Metformin improves healthspan and lifespan in mice

Martin-Montalvo, Alejandro, Mercken, Evi M., Mitchell, Sarah J., Palacios, Hector H., Mote, Patricia L., Scheibye-Knudsen, Morten, Gomes, Ana P., Ward, Theresa M. +14 more·2013·Nature Communications

DOI 10.1038/ncomms3192

Cited by (1,001)

Items 101–200 of 1,001

Insulin signalling and glucose transport in the ovary and ovarian function during the ovarian cycle
Joëlle Dupont, R. J. Scaramuzzi · 2016 · Biochemical Journal
Obesity and aging: Molecular mechanisms and therapeutic approaches
Ana L. Santos, Sanchari Sinha · 2021 · Ageing Research Reviews
Metformin attenuates lung fibrosis development via NOX4 suppression
Nahoko Sato, Naoki Takasaka, Masahiro Yoshida, Kazuya Tsubouchi, Shunsuke Minagawa, Jun Araya, Nayuta Saito, Yu Fujita, Yusuke Kurita, Kenji Kobayashi et al. · 2016 · Respiratory Research
Role of AMPK in autophagy
Shengyuan Wang, Hongyan Li, Minghao Yuan, Haixia Fan, Zhiyou Cai · 2022 · Frontiers in Physiology
Metformin decelerates aging clock in male monkeys
Yang, Yuanhan, Lu, Xiaoyong, Liu, Ning, Ma, Shuai, Zhang, Hui, Zhang, Zhiyi, Yang, Kuan, Jiang, Mengmeng, Zheng, Zikai, Qiao, Yicheng et al. · 2024 · Cell
You Are What You Host: Microbiome Modulation of the Aging Process
Heintz, Caroline, Mair, William · 2014 · Cell
Targeting immune dysfunction in aging
Simone Borgoni, Kseniya S. Kudryashova, Ksenia Burka, João Pedro de Magalhães · 2021 · Ageing Research Reviews
Metformin Effects on the Heart and the Cardiovascular System: A Review of Experimental and Clinical Data
Nesti, L., Natali, A. · 2017 · Nutrition Metabolism and Cardiovascular Diseases
The Emergence of Geroscience as an Interdisciplinary Approach to the Enhancement of Health Span and Life Span
Felipe Sierra · 2016 · Cold Spring Harbor Perspectives in Medicine
Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways
Antero Salminen, Kai Kaarniranta, Anu Kauppinen · 2016 · Ageing Research Reviews
Restoration of energy homeostasis by SIRT6 extends healthy lifespan
Asael Roichman, Sivan Elhanati, Miguel Antonio Aon, Ifat Abramovich, Andrea Di Francesco, Yael Shahar, Matan Yosef Avivi, Maor Shurgi, A. Rubinstein, Y. Wiesner et al. · 2021 · Nature Communications
Metformin‐mediated increase in DICER1 regulates microRNA expression and cellular senescence
Noren Hooten, Nicole, Martin‐Montalvo, Alejandro, Dluzen, Douglas F., Zhang, Yongqing, Bernier, Michel, Zonderman, Alan B., Becker, Kevin G., Gorospe, Myriam, Cabo, Rafael, Evans, Michele K. · 2016 · Aging Cell
Type 2 diabetes as a redox disease
James Douglas Watson · 2014 · The Lancet
Metformin extends C. elegans lifespan through lysosomal pathway
Jie Chen, Yuhui Ou, Yi Li, Shumei Hu, Li-Wa Shao, Ying Liu · 2017 · eLife
Dual-drug loaded polysaccharide-based self-healing hydrogels with multifunctionality for promoting diabetic wound healing
Weiwei Tan, Tao Long, Yanzhuo Wan, Bingchen Li, Zhilang Xu, Lei Zhao, Changdao Mu, Liming Ge, Defu Li · 2023 · Carbohydrate Polymers
Senolytics and senostatics as adjuvant tumour therapy
Susan C Short, Edward Fielder, Satomi Miwa, Thomas von Zglinicki · 2019 · EBioMedicine
Current understanding of metformin effect on the control of hyperglycemia in diabetes
Hongying An, Ling He · 2016 · Journal of Endocrinology
Strategies targeting cellular senescence
Ovadya, Yossi, Krizhanovsky, Valery · 2018 · Journal of Clinical Investigation
Therapeutic interventions for aging: the case of cellular senescence
Soto-Gamez, Abel, Demaria, Marco · 2017 · Drug Discovery Today
Mitochondria as an important target of metformin: The mechanism of action, toxic and side effects, and new therapeutic applications
Jin Feng, Xiaohui Wang, Xiaochun Ye, Irma Arés, Bernardo López-Torres, Marta Martínez, María‐Rosa Martínez‐Larrañaga, Xu Wang, Arturo Anadón, María‐Aránzazu Martínez · 2022 · Pharmacological Research
Mechanisms of development of multimorbidity in the elderly
Peter John Barnes · 2015 · European Respiratory Journal
Metformin and Autoimmunity: A “New Deal” of an Old Drug
Francesco Ursini, Emilio Russo, Gianluca Pellino, Salvatore D’Angelo, Agostino Chiaravalloti, Giovambattista De Sarro, Roberto Manfredini, Roberto DE GIORGIO · 2018 · Frontiers in Immunology
Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms
Sheng Chen, Donghao Gan, Sixiong Lin, Yiming Zhong, Mingjue Chen, Xuenong Zou, Zengwu Shao, Guozhi Xiao · 2022 · Theranostics
mTOR inhibition: A promising strategy for stabilization of atherosclerotic plaques
Wim Martinet, Hans De Loof, Guido R.Y. De Meyer · 2014 · Atherosclerosis
Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency
Lorenz Studer, Elsa Vera, Daniela Cornacchia · 2015 · Cell stem cell
Deciphering the Roles of PPARγ in Adipocytes via Dynamic Change of Transcription Complex
Xinran Ma, Dongmei Wang, Wenjun Zhao, Lingyan Xu · 2018 · Frontiers in Endocrinology
Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion
Yanqun Liu, Guanghui Tang, Yaning Li, Yang Wang, Xiaoyan Chen, Xiang Gu, Zhijun Zhang, Yongting Wang, Guo‐Yuan Yang · 2014 · Journal of Neuroinflammation
Molecular and phenotypic biomarkers of aging
Xian Xia, Weiyang Chen, Joseph McDermott, Jing-Dong Jackie Han · 2017 · F1000Research
Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal
Burkewitz, Kristopher, Morantte, Ianessa, Weir, Heather J.M., Yeo, Robin, Zhang, Yue, Huynh, Frank K., Ilkayeva, Olga R., Hirschey, Matthew D., Grant, Ana R., Mair, William B. · 2015 · Cell
Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis
Jorge Iván Castillo-Quan, Li Li, Kerri J. Kinghorn, Dobril K. Ivanov, Luke Stephen Tain, Cathy Slack, Fiona Kerr, Tobias Nespital, Janet M. Thornton, John Hardy et al. · 2016 · Cell Reports
Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults
Kulkarni, Ameya S, Brutsaert, Erika F, Anghel, Valentin, Zhang, Kehao, Bloomgarden, Noah, Pollak, Michael, Mar, Jessica C, Hawkins, Meredith, Crandall, Jill P, Barzilai, Nir · 2018 · Aging Cell
Advances in Understanding of the Role of Lipid Metabolism in Aging
Ki Wung Chung · 2021 · Cells
Metformin: A Hopeful Promise in Aging Research
Novelle, Marta G., Ali, Ahmed, Diéguez, Carlos, Bernier, Michel, de Cabo, Rafael · 2016 · Cold Spring Harbor Perspectives in Medicine
Molecular and cellular pathways contributing to brain aging
Aliabbas Zia, Ali Mohammad Pourbagher‐Shahri, Tahereh Farkhondeh, Saeed Samarghandian · 2021 · Behavioral and Brain Functions
Gene expression hallmarks of cellular ageing
Stephen Frenk, Jonathan M. Houseley · 2018 · Biogerontology
Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7
Fang, Jingqi, Yang, Jiping, Wu, Xun, Zhang, Gangming, Li, Tao, Wang, Xi'e, Zhang, Hong, Wang, Chih‐chen, Liu, Guang‐Hui, Wang, Lei · 2018 · Aging Cell
MOTS-c: a novel mitochondrial-derived peptide regulating muscle and fat metabolism
Lee, Changhan, Kim, Kyung Hwa, Cohen, Pinchas · 2016 · Free Radical Biology and Medicine
The dog aging project: translational geroscience in companion animals
Matt R. Kaeberlein, Kate E. Creevy, Daniel Promislow · 2016 · Mammalian Genome
Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy
Fei Yue, Wenjiao Li, Jing Zou, Xianhan Jiang, Guibin Xu, Hai Wei Huang, Leyuan Liu · 2017 · Cancer Research
Guidelines and Considerations for Metabolic Tolerance Tests in Mice
Raquel Benedé‐Ubieto, Olga Estévez‐Vázquez, Pierluigi Ramadori, Francisco Javier Cubero, Yulia Alexandrowna Nevzorova · 2020 · Diabetes Metabolic Syndrome and Obesity
Low Concentrations of Metformin Suppress Glucose Production in Hepatocytes through AMP-activated Protein Kinase (AMPK)*
Jia Cao, Shumei Meng, Evan Chang, Katherine Beckwith-Fickas, Lishou Xiong, Robert Norman Cole, Sally Radovick, Fredric Edward Wondisford, Ling He · 2014 · Journal of Biological Chemistry
Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence
Natalie A. Gude, Kathleen M. Broughton, Fareheh Firouzi, Mark Alan Sussman · 2018 · Nature Reviews Cardiology
Identification and Application of Gene Expression Signatures Associated with Lifespan Extension
Tyshkovskiy, Alexander, Bozaykut, Perinur, Borodinova, Anastasia A., Gerashchenko, Maxim V., Ables, Gene P., Garratt, Michael, Khaitovich, Philipp, Clish, Clary B., Miller, Richard A., Gladyshev, Vadim N. · 2019 · Cell Metabolism
Metformin regulates mitochondrial biogenesis and senescence through AMPK mediated H3K79 methylation: relevance in age-associated vascular dysfunction
Karnewar, Santosh, Neeli, Praveen Kumar, Panuganti, Devayani, Kotagiri, Sasikumar, Mallappa, Sreevidya, Jain, Nishant, Jerald, Mahesh Kumar, Kotamraju, Srigiridhar · 2018 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
New mechanisms of metformin action: Focusing on mitochondria and the gut
Hur, Kyu Yeon, Lee, Myung‐Shik · 2015 · Journal of Diabetes Investigation
Calorie restriction mimetics: Can you have your cake and eat it, too?
Donald K. Ingram, George S. Roth · 2014 · Ageing Research Reviews
What are the roles of calorie restriction and diet quality in promoting healthy longevity?
Wanda Rizza, Nicola Veronese, Luigi Fontana · 2013 · Ageing Research Reviews
AMPK in the brain: its roles in glucose and neural metabolism
Ranjithmenon Muraleedharan, Biplab Dasgupta · 2021 · FEBS Journal
Turning back time with emerging rejuvenation strategies
Salah Mahmoudi, Lucy Xu, Anne Brunet · 2018 · Nature Cell Biology
Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases
Shuaifei Ji, Mingchen Xiong, Huating Chen, Yiqiong Liu, Laixian Zhou, Yiyue Hong, Mengyang Wang, Chunming Wang, Xiaobing Fu, Xiaoyan Sun · 2023 · Signal Transduction and Targeted Therapy
The Current and Potential Therapeutic Use of Metformin—The Good Old Drug
Józef Drzewoski, M Hanefeld · 2021 · Pharmaceuticals
Mechanisms by which low glucose enhances the cytotoxicity of metformin to cancer cells both in vitro and in vivo
Zhuang, Yongxian, Chan, Daniel K., Haugrud, Allison B., Miskimins, W. Keith · 2014 · PLoS ONE
Oxidative stress, cellular senescence and ageing
Akshaj Pole, Manjari Dimri, Goberdhan P. Dimri · 2016 · AIMS molecular science
Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances
Jiang, Qiu, Liu, Jie, Huang, Shan, Wang, Xuan-Yue, Chen, Xiaowei, Liu, Guang-Hui, Ye, Keqiang, Song, Weihong, Masters, Colin L., Wang, Jun et al. · 2025 · Signal Transduction and Targeted Therapy
Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer
Maria M. Mihaylova, David M. Sabatini, Ömer H. Yilmaz · 2014 · Cell stem cell
Tipping the metabolic scales towards increased longevity in mammals
Riera, Celine E., Dillin, Andrew · 2015 · Nature Cell Biology
Metformin and Aging: A Review
Glossmann, Hartmut H., Lutz, Oliver M.D. · 2019 · Gerontology
An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo
Wang, Binsheng, Wang, Lichao, Gasek, Nathan S., Zhou, Yueying, Kim, Taewan, Guo, Chun, Jellison, Evan R., Haynes, Laura, Yadav, Sumit, Tchkonia, Tamar et al. · 2021 · Nature Aging
Longitudinal RNA-Seq Analysis of Vertebrate Aging Identifies Mitochondrial Complex I as a Small-Molecule-Sensitive Modifier of Lifespan
Mario Baumgart, Steffen Priebe, Marco Groth, Nils Hartmann, Uwe Menzel, Luca Pandolfini, Philipp Koch, Marius Felder, Michael Ristow, Christoph Englert et al. · 2016 · Cell Systems
Age-related inflammation and insulin resistance: a review of their intricate interdependency
Min Hi Park, Dae Hyun Kim, Eun Kyeong Lee, Nam Deuk Kim, Dong‐Soon Im, Jaewon Lee, Byung Pal Yu, Hae Young Chung · 2014 · Archives of Pharmacal Research
Is there a role for placental senescence in the genesis of obstetric complications and fetal growth restriction?
Zakia Sultana, Kaushik Maiti, Lee Dedman, Roger Smith · 2017 · American Journal of Obstetrics and Gynecology
Aging, lifestyle and dementia
Devin Wahl, Samantha M. Solon‐Biet, Victoria Carroll Cogger, Luigi Fontana, Stephen James Simpson, David George Le Couteur, Rosilene V. Ribeiro · 2019 · Neurobiology of Disease
AMP-Activated Protein Kinase Regulation of the NLRP3 Inflammasome during Aging
Mario David Cordero, Matthew Roy Williams, Bernhard Ryffel · 2017 · Trends in Endocrinology and Metabolism
Metformin Reduces Aging-Related Leaky Gut and Improves Cognitive Function by Beneficially Modulating Gut Microbiome/Goblet Cell/Mucin Axis
Shokouh Ahmadi, Atefeh P. Razazan, Ravinder Nagpal, Shalini Jain, Bo Wang, Sidharth Prasad Mishra, Shaohua Wang, Jamie Nicole Justice, Jingzhong Ding, Donald A. McClain et al. · 2020 · The Journals of Gerontology Series A
Metformin Activates AMP-Activated Protein Kinase by Promoting Formation of the αβγ Heterotrimeric Complex
Meng, Shumei, Cao, Jia, He, Qiyi, Xiong, Lishou, Chang, Evan, Radovick, Sally, Wondisford, Fredric E., He, Ling · 2015 · Journal of Biological Chemistry
Impact of Longevity Interventions on a Validated Mouse Clinical Frailty Index
Alice E. Kane, Sarah Nicole Hilmer, Dawn Boyer, Kristan Gavin, Dawn Nines, Susan Ellen Howlett, Rafael de Cabo, Sarah Jayne Mitchell · 2015 · The Journals of Gerontology Series A
Anti-aging pharmacology: Promises and pitfalls
Alexander M. Vaiserman, Oleh V. Lushchak, Alexander K. Koliada · 2016 · Ageing Research Reviews
Metformin use and mortality in patients with advanced chronic kidney disease: national, retrospective, observational, cohort study
Szu‐Chun Hung, Yu‐Kang Chang, Jia‐Sin Liu, Ko‐Lin Kuo, Yu‐Hsin Chen, Chih-Cheng Hsu, Der‐Cherng Tarng · 2015 · The Lancet Diabetes & Endocrinology
The Opposing Actions of Target of Rapamycin and AMP-Activated Protein Kinase in Cell Growth Control
Sravanth Kumar Hindupur, Asier González, Michael N. Hall · 2015 · Cold Spring Harbor Perspectives in Biology
Sirtuins and Insulin Resistance
Shuang Zhou, Xiaoqiang Tang, Hou‐Zao Chen · 2018 · Frontiers in Endocrinology
Metformin targets mitochondrial electron transport to reduce air-pollution-induced thrombosis
Soberanes, Saul, Misharin, Alexander V., Jairaman, Amit, Morales-Nebreda, Luisa, McQuattie-Pimentel, Alexandra C., Cho, Takugo, Hamanaka, Robert B., Meliton, Angelo Y., Reyfman, Paul A., Walter, James M. et al. · 2019 · Cell Metabolism
Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans
Yue Zhang, Anne Lanjuin, Suvagata Roy Chowdhury, Meeta Mistry, Carlos G. Silva-García, Heather J. M. Weir, Chia-Lin Lee, Caroline C. Escoubas, Emina Tabakovic, William B. Mair · 2019 · eLife
The biguanides metformin and phenformin inhibit angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells
Stefania Orecchioni, Francesca Reggiani, Giovanna Talarico, Patrizia Mancuso, Angelica Calleri, Giuliana Gregato, Valentina Labanca, Douglas McClain Noonan, Katiuscia Dallaglio, Adriana Albini et al. · 2014 · International Journal of Cancer
Role of Nrf2 and protective effects of Metformin against tobacco smoke-induced cerebrovascular toxicity
Shikha Prasad, Ravi Kiran Sajja, Mohammad Abul Kaisar, Jee Hyun Park, Heidi Villalba, Taylor Liles, Thomas J. Abbruscato, Luca Cucullo · 2017 · Redox Biology
Metformin: A Novel Weapon Against Inflammation
Bo Bai, Haibo Chen · 2021 · Frontiers in Pharmacology
Strategies and Challenges in Clinical Trials Targeting Human Aging
John C. Newman, Sofiya Milman, Shahrukh Khurshid Hashmi, Steve N. Austad, James L. Kirkland, Jeffrey B. Halter, Nir Barzilai · 2016 · The Journals of Gerontology Series A
Macronutrients and caloric intake in health and longevity
Samantha M. Solon‐Biet, Sarah Jayne Mitchell, Rafael de Cabo, David Raubenheimer, David George Le Couteur, Stephen James Simpson · 2015 · Journal of Endocrinology
Activation of AMPK by chitosan oligosaccharide in intestinal epithelial cells: Mechanism of action and potential applications in intestinal disorders
Chatchai Muanprasat, Preedajit Wongkrasant, Saravut Satitsri, Aekkacha Moonwiriyakit, Pawin Pongkorpsakol, Tharinee Mattaveewong, Rath Pichyangkura, Varanuj Chatsudthipong · 2015 · Biochemical Pharmacology
A toolbox for the longitudinal assessment of healthspan in aging mice
Ilaria Bellantuono, Rafael de Cabo, Dan Ehninger, Clara Di Germanio, Allan Lawrie, Jordan D. Miller, Sarah Jayne Mitchell, Ignacio Navas‐Enamorado, Paul K Potter, Tamar Tchkonia et al. · 2020 · Nature Protocols
Disease drivers of aging
Hodes, Richard J., Sierra, Felipe, Austad, Steven N., Epel, Elissa, Neigh, Gretchen N., Erlandson, Kristine M., Schafer, Marissa J., LeBrasseur, Nathan K., Wiley, Christopher, Campisi, Judith et al. · 2016 · Annals of the New York Academy of Sciences
Caloric restriction and cancer: molecular mechanisms and clinical implications
Ophélie Meynet, Jean‐Ehrland Ricci · 2014 · Trends in Molecular Medicine
<scp>TOR</scp>‐mediated regulation of metabolism in aging
Antikainen, Henri, Driscoll, Monica, Haspel, Gal, Dobrowolski, Radek · 2017 · Aging Cell
Upregulation of PD-L1 in Senescence and Aging
Angelique Onorati, Aaron P. Havas, Brian Lin, Jayaraj Rajagopal, Payel Sen, Peter D. Adams, Zhixun Dou · 2022 · Molecular and Cellular Biology
Offsetting the impact of smoking and e-cigarette vaping on the cerebrovascular system and stroke injury: Is Metformin a viable countermeasure?
Mohammad Abul Kaisar, Heidi Villalba, Shikha Prasad, Taylor Liles, Ali Ehsan Sifat, Ravi Kiran Sajja, Thomas J. Abbruscato, Luca Cucullo · 2017 · Redox Biology
Geroscience‐guided repurposing of FDA‐approved drugs to target aging: A proposed process and prioritization
Ameya S Kulkarni, Sandra Aleksić, David M. Berger, Felipe Sierra, George A. Kuchel, Nir Barzilai · 2022 · Aging Cell
Psychological and biological resilience modulates the effects of stress on epigenetic aging
Harvanek, Zachary M., Fogelman, Nia, Xu, Ke, Sinha, Rajita · 2021 · Translational Psychiatry
Drugs that modulate aging: the promising yet difficult path ahead
Kennedy, Brian K., Pennypacker, Juniper K. · 2014 · Translational research
Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy
Barini, Erica, Antico, Odetta, Zhao, Yingjun, Asta, Francesco, Tucci, Valter, Catelani, Tiziano, Marotta, Roberto, Xu, Huaxi, Gasparini, Laura · 2016 · Molecular Neurodegeneration
Yeast as a tool to identify anti-aging compounds
Andreas Zimmermann, Sebastian J. Hofer, Tobias Pendl, Katharina Kainz, Frank Madeo, Didac Carmona‐Gutiérrez · 2018 · FEMS Yeast Research
Autophagy in health and disease: From molecular mechanisms to therapeutic target
Guang Xiu Lu, Yu Wang, Yin Pu Shi, Zhe Zhang, Canhua Huang, Weifeng He, Chuang Wang, Han‐Ming Shen · 2022 · MedComm
Molecular Mechanisms Determining Lifespan in Short- and Long-Lived Species
Xiao Tian, Andrei Seluanov, Vera A. Gorbunova · 2017 · Trends in Endocrinology and Metabolism
New Insights into the Role of Mitochondrial Dynamics and Autophagy during Oxidative Stress and Aging in the Heart
Yoshiyuki Ikeda, Sebastiano Sciarretta, Narayani Nagarajan, Speranza Rubattu, Massimo Volpe, Giacomo Frati, Junichi Sadoshima · 2014 · Oxidative Medicine and Cellular Longevity
Caenorhabditis elegans as a model for understanding ROS function in physiology and disease
Antonio Miranda‐Vizuete, Elizabeth A. Veal · 2016 · Redox Biology
Metformin protects against intestinal barrier dysfunction via AMPKα1‐dependent inhibition of JNK signalling activation
Jun Deng, Lishan Zeng, Xueying Lai, Jing Li, Le Liu, Qianyun Lin, Ye Chen · 2017 · Journal of Cellular and Molecular Medicine
Activating Endogenous Neural Precursor Cells Using Metformin Leads to Neural Repair and Functional Recovery in a Model of Childhood Brain Injury
Parvati Dadwal, Neemat Mahmud, Laleh Sinai, Ashkan Azimi, Michael P. Fatt, Fredric Edward Wondisford, Freda D. Miller, Cindi M. Morshead · 2015 · Stem Cell Reports
Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice
Ranran Zhao, Xiaochen Xu, Fei Xu, Wei-li Zhang, Wen-lin Zhang, Liang-min Liu, Weiping Wang · 2014 · Biochemical and Biophysical Research Communications
MicroRNA Regulation of Oxidative Stress‐Induced Cellular Senescence
Huaije Bu, Sophia Wedel, Maria Silvia Cavinato, Pidder Jansen‐Dürr · 2017 · Oxidative Medicine and Cellular Longevity
Adipose Tissue Remodeling in Pathophysiology
Christopher Auger, Shingo Kajimura · 2022 · Annual Review of Pathology Mechanisms of Disease
Caloric restriction: Beneficial effects on brain aging and Alzheimer’s disease
Van Cauwenberghe, Caroline, Vandendriessche, Charysse, Libert, Claude, Vandenbroucke, Roosmarijn E. · 2016 · Mammalian Genome
Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic
Alexey Moskalev, Elizaveta Chernyagina, Vasily O. Tsvetkov, Alexander Fedintsev, Mikhail Vyacheslavovich Shaposhnikov, Vyacheslav N. Krutko, Alex A. Zhavoronkov, Brian Keith Kennedy · 2016 · Aging Cell