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Cited by 318

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

Arabidopsis WAT1 is a vacuolar auxin transport facilitator required for auxin homoeostasis

Open access
Ranocha, Philippe, Dima, Oana, Nagy, Réka, Felten, Judith, Corratgé-Faillie, Claire, Novák, Ondřej, Morreel, Kris, Lacombe, Benoît, Martinez, Yves, Pfrunder, Stephanie, Jin, Xu, Renou, Jean-Pierre, Thibaud, Jean-Baptiste, Ljung, Karin, Fischer, Urs, Martinoia, Enrico, Boerjan, Wout, Goffner, Deborah·2013·Nature Communications
DOI 10.1038/ncomms3625
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Abstract

The plant hormone auxin (indole-3-acetic acid, IAA) has a crucial role in plant development. Its spatiotemporal distribution is controlled by a combination of biosynthetic, metabolic and transport mechanisms. Four families of auxin transporters have been identified that mediate transport across the plasma or endoplasmic reticulum membrane. Here we report the discovery and the functional characterization of the first vacuolar auxin transporter. We demonstrate that WALLS ARE THIN1 (WAT1), a plant-specific protein that dictates secondary cell wall thickness of wood fibres, facilitates auxin export from isolated Arabidopsis vacuoles in yeast and in Xenopus oocytes. We unambiguously identify IAA and related metabolites in isolated Arabidopsis vacuoles, suggesting a key role for the vacuole in intracellular auxin homoeostasis. Moreover, local auxin application onto wat1 mutant stems restores fibre cell wall thickness. Our study provides new insight into the complexity of auxin transport in plants and a means to dissect auxin function during fibre differentiation. The plant hormone auxin is essential for plant development and growth and is transported across cellular membranes via specialized transporter proteins. In this study, Ranocha et al. identify the first vacuolar auxin transporter, WAT1, suggesting an involvement of the vacuole in auxin signalling.

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Metadata

Authors
Ranocha, P., Dima, O., Nagy, R., Felten, J., Corratgé-Faillie, C., Novák, O., Morreel, K., Lacombe, B., Martinez, Y., Pfrunder, S., Jin, X., Renou, J.-P., Thibaud, J.-B., Ljung, K., Fischer, U., Martinoia, E., Boerjan, W., & Goffner, D.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2013-10-16
Volume
4
Issue
1
Pages
2625-2625
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/ncomms3625
OpenAlex
W2029548988
Cited by
318
References
54
FWCI
16.46
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Arabidopsis WAT1 is a vacuolar auxin transport facilitator required for auxin homoeostasis. https://app.cochat.ai/papers/10.1038/ncomms3625
The paper
Ranocha, P., Dima, O., Nagy, R., Felten, J., Corratgé-Faillie, C., Novák, O., Morreel, K., Lacombe, B., Martinez, Y., Pfrunder, S., Jin, X., Renou, J.-P., Thibaud, J.-B., Ljung, K., Fischer, U., Martinoia, E., Boerjan, W., & Goffner, D. (2013). Arabidopsis WAT1 is a vacuolar auxin transport facilitator required for auxin homoeostasis. Nature Communications. https://doi.org/10.1038/ncomms3625

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.