The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate
Open accessAbstract
How the behaviour of somatic stem cells (SCs) is influenced by mechanical signals remains a black-box in cell biology. Here we show that YAP/TAZ regulation by cell shape and rigidity of the extracellular matrix (ECM) dictates a pivotal SC decision: to remain undifferentiated and grow, or to activate a terminal differentiation programme. Notably, mechano-activation of YAP/TAZ promotes epidermal stemness by inhibition of Notch signalling, a key factor for epidermal differentiation. Conversely, YAP/TAZ inhibition by low mechanical forces induces Notch signalling and loss of SC traits. As such, mechano-dependent regulation of YAP/TAZ reflects into mechano-dependent regulation of Notch signalling. Mechanistically, at least in part, this is mediated by YAP/TAZ binding to distant enhancers activating the expression of Delta-like ligands, serving as ‘in cis ’ inhibitors of Notch. Thus YAP/TAZ mechanotransduction integrates with cell–cell communication pathways for fine-grained orchestration of SC decisions.
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Cites
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Matrix elasticity directs stem cell lineage specification
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Role of YAP/TAZ in mechanotransduction
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Self-citationGrowth Factors, Matrices, and Forces Combine and Control Stem Cells
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TEAD mediates YAP-dependent gene induction and growth control
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Local force and geometry sensing regulate cell functions
Vogel, V., & Sheetz, M. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1890 · Cited by 2,328 · cited 1×
“These features template cell–cell and cell–extracellular matrix (ECM) adhesion sites that provide the mechanical signals to control the shape of the cell, define its localization and spatial relationships with other cells in tissues and, ultimately, regulate cell fate 2–6 .”
The Hippo Signaling Pathway in Development and Cancer
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YAP/TAZ at the Roots of Cancer
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Self-citationExtracellular-matrix tethering regulates stem-cell fate
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Cited by
Mechanobiology of YAP and TAZ in physiology and disease
Panciera, T., Azzolin, L., Cordenonsi, M., & Piccolo, S. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.87 · Cited by 1,461
Self-citationYAP/TAZ upstream signals and downstream responses
Totaro, A., Panciera, T., & Piccolo, S. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0142-z · Cited by 1,086
Self-citationHippo–YAP/TAZ signalling in organ regeneration and regenerative medicine
Moya, I. M., & Halder, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0086-y · Cited by 981
Self-organization and symmetry breaking in intestinal organoid development
Serra, D., Mayr, U., Boni, A., Lukonin, I., Rempfler, M., Challet Meylan, L., Stadler, M. B., Strnad, P., Papasaikas, P., Vischi, D., et al. (2019) · Nature · doi:10.1038/s41586-019-1146-y · Cited by 561
Signaling pathways involved in colorectal cancer: pathogenesis and targeted therapy
Li, Q., Geng, S., Luo, H., Wang, W., Mo, Y.-Q., Luo, Q., Wang, L., Song, G.-B., Sheng, J.-P., & Xu, B. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01953-7 · Cited by 546
Metadata
- Authors
- Totaro, A., Castellan, M., Battilana, G., Zanconato, F., Azzolin, L., Giulitti, S., Cordenonsi, M., & Piccolo, S.
- Venue
- Nature Communications
- Published
- 2017-05-17
- Volume
- 8
- Issue
- 1
- Pages
- 15206-15206
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2616658238
- Cited by
- 292
- References
- 67
- FWCI
- 13.44
- Type
- journal article
- Language
- en
- Open access
- gold
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