The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis
Open accessAbstract
Non-classical secretory vesicles, collectively referred to as extracellular vesicles (EVs), have been implicated in different aspects of cancer cell survival and metastasis. Here, we describe how a specific class of EVs, called microvesicles (MVs), activates VEGF receptors and tumour angiogenesis through a unique 90 kDa form of VEGF (VEGF 90K). We show that VEGF 90K is generated by the crosslinking of VEGF 165, catalysed by the enzyme tissue transglutaminase, and associates with MVs through its interaction with the chaperone Hsp90. We further demonstrate that MV-associated VEGF 90K has a weakened affinity for Bevacizumab, causing Bevacizumab to be ineffective in blocking MV-dependent VEGF receptor activation. However, treatment with an Hsp90 inhibitor releases VEGF 90K from MVs, restoring the sensitivity of VEGF 90K to Bevacizumab. These findings reveal a novel mechanism by which cancer cell-derived MVs influence the tumour microenvironment and highlight the importance of recognizing their unique properties when considering drug treatment strategies.
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Cites
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“Indeed, there appear to be multiple contributors to the limitations observed with Bevacizumab and other angiogenesis drugs 24,52,55,56 .”
Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
Costa-Silva, B., Aiello, N. M., Ocean, A. J., Singh, S., Zhang, H., Thakur, B. K., Becker, A., Hoshino, A., Mark, M. T., Molina, H., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3169 · Cited by 2,692
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Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells
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Cited by
Proteomic analysis of urinary extracellular vesicles reveal biomarkers for neurologic disease
Wang, S., Kojima, K., Mobley, J. A., & West, A. B. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.06.021 · Cited by 145
Forms of extracellular mitochondria and their impact in health
Miliotis, S., Nicolalde, B., Ortega, M., Yepez, J., & Caicedo, A. (2019) · Mitochondrion · doi:10.1016/j.mito.2019.02.002 · Cited by 138
Matrix stiffness regulates microvesicle-induced fibroblast activation
Schwager, S. C., Bordeleau, F., Zhang, J., Antonyak, M. A., Cerione, R. A., & Reinhart-King, C. A. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00418.2018 · Cited by 50
Self-citation
Metadata
- Authors
- Feng, Q., Zhang, C., Lum, D., Druso, J. E., Blank, B., Wilson, K. F., Welm, A., Antonyak, M. A., & Cerione, R. A.
- Venue
- Nature Communications
- Published
- 2017-02-16
- Volume
- 8
- Issue
- 1
- Pages
- 14450-14450
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2588995471
- Cited by
- 256
- References
- 56
- FWCI
- 10.09
- Type
- journal article
- Language
- en
- Open access
- gold
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- Feng, Q., Zhang, C., Lum, D., Druso, J. E., Blank, B., Wilson, K. F., Welm, A., Antonyak, M. A., & Cerione, R. A. (2017). A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis. Nature Communications. https://doi.org/10.1038/ncomms14450
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
