Circular RNAs: analysis, expression and potential functions

Barrett, Steven P.; Salzman, Julia

doi:10.1242/dev.128074

Cited by 885Circular RNAs in diseasesRNA Research and SplicingCancer-related molecular mechanisms research

Circular RNAs: analysis, expression and potential functions

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Barrett, Steven P., Salzman, Julia·2016·Development

DOI 10.1242/dev.128074PMC PMC4920157

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Abstract

Just a few years ago, it had been assumed that the dominant RNA isoforms produced from eukaryotic genes were variants of messenger RNA, functioning as intermediates in gene expression. In early 2012, however, a surprising discovery was made: circular RNA (circRNA) was shown to be a transcriptional product in thousands of human and mouse genes and in hundreds of cases constituted the dominant RNA isoform. Subsequent studies revealed that the expression of circRNAs is developmentally regulated, tissue and cell-type specific, and shared across the eukaryotic tree of life. These features suggest important functions for these molecules. Here, we describe major advances in the field of circRNA biology, focusing on the regulation of and functional roles played by these molecules.

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Modulation of MRE load with competing endogenous RNAs such as circular RNAs can sequester miRISC from target mRNA, leading to derepression of target mRNA.
“In this way, modulation of MRE load with competing endogenous RNAs (ceRNAs), such as with circular RNAs (circRNAs) (96), can act to sequester miRISC from target mRNA, leading to derepression of target mRNA (97).”
From Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018) · cites this paper as [96]

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Authors: Barrett, S. P., & Salzman, J.
Affiliations: Stanford Medicine (US)
Corresponding author: Salzman, Julia
ORCID: Barrett, Steven P.
Salzman, Julia
Venue: Development
Publisher: The Company of Biologists
Published: 2016-06-01
Volume: 143
Issue: 11
Pages: 1838-1847
ISSN: 0950-1991 (ISSN-L)
1477-9129
DOI: 10.1242/dev.128074
PMC: PMC4920157
OpenAlex: W2409907752
Cited by: 859
References: 67
Citations by year: 2026: 16 · 2025: 34 · 2024: 63 · 2023: 82 · 2022: 123 · 2021: 145 · 2020: 170 · 2019: 109 · 2018: 79 · 2017: 30 · 2016: 7
FWCI: 6.77
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.biologists.com/user-licence-1-1 (vor, 183 d)
Locations: Development (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: National Cancer Institute (R00CA168987)
National Institute of General Medical Sciences (R01GM116847)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords: circular RNA, circRNA expression, circRNA biogenesis, circRNA function, developmental regulation, tissue-specific gene expression, cell type specificity, eukaryotic evolution, RNA isoforms, gene expression regulation
MeSH terms: RNA, Circular, Animals, Gene Expression Regulation, Humans, Models, Genetic, RNA, RNA Splicing, Computational Biology

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Circular RNAs: analysis, expression and potential functions

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