Metformin improves healthspan and lifespan in mice

Martin-Montalvo, Alejandro, Mercken, Evi M., Mitchell, Sarah J., Palacios, Hector H., Mote, Patricia L., Scheibye-Knudsen, Morten, Gomes, Ana P., Ward, Theresa M. +14 more·2013·Nature Communications

DOI 10.1038/ncomms3192

Cited by (1,001)

Items 801–900 of 1,001

Metformin regulates macrophage polarization via the Shh signaling pathway to improve pulmonary vascular development in bronchopulmonary dysplasia
Xiaowen Xiang, Lin Zhou, Zhiwei Lin, Xia Qu, Yanru Chen, Hongping Xia · 2021 · IUBMB Life
Metformin and Dementia Risk: A Systematic Review with Respect to Time Related Biases
Jiahui Dai, Kayleen Deanna Ports, María M. Corrada, Andrew Odegaard, Joan O’Connell, Luohua Jiang · 2022 · Journal of Alzheimer s Disease Reports
Hydralazine Revives Cellular and Ocular Lens Health-Span by Ameliorating the Aging and Oxidative-Dependent Loss of the Nrf2-Activated Cellular Stress Response
Bhavana Chhunchha, Eri Kubo, Ronald R. Krueger, Dhirendra P. Singh · 2023 · Antioxidants
Metformin extends the chronological lifespan of fission yeast by altering energy metabolism and stress resistance capacity
Ceren Şeylan, Çağatay Tarhan · 2023 · FEMS Yeast Research
Mitophagy-promoting agents and their ability to promote healthy-aging
Vijigisha Srivastava, Einav Gross · 2023 · Biochemical Society Transactions
Saponins of Panax japonicus ameliorates cardiac aging phenotype in aging rats by enhancing basal autophagy through AMPK/mTOR/ULK1 pathway
Hefei Huang, Tianlun Wang, Luo-Pei Wang, Yan Huang, Weili Li, Jine Wang, Yuanlang Hu, Zhiyong Zhou · 2023 · Experimental Gerontology
Nurturing longevity through natural compounds: Where do we stand, and where do we go?
Monika N. Todorova, Martina S. Savova, Liliya V. Mihaylova, Milen I. Georgiev · 2024 · Food Frontiers
Polyphenolic Compounds: Orchestrating Intestinal Microbiota Harmony during Aging
Quélita Cristina Pereira, Isabela Monique Fortunato, Fabrício de Sousa Oliveira, Marisa Claudia Alvarez, Tanila Wood dos Santos, Marcelo Lima Ribeiro · 2024 · Nutrients
The impact of short-lived controls on the interpretation of lifespan experiments and progress in geroscience – Through the lens of the “900-day rule”
Kamil Pabis, Diogo Barardo, Jan Gruber, Olga Sirbu, Marco Malavolta, Kumar Selvarajoo, Matt R. Kaeberlein, Brian Keith Kennedy · 2024 · Ageing Research Reviews
Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster
Hrvoje Augustin, Kieran McGourty, Marcus J. Allen, Jennifer Adcott, Chi Tung Wong, Emmanuel Boucrot, Linda Partridge · 2018 · Neurobiology of Aging
Metformin fights against radiation-induced early developmental toxicity
Bin Wang, Jiali Dong, Huiwen Xiao, Yuan Li, Yuxiao Jin, Ming Cui, Shuqin Zhang, Saijun Fan · 2020 · The Science of The Total Environment
Metformin pretreatment rescues olfactory memory associated with subependymal zone neurogenesis in a juvenile model of cranial irradiation
Daniel Derkach, T. Kehtari, M. Renaud, Mohsen Heidari, Nishanth Lakshman, C. Morshead · 2021 · Cell Reports Medicine
Metformin treatment of juvenile mice alters aging-related developmental and metabolic phenotypes
Yun Xia Zhu, Yimin Fang, David Medina, Andrzej Bartke, Rong Yuan · 2021 · Mechanisms of Ageing and Development
Antecedent Metabolic Health and Metformin (ANTHEM) Aging Study: Rationale and Study Design for a Randomized Controlled Trial
Santosh Kumari, Matthew P. Bubak, Hayden M. Schoenberg, Arik Davidyan, Christian J. Elliehausen, Katrin Gaardbo Kuhn, Timothy M. VanWagoner, Rowan Karaman, Robert Hal Scofield, Benjamin F. Miller et al. · 2021 · The Journals of Gerontology Series A
Analysis of Scientometric Indicators in Publications Associated with Healthy Aging in the World, Period 2011–2020
Eric Rojas-Montesino, Diego Méndez, Yolanda Espinosa‐Parrilla, Eduardo Fuentes Q, Iván F. Palomo · 2022 · International Journal of Environmental Research and Public Health
Targeting metabolism for lupus therapy
Manan Mehta, Navdeep S. Chandel · 2015 · Science Translational Medicine
Automation of C. elegans lifespan measurement
Daniel P. Felker, Christine Reiser Robbins, Mark A. McCormick · 2019 · Translational Medicine of Aging
The Nuclear Lamina: Protein Accumulation and Disease
Carla Almendáriz-Palacios, Zoe E. Gillespie, Matthew Janzen, Valeria Martinez, Joanna M. Bridger, Troy A. A. Harkness, Darrell D. Mousseau, Christopher H. Eskiw · 2020 · Biomedicines
The significance of caloric restriction mimetics as anti-aging drugs
Nassar, Khloud, El-mekawey, Doaa, Elmasry, Ahmed E., Refaey, Mohamed S., El-Sayed Ghoneim, Mai, Elshaier, Yaseen A.M.M. · 2024 · Biochemical and Biophysical Research Communications
Evaluation of the geroprotective effects of withaferin A in Drosophila melanogaster
Liubov A. Koval, Nadezhda Vladimirovna Zemskaya, Alexander M. Aliper, Alex A. Zhavoronkov, Alexey Moskalev · 2021 · Aging
Association of Preadmission Metformin Use and Prognosis in Patients With Sepsis and Diabetes Mellitus: A Systematic Review and Meta-Analysis
Yuanzhe Li, Huayan Zhao, Yalin Guo, Yongtao Duan, Yanjun Guo, Xianfei Ding · 2021 · Frontiers in Endocrinology
Youth versus adult-onset type 2 diabetic kidney disease: Insights into currently known structural differences and the potential underlying mechanisms
Kalie L. Tommerdahl, Jessica Kendrick, Robert G. Nelson, Petter Bjornstad · 2022 · Clinical Science
Pediococcus acidilactici pA1c® Improves the Beneficial Effects of Metformin Treatment in Type 2 Diabetes by Controlling Glycaemia and Modulating Intestinal Microbiota
Miriam Cabello-Olmo, María Oneca, Raquel Urtasun, María José Pajares, Saioa Goñi, José Ignacio Riezu‐Boj, Fermin Ignacio Milagro, Josune Ayo, Ignacio Encı́o, Miguel Barajas et al. · 2023 · Pharmaceutics
Mito-metformin protects against mitochondrial dysfunction and dopaminergic neuronal degeneration by activating upstream PKD1 signaling in cell culture and MitoPark animal models of Parkinson’s disease
Muhammet Ay, Adhithiya Charli, Monica Renee Langley, Ah-Young Jang, Piyush Padhi, Huajun Jin, Vellareddy Anantharam, Balaraman Kalyanaraman, Arthi Kanthasamy, Anumantha G. Kanthasamy · 2024 · Frontiers in Neuroscience
Effects of metformin on congenital muscular dystrophy type 1A disease progression in mice: a gender impact study
Cibely Cristine Fontes de Oliveira, Bernardo Moreira Soares Oliveira, Zandra Körner, Vahid M. Harandi, Madeleine Durbeej · 2018 · Scientific Reports
Chronic metformin reduces systemic and local inflammatory proteins and improves hypertension-related cardiac autonomic dysfunction
Phablo Wendell C. Oliveira, Glauciene Januário de Sousa, Antonio Marcos Birocale, Sônia Alves Gouvêa, Suely Gomes de Figueiredo, G.R. Abreu, Nazaré Souza Bissoli · 2019 · Nutrition Metabolism and Cardiovascular Diseases
Is metformin a geroprotector? A peek into the current clinical and experimental data
Agnieszka Zajda, Kristiina M. Huttunen, Joanna Sikora, Maria Podsiedlik, Magdalena Markowicz-Piasecka · 2020 · Mechanisms of Ageing and Development
Metformin Preserves β-Cell Compensation in Insulin Secretion and Mass Expansion in Prediabetic Nile Rats
Hui Ming Huang, Bradi R. Lorenz, Paula Horn Zelmanovitz, Catherine B. Chan · 2021 · International Journal of Molecular Sciences
Efficacy of Providing the PI3K p110α Inhibitor BYL719 (Alpelisib) to Middle-Aged Mice in Their Diet
Christopher P. Hedges, Jordi Boix, Jagdish Kumar Jaiswal, Bhoopika Shetty, Peter Robin Shepherd, Troy L. Merry · 2021 · Biomolecules
Overexpression of Activated AMPK in the Anopheles stephensi Midgut Impacts Mosquito Metabolism, Reproduction and Plasmodium Resistance
Chioma Moses Oringanje, Lillian R. Delacruz, Yunan Han, Shirley Luckhart, Michael A. Riehle · 2021 · Genes
Rapamycin-induced hyperglycemia is associated with exacerbated age-related osteoarthritis
Dennis M. Minton, Christian J. Elliehausen, Martin A. Javors, Kelly S. Santangelo, Adam R. Konopka · 2021 · Arthritis Research & Therapy
Metformin inhibits human spermatozoa motility and signalling pathways mediated by protein kinase A and tyrosine phosphorylation without affecting mitochondrial function
Violeta Calle-Guisado, Lauro González‐Fernández, David Martín‐Hidalgo, Luis J Garcı́a, Maria Julia Bragado · 2018 · Reproduction Fertility and Development
Neuroprotective Effects of Diabetes Drugs for the Treatment of Neonatal Hypoxia-Ischemia Encephalopathy
Laura Poupon-Bejuit, Eridan Rocha‐Ferreira, Claire Thornton, Henrik Hagberg, Ahad A. Rahim · 2020 · Frontiers in Cellular Neuroscience
Senotherapy for chronic lung disease
Peter John Barnes · 2025 · Pharmacological Reviews
Cardiac aging: Molecular mechanisms and therapeutic interventions
Xin Li, Xiaoyan Pang, Haiyan Sun, Bingyu Zhang, Haiyan Wang, Nan Wu, Lina Yang · 2025 · Pharmacological Research
The Potential of Resveratrol to Act as a Caloric Restriction Mimetic Appears to Be Limited: Insights from Studies in Mice
Kathrin Pallauf, Ilka Günther, Gianna Kühn, Dawn Chin, Sonia de Pascual‐Teresa, Gerald H Rimbach · 2020 · Advances in Nutrition
Crotamiton derivative JM03 extends lifespan and improves oxidative and hypertonic stress resistance in Caenorhabditis elegans via inhibiting OSM-9
Keting Bao, Jiali Feng, Wenwen Liu, Zhifan Mao, Zhifan Mao, Tianyue Sun, Zhouzhi Song, Zelan Hu, Jian Li · 2022 · eLife
Extension of the Life Span by Acarbose: Is It Mediated by the Gut Microbiota?
Baiyun Wu, Jiai Yan, Ju Yang, Yanping Xia, Dan Li, Feng Zhang, Hong Cao · 2022 · Aging and Disease
Metformin promotes in vitro maturation of oocytes from aged mice by attenuating mitochondrial oxidative stress via SIRT3-dependent SOD2ac
Yongzhi Cao, Zhao Wang, Changming Zhang, Yuehong Bian, Xin Zhang, Xin Liu, Wendi Chen, Yueran Zhao · 2022 · Frontiers in Cell and Developmental Biology
Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity
Pedro S. Marra, Takehiko Yamanashi, Kaitlyn J. Crutchley, Nadia E. Wahba, Zoe‐Ella M. Anderson, Manisha Modukuri, Gloria Chang, Tammy Tran, Masaaki Iwata, Hyunkeun Ryan Cho et al. · 2023 · Aging
Empagliflozin improves kidney senescence induced by d-galactose by reducing sirt1-mediated oxidative stress
Ronghua Fang, Jie Chen, Jiangchuan Long, Binghan Zhang, Qixuan Huang, Shengbing Li, Ke Li, Qing Chen, Dongfang Liu · 2023 · Biogerontology
Metformin Induces a Caspase 3-Unrelated Apoptosis in Human Colorectal Cancer Cell Lines HCT116 and SW620
Bustanur Rosidi, Diana Priyatno, Teguh Pribadi Putra, Irawan Yusuf · 2023 · Cancer Management and Research
Geroscience-Centric Perspective for Geriatric Psychiatry: Integrating Aging Biology With Geriatric Mental Health Research
Breno Satler Diniz, Johanna Seitz‐Holland, Raghav Sehgal, Jessica Kasamoto, Albert Higgins‐Chen, Eric J. Lenze · 2023 · American Journal of Geriatric Psychiatry
Combinatorial interventions in aging
Andrey A. Parkhitko, Elizabeth Filine, Marc Tatar · 2023 · Nature Aging
Long COVID as a disease of accelerated biological aging: An opportunity to translate geroscience interventions
Areez Shafqat, Mary Clare Masters, Utkarsh Tripathi, Tamar Tchkonia, James L. Kirkland, Shahrukh Khurshid Hashmi · 2024 · Ageing Research Reviews
A novel complex I inhibitor protects against hypertension-induced left ventricular hypertrophy
Nobutoshi Matsumura, Ian M. Robertson, Shereen M. Hamza, Carrie-Lynn M. Soltys, Miranda M. Y. Sung, Grant Masson, Donna L. Beker, Jason R.B. Dyck · 2017 · American Journal of Physiology-Heart and Circulatory Physiology
Rodent diet aids and the fallacy of caloric restriction
Alexander Martin Wolf · 2021 · Mechanisms of Ageing and Development
A blast from the past: To tame time with metformin
Dionysios Xenos, Patrizia Mecocci, Virginia Boccardi · 2022 · Mechanisms of Ageing and Development
When Anti-Aging Studies Meet Cancer Chemoprevention: Can Anti-Aging Agent Kill Two Birds with One Blow?
Noriko N. Yokoyama, Andria P. Denmon, Edward Uchio, Mark L. Jordan, Dan Mercola, Xiaolin Zi · 2015 · Current Pharmacology Reports
Do actuaries believe in longevity deceleration?
Edouard H Debonneuil, Stéphane Loisel, Frédéric Planchet · 2017 · Insurance Mathematics and Economics
Metformin Reduces Lipogenesis Markers in Obese Mice Fed a Low‐Carbohydrate and High‐Fat Diet
Karla Nayara Oliveira Santana, Deborah de Farias Lelis, Keila Lopes Mendes, Jamille Fernandes Lula, Alanna Fernandes Paraíso, João Marcus Oliveira Andrade, John David Feltenberger, Júnio Cota, Diego Vicente da Costa, Alfredo Maurício Batista de Paula et al. · 2016 · Lipids
Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease
Julia C. Wilmanns, Raghav Pandey, Olivia J. Hon, Anjana Chandran, Jan Mirko Schilling, Elvira Forte, Qizhu Wu, Gaël Cagnone, Preeti Bais, Vivek M. Philip et al. · 2018 · Molecular Metabolism
Mitochondrial adaptations in liver and skeletal muscle to pro-longevity nutritional and genetic interventions: the crosstalk between calorie restriction and CYB5R3 overexpression in transgenic mice
Sandra Rodríguez-López, Sara Lopez-Bellón, José Antonio González-Reyes, María I. Burón, Rafael de Cabo, José M. Villalba · 2020 · GeroScience
Metabolic Effects of Caloric Restriction
Dudley W. Lamming, Rozalyn M. Anderson · 2014 · Wiley eBooks
Aging and metabolic dysfunction-associated steatotic liver disease: a bidirectional relationship
Chen Chen, Lin Wang · 2025 · Frontiers of Medicine
Evaluating GLP-1 receptor agonists versus metformin as first-line therapy for reducing dementia risk in type 2 diabetes
Mingyang Sun, Xiaoling Wang, Zhongyuan Lu, Yi Yang, Shuang Lv, Mengrong Miao, Wanming Chen, Szu‐Yuan Wu, Jiaqiang Zhang · 2025 · BMJ Open Diabetes Research & Care
Metformin Triggers Apoptosis and Induction of the G0/G1 Switch 2 Gene in Macrophages
Xuming Hu, Huan Luo, Chunfeng Dou, Xujing Chen, Yi Huang, Liping Wang, Songlei Xue, Zhen Sun, Shihao Chen, Qi Xu et al. · 2021 · Genes
Directly Reprogrammed Human Neurons to Understand Age-Related Energy Metabolism Impairment and Mitochondrial Dysfunction in Healthy Aging and Neurodegeneration
Camila Gudenschwager, Isadora Chavez, C. Cárdenas, C. González-Billault · 2021 · Oxidative Medicine and Cellular Longevity
Metformin ameliorates thymus degeneration of mice by regulating mitochondrial function
Yang Shu-ping, Qing Su, Yaru Zhang, Yun Sun, Yurong Chai · 2022 · International Immunopharmacology
Effects of lifespan-extending interventions on cognitive healthspan
Luka Čulig, Burcin Duan Sahbaz, Vilhelm A. Bohr · 2022 · Expert Reviews in Molecular Medicine
Disrupting the Mood and Obesity Cycle: The Potential Role of Metformin
Stacey N. Doan, Sunita K. Patel, Bin Xie, Rebecca A. Nelson, Lisa D. Yee · 2023 · Obesities
Geroprotective interventions in the 3xTg mouse model of Alzheimer’s disease
Michelle M. Sonsalla, Dudley W. Lamming · 2023 · GeroScience
Association of Metformin and Other Diabetes Medication Use and the Development of New-Onset Dry Age-Related Macular Degeneration: A Case–Control Study
Gabriel T. Kaufmann, Max J. Hyman, Reem Gonnah, Seenu M. Hariprasad, Dimitra Skondra · 2023 · Investigative Ophthalmology & Visual Science
Quantification of healthspan in aging mice: introducing FAMY and GRAIL
Dudley W. Lamming · 2024 · GeroScience
Molecular connections of obesity and aging: a focus on adipose protein 53 and retinoblastoma protein
Dinh‐Toi Chu, Yang Tao · 2017 · Biogerontology
Pharmaceutical Intervention of Aging
Minxian Qian, Baohua Liu · 2018 · Advances in experimental medicine and biology
The plasticity of ageing and the rediscovery of ground-state prevention
Alessandro Blasimme · 2021 · History & Philosophy of the Life Sciences
Cell and Cell-Free Therapies to Counteract Human Premature and Physiological Aging: MSCs Come to Light
Arantza Infante, Clara I. Rodrı́guez · 2021 · Journal of Personalized Medicine
Potential Benefits of Combined Statin and Metformin Therapy on Resistance Training Response in Older Individuals
Douglas E. Long, Kate Kosmac, Cory M. Dungan, Marcas M. Bamman, Charlotte A. Peterson, Philip A. Kern · 2022 · Frontiers in Physiology
Pioglitazone is equally effective for diabetes prevention in older versus younger adults with impaired glucose tolerance
Espinoza, Sara E., Wang, Chen-pin, Tripathy, Devjit, Clement, Stephen C., Schwenke, Dawn C., Banerji, Mary Ann, Bray, George A., Buchanan, Thomas A., Henry, Robert R., Kitabchi, Abbas E. et al. · 2016 · AGE
Metformin as a cellular protector; a synoptic view of modern evidences.
Nicolas F. Wiernsperger · 2015 · Europe PMC (PubMed Central)
A high throughput drug screening paradigm using transgenic Caenorhabditis elegans model of Alzheimer’s disease
Emelyne Teo, John Lim, Sheng Fong, Anis Larbi, Graham Daniel Wright, Nicholas S. Tolwinski, Jan Gruber · 2019 · Translational Medicine of Aging
Metformin Protects Auditory Hair Cells from Gentamicin-Induced Toxicity in vitro
Andrea Glutz, Katharina Leitmeyer, Cristian Setz, Yves Brand, Daniel Bodmer · 2015 · Audiology and Neurotology
Discovering Biological Mechanisms of Exceptional Human Health Span and Life Span
Sofiya Milman, Nir Barzilai · 2023 · Cold Spring Harbor Perspectives in Medicine
Reflecting on Concepts Relevant to Contemplating the Relationships Between Glucose–Insulin Perturbations, Nutrition, and Aging
Harry G. Preuss, Nate Mrvichin, Gilbert R. Kaats, Debasis Bagchi, Dallas L. Clouatre · 2019 · Journal of the American College of Nutrition
The goal of geroscience is life extension
Mikhail V. Blagosklonny · 2021 · Oncotarget
Effect of metformin treatment and its time of administration on joint capsular fibrosis induced by mouse knee immobilization
Kotaro Tokuda, Yoshiaki Yamanaka, Yosuke Mano, Manabu Tsukamoto, Takafumi Tajima, Hitoshi Suzuki, Makoto Kawasaki, Soshi Uchida, Eiichiro Nakamura, Ke‐Yong Wang et al. · 2021 · Scientific Reports
Evaluation of nootropic activity of telmisartan and metformin on diazepam-induced cognitive dysfunction in mice through AMPK pathway and amelioration of hippocampal morphological alterations.
E. Said, A. Elsayed, L. Rashed, E. Nadwa, Njood A. Alsuhaibani, Batool S Alfuraih, R. Mahmoud · 2021 · European Journal of Pharmacology
RRP Regulates Autophagy through the AMPK Pathway to Alleviate the Effect of Cell Senescence on Atherosclerosis
Dekun Liu, Yueyue Song, Tinging Song, Lin Lin, Lei Zhang, Qiong Yang, Xingchen Niu, Dan Liang, Jiufeng Yin, Wenqing Yang et al. · 2023 · Oxidative Medicine and Cellular Longevity
Metformin Ameliorates D-Galactose-Induced Senescent Human Bone Marrow-Derived Mesenchymal Stem Cells by Enhancing Autophagy
Pingting Ye, Lei Feng, Dan Zhang, Ruihao Li, Yixuan Wen, Xiaohan Tong, Shuo Shi, Chunyan Dong · 2023 · Stem Cells International
The Effects of Metformin on Weight Loss, Cardiovascular Health, and Longevity
Ashwin A. Pillai, Lara Melo, William H. Frishman, Wilbert S. Aronow · 2024 · Cardiology in Review
NIA Caenorhabditis Intervention Testing Program: identification of robust and reproducible pharmacological interventions that promote longevity across experimentally accessible, genetically diverse populations
Monica Driscoll, Christine A. Sedore, Brian Onken, Anna L Coleman-Hulbert, Erik Johnson, Patrick C. Phillips, Gordon J. Lithgow · 2025 · GeroScience
The cellular basis of organ failure in sepsis—signaling during damage and repair processes
Michael W Bauer, Reinhard Wetzker · 2020 · Medizinische Klinik - Intensivmedizin und Notfallmedizin
Transcriptomic landscape profiling of metformin‐treated healthy mice: Implication for potential hypertension risk when prophylactically used
Yuhong Meng, Rui Xiang, Han Yan, Yiran Zhou, Yuntao Hu, Jichun Yang, Yuan Zhou, Qinghua Cui · 2020 · Journal of Cellular and Molecular Medicine
An overview of the orexinergic system in different animal species
Idris Ayodeji Azeez, Olumayowa Olawumi Igado, James Olukayode Olopade · 2021 · Metabolic Brain Disease
The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside
María B. Birkisdóttir, Ivar van Galen, Renata M. C. Brandt, Sander Barnhoorn, Nicole van Vliet, Claire van Dijk, Bhawani Nagarajah, Sandra Imholz, Conny T. van Oostrom, Erwin Reiling et al. · 2022 · Frontiers in Aging
Silibinin, a potential fasting mimetic, inhibits hepatocellular carcinoma by triggering extrinsic apoptosis
Biying Xiao, Yanyu Jiang, Shuying Yuan, Lili Cai, Tong Xu, Lijun Jia · 2024 · MedComm
Impacts of metformin and aspirin on life history features and longevity of crickets: trade-offs versus cost-free life extension?
Harvir Hans, Asad Lone, Vadim Aksenov, C. David Rollo · 2015 · AGE
N-acetyl-l-cysteine mimics the effect of dietary restriction on lifespan and reduces amyloid beta-induced toxicity in Caenorhabditis elegans
Seung Il Oh, Sang-Kyu Park · 2017 · Food Science and Biotechnology
Effects of atorvastatin and metformin on development of pentylenetetrazole-induced seizure in mice
Mohammad Ali Zeyghami, Ebrahim Hesam, Parand Khadivar, Halimeh Khaton Hesam, Ali Ahmadnia, Abolfazl Amini · 2020 · Heliyon
The Aging Microenvironment Shapes Alveolar Macrophage Identity in Aging
Alexandra C. McQuattie‐Pimentel, Ziyou Ren, Nikita Joshi, Satoshi Watanabe, Thomas Stoeger, Monica Chi, Ziyan Lu, Lango Sichizya, Raul Piseaux Aillon, Ching-I Chen et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
Type 2 Diabetes Mellitus: A Metabolic Model of Accelerated Aging - Multi-Organ Mechanisms and Intervention Approaches
Ziran Zhang, Xiaolin He, Yuxin Sun, Jitong Li, Jia Sun · 2025 · Aging and Disease
Nicandra physalodes Extract Exerts Antiaging Effects in Multiple Models and Extends the Lifespan of Caenorhabditis elegans via DAF‐16 and HSF‐1
Jiqun Wang, Yunyuan Huang, Kaixuan Shi, Lingyuan Bao, Chao‐Jiang Xiao, Tianyue Sun, Zhifan Mao, Jiali Feng, Zelan Hu, Zhenghan Guo et al. · 2022 · Oxidative Medicine and Cellular Longevity
Metformin Alleviates Epirubicin-Induced Endothelial Impairment by Restoring Mitochondrial Homeostasis
Qi Long Sun, Huiling Jia, Shuo Cheng, Yujuan Wang, Jun Wang · 2022 · International Journal of Molecular Sciences
Τhe Endless Beauty of Metformin: Does It Also Protect from Skin Aging? A Narrative Review
Evanthia Gouveri, Νικόλαος Παπάνας · 2023 · Advances in Therapy
New Insight into the Potential Protective Function of Sulforaphene against ROS−Mediated Oxidative Stress Damage In Vitro and In Vivo
Bo Zhang, Pengtao Liu, Huakang Sheng, Yang Guo, Yongzhi Han, Lin Suo, Qipeng Yuan · 2023 · International Journal of Molecular Sciences
Aging and oral squamous cell carcinoma development: the role of cellular senescence
Sven Eric Niklander, Pablo Aránguiz, Fernando Faunes, Rene Flores · 2023 · Frontiers in Oral Health
Metformin attenuates inflammation and boosts autophagy in the liver and intestine of chronologically aged rats
Zheng Kuai, Xin Chao, Yuting He, Weiying Ren · 2023 · Experimental Gerontology
Hallmark Molecular and Pathological Features of POLG Disease are Recapitulated in Cerebral Organoids
Anbin Chen, Tsering Yangzom, Yu Hong, Bjørn Christian Lundberg, Gareth J. Sullivan, Charalampos Tzoulis, Laurence Albert Bindoff, Kristina Xiao Liang · 2024 · Advanced Science
Effect of Diabetes Mellitus and Metformin on Central Corneal Endothelial Cell Density in Eye Bank Eyes
Isaac M. Chocron, Dinesh K. Rai, Ji‐Won Kwon, Nicole Bernstein, Jimmy Yan Hu, Moonseong Heo, Jimmy K. Lee, Patrick K. Gore, Mitchell D. McCartney, Roy S. H. Chuck · 2018 · Cornea