Metformin improves healthspan and lifespan in mice

Martin-Montalvo, Alejandro, Mercken, Evi M., Mitchell, Sarah J., Palacios, Hector H., Mote, Patricia L., Scheibye-Knudsen, Morten, Gomes, Ana P., Ward, Theresa M. +14 more·2013·Nature Communications

Cited by (1,001)

Items 701–800 of 1,001

  1. G protein-coupled receptors that influence lifespan of human and animal models
    Francisco Alejandro Lagunas‐Rangel · 2021 · Biogerontology
  2. Activation of autophagy attenuates motor deficits and extends lifespan in a C. elegans model of ALS
    Hui Xu, Congcong Jia, Cheng Cheng, Haifeng Wu, Huaibin Cai, Weidong Le · 2022 · Free Radical Biology and Medicine
  3. Intestinal stem cell aging at single‐cell resolution: Transcriptional perturbations alter cell developmental trajectory reversed by gerotherapeutics
    Jiahn Choi, Michele A. Houston, Ruixuan Wang, Kenny Q. Ye, Wenge Li, Xusheng Zhang, Derek M. Huffman, Leonard H. Augenlicht · 2023 · Aging Cell
  4. Geroprotector drugs and exercise: friends or foes on healthy longevity?
    Christian J. Elliehausen, Rozalyn M. Anderson, Gary M. Diffee, Timothy W. Rhoads, Dudley W. Lamming, Troy Alan Hornberger, Adam R. Konopka · 2023 · BMC Biology
  5. Metformin‐induced mitochondrial function and ABCD 2 up‐regulation in X‐linked adrenoleukodystrophy involves AMP ‐activated protein kinase
    Jaspreet Singh, Brittany Olle, Hamid Suhail, Michelle Madden Felicella, Shailendra Giri · 2016 · Journal of Neurochemistry
  6. Integrated or Independent Actions of Metformin in Target Tissues Underlying Its Current Use and New Possible Applications in the Endocrine and Metabolic Disorder Area
    Giovanni Tulipano · 2021 · International Journal of Molecular Sciences
  7. Brain-specific targeted delivery of therapeutic agents using metal–organic framework-based nanomedicine
    Zongsu Han, Muzhaozi Yuan, Nguyen Nguyen, Hong-Cai “Joe” Zhou, James E. Hubbard, Ya Wang · 2024 · Coordination Chemistry Reviews
  8. Attojoule Hexagonal Boron Nitride‐Based Memristor for High‐Performance Neuromorphic Computing
    Jiye Kim, Jaesub Song, Hyunjoung Kwak, Changwon Choi, Kyungmi Noh, Seokho Moon, Hyeonwoong Hwang, Inyong Hwang, Hokyeong Jeong, Si‐Young Choi et al. · 2024 · Small
  9. Metformin: decelerates biomarkers of aging clocks
    Ram Abou Zaki, Assam El‐Osta · 2024 · Signal Transduction and Targeted Therapy
  10. Metformin induces the AP-1 transcription factor network in normal dermal fibroblasts
    Zoe E. Gillespie, Chenxuan Wang, Flaviu Vadan, Topaza Y. Yu, Juan Ausió, ANTHONY J. KUSALIK, Christopher H. Eskiw · 2019 · Scientific Reports
  11. Role of AMP-activated protein kinase during postovulatory aging of mouse oocytes†
    Guang-Yi Sun, Shuai Gong, Qiao-Qiao Kong, Zhibin Li, Jia Wang, Mingtao Xu, Ming‐Jiu Luo, Jing‐He Tan · 2020 · Biology of Reproduction
  12. The use of geroprotectors to prevent multimorbidity: Opportunities and challenges
    Samir Morsli, Ilaria Bellantuono · 2020 · Mechanisms of Ageing and Development
  13. Metformin alleviates the depression-like behaviors of elderly apoE4 mice via improving glucose metabolism and mitochondrial biogenesis
    Yingbin Lin, Xiaoman Dai, Jing Zhang, Xiaochun Chen · 2022 · Behavioural Brain Research
  14. Sex‐ and strain‐specific effects of mitochondrial uncoupling on age‐related metabolic diseases in high‐fat diet‐fed mice
    Leigh Goedeke, Kelsey N. Murt, Andrea Di Francesco, João Paulo Camporez, Ali R. Nasiri, Yongliang Wang, Xian‐Man Zhang, Gary W. Cline, Rafael de Cabo, Gerald I. Shulman · 2022 · Aging Cell
  15. AMPK Activator O304 Protects Against Kidney Aging Through Promoting Energy Metabolism and Autophagy
    Mingsheng Zhu, Weiwei Shen, Jiemei Li, Nan Jia, Yabing Xiong, Jinhua Miao, Chao Xie, Qiyan Chen, Kunyu Shen, Ping Meng et al. · 2022 · Frontiers in Pharmacology
  16. The Less We Eat, the Longer We Live: Can Caloric Restriction Help Us Become Centenarians?
    Tamara B. Dakic, Tanja V. Jevdjovic, Predrag Z. Vujovic, Aleksandra Mladenović · 2022 · International Journal of Molecular Sciences
  17. Multi‐Resonant Mie Resonator Arrays for Broadband Light Trapping in Ultrathin c‐Si Solar Cells
    Nayeun Lee, Muyu Xue, Jiho Hong, Jorik van de Groep, Mark L. Brongersma · 2023 · Advanced Materials
  18. New Horizons in cellular senescence for clinicians
    Miles D. Witham, Antoneta Granic, Satomi Miwa, João F. Passos, Gavin David Richardson, Avan Aihie Sayer · 2023 · Age and Ageing
  19. Dietary supplementation with Lovaza and krill oil shortens the life span of long-lived F1 mice
    Stephen R. Spindler, Patricia L. Mote, James M. Flegal · 2014 · AGE
  20. Combining a High Dose of Metformin With the SIRT1 Activator, SRT1720, Reduces Life Span in Aged Mice Fed a High-Fat Diet
    Dushani L. Palliyaguru, Robin K. Minor, Sarah Jayne Mitchell, Hector H. Palacios, Jordan J. Licata, Theresa M. Ward, Gelareh A. Abulwerdi, Peter J. Elliott, Christoph Heiner Westphal, James L. Ellis et al. · 2020 · The Journals of Gerontology Series A
  21. Does Diet Have a Role in the Treatment of Alzheimer's Disease?
    Mitchell Thelen, Holly M. Brown‐Borg · 2020 · Frontiers in Aging Neuroscience
  22. Comparison of long-term effects of metformin on longevity between people with type 2 diabetes and matched non-diabetic controls
    Joshua O Stevenson‐Hoare, Ganna Leonenko, Valentina Escott‐Price · 2023 · BMC Public Health
  23. Cardiovascular ageing: hallmarks, signaling pathways, diseases and therapeutic targets
    Pingjing Zheng, Wendi Yan, Yang-Nan Ding, Yang Zhang, Zhangwei Chen, Juying Qian, Junbo Ge · 2026 · Signal Transduction and Targeted Therapy
  24. Toxin-induced hormesis may restrain aging
    Trim Lajqi, Milan R. Stojiljkovic, Reinhard Wetzker · 2019 · Biogerontology
  25. The Double-Edged Role of Extracellular Vesicles in the Hallmarks of Aging
    Nekane Romero-García, Javier Huete-Acevedo, Cristina Mas‐Bargues, Jorge Sanz‐Ros, Mar Dromant, Consuelo Borrás · 2023 · Biomolecules
  26. Dietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female mice
    Christopher P. Hedges, Bhoopika Shetty, Sophie C. Broome, Caitlin L. MacRae, Parisa Koutsifeli, Emma J. Buckels, C. Macindoe, Jordi Boix, T. Tsiloulis, Brya G. Matthews et al. · 2023 · Nature Aging
  27. Association between serum Klotho concentration and hyperlipidemia in adults: a cross-sectional study from NHANES 2007–2016
    Shaohua Yan, Wei Luo, Li Lei, Qiuxia Zhang, Jiancheng Xiu · 2023 · Frontiers in Endocrinology
  28. Lifespan effects of simple and complex nutraceutical combinations fed isocalorically to mice
    Stephen R. Spindler, Patricia L. Mote, James M. Flegal · 2013 · AGE
  29. Harnessing Pharmacomultiomics for Precision Medicine in Diabetes: A Comprehensive Review
    Dhoha Dhieb, Dana Nizar Mustafa, Maryam Hassiba, May Alasmar, Mohamed Elsayed Mohamed Elsayed, Ameer Musa, Mahmoud Ali Zirie, Kholoud Bastaki · 2025 · Biomedicines
  30. Emerging uncertainty on the anti-aging potential of metformin
    Matthew Thomas Keys, Jesper Hallas, Richard A. Miller, Samy Suissa, Kaare Christensen · 2025 · Ageing Research Reviews
  31. Metformin delays neurological symptom onset in a mouse model of neuronal complex I deficiency
    Susana Peralta, Milena Pinto, Tania Arguello, Sofía García, Francisca Díaz, Carlos Torres Moraes · 2020 · JCI Insight
  32. Metformin Improves Stemness of Human Adipose-Derived Stem Cells by Downmodulation of Mechanistic Target of Rapamycin (mTOR) and Extracellular Signal-Regulated Kinase (ERK) Signaling
    Somaiah Chinnapaka, Katherine S. Yang, Quinn Flowers, Minhal Faisal, Wayne Vincent Nerone, Joseph Peter Rubin, Asim Ejaz · 2021 · Biomedicines
  33. Autophagy takes it all – autophagy inducers target immune aging
    Heidi Zinecker, Anna Katharina Simon · 2022 · Disease Models & Mechanisms
  34. Berberine inhibits carcinogenesis through antagonizing the ATX-LPA-LPAR2-p38-leptin axis in a mouse hepatoma model
    Gang Ren, Jianghong Guo, Chen‐Lin Feng, Yu-Wei Ding, Biao Dong, Yanxing Han, Yuhuan Li, Lulu Wang, Jian‐Dong Jiang · 2022 · Molecular Therapy — Oncolytics
  35. Effect of metformin on the epigenetic age of peripheral blood in patients with diabetes mellitus
    Man Li, Lei Duan, 蔡育倫, Benchuan Hao, Jianqiao Chen, Hongbin Liu · 2022 · Frontiers in Genetics
  36. Compound combinations targeting longevity: Challenges and perspectives
    Olga Y. Rybina, Alexander V. Symonenko, ELENA G. PASYUKOVA · 2023 · Ageing Research Reviews
  37. Mechanisms and effects of metformin on skeletal muscle disorders
    Ren Shang, Jing Miao · 2023 · Frontiers in Neurology
  38. Towards Healthy Longevity: Comprehensive Insights from Molecular Targets and Biomarkers to Biological Clocks
    Khalishah Yusri, Sanjay Kumar, Sheng Fong, Jan Gruber, Vincenzo Sorrentino · 2024 · International Journal of Molecular Sciences
  39. Metformin improves HPRT1-targeted purine metabolism and repairs NR4A1-mediated autophagic flux by modulating FoxO1 nucleocytoplasmic shuttling to treat postmenopausal osteoporosis
    Keda Yang, Xiaochuan Wang, Chi Zhang, Dian Liu, Lin Tao · 2024 · Cell Death and Disease
  40. Urothelial Senescence in the Pathophysiology of Diabetic Bladder Dysfunction—A Novel Hypothesis
    Nicole Klee, Cameron Grant McCarthy, Steven Lewis, Jaine McKenzie, Julie Vincent, Robert Clinton Webb · 2018 · Frontiers in Surgery
  41. Senotherapeutics for HIV and aging
    Matthew A. Szaniawski, Adam M. Spivak · 2019 · Current Opinion in HIV and AIDS
  42. Translatability of life‐extending pharmacological treatments between different species
    Daiana Burdusel, Cristin Coman, Diana-Larisa Ancuța, Dirk Matthias Hermann, Thorsten Roland Doeppner, Andrei Greșiță, Aurel Popa‐Wagner · 2024 · Aging Cell
  43. Postbiotics: A Promising Approach to Combat Age-Related Diseases
    Adel Hamdi, Charmaine Lloyd, Rajaraman D. Eri, Thi Thu Hao Van · 2025 · Life
  44. Kidney Disease as a Driver of Immunosenescence
    Zhuolun Song, Sarah Tsou, Friederike Martin, Mukhammad Kayumov, Yao Xiao, Hao Zhou, Reza Abdi, Stefan G. Tullius · 2025 · Journal of the American Society of Nephrology
  45. Subretinal gene therapy delays vision loss in a Bardet-Biedl Syndrome type 10 mouse model
    Ying Hsu, Sajag Bhattarai, Jacob M. Thompson, Angela Mahoney, Jacintha Thomas, Sara K. Mayer, Poppy Datta, Janelle E. Garrison, Charles C. Searby, Luk H. Vandenberghe et al. · 2022 · Molecular Therapy — Nucleic Acids
  46. An Examination of Whether Diabetes Control and Treatments Are Associated With Change in Frailty Index Across 8 Years: An Ancillary Exploratory Study From the Action for Health in Diabetes (Look AHEAD) Trial
    Felicia R. Simpson, Jamie Nicole Justice, Scott J. Pilla, Stephen B. Kritchevsky, Edward J. Boyko, Medha N. Munshi, Chloe K. Ferris, Mark Andrew Espeland · 2022 · Diabetes Care
  47. Sex differences in pharmacological interventions and their effects on lifespan and healthspan outcomes: a systematic review
    Marie Knufinke, Michael Robert MacArthur, Collin Y. Ewald, Sarah Jayne Mitchell · 2023 · Frontiers in Aging
  48. AMP Kinase Activation is Selectively Disrupted in the Ventral Midbrain of Mice Deficient in Parkin or PINK1 Expression
    Liting Hang, John Thundyil, Geraldine Goh, Kah‐Leong Lim · 2018 · NeuroMolecular Medicine
  49. Metformin Prevents H₂O₂-Induced Senescence in Human Lens Epithelial B3 Cells
    Chunmei Zhang, Mengmeng Chen, Nan Zhou, Yanhua Qi · 2020 · Medical science monitor basic research/Medical science monitor. Basic research
  50. Key Molecular Mechanisms of Aging, Biomarkers, and Potential Interventions
    Ekaterina Proshkina, Ilya A. Solovev, Mikhail Vyacheslavovich Shaposhnikov, Alexey Moskalev · 2020 · Molecular Biology
  51. Which is the Most Reasonable Anti-aging Strategy: Meta-analysis
    Yaru Liang, Zhao Wang · 2018 · Advances in experimental medicine and biology
  52. Emerging molecular mediators and targets for age-related skeletal muscle atrophy
    Lemuel A. Brown, Steve D. Guzman, Susan V. Brooks · 2020 · Translational research
  53. Editorial: Metformin: Beyond Diabetes
    Frédéric Bost, Graham Rena, Benoı̂t Viollet · 2019 · Frontiers in Endocrinology
  54. How to promote healthy aging across the life cycle
    Camilla Cocchi, Maria Beatrice Zazzara, Elena Levati, Riccardo Calvani, Graziano Onder · 2025 · European Journal of Internal Medicine
  55. Modern antidiabetic therapy by sodium-glucose cotransporter 2 inhibitors, glucagon-like peptide 1 receptor agonists, and dipeptidyl peptidase 4 inhibitors against cardiovascular diseases
    Sebastian Steven, Marin Kuntić, Thomas F. Münzel, Andreas Daiber · 2025 · Pharmacological Reviews
  56. From Neuron‐Centric to Glia‐Centric: How Aging Glial Networks Drive Neurodegenerative Disease
    Lívia de Sá Hayashide, Bruna Pessoa, G. R. Dias, Bruno Pontes, Rafael Serafim Pinto, Luan Pereira Diniz · 2026 · Journal of Neurochemistry
  57. Metformin improves performance in high‐intensity exercise, but not anaerobic capacity in healthy male subjects
    Sara Kely LEARSI, Victor José Bastos‐Silva, Adriano Eduardo Lima‐Silva, Rômulo Bertuzzi, Gustavo Gomes de Araújo · 2015 · Clinical and Experimental Pharmacology and Physiology
  58. The Physiological Conundrum That is the Domestic Dog
    Ana Gabriela Jiménez · 2021 · Integrative and Comparative Biology
  59. Understanding the role of host metabolites in the induction of immune senescence: Future strategies for keeping the ageing population healthy
    Jessica Conway, Michelangelo Certo, Janet M. Lord, Claudio Mauro, Niharika Arora Duggal · 2021 · British Journal of Pharmacology
  60. Repurposing digoxin for geroprotection in patients with frailty and multimorbidity
    Helena Lee, Daisy V. Wilson, Karina V Bunting, Dipak Kotecha, Thomas Jackson · 2023 · Ageing Research Reviews
  61. Future foods, dietary factors and healthspan
    Kaiqiang Li, Chong Wang, Yanbo Wang, Linglin Fu, Nianshu Zhang · 2023 · Journal of Future Foods
  62. Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging
    Alejandro Sola‐García, María Ángeles Cáliz‐Molina, Isabel Espadas, Michael Angelo Petr, Concepción Panadero‐Morón, Daniel González-Morán, María Eugenia Martín-Vázquez, Álvaro Jesús Narbona‐Pérez, Livia López–Noriega, Guillermo Martínez-Corrales et al. · 2023 · Communications Biology
  63. Pharmacotherapies in Dupuytren Disease: Current and Novel Strategies
    Alex G. Lambi, Steven N. Popoff, Prosper Benhaim, Mary Frances Barbe · 2023 · The Journal Of Hand Surgery
  64. The Aryl Hydrocarbon Receptor, Epigenetics and the Aging Process
    Sara Abudahab, Elvin T. Price, Mikhail G. Dozmorov, Laxmikant S. Deshpande, Joseph L. McClay · 2023 · The journal of nutrition health & aging
  65. Anti-Inflammatory Potential of the Anti-Diabetic Drug Metformin in the Prevention of Inflammatory Complications and Infectious Diseases Including COVID-19: A Narrative Review
    Trevor J. Plowman, Hannah Christensen, Myia Aiges, Emely Fernandez, Mujtaba H. Shah, Kota V. Ramana · 2024 · International Journal of Molecular Sciences
  66. Exploring the heterogeneous targets of metabolic aging at single-cell resolution
    Shuhui Sun, Mengmeng Jiang, Shuai Ma, Jie Ren, Guang‐Hui Liu · 2024 · Trends in Endocrinology and Metabolism
  67. Something old, something new and something very old: drugs for treating type 2 diabetes
    Diana Kaiser, Elke Oetjen · 2014 · British Journal of Pharmacology
  68. Artemisinin mimics calorie restriction to trigger mitochondrial biogenesis and compromise telomere shortening in mice
    Da-Ting Wang, Jiang He, Ming Wu, Si-Ming Li, Qian Gao, Qing-Ping Zeng · 2015 · PeerJ
  69. A sirtuin activator and an anti-inflammatory molecule—multifaceted roles of adjudin and its potential applications for aging-related diseases
    Weiliang Xia, Keyi Geng · 2016 · Seminars in Cell and Developmental Biology
  70. A conceptual framework for predicting and addressing the consequences of disease‐related microvascular dysfunction
    Penn Mason McClatchey, Jefferson C. Frisbee, Jane E.B. Reusch · 2017 · Microcirculation
  71. Approaches for extending human healthspan: from antioxidants to healthspan pharmacology
    Jan Gruber, Barry B. Halliwell · 2017 · Essays in Biochemistry
  72. Impact of the Antidiabetic Drug Metformin and Its Transformation Product Guanylurea on the Health of the Big Ramshorn Snail (Planorbarius corneus)
    Stefanie Jacob, Heinz‐R. Köhler, Selina Tisler, Christian Zwiener, Rita A Triebskorn · 2019 · Frontiers in Environmental Science
  73. Metformin protects red blood cells against rotenone induced oxidative stress and cytotoxicity
    Shambhoo Sharan Tripathi, Abhishek Kumar Singh, Farhan Akhtar, Ankita Chaudhary, Syed Ibrahim Rizvi · 2019 · Archives of Physiology and Biochemistry
  74. Metformin loaded cholesterol-lysine conjugate nanoparticles: A novel approach for protecting HDFs against UVB-induced senescence
    Amirhossein Nayeri Rad, Golnaz Shams, Mehdi Safdarian, Layasadat Khorsandi, Johannes Grillari, Behzad Sharif Makhmalzadeh · 2020 · International Journal of Pharmaceutics
  75. Metformin induces lactate accumulation and accelerates renal cyst progression in Pkd1-deficient mice
    Ming‐Yang Chang, Chung‐Ying Tsai, Li‐Fang Chou, Shen‐Hsing Hsu, Huang‐Yu Yang, Cheng‐Chieh Hung, Ya‐Chung Tian, Albert C.M. Ong, Chih‐Wei Yang · 2021 · Human Molecular Genetics
  76. Influence of anaerobic and aerobic exercise on age-related pathways in skeletal muscle
    Ignacio Navas‐Enamorado, Michel Bernier, Gloria Brea‐Calvo, Rafael de Cabo · 2017 · Ageing Research Reviews
  77. Nutrient-epigenome interactions: Implications for personalized nutrition against aging-associated diseases
    Hemi Missong, Riya Joshi, Naina Khullar, Suresh Thareja, Umashanker Navik, Gurjit Kaur Bhatti, Jasvinder Singh Bhatti · 2024 · The Journal of Nutritional Biochemistry
  78. Targeting multiple hallmarks of mammalian aging with combinations of interventions
    Alexander Y. Panchin, Anna Ogmen, Artem S. Blagodatski, Anastasia Egorova, Mikhail Batin, Timofey S. Glinin · 2024 · Aging
  79. Multi-omics reveals the molecular mechanisms of rapid growth in distant hybrid fish
    Xuanyi Zhang, Fanglei Liu, Bei Li, Lujiao Duan, Jianming Yu, Ziyi Huang, SiYang Huang, Hongwen Liu, Qingfeng Liu, Shaojun Liu · 2024 · Aquaculture
  80. Principles of brain aging: Status and challenges of modeling human molecular changes in mice
    Verena Kluever, Eugenio F. Fornasiero · 2021 · Ageing Research Reviews
  81. Role of Autophagy in Cardiovascular Disease and Aging
    Christos Koutouroushis, Oiendrila Sarkar · 2021 · Cureus
  82. Pharmacological Approaches to Decelerate Aging: A Promising Path
    Bahareh Hassani, Ghazal Goshtasbi, Shirin Nooraddini, Negar Firouzabadi · 2022 · Oxidative Medicine and Cellular Longevity
  83. An evaluation of aging measures: from biomarkers to clocks
    Qingyi Wang, Tongyao Hou, Qiwen Wang, Jiamin He, Lan Wang, Jianmin Si, Shujie Chen · 2022 · Biogerontology
  84. Circadian medicine for aging attenuation and sleep disorders: Prospects and challenges
    Srishti Banerjee, Sandipan Ray · 2022 · Progress in Neurobiology
  85. Life on Magnet: Long-Term Exposure of Moderate Static Magnetic Fields on the Lifespan and Healthspan of Mice
    Yixiang Fan, Xin Yu, Biao Yu, Xinmiao Ji, Xiaofei Tian, Chao Song, Xin Zhang · 2022 · Antioxidants
  86. Effects of systemic drugs on the development and progression of age-related macular degeneration
    Kara Rickford Grimes, Abhilasha Aloney, Dimitra Skondra, Jay Chhablani · 2023 · Survey of Ophthalmology
  87. The development and benefits of metformin in various diseases
    Ying Dong, Yingbei Qi, Haowen Jiang, Mi Tian, Yunkai Zhang, Chang Si Peng, Wan-Chen Li, Yi Zhang, Yubo Zhou, Yi Zang et al. · 2023 · Frontiers of Medicine
  88. Old drug, new tricks: the utility of metformin in infection and vaccination responses to influenza and SARS-CoV-2 in older adults
    Dominique E. Martin, Andreia N. Cadar, Jenna M. Bartley · 2023 · Frontiers in Aging
  89. The biguanide metformin alters phosphoproteomic profiling in mouse brain
    Rin Khang, Chi‐Hu Park, Joo‐Ho Shin · 2014 · Neuroscience Letters
  90. Metformin in Diabetic Patients with Heart Failure: Safe and Effective
    Ijeoma Ananaba Ekeruo, Amirreza Solhpour, Heinrich Taegtmeyer · 2013 · Current Cardiovascular Risk Reports
  91. Daumone fed late in life improves survival and reduces hepatic inflammation and fibrosis in mice
    Jong Hee Park, Hae Young Chung, Minkyu Kim, Jung Hwa Lee, Mankil Jung, Hunjoo Ha · 2014 · Aging Cell
  92. Metabolic Alterations at the Crossroad of Aging and Oncogenesis
    Lizzia Raffaghello, Valter Daniel Longo · 2017 · International review of cytology
  93. A brief history of modern aging research
    Kayvan Zainabadi · 2018 · Experimental Gerontology
  94. Metformin treatment prevents gallstone formation but mimics porcelain gallbladder in C57Bl/6 mice
    Mohammadreza Dorvash, Mohammad Javad Khoshnoud, Hossein Saber, Amirreza Dehghanian, Pouria Mosaddeghi, Negar Firouzabadi · 2018 · European Journal of Pharmacology
  95. Evaluation of the pharmacokinetics of metformin and acarbose in the common marmoset
    Elizabeth Fernández, Corinna N. Ross, Hanyu Liang, Martin A. Javors, Suzette D. Tardif, Adam B. Salmon · 2019 · Pathobiology of Aging & Age-related Diseases
  96. The Interconnections Between Somatic and Ovarian Aging in Murine Models
    Augusto Schneider, Tatiana D. Saccon, Driele Neske Garcia, Bianka M. Zanini, José V.V. Isola, Jéssica D. Hense, Joao Alveiro Alvarado Rincón, Marcelo Borges Cavalcante, Jeffrey B. Mason, Michael B. Stout et al. · 2020 · The Journals of Gerontology Series A
  97. PPARα agonist and metformin co-treatment ameliorates NASH in mice induced by a choline-deficient, amino acid-defined diet with 45% fat
    Shinya Okishio, Kanji Yamaguchi, Hiroshi Ishiba, Nozomi Tochiki, Kota Yano, Aya Takahashi, Seita Kataoka, Keiichiro Okuda, Yuya Seko, Yu Liu et al. · 2020 · Scientific Reports
  98. Aging as an inflammatory disease and possible reversal strategies
    Graham Pawelec · 2020 · Journal of Allergy and Clinical Immunology
  99. Targeting the Electron Transport System for Enhanced Longevity
    Marko Radovic, Lucas P. Gartzke, Simon E. Wink, Joris A. van der Kleij, Frouwkje A. Politiek, Guido Krenning · 2025 · Biomolecules
  100. Ключевые молекулярные механизмы старения, биомаркеры и потенциальные интервенции
    Ekaterina Proshkina, И. А. Соловьёв, Mikhail Vyacheslavovich Shaposhnikov, A.A. Moskalev · 2020 · Molecular Biology