The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Evidence of an inhibitory restraint of seizure activity in humans
Open accessAbstract
The location and trajectory of seizure activity is of great importance, yet our ability to map such activity remains primitive. Recently, the development of multi-electrode arrays for use in humans has provided new levels of temporal and spatial resolution for recording seizures. Here, we show that there is a sharp delineation between areas showing intense, hypersynchronous firing indicative of recruitment to the seizure, and adjacent territories where there is only low-level, unstructured firing. Thus, there is a core territory of recruited neurons and a surrounding 'ictal penumbra'. The defining feature of the 'ictal penumbra' is the contrast between the large amplitude EEG signals and the low-level firing there. Our human recordings bear striking similarities with animal studies of an inhibitory restraint, indicating that they can be readily understood in terms of this mechanism. These findings have important implications for how we localize seizure activity and map its spread. Seizure activity in the brain is characterized by the recruitment of cortical neuronal activity. Schevon and colleagues study seizure activity in human subjects and find that the recruitment of neurons is hypersynchronous and that there is an intrinsic restraint on the propagation of this activity.
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Neuronal ensemble control of prosthetic devices by a human with tetraplegia
Hochberg, L. R., Serruya, M. D., Friehs, G. M., Mukand, J. A., Saleh, M., Caplan, A. H., Branner, A., Chen, D., Penn, R. D., & Donoghue, J. P. (2006) · Nature · doi:10.1038/nature04970 · Cited by 3,295
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Presurgical evaluation of epilepsy
Rosenow, F. (2001) · Brain · doi:10.1093/brain/124.9.1683 · Cited by 1,669
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On The Cellular and Network Bases of Epileptic Seizures
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Synfire Chains and Cortical Songs: Temporal Modules of Cortical Activity
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Self-citationCortical cellular phenomena in experimental epilepsy: Interictal manifestations
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Cited by
Hippocampal GABAergic Inhibitory Interneurons
Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., & McBain, C. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00007.2017 · Cited by 889
Trujillo, C. A., Gao, R., Negraes, P. D., Gu, J., Buchanan, J., Preissl, S., Wang, A., Wu, W., Haddad, G. G., Chaim, I. A., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.08.002 · Cited by 974
Devinsky, O., Vezzani, A., O'Brien, T. J., Jette, N., Scheffer, I. E., de Curtis, M., & Perucca, P. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.24 · Cited by 959
Synchronization and desynchronization in epilepsy: controversies and hypotheses.
Jiruska, P., de Curtis, M., Jefferys, J. G. R., Schevon, C. A., Schiff, S. J., & Schindler, K. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.239590 · Cited by 678
Self-citationSeizure prediction – ready for a new era
Kuhlmann, L., Lehnertz, K., Richardson, M. P., Schelter, B., & Zaveri, H. P. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0055-2 · Cited by 450
Metadata
- Authors
- Schevon, C. A., Weiss, S. A., McKhann, G., Goodman, R. R., Yuste, R., Emerson, R. G., & Trevelyan, A. J.
- Venue
- Nature Communications
- Published
- 2012-09-11
- Volume
- 3
- Issue
- 1
- Pages
- 1060-1060
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W1970604942
- Cited by
- 425
- References
- 43
- FWCI
- 17.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Schevon, C. A., Weiss, S. A., McKhann, G., Goodman, R. R., Yuste, R., Emerson, R. G., & Trevelyan, A. J. (2012). Evidence of an inhibitory restraint of seizure activity in humans. Nature Communications. https://doi.org/10.1038/ncomms2056
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