Metformin improves healthspan and lifespan in mice

Martin-Montalvo, Alejandro, Mercken, Evi M., Mitchell, Sarah J., Palacios, Hector H., Mote, Patricia L., Scheibye-Knudsen, Morten, Gomes, Ana P., Ward, Theresa M. +14 more·2013·Nature Communications
DOI 10.1038/ncomms3192

Cited by (1,001)

Items 901–1,000 of 1,001

  1. A novel therapeutic approach to colorectal cancer in diabetes: role of metformin and rapamycin
    Alice Gerges Geagea, Manfredi Rizzo, Abdo R. Jurjus, Francesco Cappello, Angelo Leone, Giovanni Tomasello, Céline Gracia, Sahar Al Kattar, Liliane Massaad-Massade, Assaad Antoine Eid · 2019 · Oncotarget
  2. Metformin Attenuates Early-Stage Atherosclerosis in Mildly Hyperglycemic Oikawa-Nagao Mice
    Akira Asai, Yuki Shuto, Mototsugu Nagao, Momoyo Kawahara, Teruo Miyazawa, Hitoshi Sugihara, Shinichi Oikawa · 2019 · Journal of Atherosclerosis and Thrombosis
  3. Research advances on how metformin improves memory impairment in “chemobrain”
    Ahmad Hamad Alhowail, Sridevi Chigurupati · 2021 · Neural Regeneration Research
  4. New Directions in Research on Aging
    Andrzej Bartke · 2021 · Stem Cell Reviews and Reports
  5. The Role of AMP-activated Protein Kinase in Oxytosis/Ferroptosis: Protector or Potentiator?
    Antonio Jose Martins Currais, Devin Kepchia, Zhibin Liang, Pamela A Maher · 2022 · Antioxidants and Redox Signaling
  6. Chronic treatment with the anti-diabetic drug metformin rescues impaired brain mitochondrial activity and selectively ameliorates defective cognitive flexibility in a female mouse model of Rett syndrome
    Chiara Urbinati, Chiara Lanzillotta, Livia Cosentino, Daniela Valenti, Maria Cristina Quattrini, Livia Di Crescenzo, Francesca Prestia, Donatella Pietraforte, Marzia Perluigi A, Fabio Di Domenico et al. · 2022 · Neuropharmacology
  7. Senotherapeutics: An emerging approach to the treatment of viral infectious diseases in the elderly
    Zhiqiang Li, Mingfu Tian, Guolei Wang, Xianghua Cui, Jun’e Ma, Siyu Liu, Bingzheng Shen, Fang Liu, Kailang Wu, Xuan Xiao et al. · 2023 · Frontiers in Cellular and Infection Microbiology
  8. Systemic Metabolism and Mitochondria in the Mechanism of Alzheimer’s Disease: Finding Potential Therapeutic Targets
    Song, Meiying, Fan, Xiang · 2023 · International Journal of Molecular Sciences
  9. Chronic Mechanistic Target of Rapamycin Inhibition: Preventing Cancer to Delay Aging, or Vice Versa?
    Zelton Dave Sharp, Tyler Jay Curiel, Carolina Becker Livi · 2013 · Interdisciplinary topics in gerontology and geriatrics
  10. Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules That Affect Aging Pathways and Extend Caenorhabditis elegans ’ Lifespan
    Peichuan Zhang, Yuying Zhai, James M. Cregg, Kenny K. H. Ang, Michelle R. Arkin, Cynthia J. Kenyon · 2019 · G3 Genes Genomes Genetics
  11. New Insight into Metformin Mechanism of Action and Clinical Application
    Yun Yan, Karen L. Kover, Wayne V. Moore · 2020 · IntechOpen eBooks
  12. Cimicifuga racemosa Extract Ze 450 Re-Balances Energy Metabolism and Promotes Longevity
    Malena Rabenau, Benjamin Dilberger, Madeline Günther, Sylvia Krippner, Veronika Butterweck, Georg Boonen, Jürgen Drewe, Gunter Peter Eckert, Carsten Culmsee · 2021 · Antioxidants
  13. Multidimensional effects of metformin in patients with type 2 diabetes
    Lyudmila Alexandrovna Ruyatkina, D. S. Ruyatkin · 2016 · Diabetes Mellitus
  14. 90th Anniversary Commentary: Caloric Restriction Effects on Aging
    David George Le Couteur, Stephen James Simpson · 2018 · Journal of Nutrition
  15. Alive and well? Exploring disease by studying lifespan
    Brett, Jamie O, Rando, Thomas A · 2014 · Current Opinion in Genetics & Development
  16. Calorie restriction mimetics against aging and inflammation
    Sakshi Chaudhary, Mani Raj Chaudhary, Manoj Kumar Jena, Prasana Kumar Rath, Bidyut Prava Mishra, Biswaranjan Paital, Ashish Vyas, Dipak Kumar Sahoo, Prabhakar Singh, Mohammad Murtaza Mehdi · 2025 · Biogerontology
  17. Microvascular Failure in the Aging Brain: Converging Pathways of Oxidative Stress, Inflammation, and Endothelial Decline
    Jordana Mariane Neyra Chauca, Maclovia Vázquez VanDyck, Armando Espinoza Santana, Graciela Gaddy Robles Martínez, Kalid Alejandra Romero Vega, Nancy García Quintana, Vanessa Sánchez · 2026 · Biomedicines
  18. The association between aging-related monocyte transcriptional networks and comorbidity burden: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Jingzhong Ding, Kurt Lohman, Anthony J. A. Molina, Osvaldo Delbono, Alain Gerald Bertoni, Steven Shea, Wendy S. Post, Xiuqing Guo, R. Graham Barr, Ani W Manichaikul et al. · 2022 · GeroScience
  19. [Translated article] Oral Supplementation and Systemic Drugs for Skin Aging: A Narrative Review
    Daniel Morgado‐Carrasco, Javier Gil‐Lianes, E. Jourdain, Jaime Piquero‐Casals · 2022 · Actas Dermo-Sifiliográficas
  20. Metformin promotes female germline stem cell proliferation by upregulating Gata-binding protein 2 with histone β-hydroxybutyrylation
    Xiang Wang, Geng G. Tian, Weiwei Cheng, Xiaoli Yu, Xiaoyong Li, Ji Wu · 2023 · Stem Cell Research & Therapy
  21. The combination of metformin and high glucose increased longevity of Caenorhabditis elegans a DAF-16/FOXO-independent manner: cancer/diabetic model via C. elegans
    Şeyda Berk, Ali Cetin, Özgür Ülkü Özdemir, Ayşe Nur Pektaş, Nazan Yurtçu, Sevgi Durna Daştan · 2024 · Frontiers in Endocrinology
  22. Too old for healthy aging? Exploring age limits of longevity treatments
    Prerana Chaudhari, Maria Ermolaeva · 2024 · npj Metabolic Health and Disease
  23. Balancing the promise and risks of geroscience interventions
    Alan Arthur Cohen, John Beard, Luigi Ferrucci, Tamàs Fülöp, Vadim N. Gladyshev, Mahdi Moqri, Marcel G. M. Olde Rikkert, Martin A. Picard · 2025 · Nature Aging
  24. Metformin prevents diabetes development in type 1 diabetes models via suppression of mTOR and STAT3 signaling in immune cells
    Haruka Suzuki, Shuji Hasegawa, Sae Fushimi, Kanako Tagami, Minaho Nishikawa, Yuichi Kondo, Hisafumi Yasuda · 2025 · Scientific Reports
  25. The regulation of microglia by aging and autophagy in multiple sclerosis
    Xiying Wang, Ye Sun, Haojun Yu, Chunran Xue, Xuzhong Pei, Yi Chen, Yangtai Guan · 2025 · Pharmacological Research
  26. DDS promotes longevity through a microbiome-mediated starvation signal
    Haeri Choi, Sung Chun Cho, Young Wan Ha, Billie R. Ocampo, Shirley Park, Shiwen Chen, Christopher F. Bennett, Jeehae Han, Ryan Rossner, Jong‐Sun Kang et al. · 2019 · Translational Medicine of Aging
  27. Empirical versus theoretical power and type I error (false-positive) rates estimated from real murine aging research data
    Irene Alfaras, Keisuke Ejima, Camila Vieira Ligo Teixeira, Clara Di Germanio, Sarah Jayne Mitchell, Samuel Hamilton, Luigi Ferrucci, Nathan L. Price, David B. Allison, Michel Bernier et al. · 2021 · Cell Reports
  28. Aspartame and sucralose extend the lifespan and improve the health status of C. elegans
    Mohan Zhang, Shuai Chen, Yu-Hua Dai, Ting Duan, Yu Xu, Xiaolin Li, Jun Jie Yang, Xinqiang Zhu · 2021 · Food & Function
  29. Frailty as a Clinically Relevant Measure of Human Aging
    Hee‐Won Jung · 2021 · Annals of Geriatric Medicine and Research
  30. Comparing anti–aging hallmark activities of Metformin and Nano-PSO in a mouse model of genetic Creutzfeldt-Jakob Disease
    Orli Binyamin, Kati Frid, Guy Keller, Ann Saada, Ruth Gabizon · 2021 · Neurobiology of Aging
  31. Tratamiento mediante suplementación oral o fármacos sistémicos del envejecimiento cutáneo. Revisión narrativa de la literatura
    Daniel Morgado‐Carrasco, Javier Gil‐Lianes, E. Jourdain, Jaime Piquero‐Casals · 2022 · Actas Dermo-Sifiliográficas
  32. Changing ROS, NAD and AMP: A path to longevity via mitochondrial therapeutics
    Oleh V. Lushchak, Dmytro V. Gospodaryov, Olha M. Strilbytska, Maria M. Bayliak · 2023 · Advances in protein chemistry and structural biology
  33. Preclinical Studies on the Effects of Frailty in the Aging Heart
    Robert Alan Rose, Susan E. Howlett · 2024 · Canadian Journal of Cardiology
  34. Hyperactive mTORC1 signaling is unaffected by metformin treatment in aged skeletal muscle
    Cory M. Dungan, Zhuyun Li, David Charles Wright, David L. Williamson · 2015 · Muscle & Nerve
  35. Are SIRT1 activators another indirect method to increase AMPK for beneficial effects on aging and the metabolic syndrome?
    Rebecca J. Ford, Eric M. Desjardins, Gregory R. Steinberg · 2017 · EBioMedicine
  36. Clinical impact of oral antidiabetic medications in heart failure patients
    Alberto Palazzuoli, Elena Ceccarelli, Gaetano M. Ruocco, Ranuccio Nuti · 2018 · Heart Failure Reviews
  37. Reversing age-associated arterial dysfunction: insight from preclinical models
    Venkateswara Reddy Gogulamudi, Jinjin Cai, Lisa A. Lesniewski · 2018 · Journal of Applied Physiology
  38. The African turquoise killifish Nothobranchius furzeri as a model for aging research
    Hanna Reuter, Johannes Krug, Peter Singer, Christoph Englert · 2018 · Drug Discovery Today Disease Models
  39. The Discovery of Druggable Anti-aging Agents
    Gulperi Yalcin, Cheol‐Koo Lee · 2020 · Annals of Geriatric Medicine and Research
  40. Transcriptomic profiling of long- and short-lived mutant mice implicates mitochondrial metabolism in ageing and shows signatures of normal ageing in progeroid mice
    Matías Fuentealba, Daniel K. Fabian, Handan Melike Dönertaş, Janet M. Thornton, Linda Partridge · 2021 · Mechanisms of Ageing and Development
  41. Beta-guanidinopropionic acid has age-specific effects on markers of health and function in mice
    Jonathan D. Dorigatti, Kevin M. Thyne, Brett C. Ginsburg, Adam B. Salmon · 2021 · GeroScience
  42. Living Long and Well: Prospects for a Personalized Approach to the Medicine of Ageing
    Georg Fuellen, Paul N. Schofield, Thomas Flatt, R. J. Schulz, Fritz Boege, Karin Kraft, Gerald H Rimbach, Saleh Mohamed Ibrahim, Alexander Tietz, Christian Schmidt et al. · 2015 · Gerontology
  43. Metformin counteracts glucose-dependent lipogenesis and impairs transdeamination in the liver of gilthead sea bream (Sparus aurata)
    Ania Rashidpour, Jonás I. Silva-Marrero, L Tortosa Seguí, Isabel V. Baanante, Isidoro Metón · 2019 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
  44. Lipid profiling of C. elegans strains administered pro-longevity drugs and drug combinations
    Tesfahun Dessale Admasu, Krishna Chaithanya Batchu, Li Fang Ng, Amaury Cazenave‐Gassiot, Markus Rene Wenk, Jan Gruber · 2018 · Scientific Data
  45. Metabolic Regulation of Cardiovascular Aging
    Michael Gao, Toren Finkel · 2025 · Current Cardiology Reports
  46. Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms
    Zhaoxiang He, Fei Teng, Yanqing Yang, Ruiyang Guo, Mengchen Wu, Fangzhu Han, Hongtao Tian, Jiawei Wang, Yiqi Hu, Yangwei Jiang et al. · 2025 · Nature Structural & Molecular Biology
  47. Exploiting inter-tissue stress signaling mechanisms to preserve organismal proteostasis during aging
    Patricija van Oosten‐Hawle · 2023 · Frontiers in Physiology
  48. The Gehan test identifies life-extending compounds overlooked by the log-rank test in the NIA Interventions Testing Program: Metformin, Enalapril, caffeic acid phenethyl ester, green tea extract, and 17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride
    Nisi Jiang, Jonathan Gelfond, Qianqian Liu, Randy Strong, James F. Nelson · 2024 · GeroScience
  49. A mechanistic analysis of metformin's biphasic effects on lifespan and healthspan in C. elegans: Elixir in youth, poison in elder
    Zhenzhen Yu, Jia‐Jun Tu, Mei‐Ling Ou, Jin‐Xiong Cen, Kun Xue, Shaojun Li, Jing Zhou, Guo‐Dong Lu · 2024 · Mechanisms of Ageing and Development
  50. Advances in smart biomaterials that modulate the bone microenvironment to promote bone defect repair in diabetes mellitus
    Ruideng Wang, Xi He, Shilong Su, Jinwu Bai, Qian Xiang, Haifeng Liu, Fang Zhou · 2024 · Smart Materials in Medicine
  51. Metformin acts on miR-181a-5p/PAI-1 axis in stem cells providing new strategies for improving age-related osteogenic differentiation decline
    Guanhao Hong, Yulan Zhou, Shukai Yang, Shouquan Yan, Jiaxu Lu, Bo Xu, Zeyu Zhan, Hua-sheng Jiang, Bo Wei, Jiafeng Wang · 2024 · Stem Cells
  52. Microbiota-derived indole acetic acid extends lifespan through the AhR-Sirt2 pathway in Drosophila
    Zheng Cao, Cui Zhang, Lijun Liu, Hehua Lei, Huabao Zhang, Yan He, Xinzhi Li, Qingwei Xiang, Yu‐Feng Wang, Limin Zhang et al. · 2025 · mSystems
  53. Mesenchymal stem cells and exosomes: A novel therapeutic approach for aging
    Dongfeng Lan, Dan Zhang, Xiaofang Dai, Cai Ji, He Zhou, Tao Song, Xianyao Wang, Qinghong Kong, Zhengzhen Tang, Jun Tan et al. · 2025 · Experimental Gerontology
  54. Rapamycin, Not Metformin, Mirrors Dietary Restriction‐Driven Lifespan Extension in Vertebrates: A Meta‐Analysis
    Edward R. Ivimey‐Cook, Zahida Sultanova, Alexei A. Maklakov · 2025 · Aging Cell
  55. Metformin suppresses the mitochondrial and transcriptional response to exercise, revealing a conserved BCL6B-associated angiogenic program
    Matthew D. Bruss, Christian J. Elliehausen, Josef P. Clark, Dennis M. Minton, Adam R. Konopka · 2025 · Journal of Applied Physiology
  56. Metformin Treatment in Old Rats and Effects on Mitochondrial Integrity
    Allen J. Herbst, Austin N. Hoang, Chiye Kim, Judd M. Aiken, Debbie I. McKenzie, Deena S. Goldwater, Jonathan Wanagat · 2021 · Rejuvenation Research
  57. Metformin Prevents Key Mechanisms of Obesity-Related Complications in Visceral White Adipose Tissue of Obese Pregnant Mice
    Katrin Schmitz, Eva‐Maria Turnwald, Tobias Kretschmer, Ruth Janoschek, Inga Bae‐Gartz, Kathrin Voßbrecher, Merlin D. Kammerer, Angela Köninger, Alexandra Gellhaus, Marion Handwerk et al. · 2022 · Nutrients
  58. Metformin Use Is Associated With Lower Mortality in Veterans With Diabetes Hospitalized With Pneumonia
    Turab Jawaid Mohammed, Michael Bowe, Alexandria N. Plant, Mario F. Perez, Carlos A. Álvarez, Eric M. Mortensen · 2022 · Clinical Infectious Diseases
  59. Pathological Epigenetic Events and Reversibility Review: the Intersection between Hallmarks of Aging and Developmental Origin of Health and Disease
    Douglas Mark Ruden, Aditi Singh, Daniel Allen Rappolee · 2023 · Epigenomics
  60. Short-term Treatment of Daumone Improves Hepatic Inflammation in Aged Mice
    Jong Hee Park, Hunjoo Ha · 2015 · Korean Journal of Physiology and Pharmacology
  61. Metformin Indications, Dosage, Adverse Reactions, and Contraindications
    Roxana Adriana Stoica, Diana Simona Ștefan, Manfredi Rizzo, Andra‐Iulia Suceveanu, Adrian Paul Suceveanu, Cristian Serafinceanu, Anca Pantea Stoian · 2020 · IntechOpen eBooks
  62. Circulating leucocytes perpetuate stroke‐induced aortic dysfunction
    Shinichi Asano, Grant C. O’Connell, Kent Lemaster, Evan DeVallance, Kayla Branyan, James W. Simpkins, Jefferson C. Frisbee, Taura L. Barr, Paul David Chantler · 2017 · Experimental Physiology
  63. Association of Dietary and Supplement Intake of Antioxidants with Risk of Dementia: A Meta-Analysis of Cohort Studies
    Rangyin Zhao, Xiaoyong Han, Shangrong Jiang, Weijing Zhao, Jia Liu, Hongxia Zhang, Xiaoliang Mao, Min Zhang, Lili Lei, Hong You · 2023 · Journal of Alzheimer s Disease
  64. Delaying Renal Aging: Metformin Holds Promise as a Potential Treatment
    Zheng Qiao, Jin Zhao, Jinguo Yuan, Yunlong Qin, Zhanxin Zhu, Jie Liu, Shiren Sun · 2024 · Aging and Disease
  65. Revealing the role of metformin in gastric intestinal metaplasia treatment
    Ruoyu Hu, Xia Xue, Xiangdong Sun, Yang Mi, Huijuan Wen, Huayuan Xi, Fuhao Li, Pengyuan Zheng, Simeng Liu · 2024 · Frontiers in Pharmacology
  66. Metformin modulates oxidative stress via activation of AMPK/NF-κB signaling in Trisomy 21 fibroblasts: an in vitro study
    Angelika Buczyńska, Piotr Malinowski, Arkadiusz Żbikowski, Adam Jacek Kretowski, Monika Zbucka-Krętowska · 2025 · Frontiers in Molecular Biosciences
  67. Metformin inhibits nuclear egress of chromatin fragments in senescence and aging
    Takuya Kumazawa, Yanxin Xu, Yu Wang, Ji-Won Lee, Tara C. O’Brien, Chiakang Ho, Murat Çetinbaş, Aaron I. Weiner, Konrad Hochedlinger, Ruslan I. Sadreyev et al. · 2026 · Nature Aging
  68. Determinants of Cardiovascular Risk in Diabetes Beyond Hyperglycemia
    Lina Badimón, Rodrigo Hernández Vera, Gemma Vilahur · 2013
  69. Effects of metformin, rapamycin, and resveratrol on cellular metabolism of canine primary fibroblast cells isolated from large and small breeds as they age
    Ana Gabriela Jiménez, Sahil Lalwani, William Cipolli · 2021 · GeroScience
  70. Effect of Caloric Restriction on Aging: Fixing the Problems of Nutrient Sensing in Postmitotic Cells?
    Моргунова Галина Васильевна, Gregory A. Shilovsky, Alexander N. Khokhlov · 2021 · Biochemistry (Moscow)
  71. Grape seed proanthocyanidins and metformin combination attenuate hepatic endoplasmic reticulum stress in rats subjected to nutrition excess
    Baskaran Yogalakshmi, Chandrasekaran Sathiya Priya, Carani Venkatraman Anuradha · 2018 · Archives of Physiology and Biochemistry
  72. Liver antioxidant and aerobic status improves after metformin and melatonin administration in a rat model of high-fat diet and mammary carcinogenesis
    Natalia Kurhaluk, Bianka Bojková, Paweł Jan Winklewski · 2018 · Canadian Journal of Physiology and Pharmacology
  73. Metformin: A stroke of luck
    Mohamad Aljofan, Abduzhappar Gaipov · 2019 · Electronic Journal of General Medicine
  74. Senotherapeutics and HIV-1 Persistence
    Matthew A. Szaniawski, Adam M. Spivak · 2020 · Current HIV/AIDS Reports
  75. Immunosenescence in Childhood Cancer Survivors and in Elderly: A Comparison and Implication for Risk Stratification
    Petra Lázničková, Kamila Bendíčková, Tomáš Kepák, Jan Frič · 2021 · Frontiers in Aging
  76. Calorie intake rather than food quantity consumed is the key factor for the anti-aging effect of calorie restriction
    Yaru Liang, Yuqi Gao, Rui Hua, Maoyang Lu, Huiling Chen, Zhuoran Wang, Liyuan Li, Kaiqiang Hu, 尹月淼, Kang Xu et al. · 2021 · Aging
  77. Cytosolic and mitochondrial tRNA synthetase inhibitors increase lifespan in a GCN4/atf-4-dependent manner
    Christine Reiser Robbins, Bhumil Patel, Danielle L. Sawyer, Barrie M. Wilkinson, Brian Keith Kennedy, Mark A. McCormick · 2022 · iScience
  78. Characterization of hepatic fatty acids using magnetic resonance spectroscopy for the assessment of treatment response to metformin in an eNOS −/− mouse model of metabolic nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
    Begoña Lavín, Thomas R. Eykyn, Alkystis Phinikaridou, Aline Xavier, Shravan Kumar, Xabier Buqué, Patricia Aspichueta, Carlos Sing‐Long, Marco A. Arrese, René Michael Botnar et al. · 2023 · NMR in Biomedicine
  79. Association of Polymorphisms in Connective Tissue Growth Factor and Epidermal Growth Factor Receptor Genes With Human Longevity
    Timothy A. Donlon, Brian J. Morris, Qimei He, Randi Chen, Kamal Masaki, Richard Allsopp, D. Craig Willcox, Gregory J. Tranah, Neeta Parimi, Daniel S. Evans et al. · 2016 · The Journals of Gerontology Series A
  80. Hungering for Immortality.
    Joel C. Eissenberg · 2018 · Europe PMC (PubMed Central)
  81. Toxicology of pharmaceutical and nutritional longevity compounds
    Çiğdem Kahraman, Duygu Kaya Bilecenoglu, Suna Sabuncuoğlu, İ. İrem Tatlı Çankaya · 2023 · Expert Reviews in Molecular Medicine
  82. Comparative Studies of Orthovanadate Nanoparticles and Metformin on Life Quality and Survival of Senile Wistar Rats
    Nikitchenko IuV, Vladimir Klochkov, Nataliya S. Kavok, Nina A. Karpenko, Irina V. Nikitchenko, Svetlana L. Yefimova, Anatoly I. Bozhkov · 2021 · Biological Trace Element Research
  83. Metformin anticipates peak of lactate during high-intensity interval training but no changes performance or neuromuscular response in amateur swimmers
    Matheus Silva Norberto, Tarine Botta de Arruda, Jônatas Augusto Cursiol, Vitor Luiz de Andrade, Gustavo Gomes de Araújo, Marcelo Papoti · 2021 · Clinical Nutrition ESPEN
  84. Effect of Metformin on Locomotor Function Recovery in Rat Spinal Cord Injury Model: A Meta‐analysis
    Qing Chen, Dong Xie, Qiuju Yao, Lili Yang · 2021 · Oxidative Medicine and Cellular Longevity
  85. Deciphering metformin action in obese mice: A critical re-evaluation of established protocols
    Mairam Kaplanian, Cécile Philippe, Sameer Abu Eid, Martina Theresa Hackl, Matthäus Metz, Marianna Beghini, Andreea Corina Luca, Alexandra Kautzky‐Willer, Thomas Scherer, Clemens Fürnsinn · 2021 · Metabolism
  86. Inflammaging
    Claudio Franceschi, Miriam Capri, Paolo Garagnani, Rita Ostan, Aurelia Santoro, Daniela Monti, Stefano Salvioli · 2017 · Springer eBooks
  87. Effects of metformin on the uterus of d ‐galactose‐induced aging mice: Histomorphometric, immunohistochemical localization (B‐cell lymphoma 2, Bcl2‐associated X protein, and active capase3), and oxidative stress study
    Vanlal Rempuia, Borgohain Anima, Malsawmhriatzuala Jeremy, Guruswami Gurusubramanian, Pranay Punj Pankaj, Rajesh Kumar Kharwar, Vikas Kumar Roy · 2022 · Journal of Experimental Zoology Part A Ecological and Integrative Physiology
  88. Incidence of metformin use in patients with age-related macular degeneration versus normal controls: A population-based study in Olmsted County, Minnesota
    Matthew R. Starr, Lauren A. Dalvin, Jackson E. Abou Chehade, Gena M. Damento, Maria Garcia, Saumya M. Shah, David O. Hodge, Raymond Iezzi, Sophie J. Bakri · 2022 · Eye
  89. Quo vadis PGRMC? Grand-Scale Biology in Human Health and Disease
    Michael A. Cahill · 2022 · Frontiers in Bioscience-Landmark
  90. The Influence of Sildenafil–Metformin Combination on Hyperalgesia and Biochemical Markers in Diabetic Neuropathy in Mice
    Ciprian Pușcașu, Anca Ungurianu, Oana Cristina Șeremet, Corina Andrei, Dragoș Paul Mihai, Simona Negreș · 2023 · Medicina
  91. Effect of metformin on the spatial memory in aged rats
    Zobeideh Ashrostaghi, Farzaneh Ganji, Hamid Sepehri · 2015 · National Journal of Physiology Pharmacy and Pharmacology
  92. The geometric framework: An approach for studying the impact of nutrition on healthy aging
    Samantha M. Solon‐Biet, Devin Wahl, David Raubenheimer, Victoria Carroll Cogger, David George Le Couteur, Stephen James Simpson · 2018 · Drug Discovery Today Disease Models
  93. Late life metformin treatment limits cell survival and shortens lifespan by triggering an aging-associated failure of energy metabolism
    Lília Espada, Alexander Dakhovnik, Prerana Chaudhari, Asya Martirosyan, Laura Miek, Tetiana Poliezhaieva, Yvonne Schaub, Ashish Nair, Nadia Döring, Norman Rahnis et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  94. Hymecromone Promotes Longevity and Insulin Sensitivity in Mice
    Nadine Nagy, Kathryn S. Czepiel, Gernot Kaber, Darko Stefanovski, Aviv Hargil, Nina Pennetzdorfer, Robert W. Targ, Saranya Chidambaranathan Reghupaty, Thomas N. Wight, Robert B. Vernon et al. · 2024 · Cells
  95. Sex differences in cognition, anxiety-phenotype and therapeutic effect of metformin in the aged apoE-TR mice
    Yingbin Lin, Xinqun Luo, Fangyu Wang, Huange Cai, Yuanxiang Lin, Dezhi Kang, Wenhua Fang · 2025 · Biology of Sex Differences
  96. Imeglimin, a novel antidiabetic agent related to metformin, attenuates knee osteoarthritis development and progression through AMPK activation and NF-κB signaling inhibition
    Yuki Hyodo, Yukio Akasaki, Ichiro Kurakazu, Masanari Kuwahara, Taisuke Uchida, Ryota Hirose, Mamiko Sakai, Takumi Kita, Koki Kato, Yasuharu Nakashima · 2025 · Osteoarthritis and Cartilage
  97. Progress in anti-ageing drug research for age-related diseases: A review
    Ziying Zhou, Hao-tian Duan, Si-Tu Xue, Zhuorong Li · 2025 · Ageing Research Reviews
  98. Targeting brain connectivity in Alzheimer’s disease with repurposed drugs
    Lorenzo Pini, Bruno Pietro Imbimbo, Alessandra Griffa, Gilles Allali, Nunzio Pomara · 2025 · Ageing Research Reviews
  99. Enhanced non-enzymatic H2S generation extends lifespan and healthspan in male mice
    María Ángeles Cáliz‐Molina, Raúl López‐Fernández‐Sobrino, Inmaculada Pino-Pérez, Concepción Panadero‐Morón, María del Carmen Vilches-Pérez, María Camacho-Cabrera, Almudena García‐Ruiz, Leopoldo Pérez-Rosendo, Isabel Espadas, Alejandro Sola‐García et al. · 2025 · Cell Metabolism
  100. Restoring circadian rhythms in the hypothalamic paraventricular nucleus reverses aging biomarkers and extends lifespan in male mice
    Haijiao Zhao, Meimei Liao, Ran Huo, Ting He, Hongni Tian, Zeqi Li, Chen Chen, Ziqing Yu, Juan Chai, Xiaocui Song et al. · 2026 · Cell