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Cited by 171

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Increased DNA methylation variability in type 1 diabetes across three immune effector cell types

Open access
Paul, Dirk S., Teschendorff, Andrew E., Dang, Mary A.N., Lowe, Robert, Hawa, Mohammed I., Ecker, Simone, Beyan, Huriya, Cunningham, Stephanie, Fouts, Alexandra R., Ramelius, Anita, Burden, Frances, Farrow, Samantha, Rowlston, Sophia, Rehnstrom, Karola, Frontini, Mattia, Downes, Kate, Busche, Stephan, Cheung, Warren A., Ge, Bing, Simon, Marie-Michelle, Bujold, David, Kwan, Tony, Bourque, Guillaume, Datta, Avik, Lowy, Ernesto, Clarke, Laura, Flicek, Paul, Libertini, Emanuele, Heath, Simon, Gut, Marta, Gut, Ivo G, Ouwehand, Willem H., Pastinen, Tomi, Soranzo, Nicole, Hofer, Sabine E., Karges, Beate, Meissner, Thomas, Boehm, Bernhard O., Cilio, Corrado, Elding Larsson, Helena, Lernmark, Åke, Steck, Andrea K., Rakyan, Vardhman K., Beck, Stephan, Leslie, R. David·2016·Nature Communications
DOI 10.1038/ncomms13555
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Abstract

The incidence of type 1 diabetes (T1D) has substantially increased over the past decade, suggesting a role for non-genetic factors such as epigenetic mechanisms in disease development. Here we present an epigenome-wide association study across 406,365 CpGs in 52 monozygotic twin pairs discordant for T1D in three immune effector cell types. We observe a substantial enrichment of differentially variable CpG positions (DVPs) in T1D twins when compared with their healthy co-twins and when compared with healthy, unrelated individuals. These T1D-associated DVPs are found to be temporally stable and enriched at gene regulatory elements. Integration with cell type-specific gene regulatory circuits highlight pathways involved in immune cell metabolism and the cell cycle, including mTOR signalling. Evidence from cord blood of newborns who progress to overt T1D suggests that the DVPs likely emerge after birth. Our findings, based on 772 methylomes, implicate epigenetic changes that could contribute to disease pathogenesis in T1D.

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Metadata

Authors
Paul, D. S., Teschendorff, A. E., Dang, M. A. N., Lowe, R., Hawa, M. I., Ecker, S., Beyan, H., Cunningham, S., Fouts, A. R., Ramelius, A., Burden, F., Farrow, S., Rowlston, S., Rehnstrom, K., Frontini, M., Downes, K., Busche, S., Cheung, W. A., Ge, B., Simon, M.-M., Bujold, D., Kwan, T., Bourque, G., Datta, A., Lowy, E., Clarke, L., Flicek, P., Libertini, E., Heath, S., Gut, M., Gut, I. G., Ouwehand, W. H., Pastinen, T., Soranzo, N., Hofer, S. E., Karges, B., Meissner, T., Boehm, B. O., Cilio, C., Elding Larsson, H., Lernmark, Å., Steck, A. K., Rakyan, V. K., Beck, S., & Leslie, R. D.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2016-11-29
Volume
7
Issue
1
Pages
13555-13555
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/ncomms13555
OpenAlex
W2557683813
Cited by
171
References
20
FWCI
15.90
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Increased DNA methylation variability in type 1 diabetes across three immune effector cell types. https://app.cochat.ai/papers/10.1038/ncomms13555
The paper
Paul, D. S., Teschendorff, A. E., Dang, M. A. N., Lowe, R., Hawa, M. I., Ecker, S., Beyan, H., Cunningham, S., Fouts, A. R., Ramelius, A., Burden, F., Farrow, S., Rowlston, S., Rehnstrom, K., Frontini, M., Downes, K., Busche, S., Cheung, W. A., Ge, B., . . . Leslie, R. D. (2016). Increased DNA methylation variability in type 1 diabetes across three immune effector cell types. Nature Communications. https://doi.org/10.1038/ncomms13555

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.