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Genome-Wide Analysis of Arabidopsis Pentatricopeptide Repeat Proteins Reveals Their Essential Role in Organelle Biogenesis[W]

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Lurin, Claire, Andreés, Charles, Aubourg, Seébastien, Bellaoui, Mohammed, Bitton, Freédeérique, Bruyère, Cleémence, Caboche, Michel, Debast, Ceédrig, Gualberto, Joseé, Hoffmann, Beate, Lecharny, Alain, Le Ret, Monique, Martin-Magniette, Marie-Laure, Mireau, Hakim, Peeters, Nemo, Renou, Jean-Pierre, Szurek, Boris, Taconnat, Ludivine, Small, Ian·2004·The Plant Cell

Abstract

The complete sequence of the Arabidopsis thaliana genome revealed thousands of previously unsuspected genes, many of which cannot be ascribed even putative functions. One of the largest and most enigmatic gene families discovered in this way is characterized by tandem arrays of pentatricopeptide repeats (PPRs). We describe a detailed bioinformatic analysis of 441 members of the Arabidopsis PPR family plus genomic and genetic data on the expression (microarray data), localization (green fluorescent protein and red fluorescent protein fusions), and general function (insertion mutants and RNA binding assays) of many family members. The basic picture that arises from these studies is that PPR proteins play constitutive, often essential roles in mitochondria and chloroplasts, probably via binding to organellar transcripts. These results confirm, but massively extend, the very sparse observations previously obtained from detailed characterization of individual mutants in other organisms.

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Metadata

Authors
Lurin, C., Andreés, C., Aubourg, S., Bellaoui, M., Bitton, F., Bruyère, C., Caboche, M., Debast, C., Gualberto, J., Hoffmann, B., Lecharny, A., Le Ret, M., Martin-Magniette, M.-L., Mireau, H., Peeters, N., Renou, J.-P., Szurek, B., Taconnat, L., & Small, I.
Venue
The Plant Cell
Published
2004-08-01
Volume
16
Issue
8
Pages
2089-2103
ISSN
  • 1040-4651 (ISSN-L)
  • 1532-298X
OpenAlex
W2123502134
Cited by
1,306
References
0
FWCI
14.00
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Genome-Wide Analysis of Arabidopsis Pentatricopeptide Repeat Proteins Reveals Their Essential Role in Organelle Biogenesis[W]. https://app.cochat.ai/papers/10.1105/tpc.104.022236
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Lurin, C., Andreés, C., Aubourg, S., Bellaoui, M., Bitton, F., Bruyère, C., Caboche, M., Debast, C., Gualberto, J., Hoffmann, B., Lecharny, A., Le Ret, M., Martin-Magniette, M.-L., Mireau, H., Peeters, N., Renou, J.-P., Szurek, B., Taconnat, L., & Small, I. (2004). Genome-Wide Analysis of Arabidopsis Pentatricopeptide Repeat Proteins Reveals Their Essential Role in Organelle Biogenesis[W]. The Plant Cell. https://doi.org/10.1105/tpc.104.022236

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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