The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Genome-wide association mapping reveals a rich genetic architecture of complex traits in Oryza sativa
Open accessAbstract
Asian rice, Oryza sativa is a cultivated, inbreeding species that feeds over half of the world's population. Understanding the genetic basis of diverse physiological, developmental, and morphological traits provides the basis for improving yield, quality and sustainability of rice. Here we show the results of a genome-wide association study based on genotyping 44,100 SNP variants across 413 diverse accessions of O. sativa collected from 82 countries that were systematically phenotyped for 34 traits. Using cross-population-based mapping strategies, we identified dozens of common variants influencing numerous complex traits. Significant heterogeneity was observed in the genetic architecture associated with subpopulation structure and response to environment. This work establishes an open-source translational research platform for genome-wide association studies in rice that directly links molecular variation in genes and metabolic pathways with the germplasm resources needed to accelerate varietal development and crop improvement. Understanding the genetics and physiology of domesticated species is important for crop improvement. By studying natural variation and the phenotypic traits of 413 diverse accessions of rice, Zhao et al. identify many common genetic variants that influence quantitative traits such as seed size and flowering time.
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Cites
PLINK: a tool set for whole-genome association and population-based linkage analyses.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089
Principal components analysis corrects for stratification in genome-wide association studies
Price, A. L., Patterson, N. J., Plenge, R. M., Weinblatt, M. E., Shadick, N. A., & Reich, D. (2006) · Nature Genetics · doi:10.1038/ng1847 · Cited by 10,248
Self-citationGenome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines
Atwell, S., Huang, Y. S., Vilhjálmsson, B. J., Willems, G., Horton, M., Li, Y., Meng, D., Platt, A., Tarone, A. M., Hu, T. T., et al. (2010) · Nature · doi:10.1038/nature08800 · Cited by 1,780
Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS
Nicolae, D. L., Gamazon, E., Zhang, W., Duan, S., Dolan, M. E., & Cox, N. J. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000888 · Cited by 1,292
Genetic Structure and Diversity in Oryza sativa L.
Garris, A. J., Tai, T. H., Coburn, J., Kresovich, S., & McCouch, S. (2005) · Genetics · doi:10.1534/genetics.104.035642 · Cited by 1,137
Self-citationLuesse, D. R., DeBlasio, S. L., & Hangarter, R. P. (2006) · Plant Physiology · doi:10.1104/pp.106.080333 · Cited by 74
Cited by
Wani, A. A., Singh, P., Shah, M. A., Schweiggert‐Weisz, U., Gul, K., & Wani, I. A. (2012) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2012.00193.x · Cited by 583
Doubling down on genomes: Polyploidy and crop plants
Renny‐Byfield, S., & Wendel, J. F. (2014) · American Journal of Botany · doi:10.3732/ajb.1400119 · Cited by 406
A G-protein pathway determines grain size in rice
Sun, S., Wang, L., Mao, H., Shao, L., Li, X., Xiao, J., Ouyang, Y., & Zhang, Q. (2018) · Nature Communications · doi:10.1038/s41467-018-03141-y · Cited by 357
Genome-wide association mapping of salinity tolerance in rice (Oryza sativa)
Kumar, V., Singh, A., Mithra, S. V. A., Krishnamurthy, S. L., Parida, S. K., Jain, S., Tiwari, K. K., Kumar, P., Rao, A. R., Sharma, S. K., et al. (2015) · DNA Research · doi:10.1093/dnares/dsu046 · Cited by 328
NAL1 allele from a rice landrace greatly increases yield in modern indica cultivars
Fujita, D., Trijatmiko, K. R., Tagle, A. G., Sapasap, M. V., Koide, Y., Sasaki, K., Tsakirpaloglou, N., Gannaban, R. B., Nishimura, T., Yanagihara, S., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310790110 · Cited by 294
Metadata
- Authors
- Zhao, K., Tung, C.-W., Eizenga, G. C., Wright, M. H., Ali, M. L., Price, A. H., Norton, G. J., Islam, M. R., Reynolds, A., Mezey, J., McClung, A. M., Bustamante, C. D., & McCouch, S. R.
- Venue
- Nature Communications
- Published
- 2011-09-13
- Volume
- 2
- Issue
- 1
- Pages
- 467-467
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2017586115
- Cited by
- 1,408
- References
- 6
- FWCI
- 38.37
- Type
- journal article
- Language
- en
- Open access
- hybrid
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