Insights into recent findings and clinical application of YAP and TAZ in cancer

Role of YAP/TAZ in mechanotransduction

Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979 · see citing works

Oncogenic Signaling Pathways in The Cancer Genome Atlas

Sanchez-Vega, F., Mina, M., Armenia, J., Chatila, W. K., Luna, A., La, K. C., Dimitriadoy, S., Liu, D. L., Kantheti, H. S., Saghafinia, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.035 · Cited by 3,201 · see citing works

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

Zhao, B., Wei, X., Li, W., Udan, R. S., Yang, Q., Kim, J., Xie, J., Ikenoue, T., Yu, J., Li, L., et al. (2007) · Genes & Development · doi:10.1101/gad.1602907 · Cited by 3,092 · see citing works

Elucidation of a universal size-control mechanism in Drosophila and mammals

Dong, J., Feldmann, G., Huang, J., Wu, S., Zhang, N., Comerford, S. A., Gayyed, M. F., Anders, R. A., Maitra, A., & Pan, D. (2007) · Cell · doi:10.1016/j.cell.2007.07.019 · Cited by 2,370 · see citing works

The Hippo Signaling Pathway in Development and Cancer

Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.09.011 · Cited by 2,274 · see citing works

YAP/TAZ at the Roots of Cancer

Zanconato, F., Cordenonsi, M., & Piccolo, S. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.05.005 · Cited by 1,970 · see citing works

The Biology of YAP/TAZ: Hippo Signaling and Beyond

Piccolo, S., Dupont, S., & Cordenonsi, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00005.2014 · Cited by 1,797 · see citing works

Mechanisms of Hippo pathway regulation

Meng, Z., Moroishi, T., & Guan, K.-L. (2016) · Genes & Development · doi:10.1101/gad.274027.115 · Cited by 1,667 · see citing works

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

Yu, F.-X., Zhao, B., Panupinthu, N., Jewell, J. L., Lian, I., Wang, L. H., Zhao, J., Yuan, H., Tumaneng, K., Li, H., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.037 · Cited by 1,628 · see citing works

PD-1/PD-L1 pathway: current researches in cancer.

Han, Y., Liu, D., & Li, L. (2020) · PubMed Central · Cited by 1,602 · see citing works

Genetic and pharmacological disruption of the TEAD–YAP complex suppresses the oncogenic activity of YAP

Liu-Chittenden, Y., Huang, B., Shim, J. S., Chen, Q., Lee, S.-J., Anders, R. A., Liu, J. O., & Pan, D. (2012) · Genes & Development · doi:10.1101/gad.192856.112 · Cited by 1,452 · see citing works

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF ^β-TRCP

Zhao, B., Li, L., Tumaneng, K., Wang, C.-Y., & Guan, K.-L. (2010) · Genes & Development · doi:10.1101/gad.1843810 · Cited by 1,418 · see citing works

The Hippo Pathway: Biology and Pathophysiology

Ma, S., Meng, Z., Chen, R., & Guan, K.-L. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-013118-111829 · Cited by 1,387 · see citing works

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

Pajtler, K. W., Witt, H., Sill, M., Jones, D., Hovestadt, V., Kratochwil, F., Wani, K., Tatevossian, R., Punchihewa, C., Johann, P. D., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.04.002 · Cited by 1,226 · see citing works

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

Zanconato, F., Forcato, M., Battilana, G., Azzolin, L., Quaranta, E., Bodega, B., Rosato, A., Bicciato, S., Cordenonsi, M., & Piccolo, S. (2015) · Nature Cell Biology · doi:10.1038/ncb3216 · Cited by 1,219 · see citing works

The emerging roles of YAP and TAZ in cancer

Moroishi, T., Hansen, C. G., & Guan, K. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3876 · Cited by 1,156 · see citing works

The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass

Nishioka, N., Inoue, K., Adachi, K., Kiyonari, H., Ota, M., Ralston, A., Yabuta, N., Hirahara, S., Stephenson, R. O., Ogonuki, N., et al. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.02.003 · Cited by 1,083 · see citing works

Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine

Moya, I. M., & Halder, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0086-y · Cited by 981 · see citing works

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

Zhou, D., Conrad, C. H., Xia, F., Park, J.-S., Payer, B., Yin, Y., Lauwers, G. Y., Thasler, W. E., Lee, J. T., Avruch, J., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.09.026 · Cited by 916 · see citing works

The Hippo Signaling Pathway in Development and Disease

Zheng, Y., & Pan, D. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.06.003 · Cited by 867 · see citing works

Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine

Dey, A., Varelas, X., & Guan, K.-L. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0070-z · Cited by 860 · see citing works

Antisense technology: an overview and prospectus

Crooke, S. T., Baker, B. F., Crooke, R. M., & Liang, X.-H. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00162-z · Cited by 775 · see citing works

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

Rosenbluh, J., Nijhawan, D., Cox, A. G., Li, X., Neal, J. T., Schafer, E. J., Zack, T. I., Wang, X., Tsherniak, A., Schinzel, A. C., et al. (2012) · Cell · doi:10.1016/j.cell.2012.11.026 · Cited by 757 · see citing works

The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiationPreprint

Lian, I., Kim, J., Okazawa, H., Zhao, J. J., Zhao, B., Yu, J., Chinnaiyan, A. M., Israel, M. A., Goldstein, L. S. B., Abujarour, R., et al. (2010) · Genes & Development · doi:10.1101/gad.1903310 · Cited by 738 · see citing works

Alternative Wnt Signaling Activates YAP/TAZ

Park, H. W., Kim, Y. C., Yu, B., Moroishi, T., Mo, J., Plouffe, S. W., Meng, Z., Lin, K. C., Yu, F., Alexander, C. M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.013 · Cited by 708 · see citing works

YAP regulates cell mechanics by controlling focal adhesion assembly

Nardone, G., Cruz, J. O. L., Vrbský, J., Martini, C., Přibyl, J., Skládal, P., Pešl, M., Caluori, G., Pagliari, S., Martino, F. D., et al. (2017) · Nature Communications · doi:10.1038/ncomms15321 · Cited by 669 · see citing works

The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease

Varelas, X. (2014) · Development · doi:10.1242/dev.102376 · Cited by 665 · see citing works

The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain

Lamar, J. M., Stern, P., Liu, H., Schindler, J. W., Jiang, Z.-G., & Hynes, R. O. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1212021109 · Cited by 656 · see citing works

A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer

Jiao, S., Wang, H., Shi, Z., Dong, A., Zhang, W., Song, X., He, F., Wang, Y., Zhang, Z., Wang, W., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.01.010 · Cited by 602 · see citing works

The Hippo Pathway Regulates Wnt/β-Catenin Signaling

Varelas, X., Miller, B. W., Sopko, R., Song, S., Gregorieff, A., Fellouse, F. A., Sakuma, R., Pawson, T. J., Hunziker, W., McNeill, H., et al. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.03.007 · Cited by 571 · see citing works

Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway

Mo, J.-S., Meng, Z., Kim, Y. C., Park, H. W., Hansen, C. G., Kim, S., Lim, D.-S., & Guan, K.-L. (2015) · Nature Cell Biology · doi:10.1038/ncb3111 · Cited by 557 · see citing works

AMPK modulates Hippo pathway activity to regulate energy homeostasis

Wang, W., Xiao, Z.-D., Li, X., Aziz, K. E., Gan, B., Johnson, R. L., & Chen, J. (2015) · Nature Cell Biology · doi:10.1038/ncb3113 · Cited by 549 · see citing works

Restriction of intestinal stem cell expansion and the regenerative response by YAP

Barry, E., Morikawa, T., Butler, B. L., Shrestha, K., de la Rosa, R., Yan, K. S., Fuchs, C. S., Magness, S. T., Smits, R., Ogino, S., et al. (2012) · Nature · doi:10.1038/nature11693 · Cited by 537 · see citing works

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

Wang, Y., Xu, X., Maglic, D., Dill, M. T., Mojumdar, K., Ng, P. K.-S., Jeong, K. J., Tsang, Y. H., Moreno, D., Bhavana, V. H., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.001 · Cited by 500 · see citing works

Role of TAZ as Mediator of Wnt Signaling

Azzolin, L., Zanconato, F., Bresolin, S., Forcato, M., Basso, G., Bicciato, S., Cordenonsi, M., & Piccolo, S. (2012) · Cell · doi:10.1016/j.cell.2012.11.027 · Cited by 490 · see citing works

Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

Kurppa, K. J., Liu, Y., To, C., Zhang, T., Fan, M., Vajdi, A., Knelson, E. H., Xie, Y., Lim, K., Cejas, P., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2019.12.006 · Cited by 475 · see citing works

Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP

Yu, F., Luo, J., Mo, J., Liu, G., Kim, Y. C., Meng, Z., Zhao, L., Peyman, G. A., Ouyang, H. W., Jiang, W., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.017 · Cited by 464 · see citing works

Role of Merlin/NF2 inactivation in tumor biology

Petrilli, A. M., & Fernández‐Valle, C. (2015) · Oncogene · doi:10.1038/onc.2015.125 · Cited by 459 · see citing works

YAP/TAZ Signaling and Resistance to Cancer Therapy

Nguyen, C. D. K., & Yi, C. (2019) · Trends in Cancer · doi:10.1016/j.trecan.2019.02.010 · Cited by 437 · see citing works

Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis

Pastushenko, I., Mauri, F., Song, Y., de Cock, F., Meeusen, B., Swedlund, B., Impens, F., Haver, D. V., Opitz, M., Théry, M., et al. (2020) · Nature · doi:10.1038/s41586-020-03046-1 · Cited by 431 · see citing works

Defects in Yolk Sac Vasculogenesis, Chorioallantoic Fusion, and Embryonic Axis Elongation in Mice with Targeted Disruption of <i>Yap65</i>

Morin-Kensicki, E. M., Boone, B. N., Howell, M., Stonebraker, J. R., Teed, J., Alb, J. G., Magnuson, T. R., O'Neal, W., & Milgram, S. L. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.1.77-87.2006 · Cited by 429 · see citing works

Protein palmitoylation and cancer

Ko, P., & Dixon, S. J. (2018) · EMBO Reports · doi:10.15252/embr.201846666 · Cited by 429 · see citing works

Adhesion to fibronectin regulates Hippo signaling via the FAK–Src–PI3K pathway

Kim, N., & Gumbiner, B. M. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201501025 · Cited by 424 · see citing works

Physical Interaction with Yes-associated Protein Enhances p73 Transcriptional Activity

Strano, S., Munarriz, E. R., Rossi, M., Castagnoli, L., Shaul, Y., Sacchi, A., Oren, M., Sudol, M., Cesareni, G., & Blandino, G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010484200 · Cited by 418 · see citing works

YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

Stein, C., Bardet, A. F., Roma, G., Bergling, S., Clay, I., Ruchti, A., Agarinis, C., Schmelzle, T., Bouwmeester, T., Schübeler, D., et al. (2015) · PLOS Genetics · doi:10.1371/journal.pgen.1005465 · Cited by 414 · see citing works

RAP2 mediates mechanoresponses of the Hippo pathway

Meng, Z., Qiu, Y., Lin, K. C., Kumar, A., Placone, J. K., Fang, C., Wang, K.-C., Lu, S., Pan, M., Hong, A. W., et al. (2018) · Nature · doi:10.1038/s41586-018-0444-0 · Cited by 377 · see citing works

The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant gliomaPreprint

Bhat, K., Salazar, K. L., Balasubramaniyan, V., Wani, K., Heathcock, L. E., Hollingsworth, F., James, J. D., Gumin, J., Alfaro-Munoz, K. D., Kim, S. H., et al. (2011) · Genes & Development · doi:10.1101/gad.176800.111 · Cited by 377 · see citing works

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasisPreprint

Moroishi, T., Park, H. W., Qin, B., Chen, Q., Meng, Z., Plouffe, S. W., Taniguchi, K., Yu, F., Karin, M., Pan, D., et al. (2015) · Genes & Development · doi:10.1101/gad.262816.115 · Cited by 367 · see citing works

Downstream of Mutant KRAS, the Transcription Regulator YAP Is Essential for Neoplastic Progression to Pancreatic Ductal Adenocarcinoma

Zhang, W., Nandakumar, N., Shi, Y., Manzano, M., Smith, A., Graham, G., Gupta, S., Vietsch, E. E., Laughlin, S. Z., Wadhwa, M., et al. (2014) · Science Signaling · doi:10.1126/scisignal.2005049 · Cited by 360 · see citing works

TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells

Bartucci, M., Dattilo, R., Moriconi, C., Pagliuca, A., Mottolese, M., Federici, G., Benedetto, A. D., Todaro, M., Stassi, G., Sperati, F., et al. (2014) · Oncogene · doi:10.1038/onc.2014.5 · Cited by 353 · see citing works

Role of Hippo Pathway-YAP/TAZ Signaling in Angiogenesis

Gandhi, T. K. B., & Hong, W. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00049 · Cited by 349 · see citing works

Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1

Fan, R., Kim, N., & Gumbiner, B. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216462110 · Cited by 339 · see citing works

Regulation of the Hippo Pathway Transcription Factor TEAD

Lin, K. C., Park, H. W., & Guan, K. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2017.09.003 · Cited by 334 · see citing works

The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer

Cunningham, R., & Hansen, C. G. (2022) · Clinical Science · doi:10.1042/cs20201474 · Cited by 334 · see citing works

Coexistent ARID1A–PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling

Chandler, R. L., Damrauer, J. S., Raab, J. R., Schisler, J. C., Wilkerson, M. D., Didion, J. P., Starmer, J., Serber, D., Yee, D., Xiong, J., et al. (2015) · Nature Communications · doi:10.1038/ncomms7118 · Cited by 320 · see citing works

Merlin/NF2 Suppresses Tumorigenesis by Inhibiting the E3 Ubiquitin Ligase CRL4DCAF1 in the Nucleus

Li, W., You, L., Cooper, J. M., Schiavon, G., Pepe-Caprio, A., Zhou, L., Ishii, R., Giovannini, M., Hanemann, C. O., Long, S. B., et al. (2010) · Cell · doi:10.1016/j.cell.2010.01.029 · Cited by 316 · see citing works

Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway

Chan, P., Han, X., Zheng, B., DeRan, M., Yu, J., Jarugumilli, G. K., Deng, H., Pan, D., Luo, X., & Wu, X. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2036 · Cited by 313 · see citing works

Glycogen accumulation and phase separation drives liver tumor initiation

Liu, Q., Li, J., Zhang, W., Xiao, C., Zhang, S., Nian, C., Li, J., Su, D., Chen, L., Zhao, Q. C., et al. (2021) · Cell · doi:10.1016/j.cell.2021.10.001 · Cited by 312 · see citing works

Rescue of Hippo coactivator YAP1 triggers DNA damage–induced apoptosis in hematological cancers

Cottini, F., Hideshima, T., Xu, C., Sattler, M., Dori, M., Agnelli, L., ten Hacken, E., Bertilaccio, M. T. S., Antonini, E., Neri, A., et al. (2014) · Nature Medicine · doi:10.1038/nm.3562 · Cited by 310 · see citing works

The Hippo Pathway Component TAZ Promotes Immune Evasion in Human Cancer through PD-L1

van Rensburg, H. J. J., Azad, T., Ling, M., Hao, Y., Snetsinger, B., Khanal, P., Minassian, L. M., Graham, C. H., Rauh, M. J., & Yang, X. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3139 · Cited by 307 · see citing works

Transcriptional Co-repressor Function of the Hippo Pathway Transducers YAP and TAZ

Kim, M., Kim, T., Johnson, R. L., & Lim, D. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.03.015 · Cited by 293 · see citing works

SWI/SNF as mechanoregulated inhibitor of YAP/TAZ

Chang, L., Azzolin, L., di Biagio, D., Zanconato, F., Battilana, G., Xiccato, R. L., Aragona, M., Giulitti, S., Panciera, T., Gandin, A., et al. (2018) · Nature · doi:10.1038/s41586-018-0658-1 · Cited by 291 · see citing works

YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers

Galli, G. G., Carrara, M., Yuan, W.-C., Valdes-Quezada, C., Gurung, B., Pepe-Mooney, B., Zhang, T., Geeven, G., Gray, N. S., de Laat, W., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.09.001 · Cited by 290 · see citing works

Single tumor-initiating cells evade immune clearance by recruiting type II macrophagesPreprint

Guo, X., Zhao, Y., Yan, H., Yang, Y., Shen, S., Dai, X., Ji, X., Ji, F., Gong, X., Li, L., et al. (2017) · Genes & Development · doi:10.1101/gad.294348.116 · Cited by 283 · see citing works

Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling

Noland, C. L., Gierke, S., Schnier, P. D., Murray, J. M., Sandoval, W. N., Sagolla, M. S., Dey, A., Hannoush, R. N., Fairbrother, W. J., & Cunningham, C. N. (2015) · Structure · doi:10.1016/j.str.2015.11.005 · Cited by 268 · see citing works

The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway

Furth, N., & Aylon, Y. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.99 · Cited by 262 · see citing works

YAP/TAZ: Drivers of Tumor Growth, Metastasis, and Resistance to Therapy

Thompson, B. J. (2020) · BioEssays · doi:10.1002/bies.201900162 · Cited by 262 · see citing works

LATS2 Is a Tumor Suppressor Gene of Malignant Mesothelioma

Murakami, H., Mizuno, T., Taniguchi, T., Fujii, M., Ishiguro, F., Fukui, T., Akatsuka, S., Horio, Y., Hida, T., Kondo, Y., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2164 · Cited by 260 · see citing works

The Hippo pathway effector proteins YAP and TAZ have both distinct and overlapping functions in the cell

Plouffe, S. W., Lin, K. C., Moore, J. L., Tan, F. E., Ma, S., Ye, Z., Qiu, Y., Ren, B., & Guan, K. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002715 · Cited by 255 · see citing works

Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of <i>NF2</i> -deficient Mesothelioma

Tang, T. T., Konradi, A. W., Feng, Y., Peng, X., Ma, M., Li, J., Yu, F.-X., Guan, K.-L., & Post, L. (2021) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-20-0717 · Cited by 245 · see citing works

YAP Is Essential for Treg-Mediated Suppression of Antitumor Immunity

Ni, X., Tao, J., Barbi, J. J., Chen, Q., Park, B. V., Li, Z., Zhang, N., Lebid, A., Ramaswamy, A., Wei, P., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1124 · Cited by 235 · see citing works

Recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poroma and porocarcinoma

Sekine, S., Kiyono, T., Ryo, E., Ogawa, R., Wakai, S., Ichikawa, H., Suzuki, K., Arai, S., Tsuta, K., Ishida, M., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci126185 · Cited by 235 · see citing works

Tead and AP1 Coordinate Transcription and Motility

Liu, X., Li, H., Rajurkar, M., Li, Q., Cotton, J. L., Ou, J., Zhu, L. J., Goel, H. L., Mercurio, A. M., Park, J., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.104 · Cited by 231 · see citing works

Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase

Serrano, I., McDonald, P. C., Lock, F. E., Muller, W. J., & Dedhar, S. (2013) · Nature Communications · doi:10.1038/ncomms3976 · Cited by 226 · see citing works

A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesisPreprint

Chen, Q., Zhang, N., Gray, R. S., Li, H., Ewald, A. J., Zahnow, C. A., & Pan, D. (2014) · Genes & Development · doi:10.1101/gad.233676.113 · Cited by 220 · see citing works

Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice

Moya, I. M., Castaldo, S. A., den Mooter, L. V., Soheily, S., Sansores-García, L., Jacobs, J., Mannaerts, I., Xie, J., Verboven, E., Hillen, H., et al. (2019) · Science · doi:10.1126/science.aaw9886 · Cited by 219 · see citing works

Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy

Pobbati, A. V., Han, X. Y., Hung, A. W., Seetoh, W.-G., Huda, N., Chen, G.-Y., Kang, C., Chia, C. S. B., Luo, X., Hong, W., et al. (2015) · Structure · doi:10.1016/j.str.2015.09.009 · Cited by 212 · see citing works

Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC

CHAIB-OUKADOUR, I., Karachaliou, N., Pilotto, S., Servat, J. C., Cai, X., Li, X., Drozdowskyj, A., Codony, C., Yang, J. E., Hu, C., et al. (2017) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djx014 · Cited by 210 · see citing works

Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade

Zhang, Q., Meng, F., Chen, S., Plouffe, S. W., Wu, S., Liu, S., Li, X., Zhou, R., Wang, J., Zhao, B., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3496 · Cited by 206 · see citing works

Tumor‐propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis

Lau, A. N., Curtis, S. J., Brainson, C. F., Rowbotham, S. P., Mohseni, M., Wagner, D. E., Beede, A. M., Montoro, D. T., Sinkevicius, K. W., Walton, Z. E., et al. (2014) · The EMBO Journal · doi:10.1002/embj.201386082 · Cited by 203 · see citing works

Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity

McPherson, J. P., Tamblyn, L., Elia, A., Migon, E., Shehabeldin, A., Matysiak‐Zablocki, E., Lemmers, B., Salmena, L., Hakem, A., Fish, J. E., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600371 · Cited by 201 · see citing works

Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction

Bum‐Erdene, K., Zhou, D., González-Gutiérrez, G., Ghozayel, M. K., Si, Y., Xu, D. D., Shannon, H. E., Bailey, B. J., Corson, T. W., Pollok, K. E., et al. (2018) · Cell chemical biology · doi:10.1016/j.chembiol.2018.11.010 · Cited by 200 · see citing works

Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1

Zhang, H., Ramakrishnan, S. K., Triner, D., Centofanti, B., Maitra, D., Győrffy, B., Sebolt-Leopold, J. S., Dame, M. K., Varani, J., Brenner, D. E., et al. (2015) · Science Signaling · doi:10.1126/scisignal.aac5418 · Cited by 196 · see citing works

Integration of Hippo-YAP Signaling with Metabolism

Ibar, C., & Irvine, K. D. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.06.025 · Cited by 189 · see citing works

Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription

Li, Q., Sun, Y., Jarugumilli, G. K., Liu, S., Dang, K., Cotton, J. L., Xiol, J., Chan, P. Y., DeRan, M., Ma, L., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.03.002 · Cited by 180 · see citing works

Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP–TEAD Protein–Protein Interaction

Zhang, Z., Lin, Z., Zhou, Z., Shen, H. C., Yan, S. F., Mayweg, A. V. W., Xu, Z., Qin, N., Wong, J. C., Zhang, Z., et al. (2014) · ACS Medicinal Chemistry Letters · doi:10.1021/ml500160m · Cited by 177 · see citing works

A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components

Nilsson, M. B., Sun, H., Robichaux, J., Pfeifer, M., McDermott, U., Travers, J., Diao, L., Xi, Y., Tong, P., Shen, L., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz4589 · Cited by 177 · see citing works

Assembly and activation of the Hippo signalome by FAT1 tumor suppressor

Martin, D., Degese, M. S., Vitale-Cross, L., Iglesias-Bartolome, R., Valera, J. L. C., Wang, Z., Feng, X., Yeerna, H., Vadmal, V., Moroishi, T., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04590-1 · Cited by 174 · see citing works

Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity

Pearson, J. D., Huang, K., Pacal, M., McCurdy, S. R., Lü, S., Aubry, A., Yu, T., Wadosky, K. M., Zhang, L., Wang, T., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.06.016 · Cited by 172 · see citing works

Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling

Holden, J. K., Crawford, J. J., Noland, C. L., Schmidt, S., Zbieg, J. R., Lacap, J. A., Zang, R., Miller, G. M., Zhang, Y., Beroza, P., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107809 · Cited by 166 · see citing works

Crosstalk between YAP/TAZ and Notch Signaling

Totaro, A., Castellan, M., Biagio, D. D., & Piccolo, S. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.03.001 · Cited by 163 · see citing works

VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer

Jiao, S., Li, C., Qian, H., Miao, H., Zhang, L., Li, L., & Zhou, Z. (2017) · Nature Communications · doi:10.1038/ncomms14058 · Cited by 157 · see citing works

Osmotic stress‐induced phosphorylation by NLK at Ser128 activates YAP

Hong, A. W., Meng, Z., Yuan, H., Plouffe, S. W., Moon, S., Kim, W., Jho, E., & Guan, K. (2016) · EMBO Reports · doi:10.15252/embr.201642681 · Cited by 156 · see citing works

YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance

Szulzewsky, F., Holland, E. C., & Vasioukhin, V. I. (2021) · Developmental Biology · doi:10.1016/j.ydbio.2020.12.018 · Cited by 153 · see citing works

Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice

Zhang, S., Song, X., Cao, D., Xu, Z., Fan, B., Che, L., Hu, J., Chen, B., Dong, M., Pilo, M. G., et al. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.07.006 · Cited by 152 · see citing works

Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER+ breast cancer

Ma, S., Tang, T. T.-L., Probst, G. D., Konradi, A. W., Jin, C., Li, F., Gutkind, J. S., Fu, X., & Guan, K. (2022) · Nature Communications · doi:10.1038/s41467-022-28691-0 · Cited by 145 · see citing works

Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice

Kim, H.-B., Kim, M., Park, Y.-S., Park, I., Kim, T., Yang, S. Y., Cho, C. J., Hwang, D., Jung, J., Markowitz, S. D., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.11.005 · Cited by 140 · see citing works

Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAPPreprint

Chen, Q., Zhang, N., Xie, R., Wang, W., Cai, J., Choi, K.-S., David, K. K., Huang, B., Yabuta, N., Nojima, H., et al. (2015) · Genes & Development · doi:10.1101/gad.264234.115 · Cited by 136 · see citing works

Cell Junctions in Hippo SignalingPreprint

Karaman, R., & Halder, G. A. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028753 · Cited by 135 · see citing works

Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growthPreprint

Koo, J. H., Plouffe, S. W., Meng, Z., Lee, D.-H., Yang, D., Lim, D., Wang, C., & Guan, K. (2019) · Genes & Development · doi:10.1101/gad.331546.119 · Cited by 129 · see citing works

Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity

Meng, F., Yu, Z., Zhang, D., Chen, S., Guan, H., Zhou, R., Wu, Q., Zhang, Q. Y., Liu, S., Ramani, M. K. V., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.07.040 · Cited by 128 · see citing works

Role of YAP/TAZ in Cell Lineage Fate Determination and Related Signaling Pathways

Heng, B. C., Zhang, X., Aubel, D., Bai, Y., Li, X., Yan, W., Fussenegger, M., & Deng, X. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00735 · Cited by 128 · see citing works

NUAK2 is a critical YAP target in liver cancer

Yuan, W.-C., Pepe-Mooney, B. J., Galli, G. G., Dill, M. T., Huang, H., Hao, M., Wang, Y., Liang, H., Calogero, R., & Camargo, F. D. (2018) · Nature Communications · doi:10.1038/s41467-018-07394-5 · Cited by 127 · see citing works

Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening

Picco, G., Chen, E. D., García‐Alonso, L., Behan, F. M., Gonçalves, E., Bignell, G. R., Matchan, A., Fu, B., Banerjee, R., Anderson, E., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09940-1 · Cited by 127 · see citing works

EGFR-PI3K-PDK1 pathway regulates YAP signaling in hepatocellular carcinoma: the mechanism and its implications in targeted therapy

Xia, H., Dai, X., Yu, H., Zhou, S., Fan, Z., Wei, G., Tang, Q., Gong, Q., & Bi, F. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0302-x · Cited by 124 · see citing works

STRIPAK integrates upstream signals to initiate the Hippo kinase cascade

Chen, R., Xie, R., Meng, Z., Ma, S., & Guan, K. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0426-y · Cited by 119 · see citing works

YAP forms autocrine loops with the ERBB pathway to regulate ovarian cancer initiation and progression

He, C., Lv, X., Hua, G., Lele, S. M., Remmenga, S. W., Dong, J., Davis, J. S., & Wang, C. (2015) · Oncogene · doi:10.1038/onc.2015.52 · Cited by 114 · see citing works

A feed-forward loop between lncARSR and YAP activity promotes expansion of renal tumour-initiating cells

Qu, L., Wu, Z., Li, Y., Xu, Z., Liu, B., Liu, F., Bao, Y., Wu, D.-S., Liu, J., Wang, A., et al. (2016) · Nature Communications · doi:10.1038/ncomms12692 · Cited by 112 · see citing works

Multiphase coalescence mediates Hippo pathway activation

Wang, L., Choi, K., Su, T., Li, B., Wu, X., Zhang, R., Driskill, J. H., Li, H., Lei, H., Guo, P., et al. (2022) · Cell · doi:10.1016/j.cell.2022.09.036 · Cited by 110 · see citing works

Heat stress activates YAP/TAZ to induce the heat shock transcriptome

Luo, M., Meng, Z., Moroishi, T., Lin, K. C., Shen, G., Mo, F., Shao, B., Wei, X., Zhang, P., Wei, Y., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-00602-9 · Cited by 109 · see citing works

Verteporfin exhibits YAP-independent anti-proliferative and cytotoxic effects in endometrial cancer cells

Dasari, V. R., Mazack, V., Feng, W., Nash, J. D., Carey, D. J., & Gogoi, R. P. (2017) · Oncotarget · doi:10.18632/oncotarget.15614 · Cited by 108 · see citing works

Hippo signalling during development

Davis, J. R., & Tapon, N. (2019) · Development · doi:10.1242/dev.167106 · Cited by 108 · see citing works

Isoform Switch of TET1 Regulates DNA Demethylation and Mouse Development

Zhang, W., Xia, W., Wang, Q., Towers, A. J., Chen, J., Gao, R., Zhang, Y., Yen, C., Lee, A. Y., Li, Y., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.10.030 · Cited by 105 · see citing works

A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis

Shen, S., Guo, X., Yan, H., Lu, Y., Ji, X., Li, L., Liang, T., Zhou, D., Feng, X., Zhao, J. C., et al. (2015) · Cell Research · doi:10.1038/cr.2015.98 · Cited by 103 · see citing works

NOTCH-YAP1/TEAD-DNMT1 Axis Drives Hepatocyte Reprogramming Into Intrahepatic Cholangiocarcinoma

Hu, S., Molina, L. M., Tao, J., Liu, S., Hassan, M., Singh, S., Poddar, M., Bell, A. W., Sia, D., Oertel, M., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2022.05.007 · Cited by 103 · see citing works

A Potential Role of YAP/TAZ in the Interplay Between Metastasis and Metabolic Alterations

Yamaguchi, H., & Taouk, G. M. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00928 · Cited by 100 · see citing works

A feed forward loop enforces YAP/TAZ signaling during tumorigenesis

Gill, M. K., Christova, T., Zhang, Y. Y., Gregorieff, A., Zhang, L., Narimatsu, M., Song, S., Xiong, S., Couzens, A. L., Tong, J., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05939-2 · Cited by 95 · see citing works

The Emerging Role of YAP/TAZ in Tumor Immunity

Pan, Z., Tian, Y., Cao, C., & Niu, G. (2019) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-19-0375 · Cited by 95 · see citing works

Recurrent YAP1 and KMT2A Gene Rearrangements in a Subset of MUC4-negative Sclerosing Epithelioid Fibrosarcoma

Kao, Y., Lee, J., Zhang, L., Sung, Y., Swanson, D. M., Hsieh, T., Liu, Y., Agaram, N. P., Huang, H.-Y., Dickson, B. C., et al. (2019) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000001382 · Cited by 94 · see citing works

Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors

Lu, W., Wang, J., Li, Y., Tao, H., Xiong, H., Lian, F., Gao, J., Ma, H., Lu, T., Zhang, D., et al. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111767 · Cited by 94 · see citing works

The Hippo Tumor Suppressor Pathway (YAP/TAZ/TEAD/MST/LATS) and EGFR-RAS-RAF-MEK in cancer metastasis

Zinatizadeh, M. R., Miri, S. R., Zarandi, P. K., Chalbatani, G. M., Rapôso, C., Mirzaei, H. R., Akbari, M. E., & Mahmoodzadeh, H. (2019) · Genes & Diseases · doi:10.1016/j.gendis.2019.11.003 · Cited by 94 · see citing works

YAP Promotes Malignant Progression of Lkb1 -Deficient Lung Adenocarcinoma through Downstream Regulation of Survivin

Zhang, W., Gao, Y., Li, F., Tong, X., Ren, Y., Han, X., Yao, S., Long, F., Yang, Z., Fan, H., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3396 · Cited by 93 · see citing works

YAP induces an oncogenic transcriptional program through TET1-mediated epigenetic remodeling in liver growth and tumorigenesis

Wu, B.-K., Mei, S.-C., Chen, E. H., Zheng, Y., & Pan, D. (2022) · Nature Genetics · doi:10.1038/s41588-022-01119-7 · Cited by 90 · see citing works

YAP–IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis

Taniguchi, K., Moroishi, T., de Jong, P., Krawczyk, M., Grebbin, B. M., Luo, H.-Y., Xu, R.-H., Golob-Schwarzl, N., Schweiger, C., Wang, K.-P., et al. (2017) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1620290114 · Cited by 89 · see citing works

Hippo signaling instructs ectopic but not normal organ growth

Kowalczyk, W., Romanelli, L., Atkins, M., Hillen, H., González‐Blas, C. B., Jacobs, J., Xie, J., Soheily, S., Verboven, E., Moya, I. M., et al. (2022) · Science · doi:10.1126/science.abg3679 · Cited by 87 · see citing works

Recurrent Fusions Between YAP1 and KMT2A in Morphologically Distinct Neoplasms Within the Spectrum of Low-grade Fibromyxoid Sarcoma and Sclerosing Epithelioid Fibrosarcoma

Puls, F., Agaimy, A., Flucke, U. E., et al. (2020) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000001423 · Cited by 85 · see citing works

A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas

Murakami, S., Nemazanyy, I., White, S. M., Chen, H., Nguyen, C. D. K., Graham, G. T., Saur, D., Pende, M., & Yi, C. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.07.022 · Cited by 83 · see citing works

Hippo signalling maintains ER expression and ER+ breast cancer growth

Ma, S., Wu, Z., Yang, F., Zhang, J., Johnson, R. L., Rosenfeld, M. G., & Guan, K. (2021) · Nature · doi:10.1038/s41586-020-03131-5 · Cited by 82 · see citing works

YAP and β-Catenin Cooperate to Drive Oncogenesis in Basal Breast Cancer

Quinn, H. M., Vogel, R., Popp, O., Mertins, P., Lan, L., Messerschmidt, C., Landshammer, A., Lisek, K., Château‐Joubert, S., Marangoni, E., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-2801 · Cited by 81 · see citing works

The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises

Ortega, Á., Vera, I., Díaz, M. I., Navarro, C., Rojas, M., Torres, W., Parra, H., Salazar, J. J., Sanctis, J. B. D., & Bermúdez, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010430 · Cited by 81 · see citing works

Wnt Signaling Promotes Breast Cancer by Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2

Lim, S. K., Lu, S. Y., Kang, S., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-3537 · Cited by 77 · see citing works

The Hippo Pathway as a Driver of Select Human Cancers

Kulkarni, A., Chang, M. T., Vissers, J. H. A., Dey, A., & Harvey, K. F. (2020) · Trends in cancer · doi:10.1016/j.trecan.2020.04.004 · Cited by 77 · see citing works

YAP inhibits ERα and ER+ breast cancer growth by disrupting a TEAD-ERα signaling axis

Li, X., Zhuo, S., Zhuang, T., Cho, Y. S., Wu, G., Liu, Y., Mu, K., Zhang, K., Su, P., Yang, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30831-5 · Cited by 77 · see citing works

The complex entanglement of Hippo-Yap/Taz signaling in tumor immunity

White, S. M., Murakami, S., & Yi, C. (2019) · Oncogene · doi:10.1038/s41388-018-0649-6 · Cited by 75 · see citing works

SIRPγ-expressing cancer stem-like cells promote immune escape of lung cancer via Hippo signaling

Xu, C. S., Jin, G., Wu, H., Cui, W., Wang, Y.-H., Manne, R. K., Wang, G., Zhang, W., Zhang, X., Han, F., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci141797 · Cited by 73 · see citing works

A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma

Girard, C. A. J., Lecacheur, M., Jouira, R. B., Berestjuk, I., Diazzi, S., Prod’homme, V., Mallavialle, A., Larbret, F., Gesson, M., Schaub, S., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-2914 · Cited by 72 · see citing works

Heterogeneous Nuclear Ribonuclear Protein U Associates with YAP and Regulates Its Co-activation of Bax Transcription

Howell, M. T., Borchers, C. H., & Milgram, S. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401070200 · Cited by 71 · see citing works

Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma

Matsuura, K., Nakada, C., Mashio, M., Narimatsu, T., Yoshimoto, T., Tanigawa, M., Tsukamoto, Y., Hijiya, N., Takeuchi, I., Nomura, T., et al. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-523 · Cited by 69 · see citing works

A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer

Shreberk‐Shaked, M., Dassa, B., Sinha, S., Agostino, S. D., Azuri, I., Mukherjee, S., Aylon, Y., Blandino, G., Ruppin, E., & Oren, M. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-0125 · Cited by 68 · see citing works

Abstract CT006: First-in-class, first-in-human phase 1 trial of VT3989, an inhibitor of yes-associated protein (YAP)/transcriptional enhancer activator domain (TEAD), in patients (pts) with advanced solid tumors enriched for malignant mesothelioma and other tumors with neurofibromatosis 2 (NF2) mutations

Yap, T. A., Kwiatkowski, D. J., Desai, J., et al. (2023) · Cancer Research · doi:10.1158/1538-7445.am2023-ct006 · Cited by 67 · see citing works

Critical roles of phosphoinositides and NF2 in Hippo pathway regulationPreprint

Hong, A. W., Meng, Z., Plouffe, S. W., Lin, Z., Zhang, M., & Guan, K. (2020) · Genes & Development · doi:10.1101/gad.333435.119 · Cited by 66 · see citing works

TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by recruiting the ATAC histone acetyltransferase complex

Merritt, N. M., Garcia, K. C., Rajendran, D., Lin, Z., Zhang, X., Mitchell, K. A., Borcherding, N. C., Fullenkamp, C. A., Chimenti, M. S., Gingras, A., et al. (2021) · eLife · doi:10.7554/elife.62857 · Cited by 62 · see citing works

Activation of Aurora A kinase increases YAP stability via blockage of autophagy

Wang, P., Gong, Y., Guo, T., Li, M., Fang, L., Yin, S., Muhammad, K. I., Liu, Y., Xu, J., Xu, L., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1664-4 · Cited by 61 · see citing works

YAP and TAZ are dispensable for physiological and malignant haematopoiesis

Donato, E., Biagioni, F., Bisso, A., Cagánová, M., Amati, B. B., & Campaner, S. (2018) · Leukemia · doi:10.1038/s41375-018-0111-3 · Cited by 60 · see citing works

WWTR1(TAZ)-CAMTA1 reprograms endothelial cells to drive epithelioid hemangioendotheliomaPreprint

Driskill, J. H., Zheng, Y., Wu, B.-K., Wang, L., Cai, J., Rakheja, D., Dellinger, M. T., & Pan, D. (2021) · Genes & Development · doi:10.1101/gad.348221.120 · Cited by 57 · see citing works

Lipophilic statins inhibit YAP nuclear localization, co-activator activity and colony formation in pancreatic cancer cells and prevent the initial stages of pancreatic ductal adenocarcinoma in KrasG12D mice

Hao, F., Xu, Q., Wang, J., Yu, S., Chang, H.-H., Sinnett-Smith, J., Eibl, G., & Rozengurt, E. (2019) · PLOS ONE · doi:10.1371/journal.pone.0216603 · Cited by 55 · see citing works

YAP‑mediated crosstalk between the Wnt and Hippo signaling pathways (Review

Jiang, L., Li, J., Zhang, C., Shang, Y., & Lin, J. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11529 · Cited by 55 · see citing works

A tightly controlled Src-YAP signaling axis determines therapeutic response to dasatinib in renal cell carcinoma

Sun, J., Wang, X., Tang, B., Liu, H., Zhang, M., Wang, Y., Ping, F., Ding, J., Shen, A., & Geng, M. (2018) · Theranostics · doi:10.7150/thno.23964 · Cited by 53 · see citing works

ASB13 inhibits breast cancer metastasis through promoting SNAI2 degradation and relieving its transcriptional repression of YAPPreprint

Fan, H., Wang, X., Li, W., Shen, M., Wei, Y., Zheng, H., & Kang, Y. (2020) · Genes & Development · doi:10.1101/gad.339796.120 · Cited by 53 · see citing works

A phase 1, first-in-human study of IK-930, an oral TEAD inhibitor targeting the Hippo pathway in subjects with advanced solid tumors.

Tolcher, A. W., Lakhani, N. J., McKean, M. A., Lingaraj, T., Victor, L., Sánchez-Martín, M., Kacena, K. A., Malek, K. S., & Santillana, S. (2022) · Journal of Clinical Oncology · doi:10.1200/jco.2022.40.16_suppl.tps3168 · Cited by 52 · see citing works

PD-L1 confers resistance to EGFR mutation-independent tyrosine kinase inhibitors in non-small cell lung cancer via upregulation of YAP1 expression

Tung, J.-N., Lin, P.-L., Wang, Y.-C., Wu, D., Chen, C.-Y., & Lee, H. (2017) · Oncotarget · doi:10.18632/oncotarget.23161 · Cited by 51 · see citing works

β-Catenin Sustains and Is Required for YES-associated Protein Oncogenic Activity in Cholangiocarcinoma

Zhang, Y., Xu, H., Cui, G., Liang, B.-Y., Chen, X., Ko, S., Affò, S., Song, X., Liao, Y., Feng, J., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.04.028 · Cited by 50 · see citing works

P4HA2-induced prolyl hydroxylation suppresses YAP1-mediated prostate cancer cell migration, invasion, and metastasis

Zhu, M. L., Peng, R., Liang, X., Lan, Z., Tang, M., Hou, P., Song, J. H., Mak, C. S. L., Park, J., Zheng, S.-E., et al. (2021) · Oncogene · doi:10.1038/s41388-021-02000-3 · Cited by 46 · see citing works

Drugging the ‘undruggable’. Therapeutic targeting of protein–DNA interactions with the use of computer-aided drug discovery methods

Radaeva, M., Ton, A., Hsing, M., Ban, F., & Cherkasov, A. R. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.07.018 · Cited by 44 · see citing works

The expression of YAP1 is increased in high-grade prostatic adenocarcinoma but is reduced in neuroendocrine prostate cancer

Cheng, S., Prieto‐Domínguez, N., Yang, S., Connelly, Z. M., StPierre, S., Rushing, B., Watkins, A., Shi, L., Lakey, M. A., Baiamonte, L. B., et al. (2020) · Prostate Cancer and Prostatic Diseases · doi:10.1038/s41391-020-0229-z · Cited by 43 · see citing works

FGFR-inhibitor-mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance

Li, Y., Qiu, X., Wang, X., Liu, H., Geck, R. C., Tewari, A. K., Xiao, T., Font‐Tello, A., Lim, K., Jones, K. L., et al. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00781-z · Cited by 41 · see citing works

YAP/TAZ signalling in colorectal cancer: lessons from consensus molecular subtypes

Mouillet-Richard, S., & Laurent-Puig, P. (2020) · Cancers · doi:10.3390/cancers12113160 · Cited by 40 · see citing works

Somatic Hypermutation of the YAP Oncogene in a Human Cutaneous Melanoma

Zhang, X., Tang, J., Vergara, I. A., Zhang, Y., Szeto, P., Yang, L., Mintoff, C., Colebatch, A. J., McIntosh, L., Mitchell, K. A., et al. (2019) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-18-0407 · Cited by 40 · see citing works

Genomic Hippo Pathway Alterations and Persistent YAP/TAZ Activation: New Hallmarks in Head and Neck Cancer

Faraji, F., Ramirez, S. I., Quiroz, P. Y. A., Mendez-Molina, A. N., & Gutkind, J. S. (2022) · Cells · doi:10.3390/cells11081370 · Cited by 40 · see citing works

MK5 Regulates YAP Stability and Is a Molecular Target in YAP-Driven Cancers

Seo, J., Kim, M. H., Hong, H., Cho, H., Park, S., Kim, S. K., & Kim, J. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-1339 · Cited by 35 · see citing works

Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo signaling recruiting SAV1 to cell-cell contact sites

Paul, A., Annunziato, S., Lu, B., Sun, T., Evrova, O., Planas‐Paz, L., Orsini, V., Terracciano, L., Charlat, O., Yang, Z., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28567-3 · Cited by 35 · see citing works

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Vichas, A., Riley, A. K., Nkinsi, N. T., Kamlapurkar, S., Parrish, P., Lo, A., Duke, F., Chen, J.-T., Fung, I., Watson, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24841-y · Cited by 34 · see citing works

Cyclizing-berberine A35 induces G2/M arrest and apoptosis by activating YAP phosphorylation (Ser127)

Zhao, W., Liu, H., Wang, J., et al. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0759-6 · Cited by 34 · see citing works

THY1-mediated mechanisms converge to drive YAP activation in skin homeostasis and repair

Sedov, E., Koren, E., Chopra, S., Ankawa, R., Yosefzon, Y., Yusupova, M., Weiss, L. E., Mahly, A., Soffer, A., Feldman, A., et al. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00944-6 · Cited by 31 · see citing works

Crosstalk between KRAS, SRC and YAP Signaling in Pancreatic Cancer: Interactions Leading to Aggressive Disease and Drug Resistance

Rozengurt, E., & Eibl, G. (2021) · Cancers · doi:10.3390/cancers13205126 · Cited by 30 · see citing works

Targeting YAP suppresses ovarian cancer progression through regulation of the PI3K/Akt/mTOR pathway

Xiao, W., Jia, Y., Lou, H., et al. (2019) · Oncology Reports · doi:10.3892/or.2019.7370 · Cited by 28 · see citing works

Abstract ND11: The discovery and characterization of ION-537: A next generation antisense oligonucleotide inhibitor of YAP1 in preclinical cancer models

MacLeod, A. R. (2021) · Cancer Research · doi:10.1158/1538-7445.am2021-nd11 · Cited by 28 · see citing works

Loss of Arid1a and Pten in Pancreatic Ductal Cells Induces Intraductal Tubulopapillary Neoplasm via the YAP/TAZ Pathway

Fukunaga, Y., Fukuda, A., Omatsu, M., Namikawa, M., Sono, M., Masuda, T., Araki, O., Nagao, M., Yoshikawa, T., Ogawa, S., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.04.020 · Cited by 28 · see citing works

miR-143 inhibits oncogenic traits by degrading NUAK2 in glioblastoma

FU, T.-G., Wang, L., Li, W., Li, J., & Li, J. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2562 · Cited by 27 · see citing works

YAP1-FAM118B Fusion Defines a Rare Subset of Childhood and Young Adulthood Meningiomas

Schieffer, K. M., Agarwal, V., LaHaye, S., Miller, K. E., Koboldt, D. C., Lichtenberg, T. M., Leraas, K., Brennan, P. J., Kelly, B., Crist, E. R., et al. (2020) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000001597 · Cited by 27 · see citing works

Defects in Yolk Sac Vasculogenesis, Chorioallantoic Fusion, and Embryonic Axis Elongation in Mice with Targeted Disruption of Yap65

Howell, M., Stonebraker, J. R., Teed, J., et al. (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/3nn5-1a33 · Cited by 26 · see citing works

Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma

Carter, P., Schnell, U., Chaney, C. P., Tong, B., Pan, X., Ye, J., Mernaugh, G., Cotton, J. L., Margulis, V., Mao, J., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci144108 · Cited by 25 · see citing works

Integrated screens uncover a cell surface tumor suppressor gene KIRREL involved in Hippo pathway

Wang, C., Feng, X., Su, D., Chen, Z., Wang, S., Tang, M., Huang, M., Nie, L., Zhang, H., Li, S., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2121779119 · Cited by 25 · see citing works

Physical interaction with yes-associated protein enhances p73 transcriptional activity

Strano, S., Monti, O., Baccarini, A., et al. (2001) · European Journal of Cancer · doi:10.1016/s0959-8049(01)81522-7 · Cited by 23 · see citing works

Inactivation of the Hippo tumor suppressor pathway promotes melanoma

Vittoria, M. A., Kingston, N. M., Kotýnková, K., Xia, E., Hong, R., Huang, L., McDonald, S., Tilston-Lünel, A., Darp, R., Campbell, J. D., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31399-w · Cited by 23 · see citing works

Expression of NUAK2 in gastric cancer tissue and its effects on the proliferation of gastric cancer cells

Tang, L., Tong, S., Zhan, Z., et al. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3983 · Cited by 20 · see citing works

Activated TAZ induces liver cancer in collaboration with EGFR/HER2 signaling pathways

Moon, H., Park, H., Chae, M. J., Choi, H. J., ‍Kim, D. Y., & Ro, S. W. (2022) · BMC Cancer · doi:10.1186/s12885-022-09516-1 · Cited by 20 · see citing works

Phosphorylation of Tyr188 in the WW domain of YAP1 plays an essential role in YAP1-induced cellular transformation

Li, Y.-W., Guo, J., Shen, H., Li, J., Yang, N., Frangou, C. G., Wilson, K. E., Zhang, Y., Mussell, A. L., Sudol, M., et al. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1207836 · Cited by 19 · see citing works

NUAK2 silencing inhibits the proliferation, migration and epithelial‑to‑mesenchymal transition of cervical cancer cells via upregulating CYFIP2

Li, Y., Song, X., Liu, L., et al. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12457 · Cited by 19 · see citing works

Lentivirus-mediated RNA interference targeting WWTR1 in human colorectal cancer cells inhibits cell proliferation in vitro and tumor growth in vivo

Lu, X. (2012) · Oncology Reports · doi:10.3892/or.2012.1751 · Cited by 14 · see citing works

The expression of YAP1 is increased in high-grade prostatic adenocarcinoma but is reduced in neuroendocrine prostate cancerPreprint

Cheng, S., Prieto‐Domínguez, N., Yang, S., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/832360 · Cited by 14 · see citing works

NUAK family kinase 2 is a novel therapeutic target for prostate cancer

Fu, W., Zhao, M. T., Driver, L. M., Schirmer, A. U., Yin, Q., You, S., Freedland, S. J., DiGiovanni, J., Drewry, D. H., & Macias, E. (2021) · Molecular Carcinogenesis · doi:10.1002/mc.23374 · Cited by 13 · see citing works

Contributions of Yap and Taz dysfunction to breast cancer initiation, progression, and aging‐related susceptibility

Fresques, T., & LaBarge, M. A. (2020) · Aging and Cancer · doi:10.1002/aac2.12011 · Cited by 9 · see citing works

Aurintricarboxylic acid is a canonical disruptor of the TAZ-TEAD transcriptional complex

Che, K., Pobbati, A. V., Seavey, C. N., Federov, Y., Komar, A. A., Burtscher, A., Ma, S., & Rubin, B. P. (2022) · PLoS ONE · doi:10.1371/journal.pone.0266143 · Cited by 7 · see citing works

Division of labor between YAP and TAZ in non-small cell lung cancerPreprint

Shreberk‐Shaked, M., Dassa, B., Sinha, S., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.12.894733 · Cited by 6 · see citing works

Inactivation of the Hippo Tumor Suppressor Pathway Promotes MelanomaPreprint

Vittoria, M. A., Kingston, N. M., Xia, E., Hong, R., Huang, L., McDonald, S., Tilston-Lünel, A., Darp, R., Campbell, J. D., Lang, D., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.04.442615 · Cited by 4 · see citing works

YAP and β-catenin co-operate to drive oncogenesis in basal breast cancerPreprint

Quinn, H. M., Koren, E., Vogel, R., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.05.115881 · Cited by 2 · see citing works

Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a potential therapeutic target in YAP/TAZ-active cancersPreprint

Gu, Y., Wang, Y., Sha, Z., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.28.482264 · Cited by 2 · see citing works

Prostaglandin E2 Activates Yap and a Positive-Signaling Loop to Promote Colon Regeneration Following Colitis but also Carcinogenesis in Mice

Kim, H., & Myung, S. (2017) · Gastroenterology · doi:10.1016/s0016-5085(17)31446-4 · Cited by 2 · see citing works

Activated TAZ Induces Liver Cancer in Collaboration with EGFR/HER2 Signaling PathwaysPreprint

Moon, H., Choi, H. J., ‍Kim, D. Y., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-796723/v1 · Cited by 1 · see citing works

Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy

Mukhopadhyay, S., Huang, H.-Y., Lin, Z., Ranieri, M., Li, S., Sahu, S., Liu, Y., Ban, Y., Guidry, K., Hu, H., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-2729 · Cited by 105 · see citing works

TEAD Inhibition Overcomes YAP1/TAZ-Driven Primary and Acquired Resistance to KRASG12C Inhibitors

Edwards, A. C., Stalnecker, C. A., Jean Morales, A., Taylor, K. E., Klomp, J. E., Klomp, J. A., Waters, A. M., Sudhakar, N., Hallin, J., Tang, T. T., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-2994 · Cited by 91 · see citing works

Targeted Treatment against Cancer Stem Cells in Colorectal Cancer

Martínez-Pérez, J., Torrado, C., Domínguez-Cejudo, M. A., & Valladares-Ayerbes, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116220 · Cited by 18 · see citing works

Newcomers to the WW Domain-Mediated Network of the Hippo Tumor Suppressor Pathway

Sudol, M. (2010) · Genes & Cancer · doi:10.1177/1947601911401911 · Cited by 58 · see citing works

Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling

Oka, T., Remue, E., Meerschaert, K., Vanloo, B., Boucherie, C., Gfeller, D., Bader, G. D., Sidhu, S. S., Vandekerckhove, J. S., Gettemans, J., et al. (2010) · Biochemical Journal · doi:10.1042/bj20100870 · Cited by 213 · see citing works

The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration

Karpowicz, P. A., Perez, J. N., & Perrimon, N. (2010) · Journal of Cell Science · doi:10.1242/jcs.084129 · Cited by 9 · see citing works

MicroRNA-1292-5p inhibits cell growth, migration and invasion of gastric carcinoma by targeting DEK.

Hui, W., Ma, X., Zan, Y., et al. (2018) · PubMed · Cited by 27 · see citing works

STK25 directly activates LATS1/2 independent of MST/MAP4KsPreprint

Lim, S., Hermance, N. M., Mudianto, T., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/354233 · Cited by 3 · see citing works