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The genomics of selection in dogs and the parallel evolution between dogs and humans
Open accessAbstract
The genetic bases of demographic changes and artificial selection underlying domestication are of great interest in evolutionary biology. Here we perform whole-genome sequencing of multiple grey wolves, Chinese indigenous dogs and dogs of diverse breeds. Demographic analysis show that the split between wolves and Chinese indigenous dogs occurred 32,000 years ago and that the subsequent bottlenecks were mild. Therefore, dogs may have been under human selection over a much longer time than previously concluded, based on molecular data, perhaps by initially scavenging with humans. Population genetic analysis identifies a list of genes under positive selection during domestication, which overlaps extensively with the corresponding list of positively selected genes in humans. Parallel evolution is most apparent in genes for digestion and metabolism, neurological process and cancer. Our study, for the first time, draws together humans and dogs in their recent genomic evolution.
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“These results are in line with claims in other studies on domestication [49, 123–125], where categories like ‘neurological process’ frequently stand out strongly in gene ontology category enrichment analyses.”
From Self-domestication in Homo sapiens: Insights from comparative genomics (2017) · cites this paper as [124]
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Metadata
- Authors
- Wang, G.-D., Zhai, W., Yang, H.-C., Fan, R.-X., Cao, X., Zhong, L., Wang, L., Liu, F., Wu, H., Cheng, L.-G., Poyarkov, A. D., Poyarkov JR, N. A., Tang, S.-S., Zhao, W.-M., Gao, Y., Lv, X.-M., Irwin, D. M., Savolainen, P., Wu, C.-I., & Zhang, Y.-P.
- Affiliations
- Chinese Academy of Sciences (CN)
- Kunming Institute of Zoology (CN)
- Yunnan University (CN)
- Ministry of Public Security of the People's Republic of China (CN)
- Russian Academy of Sciences (RU)
- Science for Life Laboratory (SE)
- University of Science and Technology of China (CN)
- Corresponding author
- Wu, Chung-I
- Zhang, Ya-ping
- ORCID
- Venue
- Nature Communications
- Published
- 2013-05-14
- Volume
- 4
- Issue
- 1
- Pages
- 1860-1860
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2138655328
- Cited by
- 323
- References
- 60
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 14 · 2023: 20 · 2022: 23 · 2021: 18 · 2020: 38 · 2019: 32 · 2018: 47 · 2017: 28 · 2016: 33 · 2015: 20 · 2014: 21 · 2013: 5
- FWCI
- 17.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Communications (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Royal Swedish Academy of Sciences
- National Natural Science Foundation of China (91231108)
- Chinese Academy of Sciences (2013CB835200)
- Knut och Alice Wallenbergs Stiftelse
- National Key Research and Development Program of China (2013CB835200)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Human-Animal Interaction Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- dog domestication, positive selection, parallel evolution, gray wolves, dog breeds, population bottleneck, scavenging, cancer genes
- MeSH terms
- Animals, Animals, Domestic, China, Dogs, Genetics, Population, Geography, Humans, Population Dynamics, Selection, Genetic, Genetic Variation, Sequence Analysis, DNA, Evolution, Molecular, Wolves, Genomics, Principal Component Analysis, Genetic Association Studies, High-Throughput Nucleotide Sequencing, Gene Ontology
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