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Cytoglobin has potent superoxide dismutase function

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TGF-β1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis

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Genome-wide association study of coronary artery disease among individuals with diabetes: the UK Biobank

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Endothelial cell α-globin and its molecular chaperone α-hemoglobin–stabilizing protein regulate arteriolar contractility

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Regulation of Nitric Oxide Metabolism and Vascular Tone by Cytoglobin

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Emerging perspectives on cytoglobin, beyond NO dioxygenase and peroxidase

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The Antioxidative Role of Cytoglobin in Podocytes: Implications for a Role in Chronic Kidney Disease

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Characterization of tick salivary gland and saliva alphagalactome reveals candidate alpha-gal syndrome disease biomarkers

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The role of globins in cardiovascular physiology

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Endogenous Hemoprotein-Dependent Signaling Pathways of Nitric Oxide and Nitrite

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Hexa Histidine–Tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species

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HuR (Human Antigen R) Regulates the Contraction of Vascular Smooth Muscle and Maintains Blood Pressure

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Bifidobacterium reduction is associated with high blood pressure in children with type 1 diabetes mellitus

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The Hemoglobin Homolog Cytoglobin in Smooth Muscle Inhibits Apoptosis and Regulates Vascular Remodeling

Jourd’heuil, F. L., Xu, H., Reilly, T., McKellar, K., Alaoui, C. E., Steppich, J., Liu, Y. F., Zhao, W., Ginnan, R. G., Conti, D., et al. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309410 · Cited by 31 · see citing works

Functional implications of microvascular heterogeneity for oxygen uptake and utilization

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Roles of Ferredoxin-NADP+ Oxidoreductase and Flavodoxin in NAD(P)H-Dependent Electron Transfer Systems

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Tubeimoside I improves survival of mice in sepsis by inhibiting inducible nitric oxide synthase expression

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Ag@ S -nitrosothiol core–shell nanoparticles for chemo and photothermal synergistic tumor targeted therapy

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An evolutionarily ancient mechanism for regulation of hemoglobin expression in vertebrate red cells

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Role of cytoglobin, a novel radical scavenger, in stellate cell activation and hepatic fibrosis

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Extracorporeal shock wave therapy combined with engineered mesenchymal stem cells expressing stromal cell-derived factor-1 can improve erectile dysfunction in streptozotocin-induced diabetic rats

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The contribution of carbon monoxide to vascular tonus

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Defining the reducing system of the NO dioxygenase cytoglobin in vascular smooth muscle cells and its critical role in regulating cellular NO decay

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Cytoglobin protects cancer cells from apoptosis by regulation of mitochondrial cardiolipin

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The Zebrafish Cytochrome b 5 /Cytochrome b 5 Reductase/NADH System Efficiently Reduces Cytoglobins 1 and 2: Conserved Activity of Cytochrome b 5 /Cytochrome b 5 Reductases during Vertebrate Evolution

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Flipping Off and On the Redox Switch in the Microcirculation

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Endothelial cell-induced cytoglobin expression in vascular smooth muscle cells contributes to modulation of nitric oxide

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Redox sensor properties of human cytoglobin allosterically regulate heme pocket reactivity

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Redox-Regulation of α-Globin in Vascular Physiology

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Nitric Oxide Derived from Cytoglobin-Deficient Hepatic Stellate Cells Causes Suppression of Cytochrome c Oxidase Activity in Hepatocytes

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Targeted disruption of regulated endocrine-specific protein (Resp18) in Dahl SS/Mcw rats aggravates salt-induced hypertension and renal injury

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Regulation of DNA damage and transcriptional output in the vasculature through a cytoglobin-HMGB2 axis

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Cytoglobin deficiency potentiates Crb1-mediated retinal degeneration in rd8 mice

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Globins and nitric oxide homeostasis in fish embryonic development

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A covalent organic framework-based nanoreactor for enhanced chemodynamic therapy through cascaded Fenton-like reactions and nitric oxide delivery

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Cytoglobin ameliorates the stemness of hepatocellular carcinoma via coupling oxidative‐nitrosative stress signals

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Is the microvasculature tone increasing with arterial hypertension?

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Structural and functional properties of Antarctic fish cytoglobins-1: Cold-reactivity in multi-ligand reactions

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Cytoglobin regulates NO-dependent cilia motility and organ laterality during development

Rochon, E. R., Xue, J., Mohammed, M. S., Smith, C., Hay‐Schmidt, A., DeMartino, A. W., Clark, A., Xu, Q., Lo, C. W. Y., Tsang, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43544-0 · Cited by 10 · see citing works

Chronic exercise impairs nitric oxide pathway in rabbit carotid and femoral arteries

Marchio, P., Guerra‐Ojeda, S., Vila, J. M., Aldasoro, M., Vallés, S. L., Soler, C., & Mauricio, M. D. (2018) · The Journal of Physiology · doi:10.1113/jp275611 · Cited by 9 · see citing works

Regulation of nitrite reductase and lipid binding properties of cytoglobin by surface and distal histidine mutations

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Redox Regulation of Microvascular Physiology and Pathophysiology: Insights into Therapeutic Strategies and Limitations

Bulger, D. A., Zhang, Z., Hu, R., Dave, E. K., Mehta, P. K., Griendling, K. K., & Valdivia, A. (2025) · Antioxidants and Redox Signaling · doi:10.1177/15230864251372607 · Cited by 7 · see citing works

Modulating Nitric Oxide Dioxygenase and Nitrite Reductase of Cytoglobin through Point Mutations

Ukeri, J., Wilson, M. T., & Reeder, B. J. (2022) · Antioxidants · doi:10.3390/antiox11091816 · Cited by 7 · see citing works

Vitamin D may assist the UPR against sodium fluoride-induced damage by reducing RIPK1, ATG5, BECN1, oxidative stress and increasing caspase-3 in the osteoblast MC3T3-E1 cell line

Yüksek, V., Dede, S., Çetin, S., Usta, A., & Taşpınar, M. (2023) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2023.127293 · Cited by 8 · see citing works

Escorting α-globin to eNOS: α-globin–stabilizing protein paves the way

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CaSR participates in the regulation of vascular tension in the mesentery of hypertensive rats via the�PLC‑IP3/AC‑V/cAMP/RAS pathway

Zhang, W., Sun, R., Zhong, H., Tang, N., Liu, Y., Zhao, Y., Zhang, T., & He, F. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10620 · Cited by 6 · see citing works

Neuroglobin and Cytoglobin in Mammalian Nervous Systems: About Distribution, Regulation, Function, and Some Open Questions

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Modeling the Interactions Between Chemicals and Proteins to Predict the Health Consequences of Air Pollution

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Cytoglobin scavenges intracellular hydrogen peroxide and regulates redox signals in the vasculature

Jourd’heuil, F. L., Mathai, C., Pham, L. G. C., Gilliard, K., Balnis, J., Overmyer, K. A., Coon, J. J., Jaitovich, A., Boivin, B., & Jourd’heuil, D. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103633 · Cited by 5 · see citing works

Role of cytoglobin in cigarette smoke constituent-induced loss of nitric oxide bioavailability in vascular smooth muscle cells

Mahgoup, E. M., Khaleel, S. A., Elmahdy, M., Abd‐Allah, A. R. A., & Zweier, J. L. (2021) · Nitric Oxide · doi:10.1016/j.niox.2021.12.002 · Cited by 5 · see citing works

The cytoglobin-dependent transcriptome in melanoma indicates a protective function associated with oxidative stress, inflammation and cancer-associated pathways

Backer, J. D., & Hoogewijs, D. (2024) · Scientific Reports · doi:10.1038/s41598-024-69224-7 · Cited by 4 · see citing works

The knockout of cytoglobin 1 in zebrafish (Danio rerio) alters lipid metabolism, iron homeostasis and oxidative stress response

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Cytoglobin augments ferroptosis through autophagic degradation of ferritin in colorectal cancer cells

Fan, C., Luo, Z., Zheng, Q., Xu, Y., Xu, Y. Q., Chen, J., Meng, Y., Jiang, H., Liu, K., & Yang, X. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05148-0 · Cited by 4 · see citing works

The identification of key genes and pathways in polycystic ovary syndrome by bioinformatics analysis of next-generation sequencing data

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Cytoglobin at the Crossroads of Vascular Remodeling

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Cytochrome b5 reductase 4 efficiently reduces neuroglobin and cytoglobin

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Electronic cigarette vape decreases nitric oxide bioavailability in vascular smooth muscle cells via increased cytoglobin-mediated metabolism

Mahgoup, E. M., Khaleel, S. A., El‐Mahdy, M. A., & Zweier, J. L. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.12.057 · Cited by 3 · see citing works

Resistance of Nitric Oxide Dioxygenase and Cytochrome c Oxidase to Inhibition by Nitric Oxide and Other Indications of the Spintronic Control of Electron Transfer

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Epigenetic mediation may explain intergenerational associations between maternal obesogenic lifestyle and children’s birth weight: findings from the NorthPop prospective birth cohort

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Orally Administered Nanoparticle Coacervate for Therapeutic Coating of Full Gastrointestinal Tract

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Transcriptomics of a cytoglobin knockout mouse: Insights from hepatic stellate cells and brain

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Structure, function and the related mechanism of cytoglobin

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The Cytoglobin Expression Under Hypoxic Conditions in Covid-19 Cases

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Proteomic Analysis of Paraffin-Embedded Intestines from Schistosoma mansoni Infection in Mice: Highlighting Molecular Players During Acute Schistosomiasis

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Ordered Motions in the Nitric-Oxide Dioxygenase Mechanism of Flavohemoglobin and Assorted Globins with Tightly Coupled Reductases

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Dioxygen and glucose force motion of the electron-transfer switch in the iron(III) flavohemoglobin-type nitric oxide dioxygenase

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Influence of inhaled nitric oxide on bronchopulmonary dysplasia in preterm infants with PPHN or HRF at birth: a propensity score matched study

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Cytoglobin overexpression facilitates proliferation and migration of vascular smooth muscle cells

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Hemoglobin α in Pulmonary Endothelium: Ironing Out Nitric Oxide Signaling

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Dioxygen Binding and Sensing Proteins

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The Identification of Key Genes and Biological Pathways in Polycystic Ovary Syndrome and its Complications by Next Generation Squancing (NGS) and Bioinformatics AnalysisPreprint

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A role for cytoglobin in regulating intracellular hydrogen peroxide and redox signals in the vasculaturePreprint

Mathai, C., Jourd’heuil, F. L., Pham, L. G. C., Gilliard, K., Balnis, J., Jen, A., Overmyer, K. A., Coon, J. J., Jaitovich, A., Boivin, B., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.31.535146 · Cited by 1 · see citing works

Screening and identification of key biomarkers in diabetic kidney disease and its complications: Evidence from bioinformatics and next generation sequencing data analysisPreprint

Vastrad, B. M., & Vastrad, C. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.16.537071 · Cited by 1 · see citing works

Hexacoordinate Globins: Characterization and Engineering for Development of Novel Therapeutic Agents

Amdahl, M. B. (2018) · D-Scholarship@Pitt (University of Pittsburgh)

Structure Function Relationship in Hexacoordinate Heme Proteins: Mechanism of Globin X Interactions with Exogenous Ligands and Ligand Accessiblity in Cytoglobin and Neuroglobin

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Faculty Opinions recommendation of Efficient Promotion of Autophagy and Angiogenesis Using Mesenchymal Stem Cell Therapy Enhanced by the Low-Energy Shock Waves in the Treatment of Erectile Dysfunction.

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Cytoglobin regulates nitric oxide-dependent cilia motility and organ laterality in developmentPreprint

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Investigação genômica da hipertensão essencial em populações afro-brasileiras

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Molecular analysis of the human cytoglobin mRNA isoforms

Porto, E., Loula, P., Strand, S., & Hankeln, T. (2023) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2023.112422

Epigenetic mediation may explain intergenerational associations between maternal lifestyle and children’s birth weight - Findings from the NorthPop prospective birth cohortPreprint

Silva, K. D., Ulfsdotter, R. L., Bodén, S., Vinnars, M., Rydén, P., West, C. E., Domellöf, M., & Harlid, S. (2025) · medRxiv · doi:10.1101/2025.06.01.25328723

Ultrasound-activated directional and controllable nitric oxide therapy for vascular calcification repair through the modulation of eNOS/iNOS homeostasis

Liu, C., Lin, M., Dai, J., Chen, B., Wang, J., Li, J., Li, X., Jiang, Z., Xiao, M., & Tang, M. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.09.024 · Cited by 2 · see citing works

Regulation of Nitric Oxide Metabolism and Vascular Tone by Cytoglobin

Zweier, J. L., & Ilangovan, G. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7881 · Cited by 40 · see citing works

Abstract 16242: Cytoglobin Regulates Blood Pressure and Vascular Function through Metabolism of Nitric Oxide in the Vascular Wall

XiaopingLiu, AEl-Mahdy, M., SIsmail, R., MAbdelghany, T., TThuy, L., NorifumiKawada, & LZweier, J. (2013) · Circulation · Cited by 2 · see citing works

Abstract 4144122: Genetic Modulation of Cytoglobin Expression Regulates Vascular Nitric Oxide Metabolism, Vascular Tone and Blood Pressure

Mahgoup, E. M., Khaleel, S. A., Ewees, M. G., Eid, M. S., & Zweier, J. L. (2024) · Circulation · doi:10.1161/circ.150.suppl_1.4144122

Abstract 16720: Cytoglobin Regulates Cardiovascular Function and Vessel Tone by Controlling the Rate of Vascular Nitric Oxide Metabolism

Liu, X., Elmahdy, M., Ismail, R. S., Little, S. C., Thủy, L. T. T., Kawada, N., & Zweier, J. L. (2014) · Circulation · doi:10.1161/circ.130.suppl_2.16720

Abstract 14875: Cytoglobin but not Myoglobin Senses Hypoxia and Regulates NO Consumption Rate in the Vascular Wall

Liu, X., Tong, J., Zweier, J. R., Follmer, D., Hemann, C. F., & Zweier, J. L. (2012) · Circulation