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PIN Proteins Perform a Rate-Limiting Function in Cellular Auxin Efflux
Abstract
Intercellular flow of the phytohormone auxin underpins multiple developmental processes in plants. Plant-specific pin-formed (PIN) proteins and several phosphoglycoprotein (PGP) transporters are crucial factors in auxin transport–related development, yet the molecular function of PINs remains unknown. Here, we show that PINs mediate auxin efflux from mammalian and yeast cells without needing additional plant-specific factors. Conditional gain-of-function alleles and quantitative measurements of auxin accumulation in Arabidopsis and tobacco cultured cells revealed that the action of PINs in auxin efflux is distinct from PGP, rate-limiting, specific to auxins, and sensitive to auxin transport inhibitors. This suggests a direct involvement of PINs in catalyzing cellular auxin efflux.
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Domagalska, M. A., & Leyser, O. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3088 · Cited by 835
Antagonistic Regulation of PIN Phosphorylation by PP2A and PINOID Directs Auxin Flux
Michniewicz, M., Zago, M. K., Abas, L., Weijers, D., Schweighofer, A., Meskiene, I., Heisler, M. G., Ohno, C., Zhang, J., Huang, F., et al. (2007) · Cell · doi:10.1016/j.cell.2007.07.033 · Cited by 678
Self-citationHeisler, M. G., Hamant, O., Krupinski, P., Uyttewaal, M., Ohno, C., Jönsson, H., Traas, J., & Meyerowitz, E. M. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000516 · Cited by 459
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Canalization of auxin flow by Aux/IAA-ARF-dependent feedback regulation of PIN polarity
Sauer, M., Balla, J., Luschnig, C., Wiśniewska, J., Reinöhl, V., Friml, J., & Benková, E. (2006) · Genes & Development · doi:10.1101/gad.390806 · Cited by 453
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Metadata
- Authors
- Petrášek, J., Mravec, J., Bouchard, R., Blakeslee, J. J., Abas, M., Seifertová, D., Wiśniewska, J., Tadele, Z., Kubeš, M., Čovanová, M., Dhonukshe, P., Skůpa, P., Benková, E., Perry, L., Křeček, P., Lee, O. R., Fink, G. R., Geisler, M., Murphy, A. S., Luschnig, C., Zažímalová, E., & Friml, J.
- Venue
- Science
- Published
- 2006-05-12
- Volume
- 312
- Issue
- 5775
- Pages
- 914-918
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2133078492
- Cited by
- 921
- References
- 0
- FWCI
- 77.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- Petrášek, J., Mravec, J., Bouchard, R., Blakeslee, J. J., Abas, M., Seifertová, D., Wiśniewska, J., Tadele, Z., Kubeš, M., Čovanová, M., Dhonukshe, P., Skůpa, P., Benková, E., Perry, L., Křeček, P., Lee, O. R., Fink, G. R., Geisler, M., Murphy, A. S., . . . Friml, J. (2006). PIN Proteins Perform a Rate-Limiting Function in Cellular Auxin Efflux. Science. https://doi.org/10.1126/science.1123542
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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