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Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination
Open accessAbstract
Although mammalian long non-coding (lnc)RNAs are best known for modulating transcription, their post-transcriptional influence on mRNA splicing, stability and translation is emerging. Here we report a post-translational function for the lncRNA HOTAIR as an inducer of ubiquitin-mediated proteolysis. HOTAIR associates with E3 ubiquitin ligases bearing RNA-binding domains, Dzip3 and Mex3b, as well as with their respective ubiquitination substrates, Ataxin-1 and Snurportin-1. In this manner, HOTAIR facilitates the ubiquitination of Ataxin-1 by Dzip3 and Snurportin-1 by Mex3b in cells and in vitro, and accelerates their degradation. HOTAIR levels are highly upregulated in senescent cells, causing rapid decay of targets Ataxin-1 and Snurportin-1, and preventing premature senescence. These results uncover a role for a lncRNA, HOTAIR, as a platform for protein ubiquitination. The long non-coding RNA HOTAIR acts as a scaffold to bring together chromatin silencing complexes in the nucleus. Here, the authors show that HOTAIRalso serves as a scaffold between E3 ubiquitin ligases and their substrates and thereby enhances their ubiquitination.
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Self-citation
Metadata
- Authors
- Yoon, J.-H., Abdelmohsen, K., Kim, J., Yang, X., Martindale, J. L., Tominaga-Yamanaka, K., White, E. J., Orjalo, A. V., Rinn, J. L., Kreft, S. G., Wilson, G. M., & Gorospe, M.
- Venue
- Nature Communications
- Published
- 2013-12-11
- Volume
- 4
- Issue
- 1
- Pages
- 2939-2939
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2082268152
- Cited by
- 458
- References
- 38
- FWCI
- 9.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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