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Cited by 388

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor

Open access
Lu, Lu, Liu, Qi, Zhu, Yun, Chan, Kwok-Hung, Qin, Lili, Li, Yuan, Wang, Qian, Chan, Jasper Fuk-Woo, Du, Lanying, Yu, Fei, Ma, Cuiqing, Ye, Sheng, Yuen, Kwok-Yung, Zhang, Rongguang, Jiang, Shibo·2014·Nature Communications
DOI 10.1038/ncomms4067
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Abstract

A novel human coronavirus, Middle East respiratory syndrome coronavirus (MERS-CoV), has caused outbreaks of a SARS-like illness with high case fatality rate. The reports of its person-to-person transmission through close contacts have raised a global concern about its pandemic potential. Here we characterize the six-helix bundle fusion core structure of MERS-CoV spike protein S2 subunit by X-ray crystallography and biophysical analysis. We find that two peptides, HR1P and HR2P, spanning residues 998–1039 in HR1 and 1251–1286 in HR2 domains, respectively, can form a stable six-helix bundle fusion core structure, suggesting that MERS-CoV enters into the host cell mainly through membrane fusion mechanism. HR2P can effectively inhibit MERS-CoV replication and its spike protein-mediated cell–cell fusion. Introduction of hydrophilic residues into HR2P results in significant improvement of its stability, solubility and antiviral activity. Therefore, the HR2P analogues have good potential to be further developed into effective viral fusion inhibitors for treating MERS-CoV infection. MERS-CoV is a novel human coronavirus that has recently caused outbreaks of respiratory illness with high case fatality rate. Here the authors characterize the membrane fusion apparatus of MERS-CoV and develop a peptide that can inhibit virus fusion and replication in vitro.

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Metadata

Authors
Lu, L., Liu, Q., Zhu, Y., Chan, K.-H., Qin, L., Li, Y., Wang, Q., Chan, J. F.-W., Du, L., Yu, F., Ma, C., Ye, S., Yuen, K.-Y., Zhang, R., & Jiang, S.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2014-01-28
Volume
5
Issue
1
Pages
3067-3067
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/ncomms4067
OpenAlex
W1993374993
Cited by
388
References
58
FWCI
19.04
Type
journal article
Language
en
Open access
bronze

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