Obesity and cancer—extracellular matrix, angiogenesis, and adrenergic signaling as unusual suspects linking the two diseases
Open accessAbstract
Obesity is an established risk factor for several human cancers. Given the association between excess body weight and cancer, the increasing rates of obesity worldwide are worrisome. A variety of obesity-related factors has been implicated in cancer initiation, progression, and response to therapy. These factors include circulating nutritional factors, hormones, and cytokines, causing hyperinsulinemia, inflammation, and adipose tissue dysfunction. The impact of these conditions on cancer development and progression has been the focus of extensive literature. In this review, we concentrate on processes that can link obesity and cancer, and which provide a novel perspective: extracellular matrix remodeling, angiogenesis, and adrenergic signaling. We describe molecular mechanisms involved in these processes, which represent putative targets for intervention. Liver, pancreas, and breast cancers were chosen as exemplary disease models. In view of the expanding epidemic of obesity, a better understanding of the tumorigenic process in obese individuals might lead to more effective treatments and preventive measures.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Obesity is associated with chronic low-grade inflammation and a plethora of metabolic dysfunctions such as insulin resistance, impaired glucose tolerance and hypertension.
“Obesity is associated with chronic low-grade inflammation and a plethora of metabolic dysfunctions such as insulin resistance, impaired glucose tolerance and hypertension.”
From A deep-learning framework reveals whole-body perturbations at cell level (2026) · cites this paper as [13]
Obesity increases the risk of developing secondary comorbidities, including type 2 diabetes, peripheral neuropathies, cardiovascular diseases, stroke and numerous cancer types.
“Obesity increases the risk of developing secondary comorbidities, including type 2 diabetes, peripheral neuropathies, cardiovascular diseases, stroke and numerous cancer types12,13, underscoring the systemic effects of excess body fat and the need for holistic characterizations of the underlying structural and cellular changes.”
From A deep-learning framework reveals whole-body perturbations at cell level (2026) · cites this paper as [13]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Hou, M., Cui, J., Liu, J., Liu, F., Jiang, R., Liu, K., Wang, Y., Li, Y., Liu, W., & Yu, B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085808 · Cited by 73 · see citing works
RetractedBray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21492 · Cited by 84,109 · see citing works
Sorafenib in advanced hepatocellular carcinoma
Llovet, J. M., Ricci, S., Mazzaferro, V., Hilgard, P., Gane, E., Blanc, J.-F., de Oliveira, A. C., Santoro, A., Raoul, J.-L., Forner, A., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0708857 · Cited by 13,097 · see citing works
Microenvironmental regulation of tumor progression and metastasis
Quail, D. F., & Joyce, J. A. (2013) · Nature Medicine · doi:10.1038/nm.3394 · Cited by 7,994 · see citing works
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults
Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021423 · Cited by 7,696 · see citing works
Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma
Finn, R. S., Qin, S., Ikeda, M., Galle, P. R., Ducreux, M., Kim, T.-Y., Kudo, M., Breder, V., Merle, P., Kaseb, A. O., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa1915745 · Cited by 7,470 · see citing works
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
Hanahan, D., & Folkman, J. (1996) · Cell · doi:10.1016/s0092-8674(00)80108-7 · Cited by 6,885 · see citing works
A New Era of Systemic Therapy for Hepatocellular Carcinoma with Regorafenib and Lenvatinib
Kudo, M. (2017) · Liver Cancer · doi:10.1159/000462153 · Cited by 5,974 · see citing works
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
Mariathasan, S., Turley, S. J., Nickles, D., Castiglioni, A., Yuen, K., Wang, Y., Kadel III, E. E., Koeppen, H., Astarita, J. L., Cubas, R., et al. (2018) · Nature · doi:10.1038/nature25501 · Cited by 5,400 · see citing works
Foulkes, W. D., Smith, I. E., & Reis-Filho, J. S. (2010) · New England Journal of Medicine · doi:10.1056/nejmra1001389 · Cited by 4,719 · see citing works
Tumors: Wounds That Do Not Heal
Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391 · see citing works
The biology and function of fibroblasts in cancer
Kalluri, R. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.73 · Cited by 4,366 · see citing works
Genomic analyses identify molecular subtypes of pancreatic cancer
Bailey, P., Chang, D. K., Nones, K., Johns, A. L., Patch, A.-M., Gingras, M.-C., Miller, D. K., Christ, A. N., Bruxner, T. J. C., Quinn, M. C., et al. (2016) · Nature · doi:10.1038/nature16965 · Cited by 3,621 · cited 2× · see citing works
“been identified by integrated genomic analyses, one of them being the squamous subtype associated with mutations in TP53 and KDM6A [14].”
BackgroundMechanisms of fibrosis: therapeutic translation for fibrotic disease
Wynn, T. A., & Ramalingam, T. R. (2012) · Nature Medicine · doi:10.1038/nm.2807 · Cited by 3,541 · see citing works
The Extracellular Matrix: Not Just Pretty Fibrils
Hynes, R. O. (2009) · Science · doi:10.1126/science.1176009 · Cited by 3,527 · see citing works
Emerging Biological Principles of Metastasis
Lambert, A. W., Pattabiraman, D. R., & Weinberg, R. A. (2017) · Cell · doi:10.1016/j.cell.2016.11.037 · Cited by 3,075 · see citing works
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
Bergers, G., Brekken, R., McMahon, G., Vu, T. H., Itoh, T., Tamaki, K., Tanzawa, K., Thorpe, P., Itohara, S., Werb, Z., et al. (2000) · Nature Cell Biology · doi:10.1038/35036374 · Cited by 2,797 · see citing works
Whole genomes redefine the mutational landscape of pancreatic cancer
Initiative, A. P. C. G., Waddell, N., Pajic, M., Patch, A.-M., Chang, D. K., Kassahn, K. S., Bailey, P., Johns, A. L., Miller, D., Nones, K., et al. (2015) · Nature · doi:10.1038/nature14169 · Cited by 2,642 · see citing works
Estes, C., Razavi, H. A., Loomba, R. S., Younossi, Z. M., & Sanyal, A. J. (2017) · Hepatology · doi:10.1002/hep.29466 · Cited by 2,416 · see citing works
Ekstedt, M., Hagström, H., Nasr, P., Fredrikson, M., Stål, P., Kechagias, S., & Hultcrantz, R. (2015) · Hepatology · doi:10.1002/hep.27368 · Cited by 2,287 · see citing works
Tumor angiogenesis: causes, consequences, challenges and opportunities
Lugano, R., Ramachandran, M., & Dimberg, A. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03351-7 · Cited by 2,040 · see citing works
Adipose tissue remodeling and obesity
Sun, K., Kusminski, C. M., & Scherer, P. E. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45887 · Cited by 1,941 · see citing works
Induction of angiogenesis during the transition from hyperplasia to neoplasia
Folkman, J., Watson, K., Ingber, D., & Hanahan, D. (1989) · Nature · doi:10.1038/339058a0 · Cited by 1,879 · see citing works
Fibrosis: from mechanisms to medicines
Henderson, N. C., Rieder, F., & Wynn, T. A. (2020) · Nature · doi:10.1038/s41586-020-2938-9 · Cited by 1,868 · see citing works
Genes that mediate breast cancer metastasis to the brain
Bos, P. D., Zhang, X. H.-F., Nadal, C., Shu, W., Gomis, R. R., Nguyen, D. X., Minn, A. J., van de Vijver, M. J., Gerald, W. L., Foekens, J. A., et al. (2009) · Nature · doi:10.1038/nature08021 · Cited by 1,863 · see citing works
Bhaskaran, K., Douglas, I., Forbes, H., dos-Santos-Silva, I., Leon, D. A., & Smeeth, L. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60892-8 · Cited by 1,707 · see citing works
Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer
Costa, A., Kieffer, Y., Scholer-Dahirel, A., Pelon, F., Bourachot, B., Cardon, M., Sirven, P., Magagna, I., Fuhrmann, L., Bernard, C., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.01.011 · Cited by 1,705 · see citing works
Obesity and cancer risk: Emerging biological mechanisms and perspectives
Avgerinos, K. I., Spyrou, N., Mantzoros, C. S., & Dalamaga, M. (2019) · Metabolism · doi:10.1016/j.metabol.2018.11.001 · Cited by 1,567 · see citing works
Liu, L., Cao, Y., Chen, C., Zhang, X., McNabola, A., Wilkie, D. P., Wilhelm, S. M., Lynch, M. J., & Carter, C. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1377 · Cited by 1,539 · see citing works
Mederacke, I., Hsu, C. C., Troeger, J. S., Huebener, P., Mu, X., Dapito, D. H., Pradere, J.-P., & Schwabe, R. F. (2013) · Nature Communications · doi:10.1038/ncomms3823 · Cited by 1,443 · see citing works
From NASH to HCC: current concepts and future challenges
Anstee, Q. M., Reeves, H. L., Kotsiliti, E., Govaere, O., & Heikenwalder, M. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0145-7 · Cited by 1,392 · see citing works
Common variants at 30 loci contribute to polygenic dyslipidemia
Kathiresan, S., Willer, C. J., Peloso, G. M., Demissie, S., Musunuru, K., Schadt, E. E., Kaplan, L., Bennett, D., Li, Y., Tanaka, T., et al. (2009) · Nature Genetics · doi:10.1038/ng.291 · Cited by 1,364 · see citing works
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
Thaker, P. H., Han, L. Y., Kamat, A. A., Arevalo, J. M., Takahashi, R., Lu, C., Jennings, N. B., Armaiz-Pena, G., Bankson, J. A., Ravoori, M., et al. (2006) · Nature Medicine · doi:10.1038/nm1447 · Cited by 1,320 · see citing works
Horder, & Harnett, W. L. (1941) · BMJ · doi:10.1136/bmj.1.4186.493 · Cited by 1,319 · see citing works
Guerra, C., Schuhmacher, A. J., Cañamero, M., Grippo, P. J., Verdaguer, L., Pérez-Gallego, L., Dubus, P., Sandgren, E. P., & Barbacid, M. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.01.012 · Cited by 1,224 · see citing works
Cancer Cachexia: Mediators, Signaling, and Metabolic Pathways
Fearon, K. C. H., Glass, D. J., & D, D. C. G. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.06.011 · Cited by 1,203 · see citing works
Cancello, R., Henegar, C., Viguerie, N., Taleb, S., Poitou, C., Rouault, C., Coupaye, M., Pelloux, V., Hugol, D., Bouillot, J.-L., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2277 · Cited by 1,164 · see citing works
Salmon, H., Franciszkiewicz, K., Damotte, D., Dieu-Nosjean, M.-C., Validire, P., Trautmann, A., Mami-Chouaib, F., & Donnadieu, E. (2012) · Journal of Clinical Investigation · doi:10.1172/jci45817 · Cited by 1,138 · see citing works
Hagström, H., Nasr, P., Ekstedt, M., Hammar, U., Stål, P., Hultcrantz, R., & Kechagias, S. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.07.027 · Cited by 1,067 · see citing works
Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI
Khan, T., Muise, E. S., Iyengar, P., Wang, Z. V., Chandalia, M., Abate, N., Zhang, B. B., Bonaldo, P., Chua, S., & Scherer, P. E. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01300-08 · Cited by 1,053 · see citing works
Role of Matrix Metalloproteinases in Angiogenesis and Cancer
Quintero-Fabián, S., Arreola, R., Becerril‐Villanueva, E., Torres‐Romero, J. C., Arana‐Argáez, V. E., Lara‐Riegos, J., Ramírez-Camacho, M. A., & Álvarez-Sánchez, M. E. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01370 · Cited by 1,042 · see citing works
TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4
Padua, D. M., Zhang, X. H.-F., Wang, Q., Nadal, C., Gerald, W. L., Gomis, R. R., & Massagué, J. (2008) · Cell · doi:10.1016/j.cell.2008.01.046 · Cited by 947 · see citing works
Wei, S. C., Fattet, L., Tsai, J. H., Guo, Y., Pai, V. H., Majeski, H. E., Chen, A. C., Sah, R. L., Taylor, S. S., Engler, A. J., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3157 · Cited by 934 · see citing works
The sympathetic nervous system induces a metastatic switch in primary breast cancer
Sloan, E. K., Priceman, S. J., Cox, B. F., Yu, S., Pimentel, M. A., Tangkanangnukul, V., Arevalo, J. M. G., Morizono, K., Karanikolas, B. D. W., Wu, L., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0522 · Cited by 930 · see citing works
Nozawa, H., Chiu, C. W., & Hanahan, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601807103 · Cited by 926 · see citing works
Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis
Kramann, R., Schneider, R. K., DiRocco, D. P., Machado, F., Fleig, S., Bondzie, P. A., Henderson, J. M., Ebert, B. L., & Humphreys, B. D. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2014.11.004 · Cited by 922 · see citing works
Lumeng, C. N.-K., DelProposto, J. B., Westcott, D. J., & Saltiel, A. R. (2008) · Diabetes · doi:10.2337/db08-0872 · Cited by 919 · see citing works
Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue
Halberg, N., Khan, T., Trujillo, M. E., Wernstedt-Asterholm, I., Attie, A. D., Sherwani, S., Wang, Z. V., Landskroner-Eiger, S., Dineen, S., Magalang, U. J., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00192-09 · Cited by 896 · see citing works
The role of hypoxia-inducible factors in tumorigenesis
Rankin, E. B., & Giaccia, A. J. (2008) · Cell Death & Differentiation · doi:10.1038/cdd.2008.21 · Cited by 806 · see citing works
The myofibroblast matrix: implications for tissue repair and fibrosis
Klingberg, F., Hinz, B., & White, E. S. (2013) · The Journal of Pathology · doi:10.1002/path.4104 · Cited by 776 · see citing works
White, D. L., Kanwal, F., & El–Serag, H. B. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.10.001 · Cited by 766 · see citing works
The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer
Affo, S., Yu, L.-X., & Schwabe, R. F. (2017) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-052016-100322 · Cited by 757 · see citing works
A Switch from White to Brown Fat Increases Energy Expenditure in Cancer-Associated Cachexia
Petruzzelli, M., Schweiger, M., Schreiber, R., Campos‐Olivas, R., Tsoli, M., Allen, J., Swarbrick, M. M., Rose‐John, S., Rincón, M., Robertson, G. R., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.06.011 · Cited by 752 · see citing works
Takahashi, T., Yamaguchi, S., Chida, K., & Shibuya, M. (2001) · The EMBO Journal · doi:10.1093/emboj/20.11.2768 · Cited by 750 · see citing works
Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia
Kanda, M., Matthaei, H., Wu, J., Hong, S., Yu, J., Borges, M., Hruban, R. H., Maitra, A., Kinzler, K., Vogelstein, B., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2011.12.042 · Cited by 741 · see citing works
The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis.
Crewe, C., An, Y. A., & Scherer, P. E. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88883 · Cited by 732 · see citing works
Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs
Arch, J. R. S., Ainsworth, A. T., Cawthorne, M. A., Piercy, V., Sennitt, M. V., Thody, V. E., Wilson, C., & Wilson, S. (1984) · Nature · doi:10.1038/309163a0 · Cited by 728 · see citing works
Nonalcoholic fatty liver disease: Improvement in liver histological analysis with weight loss
Dixon, J. B., Bhathal, P. S., Hughes, N. R., & O'Brien, P. E. (2004) · Hepatology · doi:10.1002/hep.20251 · Cited by 727 · see citing works
Schrader, J., Gordon-Walker, T. T., Aucott, R. L., van Deemter, M., Quaas, A., Walsh, S., Benten, D., Forbes, S. J., Wells, R. G., & Iredale, J. P. (2011) · Hepatology · doi:10.1002/hep.24108 · Cited by 720 · see citing works
TGF-β in progression of liver disease
Dooley, S., & ten Dijke, P. (2012) · Cell and Tissue Research · doi:10.1007/s00441-011-1246-y · Cited by 718 · see citing works
Protection from obesity and diabetes by blockade of TGF-β/smad3 signaling
Yadav, H., Quijano, C., Kamaraju, A. K., Gavrilova, O., Malek, R., Chen, W., Zerfas, P., Zhigang, D., Wright, E. C., Stuelten, C., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.04.013 · Cited by 709 · see citing works
Molecular Pathways: Beta-Adrenergic Signaling in Cancer
Cole, S. W., & Sood, A. K. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0641 · Cited by 691 · see citing works
Fibrosis and cancer: A strained relationship
Piersma, B., Hayward, M.-K., & Weaver, V. M. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188356 · Cited by 686 · see citing works
Targeting adipose tissue in the treatment of obesity-associated diabetes
Kusminski, C. M., Bickel, P. E., & Scherer, P. E. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.75 · Cited by 678 · see citing works
Chakravarthy, A., Khan, L., Bensler, N. P., Bose, P., & De Carvalho, D. D. (2018) · Nature Communications · doi:10.1038/s41467-018-06654-8 · Cited by 656 · see citing works
Joyce, J. A., Baruch, A., Chehade, K. A. H., Meyer-Morse, N., Giraudo, E., Tsai, F., Greenbaum, D. C., Hager, J. H., Bogyo, M. S., & Hanahan, D. (2004) · Cancer Cell · doi:10.1016/s1535-6108(04)00111-4 · Cited by 643 · see citing works
Sottile, J., & Hocking, D. C. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-01-0048 · Cited by 637 · see citing works
The angiogenic switch in carcinogenesis
Baeriswyl, V., & Christofori, G. (2009) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2009.05.003 · Cited by 624 · see citing works
Herceptin acts as an anti-angiogenic cocktail
Izumi, Y., Xu, L., di Tomaso, E., Fukumura, D., & Jain, R. K. (2002) · Nature · doi:10.1038/416279b · Cited by 623 · see citing works
The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship
Hinz, B. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.05.006 · Cited by 618 · see citing works
Sympathetic Activation in Obese Normotensive Subjects
Grassi, G., Seravalle, G., Cattaneo, B. M., Bolla, G. B., Lanfranchi, A., Colombo, M., Giannattasio, C., Brunani, A., Cavagnini, F., & Mancia, G. (1995) · Hypertension · doi:10.1161/01.hyp.25.4.560 · Cited by 614 · see citing works
The extracellular matrix in tumor progression and metastasis
Eble, J. A., & Niland, S. (2019) · Clinical & Experimental Metastasis · doi:10.1007/s10585-019-09966-1 · Cited by 613 · see citing works
Tumors: Wounds That Do Not Heal—Redux
Dvorak, H. F. (2015) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0209 · Cited by 597 · see citing works
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program
Klarin, D. M., Program, T. V. M. V., Damrauer, S. M., Cho, K., Sun, Y. V., Teslovich, T. M., Honerlaw, J. P., GAGNON, D. R., DuVall, S. L., Li, J., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0222-9 · Cited by 594 · see citing works
Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia
Das, S. K., Eder, S., Schauer, S., Diwoky, C., Temmel, H., Guertl, B., Gorkiewicz, G., Tamilarasan, K. P., Kumari, P., Trauner, M. A., et al. (2011) · Science · doi:10.1126/science.1198973 · Cited by 586 · see citing works
Takahashi, T., Ueno, H., & Shibuya, M. (1999) · Oncogene · doi:10.1038/sj.onc.1202527 · Cited by 572 · see citing works
Kersten, S., Mandard, S., Tan, N. S., Escher, P., METZGER, D., Chambon, P., Gonzalez, F. J., Desvergne, B., & Wahli, W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004029200 · Cited by 560 · see citing works
Zeyda, M., Farmer, D., Todoric, J., Aszmann, O. C., Speiser, M., Györi, G., Zlabinger, G. J., & Stulnig, T. M. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803632 · Cited by 553 · see citing works
Adrenergic nerves activate an angio-metabolic switch in prostate cancer
Zahalka, A. H., Arnal-Estapé, A., Maryanovich, M., Nakahara, F., Cruz, C. D., Finley, L. W. S., & Frenette, P. S. (2017) · Science · doi:10.1126/science.aah5072 · Cited by 548 · see citing works
β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer
Renz, B. W., Takahashi, R., Tanaka, T., Macchini, M., Hayakawa, Y., Dantes, Z., Maurer, H. C., Chen, X., Jiang, Z., Westphalen, C. B., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2017.11.007 · Cited by 543 · see citing works
Beta Blockers and Breast Cancer Mortality: A Population- Based Study
Barron, T. I., Connolly, R. M., Sharp, L., Bennett, K., & Visvanathan, K. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.33.5422 · Cited by 532 · see citing works
Romeo, S., Pennacchio, L. A., Fu, Y., Boerwinkle, E., Tybjaerg-Hansen, A., Hobbs, H. H., & Cohen, J. C. (2007) · Nature Genetics · doi:10.1038/ng1984 · Cited by 511 · see citing works
Inactivating Variants in <i>ANGPTL4</i> and Risk of Coronary Artery Disease
Dewey, F. E., Gusarova, V., O’Dushlaine, C., Gottesman, O., Trejos, J., Hunt, C., Van Hout, C. V., Habegger, L., Buckler, D., Lai, K.-M. V., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1510926 · Cited by 497 · see citing works
Pirzgalska, R. M., Seixas, E., Seidman, J. S., Link, V. M., Martínez‐Sánchez, N., Mahú, I., Mendes, R., Gres, V., Kubasova, N., Morris, I., et al. (2017) · Nature Medicine · doi:10.1038/nm.4422 · Cited by 497 · see citing works
Coding Variation in <i>ANGPTL4,</i> <i>LPL,</i> and <i>SVEP1</i> and the Risk of Coronary Disease
Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1507652 · Cited by 493 · see citing works
Loss of p53 drives neuron reprogramming in head and neck cancer
Amit, M., Takahashi, H., Dragomir, M. P., Lindemann, A., Gleber-Netto, F. O., Pickering, C. R., Anfossi, S., Osman, A. A., Cai, Y., Wang, R., et al. (2020) · Nature · doi:10.1038/s41586-020-1996-3 · Cited by 483 · cited 1× · see citing works
“In patients with oral cancer, nerve density was associated with p53 status, which correlated with poor clinical outcomes [3].”
BackgroundPowe, D. G., Voss, M. J., Zänker, K. S., Habashy, H. O., Green, A. R., Ellis, I. O., & Entschladen, F. (2010) · Oncotarget · doi:10.18632/oncotarget.197 · Cited by 462 · see citing works
Molecular Bases of VEGFR-2-Mediated Physiological Function and Pathological Role
Wang, X., Bove, A. M., Simone, G., & Ma, B. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.599281 · Cited by 461 · see citing works
Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing
Camell, C. D., Sander, J., Spadaro, O., Lee, A., Nguyen, K. Y., Wing, A., Goldberg, E. L., Youm, Y.-H., Brown, C. W., Elsworth, J., et al. (2017) · Nature · doi:10.1038/nature24022 · Cited by 456 · see citing works
Fibrosis-dependent mechanisms of hepatocarcinogenesis
Zhang, D. Y., & Friedman, S. L. (2012) · Hepatology · doi:10.1002/hep.25670 · Cited by 444 · see citing works
Mechanisms of liver fibrosis and its role in liver cancer
Dhar, D., Baglieri, J., Kisseleva, T., & Brenner, D. A. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370219898141 · Cited by 440 · see citing works
Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases
Cao, Y. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3055 · Cited by 437 · see citing works
Relevance of Sympathetic Nervous System Activation in Obesity and Metabolic Syndrome
Thorp, A. A., & Schlaich, M. P. (2015) · Journal of Diabetes Research · doi:10.1155/2015/341583 · Cited by 425 · see citing works
Dulauroy, S., Di Carlo, S. E., Langa, F., Eberl, G., & Peduto, L. (2012) · Nature Medicine · doi:10.1038/nm.2848 · Cited by 418 · see citing works
Sukonina, V., Lõokene, A., Olivecrona, T., & Olivecrona, G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604026103 · Cited by 402 · see citing works
Lung metastasis genes couple breast tumor size and metastatic spread
Minn, A. J., Gupta, G. P., Padua, D., Bos, P., Nguyen, D. X., Nuyten, D., Kreike, B., Zhang, Y., Wang, Y., Ishwaran, H., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701138104 · Cited by 400 · see citing works
Seo, Y., Baba, H., Fukuda, T., Takashima, M., & Sugimachi, K. (2000) · Cancer · doi:10.1002/(sici)1097-0142(20000515)88:10 · Cited by 400 · see citing works
Incio, J., Liu, H., Suboj, P., Chin, S. M., Chen, I. X., Pinter, M., Ng, M., Nia, H., Grahovac, J., Kao, S., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-1177 · Cited by 397 · see citing works
Obesity and hepatocellular carcinoma
Caldwell, S. H., Crespo, D. M., Kang, H. S., & Al‐Osaimi, A. M. S. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.09.021 · Cited by 396 · see citing works
Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome
Bergamaschi, A., Tagliabue, E., Sørlie, T., Naume, B., Triulzi, T., Orlandi, R., Russnes, H., Nesland, J. M., Tammi, R., Auvinen, P., et al. (2007) · The Journal of Pathology · doi:10.1002/path.2278 · Cited by 387 · see citing works
Munsell, M. F., Sprague, B. L., Berry, D. A., Chisholm, G. B., & Trentham‐Dietz, A. (2013) · Epidemiologic Reviews · doi:10.1093/epirev/mxt010 · Cited by 384 · see citing works
Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction
Sun, K., Park, J., Gupta, O. T., Holland, W. L., Auerbach, P., Zhang, N., Goncalves Marangoni, R., Nicoloro, S. M., Czech, M. P., Varga, J., et al. (2014) · Nature Communications · doi:10.1038/ncomms4485 · Cited by 364 · see citing works
Stressful Life Events and Risk of Breast Cancer in 10,808 Women: A Cohort Study
Lillberg, K. (2003) · American Journal of Epidemiology · doi:10.1093/aje/kwg002 · Cited by 360 · see citing works
Vascular Permeability and Drug Delivery in Cancers
Azzi, S., Hebda, J. K., & Gavard, J. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00211 · Cited by 352 · see citing works
Adipocyte-derived endotrophin promotes malignant tumor progression
Park, J., & Scherer, P. E. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63930 · Cited by 350 · see citing works
Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis
Seo, B. R., Bhardwaj, P., Choi, S., Gonzalez, J., Eguiluz, R. C. A., Wang, K., Mohanan, S., Morris, P. G., Du, B., Zhou, X. K., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.3010467 · Cited by 342 · see citing works
A framework for the development of effective anti-metastatic agents
Anderson, R. L., Balasas, T., Callaghan, J., Coombes, R. C., EVANS, J., Hall, J. A., Kinrade, S. A., Jones, D., Jones, P. S., Jones, R. J., et al. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0134-8 · Cited by 341 · see citing works
Adipose Tissue Collagen VI in Obesity
Pasarica, M., Gawrońska‐Kozak, B., Burk, D. H., Remedios, I., Hymel, D., Gimble, J., Ravussin, É., Bray, G. A., & Smith, S. R. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0947 · Cited by 338 · see citing works
Kokolus, K. M., Capitano, M. L., Lee, C.-T., Eng, J. W.-L., Waight, J. D., Hylander, B. L., Sexton, S., Hong, C.-C., Gordon, C. J., Abrams, S. I., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1304291110 · Cited by 335 · see citing works
Association between non-alcoholic fatty liver disease and cancer incidence rate
Kim, G., Lee, H. C., Choe, J., Kim, M.-J., Lee, M. J., Chang, H.-S., Bae, I. Y., Kim, H., An, J., Shim, J. H., et al. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.09.012 · Cited by 330 · see citing works
Cao, Y. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.008 · Cited by 320 · see citing works
Martino, M. M., & Hubbell, J. A. (2010) · The FASEB Journal · doi:10.1096/fj.09-151282 · Cited by 317 · see citing works
Prognostic significance of angiogenesis in human pancreatic cancer
Ikeda, N., Adachi, M., Taki, T., Huang, C., Hashida, H., Takabayashi, A., Sho, M., Nakajima, Y., Kanehiro, H., Hisanaga, M., et al. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690248 · Cited by 315 · see citing works
Norepinephrine-induced migration of SW 480 colon carcinoma cells is inhibited by beta-blockers.
Masur, K., Niggemann, B., Zänker, K. S., & Entschladen, F. (2001) · PubMed · Cited by 308 · see citing works
Reduced sympathetic nervous activity. A potential mechanism predisposing to body weight gain.
Spraul, M., Ravussin, E., Fontvieille, A. M., Rising, R., Larson, D. E., & Anderson, E. A. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116760 · Cited by 293 · see citing works
Kim-Fuchs, C., Le, C. P., Pimentel, M. A., Shackleford, D., Ferrari, D., Angst, E., Hollande, F., & Sloan, E. K. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.02.019 · Cited by 287 · see citing works
Angiogenesis in pancreatic cancer: current research status and clinical implications
Li, S., Xu, H., Wu, C., Wang, W.-Q., Jin, W., Gao, H.-L., Li, H., Zhang, S.-R., Xu, J.-Z., Qi, Z.-H., et al. (2018) · Angiogenesis · doi:10.1007/s10456-018-9645-2 · Cited by 285 · see citing works
Huang, R.-L., Teo, Z., Chong, H. C., Zhu, P., Tan, M., Tan, C. K., Lam, C. R. I., Sng, M. K., Leong, D. T., Tan, S., et al. (2011) · Blood · doi:10.1182/blood-2011-01-328716 · Cited by 284 · see citing works
Shaashua, L., Shabat-Simon, M., Haldar, R., Matzner, P., Zmora, O., Shabtai, M., Sharon, E., Allweis, T. M., Barshack, I., Hayman, L., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-0152 · Cited by 282 · see citing works
Marcelin, G., Ferreira, A. V. M., Liu, Y., Atlan, M., Aron‐Wisnewsky, J., Pelloux, V., Botbol, Y. M., Ambrosini, M., Fradet, M., Rouault, C., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.01.010 · Cited by 280 · see citing works
A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk
Genkinger, J. M., Spiegelman, D. L., Anderson, K. E., Bernstein, L., van den Brandt, P. A., Calle, E. E., English, D. R., Folsom, A. R., Freudenheim, J. L., Fuchs, C. S., et al. (2010) · International Journal of Cancer · doi:10.1002/ijc.25794 · Cited by 279 · see citing works
García, M. R., Steinbauer, B., Srivastava, K., Singhal, M., Mattijssen, F., Maida, A., Christian, S., Hess‐Stumpp, H., Augustin, H. G., Müller‐Decker, K., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.018 · Cited by 276 · see citing works
Self-citationUnraveling the Role of Angiogenesis in Cancer Ecosystems
Zuazo-Gaztelu, I., & Casanovas, O. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00248 · Cited by 275 · see citing works
Deciphering the cellular interplays underlying obesity-induced adipose tissue fibrosis
Marcelin, G., Silveira, A. L. M., Martins, L. B., Ferreira, A. V. M., & Clément, K. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129192 · Cited by 274 · see citing works
Yamauchi, M., Barker, T. H., Gibbons, D. L., & Kurie, J. M. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93554 · Cited by 273 · see citing works
Lichtenstein, L., Mattijssen, F., de Wit, N. J. W., Georgiadi, A., Hooiveld, G. J. E. J., van der Meer, R., He, Y., Qi, L., Koster, A. M., Tamsma, J. T., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.002 · Cited by 269 · see citing works
Itakura, J., Ishiwata, T., Friess, H., Fujii, H., Matsumoto, Y., Büchler, M. W., & Korc, M. (1997) · PubMed · Cited by 268 · see citing works
Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells
Adams, T. E., Alpert, S. D., & Hanahan, D. (1987) · Nature · doi:10.1038/325223a0 · Cited by 266 · see citing works
Strain-Specific Response toβ3-Adrenergic Receptor Agonist Treatment of Diet-Induced Obesity in Mice1
Collins, S., Daniel, K. W., Petro, A. E., & Surwit, R. S. (1997) · Endocrinology · doi:10.1210/endo.138.1.4829 · Cited by 265 · see citing works
Miyazawa-Hoshimoto, S., Takahashi, K., Bujo, H., Hashimoto, N., & Saito, Y. (2003) · Diabetologia · doi:10.1007/s00125-003-1221-6 · Cited by 254 · see citing works
Galaup, A., Cazes, A., Jan, S. L., Philippe, J., Connault, E., Coz, E. L., Mekid, H., Mir, L. M., Opolon, P., Corvol, P. L., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609025103 · Cited by 252 · see citing works
Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patients
Lutgendorf, S. K., DeGeest, K., Dahmoush, L., Farley, D. B., Penedo, F. J., Bender, D., Goodheart, M. J., Buekers, T., Méndez, L., Krueger, G., et al. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.10.012 · Cited by 242 · see citing works
Local proliferation of macrophages in adipose tissue during obesity-induced inflammation
Haase, J., Weyer, U., Immig, K., Klöting, N., Blüher, M., Eilers, J., Bechmann, I., & Gericke, M. T. (2013) · Diabetologia · doi:10.1007/s00125-013-3139-y · Cited by 237 · see citing works
Leptin signaling in breast cancer: An overview
Cirillo, D., Rachiglio, A. M., Montagna, R. L., Giordano, A., & Normanno, N. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21911 · Cited by 236 · see citing works
Angiogenesis and development of adipose tissue
Christiaens, V., & LIJNEN, H. R. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.08.006 · Cited by 234 · see citing works
Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma
Paňková, D., Chen, Y., Terajima, M., Schliekelman, M. J., Baird, B. N., Fahrenholtz, M. M., Sun, L., Gill, B. J., Vadakkan, T. J., Kim, M. P., et al. (2015) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-15-0307 · Cited by 233 · see citing works
Sympathetic nervous system in obesity-related hypertension: mechanisms and clinical implications
Kalil, G. Z., & Haynes, W. G. (2011) · Hypertension Research · doi:10.1038/hr.2011.173 · Cited by 228 · see citing works
Incio, J., Ligibel, J. A., McManus, D. T., Suboj, P., Jung, K., Kawaguchi, K., Pinter, M., Babykutty, S., Chin, S. M., Vardam, T. D., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aag0945 · Cited by 222 · see citing works
Heikkilä, K., Nyberg, S. T., Theorell, T., Fransson, E. I., Alfredsson, L. S., Bjørner, J. B., Bonenfant, S., Borritz, M., Bouillon, K., Burr, H., et al. (2013) · BMJ · doi:10.1136/bmj.f165 · Cited by 219 · see citing works
Prevention of liver cancer cachexia-induced cardiac wasting and heart failure
Springer, J., Tschirner, A., Haghikia, A., von Haehling, S., Lal, H., Grzesiak, A., Kaschina, E., Palus, S., Poetsch, M. S., von Websky, K., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht302 · Cited by 211 · see citing works
Teixeira, A. F., ten Dijke, P., & Zhu, H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00605 · Cited by 210 · see citing works
Lv, M., Zhu, X., Wang, H., Wang, F., & Guan, W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115147 · Cited by 209 · see citing works
Hermes, G. L., Delgado, B., Tretiakova, M., Cavigelli, S. A., Krausz, T., Conzen, S. D., & McClintock, M. K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910753106 · Cited by 207 · see citing works
Schoenleber, S. J., Kurtz, D. M., Talwalkar, J. A., Roberts, L. R., & Gores, G. J. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6605017 · Cited by 207 · see citing works
Intentional weight loss and incidence of obesity-related cancers: the Iowa Women's Health Study
Parker, E. D., & Folsom, A. R. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802437 · Cited by 203 · see citing works
The origin and definition of brite versus white and classical brown adipocytes
Rosenwald, M., & Wolfrum, C. (2013) · Adipocyte · doi:10.4161/adip.26232 · Cited by 200 · see citing works
Dumont, N., Liu, B., DeFilippis, R. A., Chang, H., Rabban, J. T., Karnezis, A. N., Tjoe, J. A., Marx, J., Parvin, B., & Tlsty, T. D. (2013) · Neoplasia · doi:10.1593/neo.121950 · Cited by 192 · see citing works
Nonalcoholic Fatty Liver Disease Is Related to Nonalcoholic Fatty Pancreas Disease
van Geenen, E.-J. M., Smits, M. M., Schreuder, T. C. M. A., van der Peet, D. L., Bloemena, E., & Mulder, C. J. J. (2010) · Pancreas · doi:10.1097/mpa.0b013e3181f6fce2 · Cited by 188 · see citing works
A compact VEGF signature associated with distant metastases and poor outcomes
Hu, Z., Fan, C., Livasy, C., He, X., Oh, D. S., Ewend, M. G., Carey, L., Subramanian, S., West, R. B., Ikpatt, F., et al. (2009) · BMC Medicine · doi:10.1186/1741-7015-7-9 · Cited by 185 · see citing works
The microcirculation: a key player in obesity-associated cardiovascular disease
Sorop, O., Olver, T. D., van de Wouw, J., HEINONEN, I. H. A., van Duin, R. W. B., Duncker, D. J., & Merkus, D. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx093 · Cited by 174 · see citing works
Obesity, the sympathetic nervous system, and essential hypertension.
Tuck, M. L. (1992) · Hypertension · doi:10.1161/01.hyp.19.1_suppl.i67 · Cited by 171 · see citing works
Vila, I. K., Badin, P.-M., Marques, M.-A., Monbrun, L., Lefort, C., Mir, L., Louche, K., Bourlier, V., Roussel, B., Gui, P., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.062 · Cited by 165 · see citing works
Multiple lipolysis defects in the insulin resistance (metabolic) syndrome.
Reynisdottir, S., Ellerfeldt, K., Wahrenberg, H., Lithell, H., & Arner, P. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117271 · Cited by 164 · see citing works
PDGFRα signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity
Iwayama, T., Steele, C., Yao, L., Dozmorov, M. G., Karamichos, D., Wren, J. D., & Olson, L. E. (2015) · Genes & Development · doi:10.1101/gad.260554.115 · Cited by 164 · see citing works
Shao, M., Vishvanath, L., Busbuso, N. C., Hepler, C., Shan, B., Sharma, A. X., Chen, S., Yu, X., An, Y., Zhu, Y. Z., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03196-x · Cited by 163 · see citing works
Oligomerization and Regulated Proteolytic Processing of Angiopoietin-like Protein 4
Ge, H., Yang, G., Huang, L., Motola, D., Pourbahrami, T., & Li, C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307583200 · Cited by 156 · see citing works
Norepinephrine-induced invasion by pancreatic cancer cells is inhibited by propranolol
Ma (2009) · Oncology Reports · doi:10.3892/or_00000505 · Cited by 153 · see citing works
Rohm, M., Schäfer, M., Laurent, V., Üstünel, B. E., Niopek, K., Algire, C., Hautzinger, O., Sijmonsma, T., Zota, A., Medříková, D., et al. (2016) · Nature Medicine · doi:10.1038/nm.4171 · Cited by 153 · see citing works
Self-citationLachowski, D., Cortés, E., Rice, A. J., Pinato, D. J., Rombouts, K., & Hernández, A. E. D. R. (2019) · Scientific Reports · doi:10.1038/s41598-019-43759-6 · Cited by 151 · see citing works
Hu, K., Babapoor-Farrokhran, S., Rodrigues, M. W., Deshpande, M. M., Puchner, B., Kashiwabuchi, F., Hassan, S. J., Asnaghi, L., Handa, J. T., Merbs, S. L., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.6868 · Cited by 150 · see citing works
Mowers, J. C., Uhm, M., Reilly, S. M., Simon, J., Leto, D. E., Chiang, S.-H., Chang, L. C., & Saltiel, A. R. (2013) · eLife · doi:10.7554/elife.01119 · Cited by 149 · see citing works
Role and mechanism of the action of angiopoietin-like protein ANGPTL4 in plasma lipid metabolism
Kersten, S. (2021) · Journal of Lipid Research · doi:10.1016/j.jlr.2021.100150 · Cited by 146 · see citing works
Angiopoietin-like 4 Interacts with Matrix Proteins to Modulate Wound Healing*
Goh, Y. Y., Pal, M., Chong, H. C., Zhu, P., Tan, M., Punugu, L., Tan, C. K., Huang, R.-L., Sze, S. K., Tang, M. B. Y., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.108175 · Cited by 145 · see citing works
Work Stress and the Risk of Cancer: A Meta-Analysis of Observational Studies
Yang, T., Qiao, Y., Xiang, S., Li, W., Gan, Y., & Chen, Y. (2019) · International Journal of Cancer · doi:10.1002/ijc.31955 · Cited by 145 · see citing works
Genetic Variation in ANGPTL4 Provides Insights into Protein Processing and Function
Wu, Y., Romeo, S., Chang, S., Grishin, N. V., Hobbs, H. H., & Cohen, J. C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900553200 · Cited by 140 · see citing works
Tamoxifen inhibits secretion of vascular endothelial growth factor in breast cancer in vivo.
Garvin, S., & Dabrosin, C. (2003) · PubMed · Cited by 136 · see citing works
Lenvatinib May Drastically Change the Treatment Landscape of Hepatocellular Carcinoma
Kudo, M. (2018) · Liver Cancer · doi:10.1159/000487148 · Cited by 134 · see citing works
β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity
Valentine, J. M., Ahmadian, M., Keinan, O., Abu-Odeh, M., Zhao, P., Zhou, X., Keller, M. P., Gao, H., Yu, R. T., Liddle, C., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci153357 · Cited by 134 · see citing works
Partecke, L. I., Speerforck, S., Käding, A., Seubert, F., Kühn, S., Lorenz, E., Schwandke, S., Sendler, M., Keßler, W., Trung, D. N., et al. (2016) · Pancreatology · doi:10.1016/j.pan.2016.03.005 · Cited by 132 · see citing works
Xu, M., Jung, X., Hines, O. J., Eibl, G., & Chen, Y. (2018) · Pancreas · doi:10.1097/mpa.0000000000000974 · Cited by 131 · see citing works
Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis
Aryal, B. K., Singh, A. K., Zhang, X., Varela, L., Rotllán, N., Goedeke, L., Chaube, B., Camporez, J. P., Vatner, D. F., Horváth, T. L., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.97918 · Cited by 131 · see citing works
Sympathetic Neural Overdrive in the Obese and Overweight State
Grassi, G. M., Biffi, A., Seravalle, G., Trevano, F. Q., Dell’Oro, R., Corrao, G., & Mancia, G. (2019) · Hypertension · doi:10.1161/hypertensionaha.119.12885 · Cited by 131 · see citing works
Loft, A., Alfaro, A. J., Schmidt, S. F., Pedersen, F. B., Terkelsen, M. K., Puglia, M., Chow, K. K., Feuchtinger, A., Troullinaki, M., Maida, A., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.06.005 · Cited by 129 · see citing works
Self-citationβ-Adrenergic Signaling Impairs Antitumor CD8+ T-cell Responses to B-cell Lymphoma Immunotherapy
Nissen, M. D., Sloan, E. K., & Mattarollo, S. R. (2017) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-17-0401 · Cited by 125 · see citing works
Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4
Kolb, R. H., Kluz, P., Tan, Z. W., Borcherding, N. C., Bormann, N. L., Vishwakarma, A., Balcziak, L. K., Zhu, P., Davies, B. S. J., Gourronc, F. A., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0592-6 · Cited by 123 · see citing works
Haldar, R., Ricon‐Becker, I., Radin, A., Gutman, M., Cole, S. W., Zmora, O., & Ben‐Eliyahu, S. (2020) · Cancer · doi:10.1002/cncr.32950 · Cited by 122 · see citing works
Montoya, A., Amaya, C. N., Belmont, A., Diab, N., Trevino, R., Villanueva, G., Rains, S., Sanchez, L. A., Badri, N., Otoukesh, S., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.14119 · Cited by 122 · see citing works
Bergö, M. O., Olivecrona, G., & Olivecrona, T. (1996) · Biochemical Journal · doi:10.1042/bj3130893 · Cited by 121 · see citing works
Moretti, S., Massi, D., Farini, V., Baroni, G., Parri, M., Innocenti, S., Cecchi, R., & Chiarugi, P. (2013) · Laboratory Investigation · doi:10.1038/labinvest.2012.175 · Cited by 117 · see citing works
Bäckhed, F., Crawford, P. A., O’Donnell, D., & Gordon, J. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605957104 · Cited by 117 · see citing works
Beta-Blocker Drug Use and Survival among Patients with Pancreatic Adenocarcinoma
Udumyan, R., Montgomery, S., Fang, F., Almroth, H., Valdimarsdóttir, U. A., Ekbom, A., Smedby, K. E. E., & Fall, K. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0108 · Cited by 117 · see citing works
Chang, A., Le, C. P., Walker, A. K., Creed, S. J., Pon, C. K., Albold, S., Carroll, D., Halls, M. L., Lane, J. R., Riedel, B., et al. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.06.011 · Cited by 115 · see citing works
Singh, A. K., Chaube, B., Zhang, X., Sun, J., Citrin, K. M., Canfrán-Duque, A., Aryal, B., Rotllan, N., Varela, L., Lee, R. G., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci140989 · Cited by 115 · see citing works
Kirby, M. K., Ramaker, R. C., Gertz, J., Davis, N. S., Johnston, B. E., Oliver, P. G., Sexton, K. C., Greeno, E. W., Christein, J. D., Heslin, M. J., et al. (2016) · Molecular Oncology · doi:10.1016/j.molonc.2016.05.004 · Cited by 110 · see citing works
Gruber, T., Pan, C., Contreras, R. E., Wiedemann, T., Morgan, D. A., Skowronski, A. A., Lefort, S., Murat, C. D. B., Thuc, O. L., Legutko, B., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.04.007 · Cited by 110 · see citing works
Zhang, D., Ma, Q., Wang, Z., Zhang, M., Guo, K., Wang, F., & Wu, E. (2011) · Molecular Cancer · doi:10.1186/1476-4598-10-146 · Cited by 106 · see citing works
Degradation of soluble VEGF receptor-1 by MMP-7 allows VEGF access to endothelial cells
Ito, T. K., Ishii, G., Saito, S., Yano, K., Hoshino, A., Suzuki, T., & Ochiai, A. (2008) · Blood · doi:10.1182/blood-2008-08-172742 · Cited by 106 · see citing works
Feng, Y., Wang, T., Deng, Y., et al. (2010) · Hepatology · doi:10.1002/hep.24075 · Cited by 106 · see citing works
Cardiotoxicity: Cisplatin and long-term cancer survivors
Patanè, S. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.04.238 · Cited by 102 · see citing works
Schoemaker, M. J., Jones, M. E., Wright, L. B., Griffin, J. M., McFadden, E. C., Ashworth, A., & Swerdlow, A. J. (2016) · Breast Cancer Research · doi:10.1186/s13058-016-0733-1 · Cited by 98 · see citing works
Janssen, A. W. F., Katiraei, S., Bartosinska, B., Eberhard, D., Willems van Dijk, K., & Kersten, S. (2018) · Diabetologia · doi:10.1007/s00125-018-4583-5 · Cited by 96 · see citing works
Nagaraja, A. S., Dorniak, P. L., Sadaoui, N. C., Kang, Y., Lin, T., Armaiz-Peña, G. N., Wu, S. Y., Rupaimoole, R., Allen, J. K., Gharpure, K. M., et al. (2015) · Oncogene · doi:10.1038/onc.2015.302 · Cited by 95 · see citing works
The stress hormone norepinephrine increases migration of prostate cancer cells in vitro and in vivo
Barbieri, A., Bimonte, S., Palma, G., Luciano, A., Rea, D., Giudice, A., Scognamiglio, G., Mantia, E. L., Franco, R., Perdonà, S., et al. (2015) · International Journal of Oncology · doi:10.3892/ijo.2015.3038 · Cited by 94 · see citing works
TGF-β-induced differentiation into myofibroblasts involves specific regulation of two MKL1 isoforms
Scharenberg, M. A., Pippenger, B. E., Sack, R., Zingg, D., Ferralli, J., Schenk, S., Martín, I., & Chiquet‐Ehrismann, R. (2014) · Journal of Cell Science · doi:10.1242/jcs.142075 · Cited by 93 · see citing works
Springer, N. L., Iyengar, N. M., Bareja, R., Verma, A., Jochelson, M. S., Giri, D. D., Zhou, X. K., Elemento, O., Dannenberg, A. J., & Fischbach, C. (2019) · American Journal Of Pathology · doi:10.1016/j.ajpath.2019.06.005 · Cited by 92 · see citing works
Loebig, M., Klement, J., Schmoller, A., Betz, S., Heuck, N., Schweiger, U., Peters, A., Schultes, B., & Oltmanns, K. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012610 · Cited by 91 · see citing works
β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity
Valentine, J. M., Ahmadian, M., Keinan, O., Abu-Odeh, M., Zhao, P., Zhou, X., Keller, M. P., Gao, H., Yu, R. T., Liddle, C., et al. (2022) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 89 · see citing works
Regulation of cell proliferation by β-adrenergjc receptors in a human lung adenocarcinoma cell line
Schuller, H. M., & Cole, B. N. (1989) · Carcinogenesis · doi:10.1093/carcin/10.9.1753 · Cited by 86 · see citing works
Antiproliferative effects of β-blockers on human colorectal cancer cells
Coelho, M., MOZ, M., Correia, G., TEIXEIRA, A., MEDEIROS, R., & Ribeiro, L. V. P. T. (2015) · Oncology Reports · doi:10.3892/or.2015.3874 · Cited by 85 · see citing works
Daly, C. J., & McGrath, J. C. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.02.008 · Cited by 84 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Obesity: pathophysiology and therapeutic interventions
Kong, Y., Yang, H., Nie, R., Zhang, X., Zuo, F., Zhang, H., & Nian, X. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00264-9 · Cited by 89 · see citing works
A deep-learning framework reveals whole-body perturbations at cell level
Kaltenecker, D., Horvath, I., Al-Maskari, R., Chen, Y., Kolabas, Z. I., Hoeher, L., Todorov, M., Minde, D.-P., Kapoor, S., Turhan, S. G., et al. (2026) · Nature · doi:10.1038/s41586-026-10535-2 · Cited by 5 · see citing works
Self-citation
- Authors
- Pellegata, N. S., Berriel Diaz, M., Rohm, M., & Herzig, S.
- Affiliations
- University Hospital Heidelberg (DE)
- Corresponding author
- Herzig, Stephan
- Venue
- Cancer and Metastasis Reviews
- Published
- 2022-09
- Volume
- 41
- Issue
- 3
- Pages
- 517-547
- ISSN
- 0167-7659 (ISSN-L)
- 1573-7233
- PMC
- PMC9470659
- OpenAlex
- W4294992477
- Cited by
- 33
- References
- 266
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 6 · 2023: 12
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Cancer and Metastasis Reviews (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion, other-oa)
- Site cant be reached (submittedVersion, cc-by)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- Funders
- Deutsche Krebshilfe (70115158)
- H2020 European Research Council (949017)
- Helmholtz Association (Initiative, Networking Fund)
- European Foundation for the Study of Diabetes
- Helmholtz Future Topic Aging and Metabolic Programming (AMPro, ZT-0026)
- Else-Kröner-Fresenius-Stiftung (2020 EKSE.23)
- Edith-Haberland-Wagner Stiftung
- DFG (CRC/Transregio 205/2 314061271)
- Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- obesity, cancer, extracellular matrix remodeling, angiogenesis, adrenergic signaling, obesity-related cancer risk, liver cancer, pancreatic cancer, breast cancer, inflammation, hyperinsulinemia, adipose tissue dysfunction, tumor progression
- MeSH terms
- Adipose Tissue, Extracellular Matrix, Humans, Neoplasms, Obesity, Adrenergic Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
