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Cited by 159

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication

Open access
Carnevale, Daniela, Perrotta, Marialuisa, Pallante, Fabio, Fardella, Valentina, Iacobucci, Roberta, Fardella, Stefania, Carnevale, Lorenzo, Carnevale, Raimondo, De Lucia, Massimiliano, Cifelli, Giuseppe, Lembo, Giuseppe·2016·Nature Communications
DOI 10.1038/ncomms13035
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Abstract

The crucial role of the immune system in hypertension is now widely recognized. We previously reported that hypertensive challenges couple the nervous drive with immune system activation, but the physiological and molecular mechanisms of this connection are unknown. Here, we show that hypertensive challenges activate splenic sympathetic nerve discharge to prime immune response. More specifically, a vagus-splenic nerve drive, mediated by nicotinic cholinergic receptors, links the brain and spleen. The sympathetic discharge induced by hypertensive stimuli was absent in both coeliac vagotomized mice and in mice lacking α7nAChR, a receptor typically expressed by peripheral ganglionic neurons. This cholinergic-sympathetic pathway is necessary for T cell activation and egression on hypertensive challenges. In addition, we show that selectively thermoablating the splenic nerve prevents T cell egression and protects against hypertension. This novel experimental procedure for selective splenic denervation suggests new clinical strategies for resistant hypertension.

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Crossref · 10.1038/ncomms13035

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Metadata

Authors
Carnevale, D., Perrotta, M., Pallante, F., Fardella, V., Iacobucci, R., Fardella, S., Carnevale, L., Carnevale, R., De Lucia, M., Cifelli, G., & Lembo, G.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2016-09-27
Volume
7
Issue
1
Pages
13035-13035
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/ncomms13035
OpenAlex
W2525313139
Cited by
159
References
7
FWCI
7.27
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication. https://app.cochat.ai/papers/10.1038/ncomms13035
The paper
Carnevale, D., Perrotta, M., Pallante, F., Fardella, V., Iacobucci, R., Fardella, S., Carnevale, L., Carnevale, R., De Lucia, M., Cifelli, G., & Lembo, G. (2016). A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication. Nature Communications. https://doi.org/10.1038/ncomms13035

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.