Innate immune cells in ischaemic heart disease: does myocardial infarction beget myocardial infarction?
Open accessAbstract
Knowledge of macrophages in steady-state and diseased tissue is rapidly expanding, propelled by improved diagnostic capacity to detect and monitor cells in their native environments. In this review, we discuss implications for ischaemic heart disease and examine innate immune cell pathways that increase systemic leucocyte supply after myocardial infarction (MI). Acute MI alters the macrophage phenotype and supply chain from tissue resident to blood monocytes sourced from haematopoietic organs. That blood leucocytosis closely associates with cardiovascular mortality provides a strong motivation to understand why and how organ ischaemia alters cellular immunity.
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Cardiac macrophages may either tailor the delivery of iron to the myocardium or accumulate and detoxify heme which may mainly arise from tissue injury.
“In addition, their roles in the metabolic activity of the adjacent myocardium and in chronic cardiac diseases such as congestive heart failure are increasingly appreciated [199], and macrophages may either tailor the delivery of iron to the myocardium or accumulate and detoxify heme which may mainly arise from tissue injury [161, 214].”
From “Pumping iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels (2017) · cites this paper as [161]
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- Authors
- Nahrendorf, M., & Swirski, F. K.
- Affiliations
- Harvard University (US)
- Corresponding author
- Nahrendorf, Matthias
- ORCID
- Nahrendorf, Matthias
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-09-08
- Volume
- 37
- Issue
- 11
- Pages
- 868-872
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- PMC
- PMC4789592
- OpenAlex
- W2128368961
- Cited by
- 95
- References
- 64
- Citations by year
- 2026: 9 · 2025: 5 · 2024: 13 · 2023: 7 · 2022: 8 · 2021: 6 · 2020: 7 · 2019: 8 · 2018: 11 · 2017: 9 · 2016: 10 · 2015: 1
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Heart Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Institutes of Health (R01HL117829, R01NS084863)
- MGH Research Scholar Award (R01HL095612, R56AI104695)
- Howard M. Goodman Fellowship
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Keywords
- ischemic heart disease, myocardial infarction, innate immunity, macrophages, monocytes, leukocytosis, macrophage phenotype, cardiovascular mortality
- MeSH terms
- Bone Marrow Cells, Humans, Immunity, Innate, Life Style, Macrophages, Monocytes, Myocarditis, Phenotype, Spleen, Myocardial Ischemia, Cell Proliferation, Drug Discovery
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