicine · doi:10.12677/acm.2021.116389

Cancer Genomics

Carlberg, C., & Velleuer, E. (2021) · Springer eBooks · doi:10.1007/978-3-030-75699-4_5

Cancer Genomics

Carlberg, C., Velleuer, E., & Molnár, F. (2023) · Springer eBooks · doi:10.1007/978-3-031-27133-5_28

Modeling the Impact of Dedifferentiation on Colorectal Cancer Growth and Chemo-Immunotherapy Response

Wang, Y., Tan, M., & Zhou, D. (2025) · Bulletin of Mathematical Biology · doi:10.1007/s11538-025-01496-0

Towards Routine Molecular Diagnostics: Multiplex SYBR Green Real-time PCR for Rapid Molecular Screening of Recurrent Translocations in Acute Myeloid Leukemia

Tavakoli, F., Seraji, H. R., Roshandel, E., Karimpour, F., Hasheminasab, H., Shiran, N. V., Mohammadian, M., & Mohammadi, M. H. (2025) · International Journal of Cancer Management · doi:10.5812/ijcm-166704

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Rousseau, A. (2021) · doi:10.64628/aak.7aeaft9pk

Aplicaciones de la genómica en el diseño e implementación de ensayos clínicos oncológicos: hacia una nueva era en la investigación clínica

Sánchez, N., Gutiérrez-Babativa, L., & Cardona, A. (2026) · Revista Colombiana de Hematología y Oncología · doi:10.51643/22562915.832

Biomarqueurs du microenvironnement tumoral pour la stratification thérapeutique des cancers tête et cou

Lailler, C. (2021) · doi:10.70675/156d914aze7c5z424cz8478z47ab5e54396f

Tumor Whole-Genome Sequencing for Prediction of Venous Thromboembolism in Patients With Metastasized Solid Cancer

Mulder, F. I., Guman, N. A. M., van Riet, J., van Geffen, R. J., van Haaps, T. F., Hovsepjan, V., van Laarhoven, H. W. M., Cirkel, G. A., Vos, F. D., Westgeest, H. M., et al. (2026) · Circulation Genomic and Precision Medicine · doi:10.1161/circgen.124.005182

Genomic Sequencing to Guide Cancer Management

Oristaglio, J., Manso-Share, M., Madireddi, P., Wilkinson, B., Hostetter, J., Datko, M., Bett-Madhavan, A., Furman, A., & Schoelles, K. M. (2026) · doi:10.25302/ettr7.2021.7

Genomic Sequencing for Cancer Diagnosis and Therapy

Wang, L., & Wheeler, D. A. (2013) · Annual Review of Medicine · doi:10.1146/annurev-med-120811-171056 · Cited by 43 · see citing works

Cancer genome sequencing - Clinical implications: Video

Govindan, R. (2015) · Digital Commons@Becker (Washington University School of Medicine)

Cancer Genomics: New Software tools Making Sequencing more Accessible

Chen, E., Liu, P., & Lü, Y. (2014) · Personalized Medicine · doi:10.2217/pme.13.108

Cancer genomics and pathology: All Together Now

Shibata, T. (2012) · Pathology International · doi:10.1111/j.1440-1827.2012.02855.x · Cited by 7 · see citing works