The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Shifting the optimal stiffness for cell migration
Open accessAbstract
Cell migration, which is central to many biological processes including wound healing and cancer progression, is sensitive to environmental stiffness, and many cell types exhibit a stiffness optimum, at which migration is maximal. Here we present a cell migration simulator that predicts a stiffness optimum that can be shifted by altering the number of active molecular motors and clutches. This prediction is verified experimentally by comparing cell traction and F-actin retrograde flow for two cell types with differing amounts of active motors and clutches: embryonic chick forebrain neurons (ECFNs; optimum ∼1 kPa) and U251 glioma cells (optimum ∼100 kPa). In addition, the model predicts, and experiments confirm, that the stiffness optimum of U251 glioma cell migration, morphology and F-actin retrograde flow rate can be shifted to lower stiffness by simultaneous drug inhibition of myosin II motors and integrin-mediated adhesions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Use of Ranks in One-Criterion Variance Analysis
Kruskal, W. H., & Wallis, W. A. (1952) · Journal of the American Statistical Association · doi:10.1080/01621459.1952.10483441 · Cited by 13,912
Exact stochastic simulation of coupled chemical reactions
Gillespie, D. T. (1977) · The Journal of Physical Chemistry · doi:10.1021/j100540a008 · Cited by 10,136
Multiple Comparisons Using Rank Sums
Dunn, O. J. (1964) · Technometrics · doi:10.1080/00401706.1964.10490181 · Cited by 5,085
Ueber die Berührung fester elastischer Körper.
Hertz, H. (1882) · crll · doi:10.1515/crll.1882.92.156 · Cited by 4,789
Bell, G. I. (1978) · Science · doi:10.1126/science.347575 · Cited by 4,328
Cell Movement Is Guided by the Rigidity of the Substrate
Lo, C.-M., Wang, H.-B., Dembo, M., & Wang, Y.-L. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76279-5 · Cited by 3,289
Determination of Elastic Moduli of Thin Layers of Soft Material Using the Atomic Force Microscope
Dimitriadis, E. K., Horkay, F., Maresca, J., Kachar, B., & Chadwick, R. S. (2002) · Biophysical Journal · doi:10.1016/s0006-3495(02)75620-8 · Cited by 1,230
Traction fields, moments, and strain energy that cells exert on their surroundings
Butler, J. P., Tolić-Nørrelykke, I. M., Fabry, B., & Fredberg, J. J. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00270.2001 · Cited by 1,043
Traction Dynamics of Filopodia on Compliant Substrates
Chan, C. E., & Odde, D. J. (2008) · Science · doi:10.1126/science.1163595 · Cited by 936
Self-citationSubstrate stress relaxation regulates cell spreading
Chaudhuri, O., Gu, L., Darnell, M., Klumpers, D., Bencherif, S. A., Weaver, J. C., Huebsch, N., & Mooney, D. J. (2015) · Nature Communications · doi:10.1038/ncomms7365 · Cited by 889
Cytoskeletal dynamics and nerve growth
Mitchison, T., & Kirschner, M. (1988) · Neuron · doi:10.1016/0896-6273(88)90124-9 · Cited by 871
Elosegui-Artola, A., Oria, R., Chen, Y., Kosmalska, A., Pérez-González, C., Castro, N., Zhu, C., Trepat, X., & Roca-Cusachs, P. (2016) · Nature Cell Biology · doi:10.1038/ncb3336 · Cited by 858 · cited 2×
“(9) Destroy modules shorter than length lmin.”
MethodCollective cell durotaxis emerges from long-range intercellular force transmission
Sunyer, R., Conte, V., Escribano, J., Elosegui-Artola, A., Labernadie, A., Valon, L., Navajas, D., García-Aznar, J. M., Muñoz, J. J., Roca-Cusachs, P., et al. (2016) · Science · doi:10.1126/science.aaf7119 · Cited by 631
Mathematical model for the effects of adhesion and mechanics on cell migration speed
DiMilla, P. A., Barbee, K., & Lauffenburger, D. A. (1991) · Biophysical Journal · doi:10.1016/s0006-3495(91)82027-6 · Cited by 613
Independent regulation of tumor cell migration by matrix stiffness and confinement
Pathak, A., & Kumar, S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118073109 · Cited by 568
Lefranc, F., Brotchi, J., & Kiss, R. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.03.089 · Cited by 526
Identification of genes that regulate epithelial cell migration using an siRNA screening approach
Simpson, K. J., Selfors, L. M., Bui, J., Reynolds, A., Leake, D., Khvorova, A., & Brugge, J. S. (2008) · Nature Cell Biology · doi:10.1038/ncb1762 · Cited by 406
Wang, Y.-L., & Pelham, R. J. (1998) · Methods in Enzymology · doi:10.1016/s0076-6879(98)98041-7 · Cited by 372
Rigidity sensing and adaptation through regulation of integrin types
Elosegui-Artola, A., Bazellières, E., Allen, M. D., Andreu, I., Oria, R., Sunyer, R., Gomm, J. J., Marshall, J. F., Jones, J. L., Trepat, X., et al. (2014) · Nature Materials · doi:10.1038/nmat3960 · Cited by 358
The Role of Myosin II in Glioma Invasion of the Brain
Beadle, C., Assanah, M. C., Monzo, P., Vallee, R., Rosenfeld, S. S., & Canoll, P. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-03-0319 · Cited by 310
Self-citationThe kinetics of actin nucleation and polymerization.
Tobacman, L. S., & Korn, E. D. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32850-3 · Cited by 252
Bangasser, B. L., Rosenfeld, S. S., & Odde, D. J. (2013) · Biophysical Journal · doi:10.1016/j.bpj.2013.06.027 · Cited by 234
Self-citationThe E8 subfragment of laminin promotes locomotion of myoblasts over extracellular matrix.
Goodman, S. L., Risse, G., & von der Mark, K. (1989) · The Journal of cell biology · doi:10.1083/jcb.109.2.799 · Cited by 189
The cooperative nature of G-F transformation of actin
Kasai, M., Asakura, S., & Oosawa, F. (1962) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(62)91073-9 · Cited by 168
Optimal estimation of cell movement indices from the statistical analysis of cell tracking data
Dickinson, R. B., & Tranquillo, R. T. (1993) · AIChE Journal · doi:10.1002/aic.690391210 · Cited by 159
Master Equation-Based Analysis of a Motor-Clutch Model for Cell Traction Force
Bangasser, B. L., & Odde, D. J. (2013) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-013-0296-5 · Cited by 95
Self-citationBiphasic Dependence of Glioma Survival and Cell Migration on CD44 Expression Level
Klank, R. L., Decker, S. A., Bangasser, B. L., Forster, C. L., Price, M. A., Odde, T. J., SantaCruz, K. S., Rosenfeld, S. S., Canoll, P., Turley, E. A., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.024 · Cited by 93
Self-citationProtein-derivatised glass coverslips for the study of cell-to-substratum adhesion
Aplin, J., & Hughes, R. C. (1981) · Analytical Biochemistry · doi:10.1016/0003-2697(81)90057-9 · Cited by 81
Correlation Analysis of Two-Dimensional Locomotion Paths
Alt, W. (1990) · Lecture notes in biomathematics · doi:10.1007/978-3-642-51664-1_18 · Cited by 65
Physical Model for Self-Organization of Actin Cytoskeleton and Adhesion Complexes at the Cell Front
Shemesh, T., Bershadsky, A. D., & Kozlov, M. M. (2012) · Biophysical Journal · doi:10.1016/j.bpj.2012.03.006 · Cited by 59
Cited by
Effects of extracellular matrix viscoelasticity on cellular behaviour
Chaudhuri, O., Cooper-White, J., Janmey, P. A., Mooney, D. J., & Shenoy, V. B. (2020) · Nature · doi:10.1038/s41586-020-2612-2 · Cited by 2,224
Integrins as biomechanical sensors of the microenvironment
Kechagia, J. Z., Ivaska, J., & Roca-Cusachs, P. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0134-2 · Cited by 1,311
Srivastava, S., Kinnunen, P. C., Wang, Z., Ho, K. K. Y., Humphries, B. A., Chen, S., Linderman, J. J., Luker, G. D., Luker, K. E., & Garikipati, K. (2025) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1013607 · Cited by 5
“Past work focused on U251 glioma cancer cells measured a random motion coefficient (akin to diffusivity measured for a single cell) of between 60 and 300 𝜇 m 2 / hr across a range of substrate stiffnesses [51].”
Trusting the forces of our cell lines
Moro-López, M., Farré, R., Otero, J., & Sunyer, R. (2024) · Cells & Development · doi:10.1016/j.cdev.2024.203931 · Cited by 2
Metadata
- Authors
- Bangasser, B. L., Shamsan, G. A., Chan, C. E., Opoku, K. N., Tüzel, E., Schlichtmann, B. W., Kasim, J. A., Fuller, B. J., McCullough, B. R., Rosenfeld, S. S., & Odde, D. J.
- Venue
- Nature Communications
- Published
- 2017-05-22
- Volume
- 8
- Issue
- 1
- Pages
- 15313-15313
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2619683448
- Cited by
- 328
- References
- 30
- FWCI
- 11.54
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
