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Cited by 5,735

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

Open access
Zaki, Ali M., van Boheemen, Sander, Bestebroer, Theo M., Osterhaus, Albert D.M.E., Fouchier, Ron A.M.·2012·New England Journal of Medicine

Abstract

A previously unknown coronavirus was isolated from the sputum of a 60-year-old man who presented with acute pneumonia and subsequent renal failure with a fatal outcome in Saudi Arabia. The virus (called HCoV-EMC) replicated readily in cell culture, producing cytopathic effects of rounding, detachment, and syncytium formation. The virus represents a novel betacoronavirus species. The closest known relatives are bat coronaviruses HKU4 and HKU5. Here, the clinical data, virus isolation, and molecular identification are presented. The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.

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Crossref · 10.1056/nejmoa1211721

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Metadata

Authors
Zaki, A. M., van Boheemen, S., Bestebroer, T. M., Osterhaus, A. D. M. E., & Fouchier, R. A. M.
Venue
New England Journal of Medicine
Published
2012-11-08
Volume
367
Issue
19
Pages
1814-1820
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W2166867592
Cited by
5,735
References
1
FWCI
160.27
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia. https://app.cochat.ai/papers/10.1056/nejmoa1211721
The paper
Zaki, A. M., van Boheemen, S., Bestebroer, T. M., Osterhaus, A. D. M. E., & Fouchier, R. A. M. (2012). Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1211721

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.