The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
YAP regulates cell mechanics by controlling focal adhesion assembly
Open accessAbstract
Hippo effectors YAP/TAZ act as on–off mechanosensing switches by sensing modifications in extracellular matrix (ECM) composition and mechanics. The regulation of their activity has been described by a hierarchical model in which elements of Hippo pathway are under the control of focal adhesions (FAs). Here we unveil the molecular mechanism by which cell spreading and RhoA GTPase activity control FA formation through YAP to stabilize the anchorage of the actin cytoskeleton to the cell membrane. This mechanism requires YAP co-transcriptional function and involves the activation of genes encoding for integrins and FA docking proteins. Tuning YAP transcriptional activity leads to the modification of cell mechanics, force development and adhesion strength, and determines cell shape, migration and differentiation. These results provide new insights into the mechanism of YAP mechanosensing activity and qualify this Hippo effector as the key determinant of cell mechanics in response to ECM cues.
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Cites
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Cited by
Every step of the way: integrins in cancer progression and metastasis
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YAP/TAZ upstream signals and downstream responses
Totaro, A., Panciera, T., & Piccolo, S. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0142-z · Cited by 1,086
Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases
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YAP/TAZ functions and their regulation at a glance
Pocaterra, A., Romani, P., & Dupont, S. (2020) · Journal of Cell Science · doi:10.1242/jcs.230425 · Cited by 367
Insights into recent findings and clinical application of YAP and TAZ in cancer
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Metadata
- Authors
- Nardone, G., Oliver-De La Cruz, J., Vrbsky, J., Martini, C., Pribyl, J., Skládal, P., Pešl, M., Caluori, G., Pagliari, S., Martino, F., Maceckova, Z., Hajduch, M., Sanz-Garcia, A., Pugno, N. M., Stokin, G. B., & Forte, G.
- Venue
- Nature Communications
- Published
- 2017-05-15
- Volume
- 8
- Issue
- 1
- Pages
- 15321-15321
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2614669617
- Cited by
- 664
- References
- 53
- FWCI
- 21.94
- Type
- journal article
- Language
- en
- Open access
- gold
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- Nardone, G., Oliver-De La Cruz, J., Vrbsky, J., Martini, C., Pribyl, J., Skládal, P., Pešl, M., Caluori, G., Pagliari, S., Martino, F., Maceckova, Z., Hajduch, M., Sanz-Garcia, A., Pugno, N. M., Stokin, G. B., & Forte, G. (2017). YAP regulates cell mechanics by controlling focal adhesion assembly. Nature Communications. https://doi.org/10.1038/ncomms15321
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