Senescent tumor cells lead the collective invasion in thyroid cancer

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218

The senescence-associated secretory phenotype: the dark side of tumor suppression

Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206

BRAFE600-associated senescence-like cell cycle arrest of human naevi

Michaloglou, C., Vredeveld, L. C. W., Soengas, M. S., Denoyelle, C., Kuilman, T., van der Horst, C. M. A. M., Majoor, D. M., Shay, J. W., Mooi, W. J., & Peeper, D. S. (2005) · Nature · doi:10.1038/nature03890 · Cited by 2,160

The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

Bleul, C. C., Farzan, M., Choe, H., Parolin, C., Clark‐Lewis, I., Sodroski, J., & Springer, T. A. (1996) · Nature · doi:10.1038/382829a0 · Cited by 1,953

Metastasis: a question of life or death

Mehlen, P., & Puisieux, A. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1886 · Cited by 1,919

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

Tchkonia, T., Zhu, Y., van Deursen, J., Campisi, J., & Kirkland, J. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64098 · Cited by 1,774

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

Kang, T.-W., Yevsa, T., Woller, N., Hoenicke, L., Wuestefeld, T., Dauch, D., Hohmeyer, A., Gereke, M., Rudalska, R., Potapova, A., et al. (2011) · Nature · doi:10.1038/nature10599 · Cited by 1,621

Senescence in premalignant tumours

Collado, M., Gil, J., Efeyan, A., Guerra, C., Schuhmacher, A. J., Barradas, M., Benguría, A., Zaballos, A., Flores, J. M., Barbacid, M., et al. (2005) · Nature · doi:10.1038/436642a · Cited by 1,482

CXCL12 (SDF-1)/CXCR4 Pathway in Cancer

Teicher, B. A., & Fricker, S. P. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-2329 · Cited by 1,453

The impact of the senescent microenvironment on tumorigenesis: Insights for cancer therapy

Zhang, W., Zhang, K., Shi, J., Qiu, H., Kan, C., Ma, Y., Hou, N., Han, F., & Sun, X. (2024) · Aging Cell · doi:10.1111/acel.14182 · Cited by 23

Senescent endothelial cells promote liver metastasis of uveal melanoma in single-cell resolution

Ma, L., He, X., Fu, Y., Ge, S., & Yang, Z. H. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05430-1 · Cited by 22

CAMSAP3 depletion induces lung cancer cell senescence‐associated phenotypes through extracellular signal‐regulated kinase inactivation

Wattanathamsan, O., Chetprayoon, P., Chantaravisoot, N., Wongkongkathep, P., Pithi Chanvorachote, B., & Pongrakhananon, V. (2021) · Cancer Medicine · doi:10.1002/cam4.4380 · Cited by 20

Protein-Bound Uremic Toxins in Senescence and Kidney Fibrosis

Yang, Y., Mihajlovic, M., & Masereeuw, R. (2023) · Biomedicines · doi:10.3390/biomedicines11092408 · Cited by 21

Karyotype Aberrations in Action: The Evolution of Cancer Genomes and the Tumor Microenvironment

Baudoin, N. C., & Bloomfield, M. (2021) · Genes · doi:10.3390/genes12040558 · Cited by 20

The role of senescence in the pathogenesis of atrial fibrillation: A target process for health improvement and drug development

Guo, G., Watterson, S., Zhang, S., Bjourson, A. J., McGilligan, V., Peace, A. J., & Singh, T. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101363 · Cited by 22

Lack of apoptosis leads to cellular senescence and tumorigenesis in Drosophila epithelial cells

Garcia-Arias, J. M., Pinal, N., Cristobal-Vargas, S., Estella, C., & Morata, G. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01583-y · Cited by 19

Multiomic Landscape of Primary Hypothyroidism Induced by Subchronic Exposure to Low-Dose Novel PFOS Substitute OBS in Human and Murine Models

Wang, Y., Ma, K., Yin, S., Wang, W., An, H., Huang, Y., Guo, H. Y., Ao, L., Yang, Z., & Zhang, F. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.4c10565 · Cited by 19

Molecular Network-Based Identification of Circular RNA-Associated ceRNA Network in Papillary Thyroid Cancer

Liu, Q., Pan, L.-Z., Hu, M., & Ma, J.-Y. (2019) · Pathology & Oncology Research · doi:10.1007/s12253-019-00697-y · Cited by 19

Hypofractionated Radiotherapy Is Superior to Conventional Fractionation in an Orthotopic Model of Anaplastic Thyroid Cancer

Oweida, A., Phan, A. V., Court, B. V., Robin, T. P., Hararah, M. K., Bhatia, S., Milner, D. C., Lennon, S., Pike, L. A., Raben, D., et al. (2018) · Thyroid · doi:10.1089/thy.2017.0706 · Cited by 18

Netrin-1 promotes the collective cell migration of liver cancer cells in a 3D cell culture model

Han, P., Liu, J., Lei, Y., Lin, Z., Tian, D., & Yan, W. (2019) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-019-00701-8 · Cited by 18

A cellular senescence-related gene prognostic index for biochemical recurrence and drug resistance in patients with prostate cancer.

Feng, D., Shi, X., You, J., Xiong, Q., Zhu, W., Wei, Q., & Yang, L. (2022) · PubMed · Cited by 19

Cellular Senescence as a Brake or Accelerator for Oncogenic Transformation and Role in Lymphatic Metastasis

Banerjee, P., Gaddam, N., Pandita, T. K., & Chakraborty, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032877 · Cited by 17

A previously identified apoptosis inhibitor iASPP confers resistance to chemotherapeutic drugs by suppressing senescence in cancer cells

Li, H., Zhang, W., Zhao, K., Zhao, D. H., Zheng, S., & Hu, Y. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011411 · Cited by 17

The implication of ROCK 2 as a potential senotherapeutic target via the suppression of the harmful effects of the SASP: Do senescent cancer cells really engulf the other cells?

Demir, Y. D. Ş., Özdemir, A., Sucularlı, C., Benhür, E., & Ark, M. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.110007 · Cited by 16

The variant senescence‐associated secretory phenotype induced by centrosome amplification constitutes a pathway that activates hypoxia‐inducible factor ‐1α

Wu, S. K., Ariffin, J. K., Tay, S. C., & Picone, R. (2023) · Aging Cell · doi:10.1111/acel.13766 · Cited by 17

The Role of Aging and Senescence in Immune Checkpoint Inhibitor Response and Toxicity

Jain, S. S., Sojo, G. B., Sun, H., Friedland, B. N., McNamara, M. E., Schmidt, M. O., & Wellstein, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137013 · Cited by 17

Transcriptional landscape of oncogene-induced senescence: a machine learning-based meta-analytic approach

Han, Y., Micklem, G., & Kim, S. Y. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101849 · Cited by 16

Can 3D bioprinting solve the mystery of senescence in cancer therapy?

Shboul, S. A., DeLuca, V. J., Dweiri, Y. M., & Saleh, T. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101732 · Cited by 16

Immunohistochemical Expressions of Senescence-Associated Secretory Phenotype and Its Association With Immune Microenvironments and Clinicopathological Factors in Invasive Breast Cancer

Park, M. H., Choi, J. E., Kim, J.-R., & Bae, Y. K. (2021) · Pathology & Oncology Research · doi:10.3389/pore.2021.1609795 · Cited by 15

Cellular Senescence, a Novel Area of Investigation for Metastatic Diseases

Faggioli, F., Velarde, M. C., & Wiley, C. D. (2023) · Cells · doi:10.3390/cells12060860 · Cited by 15

p15INK4B is an alternative marker of senescent tumor cells in colorectal cancer

Park, S. S., Lee, Y., Park, S. H., Lim, S. B., Choi, Y. W., Shin, J. S., Kim, Y. H., Kim, J., & Park, T. J. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e13170 · Cited by 14

Senotherapy, cancer, and aging

Balducci, L., Falandry, C., & Monfardini, S. (2023) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2023.101671 · Cited by 16

Chromatin conformational changes at human satellite II contribute to the senescence phenotype in the tumor microenvironment

Miyata, K., Zhou, X., Nishio, M., Hanyu, A., Chiba, M., Kawasaki, H., Osako, T., Takeuchi, K., Ohno, S., Ueno, T., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2305046120 · Cited by 14

M1 macrophages induce PD-L1 hi cell-led collective invasion in HPV-positive head and neck squamous cell carcinoma via TNF-α/CDK4/UPS14

Wu, J., Pang, X., Yang, X., Zhang, M., Chen, B.-J., Fan, H., Wang, H., Yu, X., Tang, Y., & Liang, X. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-007670 · Cited by 13

Photoacoustic polydopamine-indocyanine green (PDA-ICG) nanoprobe for detection of senescent cells

Hartono, M., Baker, A., Else, T. R., Evtushenko, A. S., Bohndiek, S. E., Muñoz‐Espín, D., & Fruk, L. (2024) · Scientific Reports · doi:10.1038/s41598-024-79667-7 · Cited by 14

Knock-Down of Mucolipin 1 Channel Promotes Tumor Progression and Invasion in Human Glioblastoma Cell Lines

Santoni, G., Amantini, C., Nabissi, M., Maggi, F., Arcella, A., Marinelli, O., Eleuteri, A. M., Santoni, M., & Morelli, M. B. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.578928 · Cited by 13

Identification and Characterization of Senescence Phenotype in Lung Adenocarcinoma with High Drug Sensitivity

Khadirnaikar, S., Chatterjee, A., & Shukla, S. K. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.07.005 · Cited by 13

Romidepsin and tamoxifen cooperatively induce senescence of pancreatic cancer cells through downregulation of FOXM1 expression and induction of reactive oxygen species/lipid peroxidation

Okuni, N., Honma, Y., Urano, T., & Tamura, K. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07192-9 · Cited by 14

Nutritional Niches of Cancer Therapy-Induced Senescent Cells

Llop‐Hernández, À., Verdura, S., Cuyàs, E., & Menéndez, J. A. (2022) · Nutrients · doi:10.3390/nu14173636 · Cited by 13

Mitochondria in cell senescence: A Friend or Foe?

Chen, Q., Young, L. H., & Barsotti, R. (2023) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2023.02.019 · Cited by 15

Tumor-Associated Senescent Macrophages, Their Markers, and Their Role in Tumor Microenvironment

Pukhalskaia, T. V., Yurakova, T. R., Bogdanova, D. A., & Demidov, O. N. (2024) · Biochemistry (Moscow) · doi:10.1134/s0006297924050055 · Cited by 12

The crosstalk between senescence, tumor, and immunity: molecular mechanism and therapeutic opportunities

Wang, Z., Chen, C., Ai, J., Gao, Y., Wang, L., Xia, S., Jia, Y., & Qin, Y. (2025) · MedComm · doi:10.1002/mco2.70048 · Cited by 12

Delineating the Switch between Senescence and Apoptosis in Cervical Cancer Cells under Ciclopirox Treatment

Herrmann, A. L., Kuhn, B. J., Holzer, A., Krijgsveld, J., Hoppe‐Seyler, K., & Hoppe‐Seyler, F. (2021) · Cancers · doi:10.3390/cancers13194995 · Cited by 12

The cGAS/STING signaling pathway: a cross-talk of infection, senescence and tumors

Zeng, P.-H., & Yin, W.-J. (2022) · Cell Cycle · doi:10.1080/15384101.2022.2109899 · Cited by 12

Cell death mechanisms in head and neck cancer cells in response to low and high-LET radiation

Fabbrizi, M. R., & Parsons, J. L. (2022) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2021.31 · Cited by 13

Discoidin Domain Receptor 2 Mediates Lysophosphatidic Acid-Induced Ovarian Cancer Aggressiveness

Jeong, B. Y., Cho, K. H., Yoon, S.-H., Park, C. G., Park, H., & Lee, H. Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105374 · Cited by 11

Digital Spatial Profiling Identifies the Tumor Periphery as a Highly Active Biological Niche in Clear Cell Renal Cell Carcinoma

Schneider, F., Kaczorowski, A., Jurcic, C., Kirchner, M., Schwab, C., Schütz, V., Görtz, M., Zschäbitz, S., Jäger, D., Stenzinger, A., et al. (2023) · Cancers · doi:10.3390/cancers15205050 · Cited by 11

Cellular senescence: Silent operator and therapeutic target in cancer

Ramu, D., Teoh, W. S., Hirpara, J. L., & Pervaiz, S. (2021) · IUBMB Life · doi:10.1002/iub.2460 · Cited by 13

Telomeric 8-Oxoguanine Drives Rapid Premature Senescence In The Absence Of Telomere Shortening

Barnes, R. P., de Rosa, M., Thosar, S. A., Detwiler, A. C., Roginskaya, V., Van Houten, B., Bruchez, M. P., Stewart-Ornstein, J., & Opresko, P. L. (2021) · doi:10.1101/2021.05.05.442662

ACSL5 regulated acetyl-CoA to promote bladder cancer cellular senescence via 53BP1 acetylation

Luo, Y., Zeng, Y., Liu, Y., Liu, S., Dai, Y., Pan, W., Zhang, L., Zhu, R., Feng, D., Du, K., et al. (2025) · Oncogene · doi:10.1038/s41388-025-03474-1 · Cited by 10

Expression of CXCR4 and CXCR7 in papillary thyroid carcinoma and adjacent tissues and their relationship with pathologic indicators of tumor aggressiveness

Cao, X., Zhu, J., Li, X., Ma, Y., & He, Q. (2021) · Endocrine Journal · doi:10.1507/endocrj.ej21-0076 · Cited by 10

A Drosophila RNAi screen reveals conserved glioblastoma-related adhesion genes that regulate collective cell migration

Kotian, N., Troike, K. M., Curran, K. N., Lathia, J. D., & McDonald, J. A. (2021) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkab356 · Cited by 10

Senescent Tumor Cells Are Frequently Present at the Invasion Front: Implications for Improving Disease Control in Patients with Locally Advanced Prostate Cancer

Schwarz, S., Nientiedt, C., Prigge, E., Kaczorowski, A., Geisler, C., Lucena-Porcel, C., Doeberitz, M. V. K., Hohenfellner, M., & Duensing, S. M. (2023) · Pathobiology · doi:10.1159/000530430 · Cited by 10

Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard

Rothmiller, S., Jäger, N., Meier, N., Meyer, T., Neu, A., Steinritz, D., Thiermann, H., Scherer, M. A., Rummel, C., Mangerich, A., et al. (2021) · Archives of Toxicology · doi:10.1007/s00204-020-02946-5 · Cited by 10

The metastatic capacity of high-grade serous ovarian cancer cells changes along disease progression: inhibition by mifepristone

Ritch, S. J., Noman, A. S., Goyeneche, A., & Telleria, C. (2022) · bioRxiv · doi:10.1186/s12935-022-02822-5 · Cited by 9

Detection of Cellular Senescence Reveals the Existence of Senescent Tumor Cells within Invasive Breast Carcinomas and Related Metastases

Cotarelo, C., Schad, A., Schmidt, M., Hönig, A., Sleeman, J. P., & Thaler, S. (2023) · Cancers · doi:10.3390/cancers15061860 · Cited by 10

From Cancer to Rejuvenation: Incomplete Regeneration As the Missing Link (Part I: the Same origin, Different outcomes)

Baramiya, M. G., & Baranov, E. (2020) · Future Science OA · doi:10.2144/fsoa-2019-0119 · Cited by 10

Dialog between mantle cell lymphoma cells and lymphoma-associated macrophages underlies ibrutinib resistance

Sun, X., Wang, C., Cao, J., Li, J., Ma, G., Wu, X., Sun, P., Wang, Y., Huang, J., Gale, R. P., et al. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.08.023 · Cited by 9

Senescent cells in systemic aging: SASP heterogeneity, immune escape, and endocrine modulation

Qoura, L. A., Churov, A. V., Maltseva, O. N., Ерусланова, К. А., & Zeng, G. (2026) · Biogerontology · doi:10.1007/s10522-026-10449-6 · Cited by 9

PD-1 Carried on Small Extracellular Vesicles Leads to OSCC Metastasis

Zhang, L.-Z., Yang, J., Xia, H., Huang, J., Liu, H.-M., Wu, M., Liu, B., Wang, W.-M., & Chen, G. (2023) · Journal of Dental Research · doi:10.1177/00220345231165209 · Cited by 9

Radiation-Induced Cellular Senescence Reduces Susceptibility of Glioblastoma Cells to Oncolytic Vaccinia Virus

Storozynsky, Q. T., Han, X., Komant, S. J., Agopsowicz, K. C., Potts, K. G., Gamper, A. M., Godbout, R., Evans, D. H., & Hitt, M. (2023) · Cancers · doi:10.3390/cancers15133341 · Cited by 9

Breast Cancer and p16: Role in Proliferation, Malignant Transformation and Progression

Jovanović, D., Mitrović, S., Milosavljević, M. Z., Ilić, M., Stanković, V., Vuletic, M. S., Stojanovic, M. D., Milošev, D., Azanjac, G., Nedeljković, V., et al. (2021) · Healthcare · doi:10.3390/healthcare9091240 · Cited by 9

Identification of senescence-related lncRNA prognostic index correlating with prognosis and radiosensitivity in prostate cancer patients

Feng, D., Li, L., Shi, X., Zhu, W., Wang, J., Wu, R., Li, D., Wei, W., & Han, P. (2023) · Aging · doi:10.18632/aging.204888 · Cited by 8

Rab25 suppresses colon cancer cell invasion through upregulating claudin‑7 expression

Cho, S. J., Jeong, B., Yoon, S.-H., Park, C., & Lee, H. Y. (2023) · Oncology Reports · doi:10.3892/or.2023.8685 · Cited by 8

High p16INK4A expression in glioblastoma is associated with senescence phenotype and better prognosis

Park, S. S., Roh, T. H., Tanaka, Y., Kim, Y. H., Park, S. H., Kim, T.-G., Eom, S. Y., Park, T. J., Park, I., Kim, S.-H., et al. (2024) · Neoplasia · doi:10.1016/j.neo.2024.101116 · Cited by 8

Cells of all trades – on the importance of spatial positioning of senescent cells in development, healing and aging

Dworak, H., Rozmaric, T., Grillari, J., & Ogrodnik, M. B. (2025) · FEBS Letters · doi:10.1002/1873-3468.70037 · Cited by 8

Targeting Senescence in Oncology: An Emerging Therapeutic Avenue for Cancer

Meguro, S., Makabe, S., Yaginuma, K., Onagi, A., Tanji, R., Matsuoka, K., Hoshi, S., Koguchi, T., Kayama, E., Hata, J., et al. (2025) · Current Oncology · doi:10.3390/curroncol32080467 · Cited by 8

The Interplay of Aging and Cancer: Mechanisms, Implications, and Therapeutic Strategies

Wang, L., Luo, Y., Chen, X., Wang, Y., & Zhang, Y. (2025) · MedComm – Oncology · doi:10.1002/mog2.70041 · Cited by 8

Repression of YEATS2 induces cellular senescence in hepatocellular carcinoma and inhibits tumor growth

Wu, Q., Zheng, Q., Yuan, L., Gao, D., Hu, Y., Jiang, X., Zhai, Q., Liu, M., Xu, L., Xu, H., et al. (2024) · Cell Cycle · doi:10.1080/15384101.2024.2342714 · Cited by 8

Celastrol mediates CAV1 to attenuate pro-tumorigenic effects of senescent cells

Zhang, S., Zhu, N., Shi, Y., Zeng, Q., Zhang, C., Li, H., & Li, Q. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155614 · Cited by 8

Alterations of receptors and insulin-like growth factor binding proteins in senescent cells

Matuszewska, J., Krawiec, A., Radziemski, A., Uruski, P., Tykarski, A., Mikuła‐Pietrasik, J., & Książek, K. (2024) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2024.151438 · Cited by 8

Loss of myosin light chain kinase induces the cellular senescence associated secretory phenotype to promote breast epithelial cell migration

Kim, D., Cooper, J. A., & Helfman, D. M. (2024) · Scientific Reports · doi:10.1038/s41598-024-76868-y · Cited by 8

Human innate immune cell crosstalk induces melanoma cell senescence

Funck, F., Pahl, J. H. W., Kyjacová, L., Freund, L., Oehrl, S., Gräbe, G., Pezer, S., Hassel, J. C., Sleeman, J. P., Cerwenka, A., et al. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1808424 · Cited by 9

An immunosuppressive subtype of senescent tumor cells predicted worse immunotherapy response in lung adenocarcinoma

Fan, G., Xie, T., Tan, Q., Lou, N., Wang, S., Han, X., & Shi, Y. (2023) · iScience · doi:10.1016/j.isci.2023.107894 · Cited by 8

Meroterpenoids from Marine Sponge Hyrtios sp. and Their Anticancer Activity against Human Colorectal Cancer Cells

Wang, J., Yan, Y.-L., Yu, X., Pan, J.-Y., Liu, X., Hong, L., & Wang, B. (2024) · Marine Drugs · doi:10.3390/md22040183 · Cited by 7

An Aging and Senescence-Related Gene Signature for Prognosis Prediction in Clear Cell Renal Cell Carcinoma

Li, J., Gui, C., Yao, H., Luo, C., Song, H., Lin, H., Xu, Q., Chen, X., Huang, Y., Luo, J., et al. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.871088 · Cited by 7

Senescent Secretome of Blind Mole Rat Spalax Inhibits Malignant Behavior of Human Breast Cancer Cells Triggering Bystander Senescence and Targeting Inflammatory Response

Odeh, A., Eddini, H., Shawasha, L., Chaban, A., Avivi, A., Shams, I., & Manov, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065132 · Cited by 7

Origin, Metastasis, Harm, Recognition and Capture, and Elimination of Circulating Tumor Cells

Yuan, Q., Chen, L., Wan, M., Mao, C., & Shen, J. (2024) · Advanced Materials Technologies · doi:10.1002/admt.202301306 · Cited by 7

Peptide Inhibitors Targeting FOXO4-p53 Interactions and Inducing Senescent Cancer Cell-specific Apoptosis

Kang, D., Lim, Y., Ahn, D., Lee, J., & Park, C. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c00537 · Cited by 8

Improved Dose-Response Relationship of (+)-Discodermolide-Taxol Hybrid Congeners

Nadaradjane, C., Yang, C. H., Rodriguez‐Gabin, A., Ye, K. Q., Sugasawa, K., Atasoylu, O., Smith, A. B., Horwitz, S. B., & McDaid, H. M. (2018) · Journal of Natural Products · doi:10.1021/acs.jnatprod.8b00111 · Cited by 7

Senescent Thyrocytes, Similarly to Thyroid Tumor Cells, Elicit M2-like Macrophage Polarization In Vivo

Mazzoni, M., Mauro, G., Minoli, L., Cleris, L., Anania, M. C., Marco, T. D., Minna, E., Pagliardini, S., Rizzetti, M. G., Manenti, G., et al. (2021) · Biology · doi:10.3390/biology10100985 · Cited by 7

Exploring a deep learning neural architecture for closed Literature-based discovery

Cuffy, C., & McInnes, B. T. (2023) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2023.104362 · Cited by 7

MM-129 Counteracts 5-Fluorouracil-Induced Cellular Senescence in Colon Cancer via SIRT1/STAT3 Signaling Pathway

Klepacki, H., Sieklucka, B., Kałafut, J., Kowalczuk, K., Surażyński, A., Mojzych, M., Pryczynicz, A., Pawlak, D., Tiso, N., & Hermanowicz, J. M. (2025) · Cells · doi:10.3390/cells14191498 · Cited by 8

Heterogeneity of Cellular Senescence: Subtype‐Specific Mechanisms and the Emerging Role of Plasma Membrane Damage

Alghamdi, E., & Kono, K. (2025) · Cancer Science · doi:10.1111/cas.70223 · Cited by 7

Role of senescent tumor cells in building a cytokine shield in the tumor microenvironment: mathematical modeling

Kim, Y., Lee, J.-H., Lee, C., & Lawler, S. E. (2022) · Journal of Mathematical Biology · doi:10.1007/s00285-022-01850-z · Cited by 7

A predictive molecular signature consisting of lncRNAs associated with cellular senescence for the prognosis of lung adenocarcinoma

Liu, A., Wang, X., Liu, H., Yan, D., Yin, Y., Zheng, H., Liu, G., Zhang, J., & Li, Y. (2023) · PLoS ONE · doi:10.1371/journal.pone.0287132 · Cited by 6

Recent Advances and Mechanism of Nanomaterials Promoting Tumor Metastasis

Wang, W., Pang, X., Dong, M., Li, R., Liu, Z., Liang, Y., Liu, H., Ni, N., Chen, D., & Sun, X. J. (2023) · Environment & Health · doi:10.1021/envhealth.3c00132 · Cited by 6

Novel strategy of ovarian cancer implantation: Pre‐invasive growth of fibrin‐anchored cells with neovascularization

Matsuoka, A., Mizumoto, Y., Ono, M., Kagami, K., Obata, T., Terakawa, J., Maida, Y., Nakamura, M., Daikoku, T., & Fujiwara, H. (2019) · Cancer Science · doi:10.1111/cas.14098 · Cited by 6

Integrated analysis of senescence-associated genes in pancreatic ductal adenocarcinoma

Zhu, Z.-G., Chen, L., Miao, D.-L., Jin, Y., & Wu, Q. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.941389 · Cited by 5

Cellular senescence and nanoparticle-based therapies: Current developments and perspectives

Henschke, A., Mielcarek, A., Grześkowiak, B. F., Perrigue, P. M., Jaskot, K., Coy, E. L., & Moya, S. E. (2024) · Nanotechnology Reviews · doi:10.1515/ntrev-2023-0211 · Cited by 6

Digital spatial profiling identifies the tumor center as a topological niche in prostate cancer characterized by an upregulation of BAD

Huber, A., Kaczorowski, A., Schneider, F., Böning, S. H., Görtz, M., Langhoff, D., Schwab, C., Stenzinger, A., Hohenfellner, M., Duensing, A. U., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-71070-6 · Cited by 5

Exosomal dynamics: Bridging the gap between cellular senescence and cancer therapy

Aswani, B. S., Sajeev, A., Hegde, M., Mishra, A., Abbas, M., Vayalpurayil, T., Sethi, G., & Kunnumakkara, A. B. (2025) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2025.112045 · Cited by 6

Effect of β-nicotinamide mononucleotide on tumor formation and growth in a lung cancer mouse model

Pan, F., Kang, S., Zhao, Y., Dai, L., Shao, Q., Yang, Y., Chen, Q., Zhu, J., & Cui, L. (2020) · Materials Chemistry Frontiers · doi:10.1039/d0qm00897d · Cited by 5

Senescent tumor cells in colorectal cancer are characterized by elevated enzymatic activity of complexes 1 and 2 in oxidative phosphorylation

Shin, J. S., Kim, T.-G., Kim, Y. H., Eom, S. Y., Park, S. H., Lee, D. H., Park, T. J., Park, S. S., & Kim, J. (2023) · Journal of Pathology and Translational Medicine · doi:10.4132/jptm.2023.10.09 · Cited by 5

Combination treatment with hyaluronic acid synthesis and Bcl-2 inhibitors induces senolytic elimination of oral squamous cell carcinoma cells in vitro

Kamada, K., Kurio, N., Mouri, Y., & Kudo, Y. (2024) · Journal of Oral and Maxillofacial Surgery Medicine and Pathology · doi:10.1016/j.ajoms.2024.09.003 · Cited by 4

Phenotype remodelling of HNSCC cells in the muscle invasion environment

Zeng, G., Shen, Y., Sun, W., Lu, H., Liang, Y., Wu, J., & Liao, G. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05607-8 · Cited by 4

Integrative Bioinformatic Analysis of Cellular Senescence Genes in Ovarian Cancer: Molecular Subtyping, Prognostic Risk Stratification, and Chemoresistance Prediction

Li, A., & Xu, D. (2025) · Biomedicines · doi:10.3390/biomedicines13040877 · Cited by 4

A Senescence-Associated Gene Signature for Prognostic Prediction and Therapeutic Targeting in Adrenocortical Carcinoma

Peng, H., Chen, Q., Ye, L., & Wang, W. (2025) · Biomedicines · doi:10.3390/biomedicines13040894 · Cited by 4

Targeting FAK, VEGF, and MTA1 proteins with Terminalia elliptica: a computational approach for anticancer activity

Shreevatsa, B., Hegde, S., Narayan, P., Dharmashekar, C., Jain, A. S., Wani, T. A., Prabhuswamimath, S. C., Kollur, S. P., & Shivamallu, C. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1427632 · Cited by 3

Cellular Senescence in Cancer: Mechanisms, Roles in Tumor Progression, and Therapeutic Implications

Yan, J., Zhang, Y., Mao, G., Yu, J., Zhou, T., & Hao, J. (2025) · MedComm – Oncology · doi:10.1002/mog2.70029 · Cited by 3

Senolytic elimination of therapy-induced senescent cells by ABT-263 improves chemotherapeutic efficacy in esophageal squamous cell carcinoma

Zhang, D., Zhu, J., Zou, R., Zhang, H., Yu, B.-P., Li, P., Luo, Y., Jiang, Z., Hou, Y., & Zhang, J.-W. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117659 · Cited by 3

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Starck, L., Butelmann, T., Hogan, S. A., Sarem, M., Heimrich, B., Sawarkar, R., Ritz, M., Hütter, G., & Shastri, V. P. (2026) · Advanced Science · doi:10.1002/advs.202509362 · Cited by 3

The relationship between CXC chemokines and cellular senescence: from mechanisms to therapy

Kang, Y., Zhang, X., & Cui, X. (2026) · Biogerontology · doi:10.1007/s10522-026-10404-5 · Cited by 3

Role of hepatocellular senescence in the development of hepatocellular carcinoma and the potential for therapeutic manipulation

Wijayasiri, P., Astbury, S., Needham, G., Kaye, P., Bhat, M., Piccinini, A. M., & Aravinthan, A. D. (2025) · Human Cell · doi:10.1007/s13577-025-01201-2 · Cited by 4

Characteristics and immune checkpoint status of radioiodine-refractory recurrent papillary thyroid carcinomas from Ukrainian Chornobyl Tissue Bank donors

Ti, B., Rogounovitch, T., Zurnadzhy, L. Y., Mitsutake, N., Tronko, M. D., Ito, M., Bolgov, M., Chernyshov, S. V., Gulevatyi, S. V., Masiuk, S. V., et al. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1343848 · Cited by 3

Identification of a senescence-related transcriptional signature to uncover molecular subtypes and key genes in hepatocellular carcinoma

He, X., Liu, F., Xu, P., & Gong, Q. (2024) · PLoS ONE · doi:10.1371/journal.pone.0311696 · Cited by 2

Effect of Benzo[a]pyrene on Cellular Senescence in MCF7 Breast Cancer Cells

Kitamoto, N., Haga, Y., Tsujii, Y., Kubo, M., Higashisaka, K., & Tsutsumi, Y. M. (2025) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b25-00309 · Cited by 2

Senescent Factors Suppress Innate Antiviral Immunity in Aged Mice via Two Distinct Mechanisms

Zhang, X., Zhang, Q., Wang, L., Li, S., & Shu, H. (2026) · Aging Cell · doi:10.1111/acel.70471 · Cited by 2

Urinary detection of therapy-induced senescence and fibrosis using an injectable albumin-based nanoprobe

Hartono, M., Ge, J., Denholm, M., Ellis, M. G., Henríquez, J. A., Baker, A. G., Rintoul, R. C., Euser, T. G., Fruk, L., & Muñoz‐Espín, D. (2026) · Nature Aging · doi:10.1038/s43587-026-01116-z · Cited by 2

Abstract 4087: Senescent cancer cells facilitate metastasis by adhesion-mediated clustering and immune modulation

Anvar, S., Maharjan, C. K., Chen, Z., Somers, J., Jin, Z., Kates, H. R., Ramirez, S. H., Andrews, A. M., Runyon, B. M., Carelock, M. E., et al. (2026) · Cancer Research · doi:10.1158/1538-7445.am2026-4087

Senescent tumor cells: an overlooked adversary in the battle against cancer

Park, S. S., Choi, Y. W., Kim, J., Kim, H. S., & Park, T. J. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00717-5 · Cited by 100

Detection of Cellular Senescence Reveals the Existence of Senescent Tumor Cells within Invasive Breast Carcinomas and Related Metastases

Cotarelo, C., Schad, A., Schmidt, M., Hönig, A., Sleeman, J. P., & Thaler, S. (2023) · Cancers · doi:10.3390/cancers15061860 · Cited by 10

Paracrine roles of cellular senescence in promoting tumourigenesis

Gonzalez-Meljem, J. M., Apps, J. R., Fraser, H. C., & Martinez-Barbera, J. P. (2018) · British Journal of Cancer · doi:10.1038/s41416-018-0066-1 · Cited by 183

Abstract 469: Therapy-induced senescence associated secretory phenotype enhances breast cancer cell invasion and stemness via CXCR1/2-CXCR1/2 ligands axis

Choi, Y. W., Cha, H., Park, T. J., Ahn, M. S., Lee, H. W., Jeong, S. H., Kang, S. Y., Park, J. S., & Choi, J. (2018) · Cancer Research · doi:10.1158/1538-7445.am2018-469